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| 1 | A rat model of bone cancer pain显示文摘 | S.J Medhurst K Walker M Bowes B.L Kidd M Glatt M Muller M Hattenberger J Vaxelaire T O’Reilly G Wotherspoon J Winter J Green L Urban | 2002 | Pain2002，，： | 2 |
| 2 | Biomarker-guided sequential targeted therapies to overcome therapy resistance in rapidly evolving highly aggressive mammary tumors显示文摘组合指向的治疗在由堵住治疗癌症是更有效的绕过机制或导致的合成致命性。然而,他们的临床的申请被抵抗和毒性妨碍。遇见这重要挑战,我们用 ErbB2-overexpressing/PTEN-low 开发了并且测试各种各样的指向的治疗的指导 biomarker 的顺序的应用程序的一个新奇概念,高度好攻击的乳癌作为我们的模型。惊人地,从遗传上设计的鼠标与 intratumoral 异质从病人和乳房的肿瘤在两 PTEN-low/trastuzumab-resistant 乳癌支撑了 ErbB2 和下游的小径驱动器 trastuzumab 抵抗的激活。尽管 lapatinib 开始禁止了 trastuzumab 抵抗的鼠标肿瘤,肿瘤由激活表明由量的蛋白质数组出现的网络的 PI3K/mTOR 绕过抑制。有趣地,小径也是的 mTOR 的激活在 neoadjuvant 观察了表明 lapatinib 抵抗的对待 lapatinib 的病人。Trastuzumab + lapatinib 抵抗被一个 PI3K/mTOR 双 kinase 禁止者(BEZ235 ) 的顺序的申请有效地没有重要毒性克服。然而,我们的 p-RTK 数组分析证明 BEZ235 治疗在遗传上设计的老鼠肿瘤导致了增加的 ErbB2 表示和 phosphorylation,导致 BEZ235 抵抗并且在 3-D,然而并非 2-D,文化。机械学地,我们作为 BEZ235 抵抗的新奇机制识别了 ErbB2 蛋白质稳定和激活,它被随后的治疗与 lapatinib + BEZ235 联合颠倒。显著地, biomarker 指导的指向的治疗的这个顺序的应用程序在很快发展加倍的抵抗的肿瘤改变忍受极其好攻击的肿瘤的鼠标的寿命。使用的这条根本上新奇的途径有效地在一个顺序的顺序罐头指向了治疗目标和改编在在治疗期间发展抵抗的癌症的发信号的网络。 | Ozgur Sahin Qingfei Wang Samuel W Brady Kenneth Ellis Hai Wang Chia-Chi Chang Qingling Zhang Preety Priya Rui Zhu Stephen T Wong Melissa D Landis William J Muller Francisco J Esteva Jenny Chang Dihua Yu | 2014 | Cell Research2014，24，5： | 2 |
| 3 | Estimation of total PSA with a supersensitive PSA-assay during neo-adjuvant chemotherapy of prostate cancer before radical resection of prostate显示文摘 | Spitz J Enzmann T Muller W | 1999 | Anticancer Res1999，19，3： | 1 |
| 4 | Hydrothermal ablation-a new simple method for coagulating endometrium in patients with therapy resistant recurring hypermenorrhea显示文摘 | Romer T Muller J Foth D | 2000 | Contrib Gynecol Obstet2000，20，： | 1 |
| 5 | Jasmonic acid is a signal transducer in elicitor-induced plant cell cultures 显示文摘 | GUNDLACH H MULLER M J KUTCHAN T M | 1992 | Proc Natl Acad Sci USA1992，89，： | 1 |
| 6 | Estimation of total PSA with a supersensitive PSA - assay during neo - adjuvant chemo therapy of prostate cancer before radical resection of prostate 显示文摘 | SPITZ J ENZMANN T MULLER W | 1999 | Anticancer Res1999，19，4： | 1 |
| 7 | Jasmonic acid is a signal transducer in elicitor-induced plant cell cultures 显示文摘 | Gundlach H Muller M J Kutchan T M | 1992 | Proc Natl Acad Sci USA1992，89，： | 1 |
| 8 | In vivo confocal microscopy after herpes keratitis 显示文摘 | ROSENBERG M E TERVO T M T MULLER L J | 2002 | Cornea2002，21，3： | 1 |
| 9 | Automated urban area building extraction from high resolution stereo imagery显示文摘 | Kim T Muller J | | 0，，02： | 1 |
| 10 | Conductance of a Molecular Junction 显示文摘 | Reed M A Zhou C Muller C J Burgin T P Tour J M | 1997 | Science1997，278，： | 1 |
| 11 | A nitrile hydratase in the eukaryote Monosiga brevicollis 显示文摘 | Foerstner KU Doerks T Muller J | 2008 | PLoS One2008，3，12： | 1 |
| 12 | Endogenous sex hormone and cardiovascular disease in men显示文摘 | Muller M VandeSehouw Y T Thijssen J H H | 2003 | Clin Endoerinol Metab2003，88，11： | 1 |
| 13 | Effect of anaesthesia on the cytokine responses to abdominal surgery 显示文摘 | CROZIER T A MULLER J E QUITTKAT D | 1994 | Br J Anaesth1994，72，3： | 1 |
| 14 | Genome wide association (GWA) study for early onset extreme obesity supports the role of fat mass and obesity associated gene (FTO) variants显示文摘 | Hinney A Nguyen T T Scherag A Friedel S Bronner G Muller T D Grallert H Illig T Wichmann H E Rief W Schafer H and Hebebrand J | | 0，，12： | 1 |
| 15 | Function of human WIPI proteins in autophagosomal rejuvenation of endomembranes? 显示文摘 | Muller A J Proikas-Cezanne T | 2015 | FEBS Lett2015，589，14： | 1 |
| 16 | Photodynamic therapy:a novel treatment for primary brain malignancy显示文摘 | Muller P J | 2002 | Neurosci Nurs2002，33，6： | 1 |
| 17 | Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease显示文摘 | KRUGER R KUHN W MULLER T WOITALLA D GRAEBER M KOSEL S PRZUNTEK H EPPLEN J T SCHOLS L RIESS O | 1998 | Nature Genetics1998，18，2： | 1 |
| 18 | Estimation of toal PSA with a Supersensitive PSA-assay during neo-adjuvant-chemotherapy of prostate cancer before radical resection of prostate显示文摘 | Spitz J Enzmann T Muller W | 1999 | Anticancer Research1999，19，4： | 1 |
| 19 | The internal transcribed spacer 2database-a web server for(not only)low level phylogenetic analyses显示文摘 | Schultz J Muller T Achtziger M | | 0，，： | 1 |
| 20 | An- tagonistic fungal interactions influence carbon dioxide evolution from decomposing wood显示文摘 | Hiscox J Savoury M Vaughan I P Muller C T Boddy L | 2015 | Fungal Ecology2015，14，： | 1 |
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