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| 1 | Significance of scintigraphy for the localisation of obscure gastrointestinal bleedings显示文摘AIM: To determine the role of scintigraphy in patients with gastrointestinal (GI) bleeding of unknown localisation. METHODS: We performed retrospective analyses on 92 patients receiving scintigraphies from 1993 to 2000 in the University of Regensburg hospital, which were done for localisation of GI bleeding as a diagnostic step after an unsuccessful endoscopy. In addition to the scintigraphies, further diagnostic steps such as endoscopy, angiography or operations were performed. In some of the scintigraphies with negative results, a provocation test for bleeding with heparinisation was carried out. RESULTS: 73% of all scintigraphies showed a positive result. In 4.5% of the positive results, the source was located in the stomach, in 37% the source was the small bowel, in 25% the source was the right colon, in 4.5% the source was the left colon, and in 20% no clear localisation was possible. Only 4% of all scintigraphies were false positive. A reliablepositive scintigraphy was independent of the age of the examined patient. A provocation test for bleeding with heparin resulted in an additional 46% of positive scintigraphies with a reliable localisation in primary negative scintigraphies. CONCLUSION: Our results show that scintigraphy and scintigraphy with heparin provocation tests are reliable procedures. They enable a reliable localisation in about half of the obscure GI-bleeding cases. Scintigraphy is superior to angiography in locating a bleeding. It is shown that even in the age of video capsule endoscopy and double-balloon enteroscopy, scintigraphy provides a reliable and directed localization of GI bleeding and offers carefully targeted guidance for other procedures. | Tanja Brünnler Frank Klebl Sascha Mundorff Christoph Eilles Michael Reng Hans von Korn Jürgen Schlmerich Julia Langgartner Stefan Grüne | 2008 | World Journal of Gastroenterology2008，14，32： | 3 |
| 2 | Evolutionary potential of (a/b)8-barrels: functional promiscuity produced by single substitutions in the enolase superfamily 显示文摘 | Schmidt D M Z Mundorff E C Dojka M | 2003 | Biochemistry2003，42，28： | 1 |
| 3 | Improving catalytic function by ProSAR-driven enzyme evolution 显示文摘 | FOX R DAVIS C MUNDORFF E | 2007 | Nat Biotech2007，25，3： | 1 |
| 4 | Improving catalytic function by ProSAR-driven enzyme evolution显示文摘 | Fox R J Davis C S Mundorff E C | 2007 | Nat Biotechnol2007，25，3： | 1 |
| 5 | Biocatalytic asymmetric synthesit of chlral amines from ketones applied to sitagliptin manufacture显示文摘 | Savile CK Janey JM Mundorff EC | 2010 | Science2010，329，5989： | 1 |
| 6 | Biocatalytic asymmetric synthesis of chiral amines from ketones applied to sitagliptin manufacture 显示文摘 | Savile CK Janey JM Mundorff EC | 2010 | Science2010，329，5989： | 1 |
| 7 | Improving catalytic function by ProSAR -driven enzyme evolution显示文摘 | Fox R J Davis S C Mundorff E C | 2007 | Nature Bio- technology2007，25，3： | 1 |
| 8 | Biocatalytic asymmetric synthesis of chiral amines from ketones applied to sitagliptin manufacture显示文摘 | SAVILE C K JANEY J M MUNDORFF E C | 2010 | Science2010，329，5989： | 1 |
| 9 | Improving catalytic function by ProSAR driven enzyme evolution 显示文摘 | Richard J F Christopher D Mundorff E C | 2007 | Nature Biotechnology2007，25，： | 1 |
| 10 | Decreasing hospital length of stay for bronchiolitis by using an observation unit and home oxygen therapy 显示文摘 | SANDWEISS D R MUNDORFF M B HILL T | 2013 | JAMA Pediatrics2013，167，5： | 1 |
| 11 | Complications of laser prostatectomy: a review of recent data显示文摘 | Malte Rieken Nicole Ebinger Mundorff Gernot Bonkat Stephen Wyler Alexander Bachmann | 2010 | World Journal of Urology2010，，1： | 1 |
| 12 | Improving catalytic function by ProSAR-driven enzyme evolution显示文摘 | Fox R J Davis C S Mundorff E C | 2007 | Nat Biotechnol2007，25，： | 1 |
| 13 | Bio- catalytic asymmetric synthesis of chiral amines from ketones applied to sitagliptin manufacture 显示文摘 | SAVILE C K JANEY J M MUNDORFF E C | 2010 | Science2010，329，5989： | 1 |
| 14 | Biocatalytic asymmetric synthesis of chiral amines from ketones applied to sitagliptin manufacture 显示文摘 | SAVILE C K JANEY J M MUNDORFF E C | 2010 | Science2010，329，5989： | 1 |
| 15 | Biocatalytic asymmetirc synthesis of chiral amines from ketones applied to sitagliptin manufacture显示文摘 | Savile C K Janey J M Mundorff E C | 2010 | Science2010，329，： | 1 |
| 16 | Biocatalytic Asymmetric Synthesis of Chiral Amines from Ketones Applied to Sitagliptin Manufacture显示文摘 | SAVILE C K JANEY J M MUNDORFF E C | 2010 | Science2010，329，5989： | 1 |
| 17 | Hospital admission medication reconciliation in medically complex children, an ob servational study显示文摘 | Stone BIJ Boehme S Mundorff MB etal | 2010 | Arch Dis Child2010，95，4： | 1 |
| 18 | The interplay between binding energy and catalysis in the evolution of a catalytic antibody显示文摘 | Ulrich H D Mundorff E Santarsiero B D | 1997 | Nature1997，389，： | 1 |
| 19 | Biocatalytic asymmetric synthesis of chiral amines from ketones applied to sitagliptin manufacture显示文摘 | Savile C K Janey J M Mundorff E C | 2010 | Science2010，329，5989： | 1 |
| 20 | A comparative analysis of the immunological evolution of antibody 28B4显示文摘 | Yin J Mundorff EC Yang PL | 2001 | Biochemistry2001，40，10： | 1 |
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