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| 1 | Using old liver grafts for liver transplantation: Where are the limits?显示文摘The scarcity of ideal liver grafts for orthotopic liver transplantation(OLT) has led transplant teams to investigate other sources of grafts in order to augment the donor liver pool. One way to get more liver grafts is to use marginal donors, a not well-defined group which includes mainly donors > 60 years, donors with hypernatremia or macrosteatosis > 30%, donors with hepatitis C virus or hepatitis B virus positive serologies, cold ischemia time > 12 h, non-heart-beating donors, and grafts from split-livers or living-related donations. Perhaps the most practical and frequent measure to increase the liver pool, and thus to reduce waiting list mortality, is to use older livers. In the past years the results of OLT with old livers have improved, mainly due to better selection and maintenance of donors, improvements in surgical techniques in donors and recipients, and intra- and post-OLT management. At the present time, sexagenarian livers are generally accepted, but there still exists some controversy regarding the use of septuagenarian and octogenarian liver grafts. The aim of this paper is to briefly review the aging process of the liver and reported experiences using old livers for OLT. Fundamentally, the series of septuagenarian and octogenarian livers will be addressed to see if there is a limit to using these aged grafts. | Carlos Jiménez-Romero Oscar Caso Maestro Félix Cambra Molero Iago Justo Alonso Cristina Alegre Torrado Alejandro Manrique Municio Jorge Calvo Pulido Carmelo Loinaz Segurola Enrique Moreno González | 2014 | World Journal of Gastroenterology2014，20，31： | 11 |
| 2 | Malignancy After Liver Transplantation: Cumulative Risk for Development显示文摘 | E. Marqués Medina C. Jiménez Romero A. Gómez de la Cámara A. Rota Bernal A. Manrique Municio E. Moreno González | 2009 | Transplantation Proceedings2009，，6： | 1 |
| 3 | The product of par-4, a gene induced during apoptosis, interacts selectively with the atypical isoforms of protein kinase显示文摘 | MT Diaz-Meco MM Municio S Frutos | 1996 | Cell1996，86，： | 1 |
| 4 | The product of par-4, a gene induced during apoptosis, interacts selectively with the atypical isoforms of protein kinase C显示文摘 | Diaz-Meco MT Municio MM Frutos S | 1996 | Cell1996，8，： | 1 |
| 5 | The product of par-4,a gene induced during apoptosis,interacts selectively with the atypical isoforms of protein kinase C显示文摘 | Diaz -Mecro MT Municio MM Frutos S | 1996 | Cell1996，865，： | 1 |
| 6 | Evidence for the in vitro and in vivo interaction of Ras with protein kinase C zeta显示文摘 | Lozano J Municio MM | 1994 | J Biol Chem1994，269，31： | 1 |
| 7 | Mode显示文摘 | BARBER() J LAZO H MUNICIO F | 1933 | In precinct elect eng col[oq on recent developments in mierostrip antennas1933，12，： | 1 |
| 8 | The product of par- 4, a gene induced during apoptosis, interacts selectively with the atypical isoforms of protein kinase C 显示文摘 | Diaz- Meco MT Municio MM Frutos S | 1996 | Cell1996，86，5： | 1 |
| 9 | Evidence for the vitro and in vivo interaction of Ras with protein kinase 显示文摘 | Diaz- Meco MT Lozano J Municio MM | 1994 | J Biol Chem1994，269，31： | 1 |
| 10 | The product of par-4,a gene induced during apoptosis,interacts selectively with the atypical isoforms of protein kinase C显示文摘 | Diaz-Meco MT Municio MM Frutos S | 1996 | Cell1996，86，5： | 1 |
| 11 | Effects of 24, 25 ( OH ) 2D3, 1,25 (OH)2D3 and 25(OH)D3 on alkaline and tartrate-resistant acid phosphatase activities in fetal rat calvaria 显示文摘 | Municio MJ Traba ML | 2004 | J Physiol Biochem2004，60，3： | 1 |
| 12 | A dominant negative protein kinase C zeta subspecies blocks NF-kappa B activation 显示文摘 | Diaz-Meco MT Berra E Municio MM | 1993 | Mol Cell Biol1993，13，8： | 1 |
| 13 | The product of par-4, a gene induced during apoptosis, interacts selectively with the atypical isoforms of protein kinase C显示文摘 | Diaz-Meco MT Municio MM Frutos S | 1996 | Cell1996，86，5： | 1 |
| 14 | Protein kinase C zeta isoform is critical for kappa B-dependent promoter activation by sphingomyelinase显示文摘 | Lozano J Berra E Municio MM | 1994 | J Biol Chem1994，269，19： | 1 |
| 15 | Polarization of the innate immune response by prostaglandin E2: a puzzle of receptors and signals显示文摘 | Rodriguez M Do mingo E Municio C | 2014 | Mol Pharmacol2014，85，1： | 1 |
| 16 | Circadian rhythm disruption and retinal dysfunction:a bidirectional link in Alzheimer’s disease?显示文摘Dysfunction in circadian rhythms is a common occurrence in patients with Alzheimer’s disease.A predominant function of the retina is circadian synchronization,carrying information to the brain through the retinohypothalamic tract,which projects to the suprachiasmatic nucleus.Notably,Alzheimer’s disease hallmarks,including amyloid-β,are present in the retinas of Alzheimer’s disease patients,followed/associated by structural and functional disturbances.However,the mechanistic link between circadian dysfunction and the pathological changes affecting the retina in Alzheimer’s disease is not fully understood,although some studies point to the possibility that retinal dysfunction could be considered an early pathological process that directly modulates the circadian rhythm. | Laura Carrero DesireéAntequera Cristina Municio Eva Carro | 2024 | Neural Regeneration Research2024，19，9： | 0 |
| 17 | Implication of salivary lactoferrin and periodontal-mediated infections in Alzheimer's disease显示文摘Lactoferrin is an antimicrobial prote in characterized by the exertion of many protective functions,including antibacterial,antifungal,antiviral,and antiparasitic properties,as well as anti-inflammatory and immunomodulatory activities(Kruzel et al.,2017).Lactoferrin is one of the major proteins present in exocrine secretions,including saliva,and is therefore associated with host defense against oral pathogens and control of the oral microbiome.In recent years,it has become clear that alterations in the oral microbiome may contribute to opportunistic pathogen infections in the brains of Alzheimer’s disease(AD)patients and thus participate in or contribute to the development of this neurodegenerative disease(Sureda et al.,2020).Pathogenic oral microbes can affect neurological processes by entering brain tissue through various pathways and directly damaging the central nervous system.In the central nervous system,oral microbes may trigger an immune response that increases amyloidβ(Aβ)production and may even trigger the Aβcascade to promote the onset of AD,as we discuss in our previous study supporting the“infectious hypothesis”in AD(González-Sánchez et al.,2020). | Cristina Municio Eva Carro | 2023 | Neural Regeneration Research2023，18，12： | 0 |
| 18 | Aquaporin 5 in Alzheimer’s disease:a link between oral and brain pathology?显示文摘The involvement of aquaporins(AQPs)in the development of diseases has been widely described(Azad et al.,2021).AQP5 has been described in astrocytes changing after traumatic brain injuries(Chai et al.,2013),but the precise role of AQP5 in Alzheimer’s disease(AD)pathology is yet to be understood.We have recently reported that AQP5 expression changes during the development of AD(Antequera et al.,2022).The AQP5 expression in salivary glands is decreased in 6-month-old APP/PS1 mice and AD patients.This decrease in AQP5 expression could be involved in the mechanism of salivary gland dysfunction described in a previous study(Antequera et al.,2021).Now,we propose a new indirect role of AQP5 in the connection between infection-induced oral dysbiosis and AD(Sureda et al.,2020).Here,we suggest that the proinflammatory response induced by oral pathogen infection results in the downregulation of AQP5 contributing to the salivary gland secretory dysfunction.All these alterations destabilize the peripheral immune-inflammatory balance and exacerbate neuroinflammation and neurodegeneration leading to AD pathology. | Cristina Municio Eva Carro | 2023 | Neural Regeneration Research2023，18，7： | 0 |
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