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| 1 | 妊娠期高血压免疫因子、肿瘤坏死因子α、血管紧张素Ⅱ1型受体自身抗体对妊娠可溶性fms样酪氨酸1和可溶性Endoglin产物的影响显示文摘最近研究发现先兆子痫中血管新生因子、可溶性fms样酪氨酸激酶(sFlt-1)和可溶性Endoglin(sEn-doglin)不平衡;然而尚不清楚它们过度分泌的启动机制。方法:长期给予怀孕大鼠肿瘤坏死因子α(tumor necrosis factor-α,TNF-α)或抗血管紧张素Ⅱ受体的自身抗体(AT1-AA),测定其循环和胎盘的sFlt-1和(或)sEndoglin以确定这些因素的免疫调节作用。 | Parrish MR Murphy SR Rutland S Wallace K Wenzel K Wallukat G Keiser S Ray LF Dechend R Martin JN Granger JP La Marca B 黄晓斌 | 2010 | 中华高血压杂志2010，18，12： | 5 |
| 2 | C-reactive protein and radiographic findings of lower respiratory tract infection in infants显示文摘AIM To evaluate the association between C-reactive protein(CRP) and radiological evidence of lower respiratory tract infection(LRTI) in infants.METHODS All patients aged less than 4 years who presented with suspected lower respiratory tract infection,who received a peri-presentation chest radiograph and CRP blood measurement over an 18-mo period were included in the study.Age,gender,source of referral,CRP,white cell count,neutrophil count along with the patients' symptoms and radiologist's report were recorded.RESULTS Three hundred and eleven patients met the inclusioncriteria.Abnormal chest radiographs were more common in patients with elevated CRP levels(P < 0.01).Radiologic signs of LRTI were identified in 73.7% of chest radiographs when a patient had a CRP level between 50-99 mg/L.CRP levels were a better predictor of positive chest radiograph findings for those aged greater than I year compared to those 1 year or less.CONCLUSION CRP may be used in patients with suspected LRTI diagnosis to select those who are likely to have positive findings on chest radiograph,thus reducing unnecessary chest radiographs. | Maria Twomey Hannah Fleming Fiachra Moloney Kevin P Murphy Lee Crush Siobhan B O’Neill Oisin Flanagan Karl James Conor Bogue Owen J O’Connor Michael M Maher | 2017 | World Journal of Radiology2017，9，4： | 2 |
| 3 | Updates on therapies for chronic prostatitis/chronic pelvic pain syndrome显示文摘Prostatitis comprises of a group of syndromes that affect almost 50% of men at least once in their lifetime and makeup the majority of visits to the Urology Clinics.After much debate, it has been divided into four distinct categories by National Institutes of Health namely(1) acute bacterial prostatitis;(2) chronic bacterial prostatitis;(3) chronic prostatitis/chronic pelvic pain syndrome(CP/CPPS) which is further divided into inflammatory and non-inflammatory CP/CPPS; and(4)asymptomatic inflammatory prostatitis. CP/CPPS has been a cause of great concern for both patients and physicians because of the lack of presence of thoroughinformation about the etiological factors along with the difficult-to-treat nature of the syndrome. For the presented manuscript an extensive search on PubM ed was conducted for CP/CPPS aimed to present an updated review on the evaluation and treatment options available for patients with CP/CPPS. Several diagnostic criteria's have been established to diagnose CP/CPPS, with prostatic/pelvic pain for at least 3 mo being the major classifying symptom along with the presence of lower urinary tract symptoms and/or ejaculatory pain. Diagnostic tests can help differentiate CP/CPPS from other syndromes that come under the heading of prostatitis by ruling out active urinary tract infection and/or prostatic infection with uropathogen by performing urine cultures, Meares-Stamey Four Glass Test, Preand Post-Massage Two Glass Test. Asymptomatic inflammatory prostatitis is confirmed through prostate biopsy done for elevated serum prostate-specific antigen levels or abnormal digital rectal examination. Researchers have been unable to link a single etiological factor to the pathogenesis of CP/CPPS, instead a cluster of potential etiologies including atypical bacterial or nanobacterial infection, autoimmunity, neurological dysfunction and pelvic floor muscle dysfunction are most commonly implicated. Initially monotherapy with anti-biotics and alpha adrenergic-blockers can be tried, but its success has only been observed in treatment nave population. Other pharmacotherapies including phytotherapy, neuromodulatory drugs and anti-inflammatories achieved limited success in trials. Complementary and interventional therapies including acupuncture, myofascial trigger point release and pelvic floor biofeedback have been employed. This review points towards the fact that treatment should be tailored individually for patients based on their symptoms. Patients can be stratified phenotypically based on the UPOINT system constituting of Urinary, Psychosocial, Organ-specific, Infectious, Neurologic/Systemic and symptoms of muscular Tenderness and the treatment algorithm should be proposed accordingly. Treatment of CP/CPPS should be aimed towards treating local aswell as central factors causing the symptoms. Surgical intervention can cause significant morbidity and should only be reserved for treatment-refractory patients that have previously failed to respond to multiple drug therapies. | Asfandyar Khan Adam B Murphy | 2015 | World Journal of Pharmacology2015，4，1： | 2 |
| 4 | A comparison of model-based and regression classification techniques applied to near infrared spectroscopic data in food authentication studies显示文摘 | TOHER D DOWNEY G MURPHY T B | 2007 | Chemometrics and Intelligent Laboratory Systems2007，89，2： | 1 |
| 5 | Local dynamics in DNA by temperature-dependent stokes shifts of an intercalated dye 显示文摘 | Brauns E B Murphy C J Berg M A | 1998 | J Am Chem Soc1998，120，： | 1 |
| 6 | Impact of preexisting statin use on adhesion molecule expression in patients presenting with acute coronary syndromes显示文摘 | MURPHY R T FOLEY J B MULVIHILL N | 2001 | Am J Cardiol2001，87，： | 1 |
| 7 | The CD200 receptor is a novel and potent regulator of murine and human mast cell function显示文摘 | MURPHY C A JOYCE B L | 2005 | J Immunol2005，174，： | 1 |
| 8 | Development of effective vaccines against pandemic influenza显示文摘 | Subbarao K Murphy B R Fauci A S | 2006 | Immunity2006，24，1： | 1 |
| 9 | Sulfonated poly(aryl ether eher ketone ketone) s containing fluorinated moieties as proton exchange membrane materials显示文摘 | LIU B K1M D S MURPHY J | 2006 | J Membr Sci2006，，： | 1 |
| 10 | Natrelle saline-filled breast implants:a prospective 10-year study显示文摘 | Walker PS Walls B Murphy DK | 2009 | Aesthet Surg J2009，29，1： | 1 |
| 11 | Age-related differences in the neural substrates of cross-modal olfactory recognition memory: an fMRI investigation显示文摘 | Cerf-Ducastel B Murphy C | 2009 | Brain Res2009，1285，： | 1 |
| 12 | Deciphering the biology of My cobacterium tuberculosis from the complete genome sequence 显示文摘 | Cole S T Brosch R Parkhill J Gamier T Churcher C Harris D Gordon S V Eiglmeier K Gas S Barry C E Tekaia F Badcock K Basham D Brown D Chillingworth T Cormor R Davies R Devlin K FeltweU T Gentles S Hamlin N Holroyd S Hornsby T Jagels K Kroghs A McLean J Moule S Murphy L Oliver K Osborne J Quail M A Rafandream M A Rogers J Rutter S Seeger K Skelton J Squaraes R Squares S Sulston J E Taylo K Whitehead S Barrell B G | 1998 | Nature1998，393，： | 1 |
| 13 | Controlling nitrification in a water distribution system using sodium chlorite 显示文摘 | O' CONMOR T MURPHY B O' CONMOR J T | 2001 | Water Engineering & Management2001，148，9： | 1 |
| 14 | Pathogenesis of bronehopulmonary dysplttsia显示文摘 | HAYES D Jr FEOLA D J MURPHY B S | 2010 | Respiration2010，79，5： | 1 |
| 15 | Complex dynamics and synchroniza tion of delayed-feedback nonlinear oscillators显示文摘 | Murphy T E Cohen A B Ravoori B | 2010 | Philosophical Transactions of the Royal Society A-Mathematical Physical and Engineering Sciences2010，368，1911： | 1 |
| 16 | Biosynthesis of amphoteri- cin derivatives lacking exocyclic carboxyl groups显示文摘 | Carmody M Murphy B Byrne B | 2005 | Journal of Bio- logical Chemistry2005，280，34： | 1 |
| 17 | Production of ammonia by heteroge- neous catalysis in a packed-bed dielectric-barrier discharge: influence of argon addition and voltage显示文摘 | Hong J Prawer S Murphy A B | 2014 | IEEE Transactions on Plasma Science2014，42，10： | 1 |
| 18 | Generation of multiple fame-sold-X-receptor isoforms through the use of ahemative promoters 显示文摘 | Huber R M Murphy K Miao B | 2002 | Gene2002，290，12： | 1 |
| 19 | Oxaliplatin and capecitabine inpatients with metastatic adenocarcinoma of the esophagus, gastroesophgealjunction and gastric cardia: a phase Ⅱ study from thenorth central cancer treatment group 显示文摘 | Jatoi A Murphy B Foster NR | 2006 | Ann Oncol2006，17，1： | 1 |
| 20 | Tempo and scale of Late Paleocene and Early Eocene carbon isotope cycles: Im'- plications for the origin of hyperthermals显示文摘 | Zachos J C McCarren H Murphy B | 2010 | Earth and Plane tary Science Letters2010，299，： | 1 |
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