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| 1 | Efficacy of peroral endoscopic myotomy vs other achalasia treatments in improving esophageal function显示文摘AIM: To assess and compare the esophageal function after peroral endoscopic myotomy(POEM) vs other conventional treatments in achalasia.METHODS: Chart review of all achalasia patients who underwent POEM, laparoscopic Heller myotomy(LHM) or pneumatic dilation(PD) at our institution between January 2012 and March 2015 was performed. Patient demographics, type of achalasia, prior treatments, pre- and post-treatment timed barium swallow(TBE) and high-resolution esophageal manometry(HREM) findings were compared between the three treatment groups. Patients who had both pre- and 2 mo posttreatment TBE or HREM were included in the final analysis. TBE parameters compared were barium column height, width and volume of barium remaining at 1 and 5 min. HREM parameters compared were basal lower esophageal sphincter(LES) pressures and LES-integrated relaxation pressures(IRP). Data are presented as mean ± SD, median [25th, 75 th percentiles] or frequency(percent). Analysis of variance, KruskalWallis test, Pearsons χ~2 test and Fishers Exact tests were used for analysis.RESULTS: A total of 200 achalasia patients were included of which 36 underwent POEM, 22 underwent PD and 142 underwent LHM. POEM patients were older(55.4 ± 16.8 years vs 46.5 ± 15.7 years, P = 0.013) and had higher BMI than LHM(29.1 ± 5.9 kg/m^2 vs 26 ± 5.1 kg/m^2, P = 0.012). More number of patients in POEM and PD groups had undergone prior treatments compared to LHM group(72.2% vs 68.2% vs 44.3% respectively, P = 0.003). At 2 mo post-treatment, all TBE parameters including barium column height, width and volume remaining at 1 and 5 min improved significantly in all three treatment groups(P = 0.01 to P < 0.001) except the column height at 1 min in PD group(P = 0.11). At 2 mo post-treatment, there was significant improvement in basal LES pressure and LES-IRP in both LHM(40.5 mm Hg vs 14.5 mm Hg and 24 mm Hg vs 7.1 mm Hg respectively, P < 0.001) and POEM groups(38.7 mm Hg vs 11.4 mm Hg and 23.6 mm Hg vs 6.6 mm Hg respectively, P < 0.001). However, when the efficacy of three treatments were compared to each other in terms of improvement in TBE or HREM parameters at 2 mo, there was no significant difference(P > 0.05).CONCLUSION: POEM, PD and LHM were all effective in improving esophageal function in achalasia at shortterm. There was no difference in efficacy between the three treatments. | Madhusudhan R Sanaka Umar Hayat Prashanthi N Thota Ramprasad Jegadeesan Monica Ray Scott L Gabbard Neha Wadhwa Rocio Lopez Mark E Baker Sudish Murthy Siva Raja | 2016 | World Journal of Gastroenterology2016，22，20： | 7 |
| 2 | On using peak amplitude and rise time for AE source显示文摘 | Majeed M A Murthy C R L | 2002 | Sadhana2002，27，3： | 1 |
| 3 | Uniform and critical flow computations显示文摘 | Patti R G Murthy J S R Ghosh L K | | 0，，04： | 1 |
| 4 | Pharmacokinetics and biodistribution studies of doxorubicin loaded poly(butyl cyanoacrylate) nanoparticles synthesized by two different techniques显示文摘 | Reddy L H Murthy R S | 2004 | Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub2004，148，2： | 1 |
| 5 | Synopsis of the National Institute for Health and Clinical Excellence guideline for prevention of delirium显示文摘 | O'Mahony R Murthy L Akunne A | 2011 | Ann Intern Med2011，154，11： | 1 |
| 6 | Effect of angiotensin Ⅱ type 1 receptor blockade on experimental hepatic fibrogenesis显示文摘 | Paizis G Gilbert R E Cooper M E Murthi P Schembri J M Wu L L | 2001 | J Hepatol2001，35，： | 1 |
| 7 | Trajectory planning with collision avoidance for autonomous helicopter by evolutionary methods path显示文摘 | Zhao L Murthy V R | 2006 | AIAA Journal2006，10，6： | 1 |
| 8 | A model with nonzero rise time for AE signals显示文摘 | Majeed M A Murthy C R L | 2001 | Sadhana2001，25，5： | 1 |
| 9 | Photoluminescence investigations of Zn2 SiO4 co -doped with Eu^3 + and Tb^3+ ions 显示文摘 | Natarajan V Murthy K V R Kumar M L J | 2005 | Solid State Commun2005，134，4： | 1 |
| 10 | Analysisof composite single lap joints using numerical and ex-perimental approach显示文摘 | Kumar V R L Bhat M R Murthy C R L | 2014 | Journal of Adhesion Scienceand Technology2014，28，10： | 1 |
| 11 | Composite of TiO2 nanowires and Nafion as humidity sensor material显示文摘 | WU R J SUN Y L LIN C C CHEN W H MURTHY C | 2006 | Sensors and Actuators B:Chemical2006，115，1： | 1 |
| 12 | On Using Peak Amplitude and Rise Time for AE Source Characterization 显示文摘 | Majeed M A Murthy C R L | 2002 | Sadhana2002，27，3： | 1 |
| 13 | Preparation and purification of gamma gamma enolase(neuron-specific enolase) using high performance anion exchange chromatography 显示文摘 | Viallard J L Ven Murthy M R Dastugue B | 1988 | Neurochem Res1988，13，1： | 1 |
| 14 | Effect ofa polymerizable cosurfactant on the microstructure and drug-release properties of nanoparticles synthesized through emulsion polymerization显示文摘 | Bhawal S Reddy L H Murthy R S R | 2004 | Journal of Applied Polymer Science2004，92，1： | 1 |
| 15 | Characterization of steroid receptors in human prostate using mibolerone显示文摘 | Murthy L R Johnson M P Rowley D R | 1986 | Prostate1986，8，3： | 1 |
| 16 | Fine strueture of connective tissue after ingestion of cadmium: Observations on interstilium on male rat lung 显示文摘 | Miller M L Murthy L Sorenson J R | 2004 | Arch Pathol2004，98，6： | 1 |
| 17 | Floating dosage systems in drug delivery显示文摘 | Reddy L H Murthy R S | 2002 | Crit Rev Ther Drug Carrier Syst2002，19，6： | 1 |
| 18 | A prospective open-label pilot study of fluvastatin on proinflammatory and prothrombotic biomarkers in antiphospholipid antibody positive patients 显示文摘 | Erkan D Willis R Murthy V L | 2014 | Ann Rheum Dis2014，73，6： | 1 |
| 19 | Principal pivoting method for solving column sufficient complementarity problems显示文摘 | MURTHY G S R | 2000 | SIAM J Matrix Anal Appl2000，22，： | 1 |
| 20 | Canopy position affects the temperature response of leaf respiration in Populus deltoides显示文摘 | Griffm K L Turabull M Murthy R | 2002 | New Phytologist2002，154，3： | 1 |
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