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| 1 | Impact of preoperative chemoradiotherapy on survival in patients with resectable pancreatic cancer显示文摘AIM:To explore whether preoperative chemoradiation therapy improves survival of patients with pancreatic cancer undergoing resectional surgery. METHODS:Forty-seven patients with a malignant pancreatic tumor localized in the head or uncinate process of the pancreas underwent radical pancreaticoduodenectomy. Twenty-two received chemoradiation therapy (gemcitabine and radiation dose 50.4 Gy) before surgery (CRR) and 25 patients underwent surgery only (RO). The study was non-randomised. Patients were identified from a prospective database. RESULTS:The median survival time was 30.2 mo in the CRR group and 35.9 mo in the RO group. No statistically significant differences were found in subclasses according to lymph node involvement,TNM stages,tumor size,or perineural invasion. The one,three and five year survival rates were 81%,33% and 33%,respectively,in the CRR group and 72%,47% and 23%,respectively,in the RO group. In ductal adenocarcinoma,the median survival time was 27 mo in the CRR group and 20 mo in the RO group. No statistically significant differences were found in the above subclasses. The one,three and five year survival rates were 79%,21% and 21%,respectively,in the CRR group and 64%,50% and 14%,respectively,in the RO group. The overall hospital mortality rate was 2%. The morbidity rate was 45% in the CRR group and 32% (NS) in the RO group. CONCLUSION:Major multicenter randomized studies are needed to conclusively assess the impact of neoadjuvant treatment in the management of pancreatic cancer. | Plvi Vento Harri Mustonen Timo Joensuu Pivi Krkkinen Eero Kivilaakso Tuula Kiviluoto | 2007 | World Journal of Gastroenterology2007，13，21： | 8 |
| 2 | Toremifene in the treatment of breast cancer显示文摘Although more widespread screening and routine adjuvant therapy has improved the outcome for breast cancer patients in recent years, there remains considerable scope for improving the efficacy, safety and tolerability of adjuvant therapy in the early stage disease and the treatment of advanced disease. Toremifene is a selective estrogen receptor modifier(SERM) that has been widely used for decades in hormone receptor positive breast cancer both in early and late stage disease. Its efficacy has been well established in nine prospective randomized phase Ⅲ trials compared to tamoxifen involving more than 5500 patients, as well as in several large uncontrolled and non-randomized studies. Although most studies show therapeutic equivalence between the two SERMs, some show an advantage for toremifene. Several meta-analyses have also confirmed that the efficacy of toremifene is at least as good as that of tamoxifen. In terms of safety and tolerability toremifene is broadly similar to tamoxifen although there is some evidence that toremifene is less likely to cause uterine neoplasms, serious vascular events andit has a more positive effect on serum lipids than does tamoxifen. Toremifene is therefore effective and safe in the treatment of breast cancer. It provides not only a useful therapeutic alternative to tamoxifen, but may bring specific benefits. | Mika VJ Mustonen Seppo Pyrh?nen Pirkko-Liisa Kellokumpu-Lehtinen | 2014 | World Journal of Clinical Oncology2014，5，3： | 5 |
| 3 | Carbonic anhydrase enzymes Ⅱ, Ⅶ, Ⅸ and Ⅻ in colorectal carcinomas显示文摘AIM To investigate expression of four alpha-carbonic anhydrases(CAs) in colorectal carcinomas(CRC) and compare the results with patients' survival.METHODS Colorectal carcinoma samples from 539 CRC patients and control tissues were arranged as tissue microarrays and analyzed with antibodies against CA Ⅱ, CA Ⅶ, CA Ⅸ, and CA Ⅻ. Intensity and extent of staining were both scored from 0 to 3 in each sample. These enzyme expression levels were then correlated to patients' survival and clinicopathological parameters, which were tumor differentiation grade and stage, site of tumor, patients' age, and gender. Kaplan-Meier analysis and Cox regression hazard ratio model were used to analyze survival data. RESULTS CA Ⅱ and CA Ⅻ staining intensities correlated with patients' survival in that higher expression indicated poorer prognosis. In Cox regression analysis one unit increase in the CA Ⅱ intensity increased the hazard ratio to 1.19 fold(CI: 1.04-1.37, P = 0.009). A significant correlation was also found when comparing CA Ⅻ staining intensity with survival of CRC patients(HR = 1.18, 95%CI: 1.01-1.38, P = 0.036). The extent of CA Ⅻ immunostaining did not correlate to the patients' survival(P = 0.242, Kaplan-Meier analysis). A significant interaction between age group and extent of the CA Ⅱ staining was found. Increased extent of CA Ⅱ had a significant hazard ratio among patients 65 years and older(1.42, 95%CI: 1.16-1.73, P = 0.0006). No correlations were found between CA Ⅶ(intensity P = 0.566, extent P = 0.495, Kaplan-Meier analysis), or CA Ⅸ(intensity P = 0.879, extent P = 0.315, KaplanMeier analysis) immunostaining results and survival, or the other parameters. CONCLUSION The present findings indicate that CA Ⅱ and CA Ⅻ could be useful in predicting survival in CRC. | Pia Viikil? Antti J Kivel? Harri Mustonen Selja Koskensalo Abdul Waheed William S Sly Jaromir Pastorek Silvia Pastorekova Seppo Parkkila Caj Haglund | 2016 | World Journal of Gastroenterology2016，22，36： | 3 |
| 4 | Vasohibin-1 and vasohibin-2 expression in gastric cancer cells and TAMs显示文摘 | Zhanlong Shen Tuuli Kauttu Hanna Sepp?nen Sanna Vainionp?? Yingjiang Ye Shan Wang Harri Mustonen Pauli Puolakkainen | 2012 | Medical Oncology2012，，4： | 2 |
| 5 | Expression of cellular fibronectin and tenascin in the rabbit cornea after excimer laser photorefractive keratectomy:a 12 month study显示文摘 | Latvala T Tervo K Mustonen R | 1995 | Br J Ophthalmol1995，79，： | 2 |
| 6 | Fecal calprotectin concentration predicts outcome in inflammatory bowel disease after induction therapy with TNFα blocking agents显示文摘 | Pauliina Molander Clas‐G?ran af Bj?rkesten Harri Mustonen Johanna Haapam?ki Matti Vauhkonen Kaija‐Leena Kolho Martti F?rkkil? Taina Sipponen | 2012 | Inflamm Bowel Dis2012，，11： | 2 |
| 7 | Expression of the fms-like tyrosine kinase 4 gene becomes restricted to lymphatic endothelium during development显示文摘 | Korhonen J Mustonen T | 1995 | Proc Natl Acad Sci USA1995，92，8： | 1 |
| 8 | Multigenerational exposure to phytosterols in the mouse 显示文摘 | Ari Ryokkynen Ulla-Riitta Kayhko Anne-Mari Mustonen | 2005 | Repro- ductive Toxicology2005，19，： | 1 |
| 9 | MRI of acute meniscal injury associated with tibial plateau fractures : prevalence, type, and loca- tion显示文摘 | Antti OT Mustonen MP Koivikko J | 2008 | AJR Am J Roentgeno12008，191，4： | 1 |
| 10 | Hantavirus infectionin Europe显示文摘 | Vapalahti 0 Mustonen J Lundkvist A | 2003 | Lancet Infect Dis2003，3，0： | 1 |
| 11 | Segond fracture combined with tibial plateau fracture 显示文摘 | Peltola EK Mustonen AO Lindahl J et a/ | 2011 | AJR Am J ~Roentgenol2011，197，6： | 1 |
| 12 | Phytosterols Act as Endocrine and Metabolic Disruptors in the European Polecat 显示文摘 | Nieminen P Mustonen A M Lindstrom-Seppa P | 2002 | Toxicology and Applied Pharmacology2002，178，： | 1 |
| 13 | Vascular endothelial growth factor is induced in response to transforming growth factor-beta in fibroblastic and epithelial cells显示文摘 | Pertovaara L KaiPainen A Mustonen T | 1994 | J Biol Chem1994，26，32： | 1 |
| 14 | Proinflammatory effects of pancreatic elastase are mediated through TLR4 and NF-kappaB 显示文摘 | Hietaranta A Mustonen H Puolakkainen P | 2004 | Biochem Biophys Res Commun2004，323，1： | 1 |
| 15 | Endothelial receptor tyrosine kinases involved in angiogenesis显示文摘 | Mustonen T Alitalok | 1995 | J Cell Biol1995，129，129： | 1 |
| 16 | Long- lived Memory T Lymphocyte Responses Afte Hantavirus Infection 显示文摘 | Van Epps HL Masanori Terajima Jukka Mustonen | 2002 | Exp Med2002，196，5： | 1 |
| 17 | Tumour necrosis factor-like weak inducer of apoptosis ( TWEAK ) and its receptor Fnl4 during cardiac remodelling in rats 显示文摘 | Mustonen E Sakkinen H Tokola H | 2010 | Acta Physiol ( Oxf)2010，199，1： | 1 |
| 18 | Long-lived memory T lymphocyte responses after Hantavirus infection 显示文摘 | Terajima M Mustonen J | 2002 | J Exp Med2002，196，5： | 1 |
| 19 | Retinopay is independently related to microalbuminuria in type 2 diabetes mellitus显示文摘 | Wirta O Pasternack A Mustonen J | 1999 | Clin Nephrol1999，51，6： | 1 |
| 20 | Nor- malhuman corneal populations evaluated by in vivo scan- ningslit confocal microscopy 显示文摘 | Mustonen RK Mcdonald MB Srivannaboon S | 1998 | Cornea1998，17，： | 1 |
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