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| 1 | Engineering an enthesis-like graft for rotator cuff repair:An approach to fabricate highly biomimetic scaffold capable of zone-specifically releasing stem cell differentiation inducers显示文摘Rotator cuff(RC)attaches to humerus across a triphasic yet continuous tissue zones(bone-fibrocartilage-tendon),termed“enthesis”.Regrettably,rapid and functional enthesis regeneration is challenging after RC tear.The existing grafts bioengineered for RC repair are insufficient,as they were engineered by a scaffold that did not mimic normal enthesis in morphology,composition,and tensile property,meanwhile cannot simultaneously stimulate the formation of bone-fibrocartilage-tendon tissues.Herein,an optimized decellularization approach based on a vacuum aspiration device(VAD)was developed to fabricate a book-shaped decellularized enthesis matrix(O-BDEM).Then,three recombinant growth factors(CBP-GFs)capable of binding collagen were synthesized by fusing a collagen-binding peptide(CBP)into the N-terminal of BMP-2,TGF-β3,or GDF-7,and zone-specifically tethered to the collagen of O-BDEM to fabricate a novel scaffold(CBP-GFs/O-BDEM)satisfying the above-mentioned requirements.After ensuring the low immunogenicity of CBP-GFs/O-BDEM by a novel single-cell mass cytometry in a mouse model,we interleaved urine-derived stem cell-sheets into this CBP-GFs/O-BDEM to bioengineer an enthesis-like graft.Its high-performance on regenerating enthesis was determined in a canine model.These findings indicate this CBP-GFs/O-BDEM may be an excellent scaffold for constructing enthesis-like graft to patch large/massive RC tears,and provide breakthroughs in fabricating graded interfacial tissue. | Can Chen Qiang Shi Muzhi Li Yang Chen Tao Zhang Yan Xu Yunjie Liao Shulin Ding Zhanwen Wang Xing Li Chunfeng Zhao Lunquan Sun Jianzhong Hu Hongbin Lu | 2022 | Bioactive Materials2022，7，10： | 4 |
| 2 | Cloning and identification of a novel RNF6 transcrip-tional splice variant Spg2 in human development显示文摘RING finger proteins are zinc finger proteins containing the RING motifs. They act mainly as E3 ubiq-uitin ligases, bind the ubiquitin E2 conjugating enzyme and promote degradation of targeted proteins, Many novel genes have been isolated and differentially expressed in human adult and embryo testis by a testis cDNA-array differential display technique. A novel RING finger cDNA is highly expressed in adult testis and at low level in fetal testis. It was named Spg2. It contains a 2055 nucleotide ORF, en-codes a 685-amino-acid RNF6 protein, and has a RING finger in its C terminal. NCBI Blast shows that the gene is located on chromosome 13 and contains five exons. A multiple tissue expression profile also indicates that it is highly expressed in human testis, so we speculate that it may be associated with human spermatogenesis by virtue of the action of its RING domain. | ZHU Li TONG GuoQin CHEN Jie WANG Yun WANG SaiQun ZHAO MuZhi LI JianMin MA JianHua | 2008 | Science China(Life Sciences)2008，51，4： | 3 |
| 3 | Design and analysis of a new high frequency double-servodirect drive rotary valve显示文摘Researchers have investigated direct drivevalve for many years to solve problems, such as fluidforce imbalance and switching frequency. The structure ofthe rotary valve has received considerable research interestbecause of its favorable dynamic properties and simplestructure. This paper studied the high frequency double-servo direct drive rotary valve (DDRV), and proposed anovel structure and drive method satisfying high reversingfrequency and adequate quantity of flow. Servo motors areintegrated into the valve by the innovative structure, whichis designed to equilibrate the unbalanced radial fluid forcewith the symmetric distributed oil ports. Aside from thefast reversing function of the valve, the DDRV presentedhigh performance in linearity of the flow quantity andvalve opening as a result of the fan-shaped flow ports. Inaddition, a computational fluid dynamics (CFD) methodbased on Fluent was conducted to verify the flux regulationeffect of the height change of the adjustable boss. | Muzhi ZHU Shengdun ZHAO Jingxiang LI | 2016 | Frontiers of Mechanical Engineering2016，11，4： | 3 |
| 4 | SrAl_(2)O_(4) crystallite embedded inorganic medium with super-long persistent luminescence,thermoluminescence, and photostimulable luminescence for smart optical information storage显示文摘As a leader of long persistent luminescence(LPL) materials, the optical properties of aluminate phosphor have remained unsurpassed for many years. As a powder material, its practical application will always be limited to the field of security signs. In this paper, the SrAl_(2)O_(4)∶Eu^(2+), Dy^(3+)inorganic solid material with comparable LPL properties to powder materials was obtained. The crystallization mechanism and crystallite micro-morphology of inorganic glass materials have been studied, and a new opinion is put forward that the large-size SrAl_(2)O_(4)crystallites in the glass matrix are stacked by rod-shaped crystals arranged in a regular direction. In addition,the SrAl_(2)O_(4)∶Eu^(2+), Dy^(3+)glass obtained cannot only collect high-energy photons but also is sensitive to lowenergy sunlight. The results show that the material exhibits superior performance in LPL, thermoluminescence,and photostimulable luminescence. Based on this property, a new application of this material in the field of information storage was explored. This paper has a certain reference value for the development and application of aluminate LPL materials in the field of smart optical information storage. | Panpan Li Youjie Hua Renguang Ye Muzhi Cai Shiqing Xu Junjie Zhang | 2022 | Photonics Research2022，10，2： | 1 |
| 5 | Effects of trace calcium and strontium on microstructure and properties of Cu-Cr alloys显示文摘Cu-0.57Cr-0.01Ca and Cu-0.58Cr-0.01Sr(wt.%)alloys were fabricated and processed by thermo-mechanical treatment.Their mechanical and electrical properties and microstructure were investigated in detail and compared with those of a Cu-0.57Cr(wt.%)alloy.The results showed that the softening resistance of the Cu-Cr alloy was significantly improved by the additions of Ca and Sr elements.Compared with the Cu-Cr alloy,the deformation microstructure of the Cu-Cr-Ca and Cu-Cr-Sr alloys was more difficult to recrystallize at elevated temperatures,and the Cr precipitates in the Cu-Cr-Ca and Cu-Cr-Sr alloys were smaller in size and had an FCC structure at any given aging state.The high strengths of the Cu-Cr-Ca and Cu-Cr-Sr alloys were mainly attributed to the dislocation strengthening provided by high-density dislocations and the precipitate strengthening provided by fine Cr precipitates.First-principles calculation showed that the segregations of Ca and Sr atoms at interface between Cr precipitates and copper matrix were favorable in energetics.This segregation effectively hindered the growth of Cr precipitates and significantly enhanced the pinning effect on the motion of dislocations and subgrain boundaries,eventually leading to the improvement in the softening resistance of the Cu-Cr alloy. | Muzhi Ma Zhu Xiao Xiangpeng Meng Zhou Li Shen Gong Jie Dai Hongyun Jiang Yanbin Jiang Qian Lei Haigen Wei | 2022 | Journal of Materials Science & Technology2022，，17： | 1 |
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