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| 1 | 重组脊髓灰质炎病毒用于治疗复发胶质母细胞瘤(英文)显示文摘Background The prognosis of patients with recurrent World Health Organization(WHO)grade IV malignant glioma is dismal,and there is currently no effective therapy.We conducted a dose-finding and toxicity study in this population of patients,evaluating convection-enhanced,intratumoral delivery of the recombinant nonpathogenic polio-rhinovirus chimera(PVSRIPO).PVSRIPO recognizes the poliovirus receptor CD155,which is widely expressed in neoplastic cells of solid tumors and in major components of the tumor microenvironment.Methods We enrolled consecutive adult patients who had recurrent supratentorial WHO grade IV malignant glioma,confirmed on histopathological testing,with measurable disease(contrast-enhancing tumor of≥1 cm and≤5.5 cm in the greatest dimension).The study evaluated seven doses,ranging between 107 and 1010 50%tissue-culture infectious doses(TCID50),first in a dose-escalation phase and then in a dose-expansion phase.Results From May 2012 through May 2017,a total of 61 patients were enrolled and received a dose of PVSRIPO.Dose level-1(5.0×107TCID50)was identified as the phase 2 dose.One dose-limiting toxic effect was observed;a patient in whom dose level 5(1010TCID50)was administered had a grade 4 intracranial hemorrhage immediately after the catheter was removed.To mitigate locoregional inflammation of the infused tumor with prolonged glucocorticoid use,dose level 5 was deescalated to reach the phase 2 dose.In the dose-expansion phase,19%of the patients had a PVSRIPO-related adverse event of grade 3 or higher.Overall survival among the patients who received PVSRIPO reached a plateau of 21%(95%confidence interval,11 to 33)at 24 months that was sustained at 36 months.Conclusions Intratumoral infusion of PVSRIPO in patients with recurrent WHO grade IV malignant glioma confirmed the absence of neurovirulent potential.The survival rate among patients who receivedPVSRIPO immunotherapy was higher at 24 and 36 months than the rate among historical controls. | Desjardins A Gromeier M Herndon JE 2nd Beaubier N Bolognesi DP Friedman AH Friedman HS McSherry F Muscat AM Nair S Peters KB Randazzo D Sampson JH Vlahovic G Harrison WT McLendon RE Ashley D Bigner DD | 2018 | 中华神经外科疾病研究杂志2018，17，4： | 2 |
| 2 | Bayesian network classifiers显示文摘 | FRIEDMAN N GEIGER D GOLDSZMIDT M | 1997 | Machine Learning1997，29，3： | 1 |
| 3 | Using Bayesian networks to analyze expression data 显示文摘 | FRIEDMAN N LINIAL M NACHMAN I | 2000 | Journal of Computational Biology2000，7，3： | 1 |
| 4 | Comparing models of rapidly rotating relativistic stars constructed by two numerical methods显示文摘 | STERGIOULAS N FRIEDMAN J L | 1995 | AP J1995，444，： | 1 |
| 5 | Evaluation of coefficients for the weighted sum of gray gases model 显示文摘 | Smith T F Shen Z F Friedman J N | 1982 | ASMEJ Heat Transfer1982，，104： | 1 |
| 6 | Important causes of visual impairment in the world today显示文摘 | Congdon N G Friedman D S Lietman T | 2003 | JAMA2003，290，15： | 1 |
| 7 | Orally disintegrating selegiline in Parkinson patients with dopamine ago-nist-related adverse effects显示文摘 | Lyons KE Friedman JH Hermanowicz N | 2010 | Clin Neuropharmaeol2010，33，1： | 1 |
| 8 | Serum amyloid A (SAA) variations in patients with cancer: correlation with disease activity, stage, primary site, and prognosis 显示文摘 | Biran H Friedman N Neumann L | 1986 | J Clin Pathol1986，39，7： | 1 |
| 9 | Risk for gastric cancer in people with CagA positive or CagA negative Helicobacter pylori infection显示文摘 | Parsonnet J Friedman GD Orentreich N | 1997 | Gut1997，40，3： | 1 |
| 10 | Building classifiers using Bayesian network显示文摘 | FRIEDMAN N GOLDSZMIDT M | 1996 | In proc Nation Conference on Artificial Intelligence Menlo park CA:AAAI Press1996，1996，： | 1 |
| 11 | Frequent premature ventric- ular complexes originating from the right ventrieular outflow tract are associated with left ventricular dysfunction 显示文摘 | Kanei Y Friedman M Ogawa N | 2008 | Ann Noninva- sive Eleetrocardio12008，13，1： | 1 |
| 12 | Protein kinase C mediates basie fibroblast growth factor pm- lection of endothelial cells against radiation - induced apoptosis 显示文摘 | HAIMOVlTZ FRIEDMAN A BALABAN N MCI OUGHI IN M el al | 1994 | Cancer Res1994，54，10： | 1 |
| 13 | Echocardio- graphic evidence for impaired myocardial performance in chil- dren with type I diabetes mellitus显示文摘 | Friedman N E Levitsky L L Edidin D V | 1982 | Am J Med1982，73，6： | 1 |
| 14 | Peripheral- ly inserted central catheter (PICC) fracture and emboliza- tion in the pediatric population 显示文摘 | Chow L M Friedman J N Macarthur C | 2003 | J Pediatr2003，142，2： | 1 |
| 15 | Stimulation and proliferation of primary rat hepatic stellate cells by cytochrome P450 2El-derived reactive oxygen species显示文摘 | Nieto N Friedman SC Cederbaum AI | 2002 | Hepatology2002，35，1： | 1 |
| 16 | Review of ranking methods in the data envelopment analysis eontext 显示文摘 | Adler N Friedman L Zilla SS | 2002 | European Journal of Operational Research2002，140，： | 1 |
| 17 | Targetd insult to subsurface cortical blood vessels using ultrashort laser pulses:three models of stroke显示文摘 | N Nishimura C B Schaffer B Friedman | 2006 | Nature Methods2006，3，2： | 1 |
| 18 | Targeted insult to subsurface cortical blood vessels using ultrashort laser pulses: three models of stroke 显示文摘 | Nishimura N Schaffer CB Friedman B | 2006 | Nat Meth2006，3，2： | 1 |
| 19 | Spontaneous isolated dissection of the celiac artery:CT findings in adults显示文摘 | D'Ambrosio N Friedman B Siegel D | | 0，，06： | 1 |
| 20 | Femtosecond laser capsulotomy显示文摘 | FRIEDMAN N J PALANKER DV SCHUELE G ANDERSEN D MARCELLINO G SEIBEL BS | 2011 | J Cataract Refract Surg2011，37，7： | 1 |
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