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| 1 | 非洲裔美国人体力活动与高血压发生的相关性显示文摘非洲裔美国人在美国各种族(民族)中高血压患病率(男性为40.8%,女性为41.5%)最高。有证据表明,与美国其他种族(民族)相比,非洲裔美国人高血压与因心肌梗死、脑卒中和终末期肾脏疾病引起的过早功能丧失和死亡呈不成比例地升高相关。需要确定控制非洲裔美国人危险因素的措施,以减轻其发生高血压的风险。在许多其他人群中已证实,体力活动对预防高血压有保护作用。因此,高血压指南推荐采用体力活动作为预防性生活行为方式。 | Diaz KM Booth JN 3rd Seals SR Abdalla M Dubbert PM Sims M Ladapo JA Redmond N Muntner P Shimbo D | 2017 | 中华高血压杂志2017，25，2： | 10 |
| 2 | 常规脂蛋白检测和载脂蛋白在心血管病预测中的比较显示文摘总胆固醇和高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)测量值对于心血管病风险评估至关重要,但对于其他脂质用于风险预测的效用一直存在争议。该研究纳入来自英国生物银行(Biobank)的无基线心血管病、未服用他汀类药物、有相关的脂质指标(n=346 686)的受试者。 | Welsh C Celis-Morales CA Brown R Mackay DF Lewsey J Mark PB Gray SR Ferguson LD Anderson JJ Lyall DM Cleland JG Jhund PS Gill J MR Pell JP Sattar N Welsh P 刘青(译) 叶鹏(摘、审校) | 2019 | 中华高血压杂志2019，27，7： | 10 |
| 3 | Treatment of hepatitis C virus genotype 4 with peginterferon alfa-2a: Impact of bilharziasis and fibrosis stage显示文摘AIM: To evaluate pegylated interferon alpha2a (PegIFN- α2a) in Egyptian patients with HCV genotype 4, and the impact of pretreatment viral load, co-existent bilharziasis and histological liver changes on response rate. METHODS: A total of 73 na?ve patients (61 with history of bilharziasis) with compensated chronic HCV genotype 4 were enrolled into: group A (38 patients) who received 180 mg PegIFN-alpha2a subcutaneously once weekly for a year and group B (35 patients) received IFN alpha-2a 3 MU 3 times weekly. Ribavirin was added to each regimen at a dose of 1200 mg. Patients were followed for 72 wk and sustained response was assessed. RESULTS: Significant improvement in both end of treatment response (ETR) (P < 0.002) and sustained response (SR) (P < 0.05) was noted with pegylated interferon, where ETR was achieved in 29 (76.3%) and 14 patients (40%) in both groups respectively, and 25 patients in group A (65.8%) and 9 (25.7%) in group B could retain negative viraemia by the end of follow up period. Sustained virological response (SVR) showed a significant negative correlation with age and positive correlation with pretreatment inflammation in patients receiving PegIFN. Viral clearance after 3 mo of therapy was associated with high incidence of ETR and SR (P < 0.001), but without significant difference between both forms of interferon. Significant improvement in response was achieved in patients with high grade fibrosis (grade 3 and 4) with PegIFN-α2a, where SR was seen in 5 out of 13 patients in group A, but none in group B. There was no significant difference in response betweenbilharzial and non-bilharzial patients in both groups. In terms of safety and tolerability, neutropenia was the predominant side effect; both drugs were comparable. CONCLUSION: PegIFN-α2a combined with ribavirin results in improvement in sustained response in HCV genotype 4, irrespective of history of bilharzial infestation. | MF Derbala SR Al Kaabi NZ El Dweik F Pasic MT Butt R Yakoob A Al-Marri AM Amer N Morad A Bener | 2006 | World Journal of Gastroenterology2006，12，35： | 3 |
| 4 | Advances and new perspectives in the treatment of metastatic colon cancer显示文摘During the last decade we have witnessed an unprec-edented outburst of new treatment approaches for the management of metastatic colon cancer.Anti-angio-genic drugs,epidermal growth factor receptor blockers and multi-kinase inhibitors have all resulted in small but consistent improvement in clinical outcomes.However,this progress has paradoxically leaded us into new chal-lenges.In many cases the clinical development was done in parallel and the lack of head-to-head compari-son evolved into circumstances where several valid new'standards of care'are available.Even though desir-able in essence,the availability of many options as well as different possible combinations frequently leaves the busy clinician in the difficult situation of having to choose between one or the other,sometimes without solid evidence to support each decision.In addition,progress never stops and new agents are continuously tested.For these reason this review will try to summa-rize all the clinical trials that constitute the theoretical framework that support our daily practice but will also procure the reader with rational answers to common clinical dilemmas by critically appraising the current literature.Lastly,we will provide with a compilation of promising new agents that may soon become our next line of defense against this deadly disease. | Gonzalo Recondo Jr Enrique Díaz-Cantón Máximo de la Vega Martin Greco Gonzalo Recondo Sr Matias E Valsecchi | 2014 | World Journal of Gastrointestinal Oncology2014，6，7： | 2 |
| 5 | Humanization of yeast to produce complex terminally sialylated glycoproteins 显示文摘 | HAMILTON SR DAVIDSON RC SETHURAMAN N | 2006 | Science2006，313，5792： | 1 |
| 6 | Intermittent vs continuous hypoxia: effects on ventilation and erythmpoiesis in humans 显示文摘 | Garcia N Hopkins SR Powell FL | 2000 | Wilderness Environ Med2000，11，3： | 1 |
| 7 | Resting peripheral blood fiow in normal pregnancy and in preeclampsia显示文摘 | Anim-Nyame N Sooranna SR Johnson MR etal | 2000 | Climsci2000，99，： | 1 |
| 8 | A pilot prospective randomized trial of postoperative epoetin alfa in patients undergoing major operation for upper gastrointestinal malignancy 显示文摘 | GROBMYEH SR HEMMING AW HARRIS N | 2011 | Am J Clin Oncol2011，32，6： | 1 |
| 9 | Unusual Helicobacter pylori in gastric resection specimens: an old friend with a new look显示文摘 | Aggarwal N Snyder P Owens SR | 2011 | Int J Surg Pathol2011，19，： | 1 |
| 10 | Longitudinal analysis of maternal plasma leptin concentrations during normal pregnancy and preeclampsia显示文摘 | Soorana SR SteerPJ | 2000 | HUM Reprod2000，15，： | 1 |
| 11 | Cloning and characterization of rat dentin matrix prmein 1 (DMPI) gem and its 5' - upstream region显示文摘 | Thotakura SR Karthikeyan N Smith T | 2000 | J Bid Chem2000，275，10： | 1 |
| 12 | Phase Ⅱ trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor显示文摘 | SALTZ L B MEROPOL N J LOEHRER P J Sr | 2004 | J Clin Oncol2004，22，7： | 1 |
| 13 | The empirical mode decomposition and the Hilbert spectrum for nonlinear and non--sta- tionary time series analysis 显示文摘 | HUANG N E ZHEN Shen LONG SR etal | 1998 | Proc R Soc Lond A1998，454，： | 1 |
| 14 | Effects of hydrogenation and additives on cooking oil performance of soybean oil显示文摘 | Frankel E N Warner K Moulton Sr K J | 1985 | Journal of the American Oil Chemists’Society1985，62，9： | 1 |
| 15 | Serum response factor mediates NGF-de- pendent target irmervation by embryonic DRG sensory neurons显示文摘 | Wickramasinghe SR Alvania RS Ramanan N | 2008 | Neuron2008，58，： | 1 |
| 16 | Tables for predicting adult height from skeletal age: revised for use with the Greulich Pyle hand standards显示文摘 | Baley N and Pinneau SR | 1952 | J Pediatr1952，40，4： | 1 |
| 17 | Prostaglandin F2 α receptor regulation in human uterine myocytes显示文摘 | Liang Z Sooranna SR Engineer N | 2008 | Mol Hum Reprod2008，14，4： | 1 |
| 18 | Serum concentrations of organochlorine compounds and endometrial cancer risk ( United States) 显示文摘 | Brock JW Potischman N | 1998 | Cancer Causes Control1998，9，4： | 1 |
| 19 | Novel biodegradable electrospun membrane:scaffold for tissue engineering显示文摘 | Bhattarai SR Bhattarai N Yi HK | 2004 | Biomaterials2004，25，： | 1 |
| 20 | Comparison of chloral hydrate with and without promethazine in the young children显示文摘 | Houpt MZ Weiss N J Koenigsberg SR | 1985 | Pediatr Dent1985，7，1： | 1 |
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