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| 1 | Mucinous cystadenoma of the appendix associated with adenocarcinoma of the sigmoid colon and hepatocellular carcinoma of the liver:Report of a case显示文摘附录的粘蛋白的包囊腺瘤是一个稀罕条件并且与附录的普通名字粘液囊肿代表三个实体之一。它被腔的膀胱的膨胀在它内与粘液的壅滞描绘。组织病理学说地,粘液囊肿被划分成三个组:焦点或弥漫的粘膜增生,粘蛋白的包囊腺瘤和粘蛋白的包囊腺癌。这个条件经常与另外的瘤形成被联系,特别冒号和卵巢的腺癌。我们这里描述与腹的不快,便秘,在凳子的新鲜的血和经常的泌尿介绍了的 57 岁男性病人。他有与结肠的腺癌和肝的肝细胞癌联系的附录的一个大包囊腺瘤。病人经历了正确 haemicolectomy, S 字形的冒号切除术和肝的部分切除术。现在, 3 年以后,他没有疾病恶化的证据。根据这,我们在这些病人强调精确外科手术前的诊断的需要和整个腹部的 intraoperative 探索。 | Srdjan P Djuranovic Milan M Spuran Nada V Kovacevic Milenko B Uqliesic Dragutin M Kecmanovic Marian T Micev | 2006 | World Journal of Gastroenterology2006，12，12： | 12 |
| 2 | Modalities of testing Helicobacter pylori in patients with nonmalignant bile duct diseases显示文摘AIM: This paper describes the procedure of detection ofHelicobacter pylori ( H. pylori) in bile specimens in patientssuffering from benign diseases of biliary ducts (lithiasiswith/without nonspecific cholangitis).METHODS: The group of 72 patients entering the studyconsisted of 32 male and 40 female (45 % and 55 %,respectively). Bile was obtained during ERCP in 68 patients,and during cholecystectomy in 4 patients. A fast urease test(FUT) to determine the existence of H. pylori in gastricmucosa was carried out for all the patients during theendoscopic examination. The existence of genetic materialof H. pylori was determined by detection of ure A gene bythe method of nested PCR. The results of this reaction wereshown by electrophoresis on l0 g@ L-1 agarose gel in a bandof 256 bp.RESULTS: The majority of the patients included in our studyhad biliary lithiasis without signs of cholangitis (48 patients,67 %), whereas other patients were complicated bycholangitis (17 patients, 24 %). Seven patients (9 %) hadnormal ERCP, forming thus the control group. In the groupof patients with lithiasis 26 patients (54.2 %) had positivePCR of H. pylori in bile and among the patients withassociated cholangitis positive PCR was detected in 9patients (52.9 % ). Among the seven patients with nornalERCP only one (14 %) had positive PCR of H. pylori. Ahigh percentage of H. pylori infection of gastric mucosawas observed (57 patients, 79 % ) : It was also observed thatits slightly higher positivity was in the patients with distinctbile pathology: 81% FUT positive patients in the group withcholedocholithiasis alone and 76 % in the group withcholedocholithiasis associated with cholangitis. Seventy-onepercent of the patients with regular findings had positive FUT.CONCLUSION: The prevalence of H. pylori infection both inbile and in gastric mucosa in patients with benign diseasesof biliary ducts does not show a statistically significantdifference in relation to the prevalence of the same with thepatients with normal ERCP. The existence of H. pyloriinfection possibly does not play a role in pathogenesis ofbenign biliary diseases. | Milutin Bulajic Bojan Stimec Miroslav Milicevic Matthias Loehr Petra Mueller Ivan Boricic Nada Kovacevic Mirko Bulajic | 2002 | World Journal of Gastroenterology2002，8，2： | 6 |
| 3 | Biochemical markers for non-invasive assessment of disease stage in patients with primary biliary cirrhosis显示文摘AIM: To evaluate different biochemical markers and their ratios in the assessment of primary biliary cirrhosis (PBC) stages. METHODS: This study included 112 patients with PBC who underwent a complete clinical investigation. We analyzed the correlation (Spearman's test) between ten biochemical markers and their ratios with different stages of PBC. The discriminative values were compared using areas under receiver operating characteristic (ROC) curves. RESULTS: The mean age of patients included in the study was 53.88 ± 10.59 years, including 104 females and 8 males. We found a statistically significant correlation between PBC stage and Aspartate aminotransferase (AST), Alanine aminotransferase (ALT) to platelet ratio (APRI), ALT/platelet count, AST/ALT, ALT/AST and ALT/Cholesterol ratios, with the values of Spearman's rho of 0.338, 0.476, 0.404, 0.356, 0.351 and 0.325, respectively. The best sensitivity and specificity was shown for AST/ALT, with an area under ROC of 0.660. CONCLUSION: Biochemical markers and their ratios do correlate with different sensitivity to and specificity of PBC disease stage. The use of biochemical markers and their ratios in clinical evaluation of PBC patients may reduce, but not eliminate, the need for liver biopsy. | Tamara Alempijevic Miodrag Krstic Rada Jesic Ivan Jovanovic Aleksandra Sokic Milutinovic Nada Kovacevic Slobodan Krstic Dragan Popovic | 2009 | World Journal of Gastroenterology2009，15，5： | 4 |
| 4 | Right liver lobe/albumin ratio:Contribution to non-invasive assessment of portal hypertension显示文摘瞄准:学习价值生物化学并且在存在的预言和食道的静脉曲张的尺寸的 ultraso-nographic 参数。方法:学习包括经历了一个完全的生物化学的工作在上面的选择肝脏硬化症的病人,上面内视镜的 digestive 和 ultrasonographic 考试。白朊 / 权利肝脑叶直径和血小板计数 / 脾直径比率是计算的。在食道的静脉曲张的计算比率和存在和度之间的关联被评估。结果:94 个题目(62 男性, 32 女性) ,与 52.32 +/- 的吝啬的年龄 13.60 年,被学习。孩子呸班 A 占了 42.6% ,班 B 37.2% ,而班 C 20.2% 。,食道的静脉曲张(OE ) 没被上面的消化内视镜检查法在 24.5% 表明我在 22.3% 病人,被发现的 OE 等级在 33.0% 分级 II,在 16.0% 分级 III,并且分级在 4.3% 的 IV。正确的肝脑叶直径 / 白朊比率的吝啬的价值是 5.51 +/- 1.82 (从 2.76 ~ 11.44 的范围) 当吝啬的血小板计数 / 脾直径比率是 1017.75 +/- 时 729.36 (从 117.39 ~ 3362.50 的范围) 分别地。统计上重要的关联被枪兵在 OE 等级和计算比率之间的测试证明。P 价值是 0.481 并且 -0.686, 分别地。结论:正确的肝脑叶直径 / 白朊和血小板计数 / 脾直径比率是提供对食道的静脉曲张,并且他们与肝肝硬化在病人分级的存在的决心恰当的精确信息的非侵略的参数。 | Tamara Alempijevic Vladislava Bulat Srdjan Djuranovic Nada Kovacevic Rada Jesic Dragan Tomic Slobodan Krstic Miodrag Krstic | 2007 | World Journal of Gastroenterology2007，13，40： | 4 |
| 5 | Double common bile duct: A case report显示文摘Double common bile duct (DCBD) is a rare congenital anomaly in which two common bile ducts exist. One usually has normal drainage into the papilla duodeni major and the other usually named accessory common bile duct (ACBD) opens in different parts of upper gastrointestinal tract (stomach, duodenum, ductus pancreaticus or septum). This anomaly is of great importance since it is often associated with biliary lithiasis, choledochal cyst, anomalous pancreaticobiliary junction (APBJ) and upper gastrointestinal tract malignancies. We recently recognized a rare case of DCBD associated with APBJ with lithiasis in better developed common bile duct. The opening site of ACBD was in the pancreatic duct. The anomaly was suspected by transabdominal ultrasonography and finally confirmed by endoscopic retrograde cholangiopancreatography (ERCP) followed by endoscopic sphincterotomy and stone extraction. According to the literature, the existence of DCBD with the opening of ACBD in the pancreatic duct is most frequently associated with APBJ and gallbladder carcinoma. In case of DCBD, the opening site of ACBD is of greatest clinical importance because of its close implications with concomitant pathology. The adequate diagnosis of this rare anomaly is significant since the operative complications may occur in cases with DCBD which is not recognized prior to surgical treatment. | Srdjan P Djuranovic Milenko B Ugljesic Nenad S Mijalkovic Viktorija A Korneti Nada V Kovacevic Tamara M Alempijevic Slaven V Radulovic Dragan V Tomic Milan M Spuran | 2007 | World Journal of Gastroenterology2007，13，27： | 1 |
| 6 | Immunmodulatory effects of the meth- anolic extract of Epimedium alpinum in vitro 显示文摘 | Nada Kovacevic | 2006 | Fitotera- pic2006，77，： | 1 |
| 7 | Immu- nomodulatory effects of the methanolic extract of Epimedium alpi- hum in vitro 显示文摘 | Nada Kovacevic Miodrag Colic Aleksandar Backovic | 2006 | Fitoterapia2006，77，78： | 1 |
| 8 | Validation of the chronic liver disease questionnaire in Serbian patients显示文摘AIM:To translate into Serbian and to investigate the validity of the cross-culturally adapted the chronic liver disease questionnaire(CLDQ).METHODS:The questionnaire was validated in 103 consecutive CLD patients treated between October 2009 and October 2010 at the Clinic for Gastroenterology,Clinical Centre of Serbia,Belgrade(Serbia).Exclusion criteria were:age < 18 years,psychiatric disorders,acute complications of CLD(acute liver failure,variceal bleeding,and spontaneous bacterial peritonitis),hepatic encephalopathy(grade > 2)and liver transplantation.Evaluation of the CLDQ was done based on the following parameters:(1)acceptance is shown by the proportion of missing items;(2)internal reliabilities were assessed for multiple item scales by using Cronbach alpha coefficient;and(3)in order to assess whether the allocation of items in the domain corresponds to their distribution in the original questionnaire(construction validity),an exploratory factor analysis was conducted.Discriminatory validity was determined by comparing the corresponding CLDQ score/sub-score in patients with different severity of the diseases.RESULTS:The Serbian version of CLDQ questionnaire completed 98% patients.Proportion of missing items was 0.06%.The total time needed to fill the questionnaire was ranged from 8 to 15 min.Assistance in completing the questionnaire required 4.8% patients,while 2.9% needed help in reading,and 1.9% involved writing assistance.The mean age of the selected patients was 53.8 ± 12.9 years and 54.4% were men.Average CLDQ score was 4.62 ± 1.11.Cronbach's alpha for the whole scale was 0.93.Reliability for all domains was above 0.70,except for the domain 'Activity'(0.49).The exploratory factor analysis model revealed 6 factors with eigenvalue of greater than 1,explaining 69.7% of cumulative variance.The majority of the items(66%)in the Serbian version of the CLDQ presented the highest loading weight in the domain assigned by the CLDQ developers:'Fatigue'(5/5),'Emotional function'(6/8),'Worry'(5/5),'Abdominal symptoms'(0/3),'Activity'(0/3),'Systemic symptoms'(3/5).The scales 'Fatigue' and 'Worry' fully corresponded to the original.The factor analysis also revealed that the factors 'Activity' and 'Abdominal symptoms' could not be replicated,and two new domains 'Sleep' and 'Nutrition' were established.Analysis of the CLDQ score/sub-score distribution according to disease severity demonstrated that patients without cirrhosis had lower total CLDQ score(4.86 ± 1.05)than those with cirrhosis Child's C(4.31 ± 0.97).Statistically significant difference was detected for the domains 'Abdominal symptoms' [F(3)= 5.818,P = 0.001] and 'Fatigue' [F(3)= 3.39,P = 0.021].Post hoc analysis revealed that patients with liver cirrhosis Child's C had significantly lower sub-score 'Abdominal symptoms' than patients without cirrhosis or liver cirrhosis Child's A or B.For domain 'Fatigue',patients with cirrhosis Child's C had significantly lower score,than non-cirrhotic patients.CONCLUSION:The Serbian version of CLDQ is well accepted and represents a valid and reliable instrument in Serbian sample of CLD patients. | Dusan Dj Popovic Nada V Kovacevic Darija B Kisic Tepavcevic Goran Z Trajkovic Tamara M Alempijevic Milan M Spuran Miodrag N Krstic Rada S Jesic Zobair M Younossi Tatjana D Pekmezovic | 2013 | World Journal of Gastroenterology2013，19，30： | 1 |
| 9 | Polyphenol Content and Antioxidant Activity ofMaychs Strgma Extracts 显示文摘 | ZORAN MAKSIMOVIC DORDE MALENCIC NADA KOVACEVIC | 2005 | Bioresource Technolohy2005，95，： | 1 |
| 10 | Immunomodulatory effects of the methanolic extract of Epirnediurn alpinum in vitro 显示文摘 | Nada Kovacevic Miodrag Colic Aleksandar Backovic | 2006 | Fitoterapia2006，77，： | 1 |
| 11 | Polyphenol contents and antioxidant activity of Maydis stigma extracts显示文摘 | Zoran Maksimovic Dorde Malencic Nada Kovacevic | 2005 | Bioresourse Technoligy2005，96，： | 1 |
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