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| 1 | Heterogeneity in mouse spasmolytic polypeptide-expressing metaplasia lineages identifies markers of metaplastic progression显示文摘 | Victoria G Weis Josane F Sousa Bonnie J LaFleur Ki Taek Nam Jared A Weis Paul E Finke Nadia A Ameen James G Fox James R Goldenring | 2013 | Gut2013，，9： | 3 |
| 2 | Safety,immunogenicity,and protection provided by unadjuvanted and adjuvanted formulations of a recombinant plant-derived virus-like particle vaccine candidate for COVID-19 in nonhuman primates显示文摘Although antivirals are important tools to control severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection,effective vaccines are essential to control the current coronavirus disease 2019(COVID-19)pandemic.Plant-derived virus-like particle(VLP)vaccine candidates have previously demonstrated immunogenicity and efficacy against influenza.Here,we report the immunogenicity and protection induced in rhesus macaques by intramuscular injections of a VLP bearing a SARS-CoV-2 spike protein(CoVLP)vaccine candidate formulated with or without Adjuvant System 03(AS03)or cytidine-phospho-guanosine(CpG)1018.Although a single dose of the unadjuvanted CoVLP vaccine candidate stimulated humoral and cell-mediated immune responses,booster immunization(at 28 days after priming)and adjuvant administration significantly improved both responses,with higher immunogenicity and protection provided by the AS03-adjuvanted CoVLP.Fifteen micrograms of CoVLP adjuvanted with AS03 induced a polyfunctional interleukin-2(IL-2)-driven response and IL-4 expression in CD4 T cells.Animals were challenged by multiple routes(i.e.,intratracheal,intranasal,and ocular)with a total viral dose of 106 plaque-forming units of SARS-CoV-2.Lower viral replication in nasal swabs and bronchoalveolar lavage fluid(BALF)as well as fewer SARS-CoV-2-infected cells and immune cell infiltrates in the lungs concomitant with reduced levels of proinflammatory cytokines and chemotactic factors in the BALF were observed in animals immunized with the CoVLP adjuvanted with AS03.No clinical,pathologic,or virologic evidence of vaccineassociated enhanced disease was observed in vaccinated animals.The CoVLP adjuvanted with AS03 was therefore selected for vaccine development and clinical trials. | Stéphane Pillet Prabhu SArunachalam Guadalupe Andreani Nadia Golden Jane Fontenot Pyone Pyone Aye Katharina Röltgen Gabrielle Lehmicke Philipe Gobeil Charlotte Dubé Sonia Trépanier Nathalie Charland Marc-AndréD’Aoust Kasi Russell-Lodrigue Christopher Monjure Robert V.Blair Scott D.Boyd Rudolf P.Bohm Jay Rappaport François Villinger Nathalie Landry Bali Pulendran Brian J.Ward | 2022 | Cellular & Molecular Immunology2022，19，2： | 2 |
| 3 | Synthesis,characterization and antimicrobial activity of poly ( N-vinyl imidazole ) grafted carboxymethyl chitosan显示文摘 | Magdy W Sabaa Nadia A Mohamed Riham R Mohamed | 2010 | Carbohydrate Polymers2010，79，4： | 1 |
| 4 | The stem cell challenge 显示文摘 | Robert L Nadia R | 2004 | Sci Am2004，290，6： | 1 |
| 5 | Neuroprotection by misoprostol against rotenone-induced neurotoxicity in rat brain显示文摘Objective: To investigate the effect of the prostaglandin E1 analogue misoprostol on oxidative stress and neurodegeration caused by subcutaneous rotenone administration in rats. Methods:Rotenone was administered in a dose of 1.5 mg/kg every other day for 2 weeks. Starting from the 1 st day of rotenone injection, rats were subcutaneously treated with misoprostol at doses of10, 100 or 1 000 μg/kg. Rats were evaluated for brain lipid peroxidation(malondialdehyde:MDA), reduced glutathione(GSH), nitric oxide(NO) levels, and paraoxonase-1(PON-1) activity.The concentrations of the anti-apoptotic protein B cell/lymphoma-2(Bcl-2) were determined in the striatum. Histopathologic examination and the expression of inducible nitric oxide synthase(iNOS) in the cerebral cortex and striatum were also performed. Results: Compared with the vehicle-treated group, rotenone caused a significant increase in brain lipid proxidation(MDA)by 61%(P<0.05) accompanied by an increase in NO by 73.1%(P<0.05) and a decrease in GSH concentration by 29.4%(P<0.05). In addition, brain PON-1 activity significantly decreased by63.0%(P<0.05) and striatal Bcl-2 significantly decreased by 27.9%(P<0.05) with respect to the corresponding control value. Brain sections from rotenone treated rats showed extensive dark pyknotic and apoptotic nuclei in neurons, shrunken cytoplasm and perineuronal vacuolation.Rotenone also caused pronounced expression of iNOS in the cerebral cortex and striatum.Treatment with misoprostol at doses of 100 and 1 000 μg/kg resulted in decreased brain MDA(by 16.5%-23.0%)(P<0.05) and NO levels(by 37.1%-40.7%)(P<0.05) and increased GSH concentrations(by 18.8%-30.1%)(P<0.05). PON-1 activity was significantly increased by80.0%-114.8%(P<0.05) by misoprostol at 100 and 1 000 μg/kg, respectively. In addition,misoprostol treatment restored striatal Bcl-2 concentrations to its normal value. Misoprostol treatment resulted in markedly reduced brain injury and decreased iNOS expression in the cerebral cortex and striatum of rotenone intoxicated rats. Conclusions: These data suggest that misoprostol prevents the rotenone-induced neurodegeneration in rat brain by reducing brain oxidative stress. | Omar M.E.Abdel-Salam Amany A Sleem Eman R Youness Nadia A Mohammed Enayat A Omara | 2018 | Asian Pacific Journal of Tropical Medicine2018，11，1： | 1 |
| 6 | C - Reactive Protein Enhances LOX - 1 Expression in Human Aortic Endothelial Cells: Relevance of LOX - 1 to C - Reactive Protein - Induced Endothelial Dysfunction显示文摘 | Ling L Nadia R Tatsuya S | 2004 | Circ Res2004，95，： | 1 |
| 7 | SA13-26 :application of Plackett-Burman experimental design to evaluate culture requirements 显示文摘 | Nadia A Soliman M M Berekaa Y R Polyglutamic acid (PGA) production by Bacillus sp | 2005 | Applied Microbiology and Biotechnology2005，69，： | 1 |
| 8 | Synthesis and characterization of some novel antimicrobial thiosemicarbazone O-carboxymethyl chitosan derivatives显示文摘 | Nadia A Mohamed Riham R Mohamed Rania S Seoudi | 2014 | International Journal of Biological Macromolecules2014，63，2： | 1 |
| 9 | Isolation and analysis of single cells from the mouse heart显示文摘 | Alexander R Pinto Anjana Chandran Nadia A | 2013 | J Immunol Methods2013，393，： | 1 |
| 10 | Impact of Epidural Analgesia on Mortality and Morbidity After Surgery: Systematic Review and Meta-analysis of Randomized Controlled Trials显示文摘 | Daniel M. P?pping Nadia Elia Hugo K. Van Aken Emmanuel Marret Stephan A. Schug Peter Kranke Manuel Wenk Martin R. Tramèr | 2014 | Annals of Surgery2014，，6： | 1 |
| 11 | Thermal Degradation Behavior of Poly(vinyl chloride) in Presence of Poly (N-acryloyl-N'-cyanoacetohydrazide)显示文摘 | Nadia Ahmed Mohamed Zeinab R Farag Magdy W Sabaa | 2008 | Journal of Applied Polymer Science2008，109，： | 1 |
| 12 | Synthesis and characterization of some novel antimicrobial thiosemicarbazone O-carboxymethyl chitosan derivatives 显示文摘 | Nadia A Mohamed Riham R Mohamed Rania S Seoudi | 2014 | International Jounml of Biological Macromolecules2014，63，2： | 1 |
| 13 | Preoperative prescription of suppository diclofenac for spinal anesthesia显示文摘 | Ebrahim AJ Mozaffar R Nadia BH | 2013 | Ann Afr Med2013，12，1： | 1 |
| 14 | Expan ding monomeric pyrophosphate complexes beyond platinum显示文摘 | NADIA M VORTHERMS A R HOFFMAN A E | 2010 | Inorganic Chemistry2010，49，15： | 1 |
| 15 | Chro-nic inflamma-tion and inceased arterial stiffness in pa-tients with cardiac syndrome X显示文摘 | ARROYO E R NADIA M PABLO A | 2003 | Eur Heart J2003，24，： | 1 |
| 16 | Controlling the dispersion of multi-wall carbon nanotubes in aqueous sur- factant solution显示文摘 | YU J R NADIA G KONING C E | 2007 | Carbon2007，45，： | 1 |
| 17 | Thermal Degradation Behavior of Poly (vinyl chloride) in the Presence of Poly(glyeidyl methaerylate)显示文摘 | Magdy W Sabaa Zeinab R Farag Nadia A Mohamed | 2008 | Journal of Applied Polymer Science2008，110，： | 1 |
| 18 | Purification of transmem- brane proteins from Saccharomyces cerevisiae for X-ray crystallography显示文摘 | Kathleen MC Nadia F Katrina R | 2010 | Protein Expr Purif2010，71，： | 1 |
| 19 | Effect of Perioperative Systemic α2 Agonists on Postoperative Morphine Consumption and Pain Intensity: Systematic Review and Meta-analysis of Randomized Controlled Trials显示文摘 | Grégoire Blaudszun Christopher Lysakowski Nadia Elia Martin R. Tramèr | 2012 | Anesthesiology2012，，： | 1 |
| 20 | Evaluation of the prognostic significance of androgen receptor expression in metastatic breast cancer显示文摘 | Walter S Peter R Nadia D | 2006 | Virchows Arch2006，449，1： | 1 |
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