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| 1 | Identification of squamous cell carcinoma associated proteins by proteomics and loss of beta tropomyosin expression in esophageal cancer显示文摘AIM: To assess the proteome of normal versus tumor tissue in squamous cell carcinoma of the esophagus (SCCE) in Iranian patients and compare our results with former reports by using proteomics. METHODS: Protein was extracted from normal and tumor tissues. Two dimensional electrophoresis was carried out and spots with differential expression were identified with mass spectrometry. RNA extraction and RT-PCR along with immunodetection were performed. RESULTS: Fourteen proteins were found whose expression levels differed in tumor compared to normal tissues. Mass spectrometric analysis resulted in the identification of β-tropomyosin (TMβ), myosin light chain 2 (and its isoform), myosin regulatory light chain 2, peroxyredoxin 2, annexinⅠand an unknown polypeptide as the down regulated polypeptides in tumor tissue. Heat shock protein 70 (HSP70), TPM4-ALK fusion oncoprotein 2, myosin light polypeptide 6, keratinⅠ, GH16431p and calreticulin were the up-regulated polypeptides found in tumor tissue. Several of these proteins, such as TMβ,HSP70, annexinⅠ, calreticulin, TPM4-ALK and isoforms of myosins, have been well recognized in tumorigenesis of esophageal or other types of cancers. CONCLUSION: Our study not only supports the involve- ment of some of the formerly reported proteins in SCCE but also introduces additional proteins found to be lost in SCCE, including TMβ. | Ferdous Rastgar Jazii Zahra Najafi Reza Malekzadeh Thomas P Conrads Abed Ali Ziaee Christian Abnet Mansour Yazdznbod Ali Asghar Karkhane Ghasem H Salekdeh | 2006 | World Journal of Gastroenterology2006，12，44： | 14 |
| 2 | Application of machine learning in the fault diagnostics of air handling units显示文摘 | Najafi M Auslander D M Bartlett P L | 2012 | Applied Energy2012，96，： | 1 |
| 3 | Energy and cost opti- mization of a plate and fin heat exchanger using genetic al- gorithm 显示文摘 | Najafi H Najafi B Hoseinpoori P | 2011 | Applied Thermal Engineering2011，31，10： | 1 |
| 4 | Out- comes and quality of life in patients>85 years of age with ST-elevation myocardial infarction显示文摘 | SHAH P NAJAFI A H PANZA J A | 2009 | Am J Cardiol2009，103，： | 1 |
| 5 | Crystallization Be- havior and Morphology of Polylactide and PLA/Clay Nanocomposites in the Presence of Chain Extenders显示文摘 | Najafi N Heuzey M C Carreau P J | 2012 | Polymer Engineering and Science2012，，10： | 1 |
| 6 | Energy and cost op- timization of a plate and fin heat exchanger using genetic algo- rithm 显示文摘 | NAJAFI H NAJAFI B HOSEINPOORI P | 2011 | Applied Thermal Engineering2011，31，10： | 1 |
| 7 | Control of Ther- mal Degradation of Polylactide (PLA)-Clay Nanocompo- sites using Chain Extenders显示文摘 | Najafi N Heuzey M C Carreau P J | 2012 | Polymer Degradation and Stability2012，97，： | 1 |
| 8 | Evaluation of urban treated wastewater and irrigation method on growth indices of landscaping plants in arid and semi-arid regions显示文摘 | Najafi P Shams J Shams A | 2014 | Research on Crops2014，15，3： | 1 |
| 9 | Control of thermal degra- dation of polylactide (PLA) -clay nanocomposites using chain ex- tenders 显示文摘 | Najafi N Heuzey M C Carreau P J | 2012 | Polymer Degradation and Stability2012，97，4： | 1 |
| 10 | Epidemiologic aspects of the Bam earthquake in Iran:the nephrologic perspective显示文摘 | Hatamizadeh P Najafi I Vanholder R | 2006 | Am J Kidney Dis2006，47，3： | 1 |
| 11 | Outcomes and quality of life in patients 》 = 85 years of age with ST-elevation myocardial infarction显示文摘 | Shah P Najafi AH Panza JA | 2009 | American Journal of Cardiology2009，103，2： | 1 |
| 12 | Control of Thermal Degradation of Polylaetide (PLA)-clay Nano composites Using Chain Extenders 显示文摘 | Najafi N Heuzey C M Carreau J P | 2012 | Polym Degrad Stabil2012，97，： | 1 |
| 13 | 显示文摘 | Najafi N Heuzey M C Carreau P J | 2012 | Polymer Degra dation and Stability2012，，97： | 1 |
| 14 | Comparison of the effect of aminophylline and low PEEP vs high PEEP on EGF concentration in critiealJy ill patients with ALI/ARDS显示文摘 | Salari P Mojtahehzadeh M Najafi A | 2005 | J Clin Phann Ther2005，30，2： | 1 |
| 15 | Control of Thermal Degradation of Polylactide (PLA)-clay Nano composites Using Chain Extenders显示文摘 | Najafi N Heuzey C M Carreau J P | 2012 | Polymer Degra- dation and Stability2012，97，： | 1 |
| 16 | Polylactide (PEA) clay Nanocomposites Prepared by Melt Com- pounding in the Presence of a Chain gxtender显示文摘 | Najafi N Heuzey C M Carreau J P | 2012 | Com- posites Science and Technology2012，72，： | 1 |
| 17 | Efficient electron injection from solution-processed cesium stearate interlayers in organic light-emitting diodes 显示文摘 | Wetzelaer G A H Najafi A Kist R J P | 2013 | Applied Physics Letters2013，102，5： | 1 |
| 18 | A fiber-ceramic matrix composite material model for osteonal cortical bone fracture micromechanics: Solution of arbitrary microcracks interaction 显示文摘 | Najafi A R Arshi A R Saffar K P | 2009 | Journal of the Mechanical Behavior of Biomedical materials2009，29，6： | 1 |
| 19 | A fully integrated neural recording amplifier with DC input stabilization 显示文摘 | MOHSENI P NAJAFI K | 2004 | IEEE Trans Biomed Circ -Syst2004，51，5： | 1 |
| 20 | Epidemiologic aspects of the Barn earthquake in Iran:the nephrologic perspective显示文摘 | Hatamizadeh P Najafi I Vanholder R | | 0，，03： | 1 |
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