6篇
您的检索式：作者名="NAM Jungho"
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| 1 | Artificial Nanoscale Erythrocytes from Clinically Relevant Compounds for Enhancing Cancer Immunotherapy显示文摘Because of enhanced e cacy and lower side e ects,cancer immunotherapies have recently been extensively investigated in clinical trials to overcome the limitations of conventional cancer monotherapies.Although engineering attempts have been made to build nanosystems even including stimulus nanomaterials for the e cient delivery of antigens,adjuvants,or anticancer drugs to improve immunogenic cancer cell death,this requires huge R&D e orts and investment for clinically relevant findings to be approved for translation of the nanosystems.To this end,in this study,an air–liquid two-phase electrospray was developed for stable bubble pressing under a balance between mechanical and electrical parameters of the spray to continuously produce biomimetic nanosystems consisting of only clinically relevant compounds[paclitaxel-loaded fake blood cell Eudragit particle(Eu-FBCP/PTX)]to provide a conceptual leap for the timely development of translatable chemo-immunotherapeutic nanosystems.This was pursued as the e cacy of systems for delivering anticancer agents that has been mainly influenced by nanosystem shape because of its relevance to transporting behavior to organs,blood circulation,and cell–membrane interactions.The resulting Eu-FBCP/PTX nanosystems exhibiting phagocytic and micropinocytic uptake behaviors can confer better e cacy in chemo-immunotherapeutics in the absence and presence of anti-PD-L1 antibodies than similar sized PTX-loaded spherical Eu particles(Eu-s/PTX). | Wenquan Ou Kang Sik Nam Dae Hoon Park Jungho Hwang Sae Kwang Ku Chul Soon Yong Jong Oh Kim Jeong Hoon Byeon | 2020 | Nano-Micro Letters2020，12，7： | 1 |
| 2 | Carrying capacity of an uninhabited island off the southwestern coast of Korea显示文摘 | NAM Jungho CHANG Wonkeun KANG Daeseok | 2010 | Ecological Model- ling2010，，221： | 1 |
| 3 | Carrying capacity of an uninhabited island off the southwestern coast of Korea显示文摘 | Nam Jungho Chang Wonkeun Kang Daeseok | 2010 | Ecological Modelling2010，221，17： | 1 |
| 4 | Designation processes for marine protected areas in the coastal wetlands of South Korea显示文摘 | Jungho Nam Jongseong Ryu David Fluharty Chul-hwan Koh Karen Dyson Won Keun Chang Hee-Jung Choi Daeseok Kang Jong Seong Khim Chang-Hee Lee | 2010 | Ocean and Coastal Management2010，，11： | 1 |
| 5 | Carrying capacity of an uninhabited island off the southwestern coast of Korea显示文摘 | Jungho Nam Wonkeun Chang Daeseok Kang | 2010 | Ecological Modelling2010，，17： | 1 |
| 6 | Inflammatory conversion of quiescent osteoblasts by metastatic breast cancer cells through pERKl/2 aggravates cancer-induced bone destruction显示文摘Disruption of bone homeostasis caused by metastatic osteolytic breast cancer cells increases inflammatory osteolysis and decreases bone formation,thereby predisposing patients to pathological fracture and cancer growth.Alteration of osteoblast function induces skeletal diseases due to the disruption of bone homeostasis.We observed increased activation of pERK1/2 in osteolytic breast cancer cells and osteoblasts in human pathological specimens with aggressive osteolytic breast cancer metastases.We confirmed that osteolytic breast cancers with high expression of pERK1/2 disrupt bone homeostasis via osteoblastic ERK1/2 activation at the bone-breast cancer interface.The process of inflammatory osteolysis modulates ERK1/2 activation in osteoblasts and breast cancer cells through dominant-negative MEK1 expression and constitutively active MEK1 expression to promote cancer growth within bone.Trametinib,an FDA-approved MEK inhibitor,not only reduced breast cancer-induced bone destruction but also dramatically reduced cancer growth in bone by inhibiting the inflammatory skeletal microenvironment.Taken together,these findings suggest that ERK1/2 activation in both breast cancer cells and osteoblasts is required for osteolytic breast cancer-induced inflammatory osteolysis and that ERK1/2 pathway inhibitors may represent a promising adjuvant therapy for patients with aggressive osteolytic breast cancers by altering the shared cancer and bone microenvironment. | Jungho Back Minh Nam Nguyen Lu Li Saelim Lee Inkyu Lee Fancheng Chen Lauren Gillinov Yeon-Ho Chung Kareme D.Alder Hyuk-Kwon Kwon Kristin E.Yu Christopher M.Dussik Ziehen Hao Michael J.Flores Yoseph Kim Izuchukwu K.Ibe Alana M.Munger Sung Wook Seo Francis Y.Lee | 2021 | Bone Research2021，9，4： | 0 |
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