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| 1 | Predictors of hypoglycemia in insulin-treated patients with type 2 diabetes mellitus in Basrah显示文摘AIM To measure the incidence and determinants(predictors) of hypoglycemia among patients with type 2 diabetes mellitus(T2DM) who were on insulin treatment for at least one year. METHODS The present study is an out-patients based inquiry about the risk and predictors of hypoglycemia among patients with T2DM seeking care at the Al-Faiha Specialized Diabetes, Endocrine, and Metabolism Center, in Basrah over a period of 7 mo(from 15^(th) of April, 2013 to 15^(th) of October, 2013). The data used in the study were based on all detailed interview and selected laboratory investigations. A total of 336 patients could be included in the study.RESULTS The incidence of overall hypoglycemia among the studied patients was 75.3% within the last 3 mo preceding the interview. The incidence of hypoglycemia subtypes were 10.2% for severe hypoglycemia requiring medical assistance in the hospital, 44.36% for severe hypoglycemia treated at home by family; this includes both confirmed severe hypoglycemia with an incidence rate of 14.6% and unconfirmed severe hypoglycemia for which incidence rate was 29.76%. Regarding mild self-treated hypoglycemia, the incidence of confirmed mild hypoglycemia was 21.42%, for unconfirmed mildhypoglycemia the incidence rate was 50.0% and for total mild hypoglycemia, the incidence rate was 71.42%. The most important predictors of hypoglycemia were a peripheral residence, increasing knowledge of hypoglycemia symptoms, in availability and increasing frequency of self-monitoring blood glucose, the presence of peripheral neuropathy, higher diastolic blood pressure, and lower Hemoglobin A1c.CONCLUSION Hypoglycemia is very common among insulin-treated patients with T2DM in Basrah. It was possible to identify some important predictors of hypoglycemia. | Dhuha Tarik Nassar Omran S Habib Abbas Ali Mansour | 2016 | World Journal of Diabetes2016，7，18： | 3 |
| 2 | Diallyl sulfide protects against N-nitrosodiethylamine-induced liver tumorigenesis:Role of aldose reductase显示文摘AIM: To evaluate the protective effect of diallyl sulfide (DAS) against N-nitrosodiethylamine (NDEA)-induced liver carcinogenesis.METHODS: Male Wistar rats received either NDEA or NDEA together with DAS as protection.Liver energy metabolism was assessed in terms of lactate,pyruvate,lactate/pyruvate,ATP levels,lactate dehydrogenase (LDH) and glucose-6-phosphate dehydrogenase (G6PD) activities.In addition,membrane disintegration of the liver cells was evaluated by measuring lipid-peroxidation products,measured as malondialdehyde (MDA); nitric oxide (NO) levels; glucose-6-phosphatase (G6Pase),catalase (CAT) and superoxide dismutase (SOD) activities.Liver DNA level,glutathione-S-transferase (GST) and cytochrome c oxidase activities were used as DNA fragmentation indices.Aldose reductase (AR) activity was measured as an index for cancer cells resistant to chemotherapy and histopathological examination was performed on liver sections from different groups.RESULTS: NDEA significantly disturbed liver functions and most of the aforementioned indices.Treatment with DAS significantly restored liver functions and hepatocellular integrity; improved parameters of energy metabolism and suppressed free-radical generation.CONCLUSION: We provide evidence that DAS exerts a protective role on liver functions and tissue integrity in face of enhanced tumorigenesis caused by NDEA,as well as improving cancer-cell sensitivity to chemotherapy.This is mediated through combating oxidative stress of free radicals,improving the energy metabolic state of the cell,and enhancing the activity of G6Pase,GST and AR enzymes. | Safinaz S Ibrahim Noha N Nassar | 2008 | World Journal of Gastroenterology2008，14，40： | 2 |
| 3 | Current systematic reviews and meta-analyses of COVID-19显示文摘BACKGROUND Coronavirus disease 2019(COVID-19)has left a significant impact on the world's health,economic and political systems;as of November 20,2020,more than 57 million people have been infected worldwide,with over 1.3 million deaths.While the global spotlight is currently focused on combating this pandemic through means ranging from finding a treatment among existing therapeutic agents to inventing a vaccine that can aid in halting the further loss of life.AIM To collect all systematic reviews and meta-analyses published related to COVID-19 to better identify available evidence,highlight gaps in knowledge,and elucidate further meta-analyses and umbrella reviews that are yet to be performed.METHODS We explored studies based on systematic reviews and meta-analyses with the keyterms,including severe acute respiratory syndrome(SARS),SARS virus,coronavirus disease,COVID-19,and SARS coronavirus-2.The included studies were extracted from Embase,Medline,and Cochrane databases.The publication timeframe of included studies ranged between January 01,2020,to October 30,2020.Studies that were published in languages other than English were not considered for this systematic review.The finalized full-text articles are freely accessible in the public domain.RESULTS Searching Embase,Medline,and Cochrane databases resulted in 1906,669,and 19 results,respectively,that comprised 2594 studies.515 duplicates were subsequently removed,leaving 2079 studies.The inclusion criteria were systematic reviews or meta-analyses.860 results were excluded for being a review article,scope review,rapid review,panel review,or guideline that produced a total of 1219 studies.After screening articles were categorized,the included articles were put into main groups of clinical presentation,epi-demiology,screening and diagnosis,severity assessment,special populations,and treatment.Subsequently,there was a second subclassification into the following groups:gastrointestinal,cardiovascular,neurological,stroke,thrombosis,anosmia and dysgeusia,ocular manifestations,nephrology,cutaneous manifestations,D-dimer,lymphocyte,anticoagulation,antivirals,convalescent plasma,immunosuppressants,corticosteroids,hydroxychloroquine,renin-angiotensin-aldosterone system,technology,diabetes mellitus,obesity,pregnancy,children,mental health,smoking,cancer,and transplant.CONCLUSION Among the included articles,it is clear that further research is needed regarding treatment options and vaccines.With more studies,data will be less heterogeneous,and statistical analysis can be better applied to provide more robust clinical evidence.This study was not designed to give recommendations regarding the management of COVID-19. | Mahmoud Nassar Nso Nso Mostafa Alfishawy Anastasia Novikov Salim Yaghi Luis Medina Bahtiyar Toz Sofia Lakhdar Zarwa Idrees Yungmin Kim Dawa Ongyal Gurung Raheel S Siddiqui David Zheng Mariam Agladze Vikram Sumbly Jasmine Sandhu Francisco Cuevas Castillo Nadya Chowdhury Ravali Kondaveeti Sakil Bhuiyan Laura Guzman Perez Riki Ranat Carlos Gonzalez Harangad Bhangoo John Williams Alaa Eldin Osman Joyce Kong Jonathan Ariyaratnam Mahmoud Mohamed Ismail Omran Mariely Lopez Akwe Nyabera Ian Landry Saba Iqbal Anoosh Zafar Gondal Sameen Hassan Ahmed Daoud Bahaaeldin Baraka Theo Trandafirescu Vincent Rizzo | 2021 | World Journal of Virology2021，10，4： | 2 |
| 4 | In vitro and in vivo effects of tPA and PAI-1 on blood vessel tone显示文摘 | Nassar T Akkawi S Shina A | 2004 | Blood2004，103，3： | 1 |
| 5 | Deltamethrin-induced testicular apoptosis in rats:The protective effect of nitric oxide synthese inhibitor显示文摘 | EIGOHARY M AWARA W M NASSAR S | 1991 | Toxicology1991，132，： | 1 |
| 6 | Comparative cost of colour removal from textile effluents using natural adsorbents显示文摘 | NASSAR M M EL-GEUNDI M S | 1991 | Journal of chemical technology and biotechnology1991，50，2： | 1 |
| 7 | Wavelet de-noising for IMU alignment显示文摘 | E1-Sheimy N Nassar S Noureldin A | | 0，，10： | 1 |
| 8 | The significance of cystic duct stones encountered during Laparoscopic cholecystectomy 显示文摘 | Mahmud S Hamza Y Nassar HM | 2001 | Surg Endosc2001，15，： | 1 |
| 9 | Wave- let de-noising for IMU alignment显示文摘 | EL-SHEIMY N NASSAR S NOURELDIN A | 2004 | IEEE Aerospace and Electronic Systems Magazine2004，19，10： | 1 |
| 10 | Hydrothermal Synthesis of Cobalt Carbonates Using Different Counter Ions : An Efficient Precursor to Nano-sized Cobalt Oxide ( Co304 ) 显示文摘 | Nassar M Y Ahmed I S | 2011 | Polyhedron2011，30，15： | 1 |
| 11 | The significance of cystic duct stones encountered during laparoscopic cholecystectomy显示文摘 | Mahmud S Hamza Y Nassar HM | 2001 | Surg Endosc2001，15，10： | 1 |
| 12 | Dettamethrininduced testicular apoptosis in rats, the protective effect of nitric oxide synthase inhibitor 显示文摘 | El Gohary M Awara WM Nassar S | 1999 | Toxicalogy1999，132，1： | 1 |
| 13 | Fuzzy- Bayesian Network for Refrigeration Compressor Performance Prediction and Test Time Reduction 显示文摘 | Penz C A Flesch C A Nassar S M | 2012 | Expert Systems with Applications2012，39，4： | 1 |
| 14 | Solid olive waste in environmental cleanup: Oil recovery and carbon production for water purification显示文摘 | A EI-Hamouz H S Hilal N Nassar | 2007 | J Environ Manage2007，84，： | 1 |
| 15 | The significance of cystic duct stones encountered during laparoscopic cholecystectomy 显示文摘 | Mahmud S Hamza Y Nassar HM | 2001 | Surg Endosc2001，15，5： | 1 |
| 16 | The significance of cystic duct stones encountered during laparoscopic cholecystectomy显示文摘 | Mahmud S Hamza Y Nassar AH | 2001 | Surgical Endoscopy2001，15，5： | 1 |
| 17 | Function-alized silica synthesized by sol-gel process显示文摘 | NASSAR E J NERI C R CALEFI P S | 1999 | Journalof N on-Crystal line Solids1999，247，： | 1 |
| 18 | Improving positioning accuracy during kinematic DGPS outage periods using SINS/DGPS integration and SINS data denoising显示文摘 | Nassar S Noureldin A E1-Sheimy N | 2004 | Survey Reviw2004，37，292： | 1 |
| 19 | Real-time PCR hTERT mRNA pattern in tumor core,edge, resection margin, and lymph nodes in laryngeal tumors: relation to proliferative index and impact on prognosis 显示文摘 | Eissa S Kenawy G Moteleb F A El-Magkhzangy A N Nassar M | 2005 | Clin Bioehem2005，38，： | 1 |
| 20 | The influence of dietary marine oil ( polepa ) and evening primrose oil ( efamol ) on prostaglandin production by the rat mesenteric vasculature 显示文摘 | Nassar B A Manku M S Huang Y S | 1987 | Prostaglandins Leukotr and Medicine1987，26，： | 1 |
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