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| 1 | Empagliflozin alleviates podocytopathy and enhances glomerular nephrin expression in db/db diabetic mice显示文摘BACKGROUND Modern guidelines recommend sodium-glucose cotransporter-2(SGLT2)inhibitors as the preferred antihyperglycemic agents for patients with type 2 diabetes and chronic kidney disease.However,the mechanisms underlying the renal protective effect of SGLT2 inhibitors are not fully understood.structure of podocytes and nephrin expression in glomeruli in db/db diabetic mice.METHODS We treated 8-wk-old male db/db mice with EMPA(10 mg/kg/d)or vehicle for 8 wk.Age-matched male db/+mice were included as non-diabetic controls.Parameters of body composition,glycemic and lipid control,and plasma concentrations of leptin,insulin and glucagon were assessed.We evaluated renal hypertrophy as kidney weight adjusted to lean mass,renal function as plasma levels of creatinine,and albuminuria as the urinary albumin-to-creatinine ratio(UACR).Renal structures were studied by light and transmission electron microscopy with a focus on mesangial volume and podocyte structure,respectively.Glomerular nephrin and transforming growth factor beta(TGF-β)were assessed by immunohistochemistry.RESULTS Severe obesity and hyperglycemia developed in db/db mice prior to the start of the experiment;increased plasma concentrations of fructosamine,glycated albumin,cholesterol,leptin,and insulin,and elevated UACR were detected.Mesangial expansion,glomerular basement membrane thickening,and increased area of TGF-βstaining in glomeruli were revealed in vehicle-treated mice.Podocytopathy was manifested by effacement of foot processes;nephrin-positive areas in glomeruli were reduced.EMPA decreased the levels of glucose,fructosamine and glycated albumin,UACR,kidney hypertrophy,mesangial expansion,glomerular basement membrane thickening,and glomerular TGF-βstaining,alleviated podocytopathy and restored glomerular staining of nephrin.CONCLUSION These data indicate that EMPA attenuates podocytopathy in experimental diabetic kidney disease.The anti-albuminuric effect of EMPA could be attributed to mitigation of podocyte injury and enhancement of nephrin expression. | Vadim V Klimontov Anton I Korbut Iuliia S Taskaeva Nataliya P Bgatova Maksim V Dashkin Nikolai BOrlov Anna S Khotskina Evgenii L Zavyalov Thomas Klein | 2020 | World Journal of Diabetes2020，11，12： | 2 |
| 2 | Role of the physico-chemical factors in the purification process of water from surface-active matter by biosorption显示文摘 | NATALIYA K MARGRETHE W N SERGEY S | 2002 | Water Research2002，36，20： | 1 |
| 3 | On the reaction scheme and liquidus surface in the ternary system Al-Fe-Si显示文摘 | Nataliya K Franz W Julius C S | 2007 | Metallurgical and Materials Transantions2007，38，： | 1 |
| 4 | Adenosine receptor-mediated adhesion of endothelial progenitors to cardiac microvascular endothelial cells显示文摘 | SERGEY R NATALIYA V S ANNA E G | 2008 | Circ Res2008，102，3： | 1 |
| 5 | Diblock copolymer healing 显示文摘 | NATALIYA A Y JASON L SIBENER S J | 2009 | Polymer2009，50，： | 1 |
| 6 | Synthesis and X-ray studyof novel azofurazan-annulated macrocylic I actams显示文摘 | Aleksei B S Nataliya S A Dmitrii E D | 2005 | J Hetero-cyclic Chem2005，42，4： | 1 |
| 7 | Visible-light photocatalytic activity of TiO2/ZnS nanocomposites prepared by homogeneous hydrolysis 显示文摘 | Stengl V Bakardjievaa S Nataliya M | 2008 | Microporous and Mesoporous Materials2008，110，23： | 1 |
| 8 | A 3D optical metamaterial made by self-assembly显示文摘 | Silvia Vignolini Nataliya A Yufa Pedro S Cunha | 2012 | Adv Ma- ter2012，24，10： | 1 |
| 9 | Diblock copolymer healing 显示文摘 | Yufa Nataliya A Li J Sibener S J | 2009 | Polymer2009，50，12： | 1 |
| 10 | Synthesis and X-ray study of novel azofurazan-annulated macrocyclic lactams显示文摘 | Aleksei 8 Sheremetev Nataliya S Aleksandrova Dmitrii E Dmitriev | 2005 | J Heterocyclic Chem2005，42，： | 1 |
| 11 | Effect of the reaction parameters on the particle size in the disper- sion polymerization of 2-hydroxyethyl and glycidyl meth- acrylate in the presence of a ferrofluid 显示文摘 | DANIEL H NATALIYA S FRANTISEK L | 2003 | Polymer Sci- ence Part A: Polymer Chemistry2003，41，： | 1 |
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