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| 1 | The impact of ipsilateral testicular atrophy on semen quality and sperm DNA fragmentation response to varicocele repair显示文摘Varicoceles adversely impact semen quality and sperm DNA fragmentation,which typically improve with surgical repair.Some men with varicoceles have ipsilateral testicular atrophy due to damage from the varicocele.This study assessed semen quality and the sperm DNA fragmentation index(DFI)response to varicocele repair in men with ipsilateral testicular atrophy(TA)versus men with no testicular atrophy(NTA).Semen parameter values and DFI in both groups were compared preoperatively and postoperatively.The Mann-Whitney U test and the Wilcoxon signed-rank test were used where appropriate.There were 20 men in the TA group and 121 men in the NTA group with no difference in age,varicocele grade,or preoperative semen parameter values between the two groups.The NTA group had a higher preoperative DFI than the TA group.Both groups showed improvement in semen quality postoperatively,only the TA group showed a significant improvement in DFI,whereas the NTA group showed significant improvements in several parameter values and DFI.The change from preoperative to postoperative parameter values when comparing the two groups revealed a difference in total sperm motile count and DFI,with a larger mean improvement in the NTA group than in the TA group.Both TA and NTA groups showed improved semen quality and DFI after varicocele repair,but the NTA group had more improvement than the TA group.However,only total motile count(TMC)and DFI had a significantly greater mean change in preoperative to postoperative response in the NTA group than in the TA group. | Parviz K Kavoussi Natasha Abdullah Melissa S Gilkey Caitlin Hunn G Luke Machen Shu-Hung Chen Keikhosrow M Kavoussi Amy Esqueda J David Wininger Shahryar K Kavoussi | 2021 | Asian Journal of Andrology2021，23，2： | 2 |
| 2 | Re-referral to child protective services:The influence of child,family,and case characteristics on risk status显示文摘 | Christian M C Natasha B Karol H K | 2007 | Child Abuse & Neglect2007，31，： | 1 |
| 3 | Targeting caspases in cancer therapeutics显示文摘 | Patrick H Murli M Natasha K | 2013 | J Biol Chem2013，394，7： | 1 |
| 4 | Spin crossover intermediate plateau stabilization in a flexible 2-D hofmann-type coordination polymer 显示文摘 | Natasha F S Florence R Cameron J K | 2014 | Chemical Communication2014，50，29： | 1 |
| 5 | Doxorubicin-induced cardiomyopathy显示文摘 | Singal Pawan K Iliskovic Natasha | 1998 | N Eng Med1998，339，13： | 1 |
| 6 | Xytooli- gosaccharides as prebiotics from agricultural by - products: Production and applications 显示文摘 | Samanta A K Natasha Jayapal Jayaram Sohini Roy C | 2015 | Bioactive Carbohydrates and Dietary Fibre2015，5，1： | 1 |
| 7 | Isolation and structure ofsome constituents of the Australian medicinal plant Tinospora smi-lacina显示文摘 | Natasha L H Donald P A S William K | 1998 | Aust J Chem1998，51，： | 1 |
| 8 | Laryngeal mask airway in laryngoscopies: a safer alternative for the difficult airway显示文摘 | Nazish K Jeff E Natasha M | 2009 | ORL2009，71，： | 1 |
| 9 | Significancein replication of the terminal nucleotides of the Flavivirus genome显示文摘 | Khromykh AA Natasha K Ondratieva SgroJY | | 0，，： | 1 |
| 10 | A clinically relevant combination treatment with doxorubicin and cyclophosphamide does not induce hepatotoxicity in C57BL/6J mice显示文摘Background and aims:Chronic exposure to chemotherapeutics can lead to severe adverse events including hepatotoxicity.A combination chemotherapy regimen of doxorubicin(DOX)and cyclophos-phamide(CPS)is employed in treatment of several cancers such as leukemia,lymphoma,and breast cancer.It is not well understood whether a combination therapy with DOX and CPS can induce hepa-totoxicity.We therefore sought to determine whether co-administration of DOX and CPS at their clini-cally relevant doses and frequency results in hepatotoxicity.Methods:Male C57BL/6J mice received one intraperitoneal injection of saline or DOX-2 mg/kg and CPS-50 mg/kg once a week for 4 weeks.After the treatment period,liver histology and various serum bio-markers of hepatotoxicity were assessed.Results:Co-treatment with DOX and CPS did not alter the serum levels of alanine aminotransferase(ALT),alkaline phosphatase(ALP),bilirubin,albumin,globulin,or total protein.Similarly,co-administration of DOX and CPS did not result in a noticeable change in liver histology.However,it was notable that the concomitant treatment with DOX and CPS resulted in a significant increase in serum levels of aspartate aminotransferase(AST).Elevated serum AST levels were also associated with increased serum creatinine kinase(CK)levels,suggesting that the elevated serum AST levels are likely due to muscle injury following the co-administration of DOX and CPS.Conclusions:Taken together,our results,for the first time,suggest that co-administration of DOX and CPS,at their clinically relevant doses and frequency does not induce a significant hepatotoxicity in the mice. | Satyanarayana R Pondugula Julia M Salamat Kodye L Abbott Patrick C Flannery Mohammed Majrashi Mohammed Almaghrabi Manoj Govindarajulu Sindhu Ramesh Maninder Sandey Suneel K Onterue Chen-Che J Huang Yoshimi Iwaki Kristina Gill Natasha Narayanan Edwin McElroy Darshini Desai Rishi Nadar Timothy Moore Muralikrishnan Dhanasekaran | 2021 | Liver Research2021，5，4： | 1 |
| 11 | Work related stress, burnout, job satisfaction and general health of nurses显示文摘 | Natasha K Brian O Karl P | 2015 | Int J Environ Res Public Health2015，12，： | 1 |
| 12 | The impact of performance-based compensation on misreporting显示文摘 | Natasha B Simi K | 2006 | Journal of Financial Economics2006，79，1： | 1 |
| 13 | B5-deficient vaccinia virus as a vaccine vector for the expression of a foreign antigen in vaccinia immune animals显示文摘 | Kendra MV Natasha G Heesun K | 2007 | Virology2007，361，2： | 1 |
| 14 | The Impact of Performance Based Com- pensation on Misreporting 显示文摘 | Natasha B Simi K | 2006 | Journal of Financial Economics2006，，79： | 1 |
| 15 | Xylooligosaccharides as prebiotics from agricultur- al by-products: Production and applications显示文摘 | SAMANTA A K NATASHA JAYAPAL JAYARAM C | 2015 | Bioactive Carbohydrates and Dietary Fibre2015，5，1： | 1 |
| 16 | Work related stress, burnout job Satisfaction and general health of nurses显示文摘 | Natasha K Brian O Karl P | 2015 | Internationa Journal of Environmental Research and Public Health2015，12，： | 1 |
| 17 | Sensitive and se- lectlve liquid chromatography/tandem mass spectrometry methods for quantitative analysis of 1-methyl-4-phenyl pyridinium (MPP+ ) in mouse striatal tissue显示文摘 | MEI Y Z NATASHA K MEI-LI A S | 2008 | J Chromatogr B2008，874，12： | 1 |
| 18 | Relationship of adolescent polycystic ovary syndrome to parental metabolic syndrome显示文摘 | Natasha I Elizabeth E Masha K | 2006 | Clin Endocrinol Metab2006，91，4： | 1 |
| 19 | Preva- lence of Depression and Glucose Abnormality in an Urbanizing Rural Population of Bangladesh显示文摘 | NATASHA K HUSSAIN A AZAD KHAN AK | 2015 | Diabetes Metab J2015，39，3： | 1 |
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