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| 1 | Non-alcoholic fatty liver disease and diabetes: From physiopathological interplay to diagnosis and treatment显示文摘Non-alcoholic fatty liver disease(NAFLD)is highly prevalent in patients with diabetes mellitus and increasing evidence suggests that patients with type 2diabetes are at a particularly high risk for developing the progressive forms of NAFLD,non-alcoholic steatohepatitis and associated advanced liver fibrosis.Moreover,diabetes is an independent risk factor for NAFLD progression,and for hepatocellular carcinoma development and liver-related mortality in prospective studies.Notwithstanding,patients with NAFLD have an elevated prevalence of prediabetes.Recent studies have shown that NAFLD presence predicts the development of type2 diabetes.Diabetes and NAFLD have mutual pathogenetic mechanisms and it is possible that genetic and environmental factors interact with metabolic derangements to accelerate NAFLD progression in diabetic patients.The diagnosis of the more advanced stages of NAFLD in diabetic patients shares the same challenges as in non-diabetic patients and it includes imaging and serological methods,although histopathological evaluation is still considered the gold standard diagnostic method.An effective established treatment is not yet available for patients with steatohepatitis and fibrosis and randomized clinical trials including only diabetic patients are lacking.We sought to outline the published data including epidemiology,pathogenesis,diagnosis and treatment of NAFLD in diabetic patients,in order to better understand the interplay between these two prevalent diseases and identify the gaps that still need to be fulfilled in the management of NAFLD in patients with diabetes mellitus. | Nathalie C Leite Cristiane A Villela-Nogueira Claudia R L Cardoso Gil F Salles | 2014 | World Journal of Gastroenterology2014，20，26： | 21 |
| 2 | Functionalization of Single- and Multi-Walled Carbon Nanotubes with Cationic Amphiphiles for Plasmid DNA Complexation and Transfection显示文摘The possibility of delivering DNA effi ciently to cells represents a crucial issue for the treatment of both genetic and acquired diseases.However,even although the effi ciency of non-viral transfection systems has improved in the last decade,none have yet proven to be suffi ciently effective in vivo.We report herein our results on the functionalization of single-walled carbon nanotubes(SWNT)and multi-walled carbon nanotubes(MWNT)by two cationic amphiphiles(lipid RPR120535 and pyrenyl polyamine),their use for the complexation of plasmid DNA,and their efficiency in transfecting cells in vitro.The experiments have shown that the efficiency of transfection is higher when using SWNT instead of MWNT,and that transfection effi ciency is similar or slightly higher when using nanoplexes(SWNT/lipid RPR120535/DNA)instead of lipoplexes(lipid RPR120535/DNA)and several orders of magnitude higher than that of naked DNA.This study therefore shows both that the transfection is better when using SWNTs and that it is dependent on the nature of the amphiphilic molecules adsorbed on the nanotubes. | Cyrille Richard Nathalie Mignet Céline Largeau Virginie Escriou Michel Bessodes Daniel Scherman | 2009 | Nano Research2009，2，8： | 3 |
| 3 | Cyclosporin A inhibits hypoxia-induced pulmonary hypertension and right ventricle hypertrophy 显示文摘 | NATHALIE VALE'RIE N C ANDRE P | 2006 | Am d Respir Crit Care Med2006，174，6： | 1 |
| 4 | Effect of pKa on the kinetics of carbon dioxide absorption in aqueous alkanolamine solutions containing carbonic anhydrase at 298 K 显示文摘 | Nathalie J M C Penders-van E Sylvie F | 2015 | Chemical Engineering Journal2015，259，1： | 1 |
| 5 | Selective proges terone receptor modulators and progesterone antagonists: mechanisms of action and clinical applications显示文摘 | Nathalie C B Meduri G Bo'uchard P | 2005 | Hum Re prod Update2005，11，： | 1 |
| 6 | Prvcyanidins are themost abundant polyphenols in dessert apples at maturity显示文摘 | SYLVAIN G BOURVELLEC L C NATHALIE M | 2002 | Lebensm Wiss u Teehnol2002，35，3： | 1 |
| 7 | Collabora- tive networked organizations--concepts and practice in manu- facturing enterprises显示文摘 | LUIS M C HAMIDEH A NATHALIE G | 2009 | Computers Industrial Engineer- ing2009，57，1： | 1 |
| 8 | Determining Robust Impacts of Land-Use-Induced Land Cover Changes on Surface Climate over North America and Eurasia: Results from the First Set of LUCID Experiments显示文摘 | de Noblet-Ducoudré Nathalie Boisier Juan-Pablo Pitman Andy Bonan G B Brovkin V Cruz Faye Delire C Gayler V van den Hurk B J J M Lawrence P J van der Molen M K Müller C Reick C H Strengers B J Voldoire A | 2012 | EN2012，，9： | 1 |
| 9 | Antigen bias in T cell cross-priming显示文摘 | Monika C W Nathalie B Arnold H B | 2004 | Science2004，304，： | 1 |
| 10 | Determining Robust Impacts of Land-Use-Induced Land Cover Changes on Surface Climate over North America and Eurasia: Results from the First Set of LUCID Experiments显示文摘 | de Noblet-Ducoudré Nathalie Boisier Juan-Pablo Pitman Andy Bonan G B Brovkin V Cruz Faye Delire C Gayler V van den Hurk B J J M Lawrence P J van der Molen M K Müller C Reick C H Strengers B J Voldoire A | 2012 | EN2012，，9： | 1 |
| 11 | Sucrose Metabolism in Plastids 显示文摘 | Nathalie Gerrits Stefan C H J Turk Kees P M van Dun | 2001 | Plant Physiology2001，125，2： | 1 |
| 12 | Gamma-glutamyl transpeptidase gene organization and expression:a comparative analysis in rat,mouse,pig and human species显示文摘 | Naima C Nathalie H Georges G | 1999 | Comparative Biochemistry and Physiology Part B1999，122，4： | 1 |
| 13 | Usefulness of 2‐[<sup>18</sup>F]‐fluoro‐2‐deoxy‐ d ‐glucose–Positron Emission Tomography/Computed Tomography for Staging and Evaluation of Treatment Response in IgG4‐Related Disease: A Retrospective Multicenter Study显示文摘 | Mikael Ebbo Aurélie Grados Eric Guedj Delphine Gobert Cécile Colavolpe Mohamad Zaidan Agathe Masseau Fanny Bernard Jean‐Marie Berthelot Nathalie Morel Fran?ois Lifermann Sylvain Palat Julien Haroche Xavier Mariette Bertrand Godeau Emmanuelle Bernit Nathal | 2014 | Arthritis Care & Research2014，，1： | 1 |
| 14 | Regulation of acp 1, encoding a non-aspartyl acid protease expressed during pathogenesis of Sclerotinia sclerotiorum 显示文摘 | Nathalie P Sandrine C Genevieve B G | 2001 | Microbiology2001，147，： | 1 |
| 15 | Photodynamic therapy for nonmelanoma skin cacers current review and update显示文摘 | Nathalie C Zeitouni A Sherry S | 2003 | Mol Immunol2003，39，： | 1 |
| 16 | 显示文摘 | Nathalie G Stephane G Jean-Louis C | 1993 | J Food Sci1993，58，： | 1 |
| 17 | Differential mechanism is involved during heparin and cryopreservation-induced capaeitation of bovine spermatozoa显示文摘 | Nathaly C Janice L B A | 2005 | Biol Reprod2005，69，： | 1 |
| 18 | Regulation of acp1, encoding a non-aspartyl acid protease expressed during pathogenesis of Sclerotinia sclerotiorum显示文摘 | SANDRINE C GENEVIEVE B CHRISTINE R MICHEL F | 2001 | Microbiology2001，147，： | 1 |
| 19 | Optimal executive compensation: Should private benefits be prohibited 显示文摘 | Christian A Nathalie C Morand P | 2006 | Re- vued Economie Politique2006，，6： | 1 |
| 20 | Govermentand voluntar y sector differences in organizationalcapacity to do and use evaluation显示文摘 | Bradley Cousins Swee C Goh CatherineElliott Tim Aubr y Nathalie Gilbert | 2014 | Evaluation andProgram Planning2014，，44： | 1 |
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