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| 1 | Analytical methodologies for determination of methotrexate and its metabolites in pharmaceutical,biological and environmental samples显示文摘Methotrexate(MTX)is a folate antagonist drug used for several diseases,such as cancers,various malignancies,rheumatoid arthritis(RA)and inflammatory bowel disease.Due to its structural features,including the presence of two carboxylic acid groups and its low native fluorescence,there are some challenges to develop analytical methods for its determination.MTX is metabolized to 7-hydroxymethotrexate(7-OH-MTX),2,4-diamino-N10-methylpteroic acid(DAMPA),and the active MTX polyglutamates(MTXPGs)in the liver,intestine,and red blood cells(RBCs),respectively.Additionally,the drug has a narrow therapeutic range;hence,its therapeutic drug monitoring(TDM)is necessary to regulate the pharmacokinetics of the drug and to decrease the risk of toxicity.Due to environmental toxicity of MTX;its sensitive,fast and low cost determination in workplace environments is of great interest.A large number of methodologies including high performance liquid chromatography equipped with UVevisible,fluorescence,or electrochemical detection,liquid chromatography-mass spectroscopy,capillary electrophoresis,UVevisible spectrophotometry,and electrochemical methods have been developed for the quantitation of MTX and its metabolites in pharmaceutical,biological,and environmental samples.This paper will attempt to review several published methodologies and the instrumental conditions,which have been applied to measure MTX and its metabolites within the last decade. | Forough Karami Sara Ranjbar Younes Ghasemi Manica Negahdaripour | 2019 | Journal of Pharmaceutical Analysis2019，9，6： | 7 |
| 2 | Revised definition of optical flow: integration of radiometric and geometric cues for dynamic scene analysis 显示文摘 | Negahdaripour S | 1998 | IEEE Transactions on Pattern Analysis and Maehine Intelligence1998，20，9： | 1 |
| 3 | Fast im- age blending using watersheds and graph cuts显示文摘 | Gracias N Mahoor M Negahdaripour S | 2009 | Image and Vision CompJting2009，27，5： | 1 |
| 4 | An Innovatio-Based Methodology for HVAC System Fault Detection 显示文摘 | Usoro P B Schick I C Negahdaripour S | 1985 | Dynamic Systems1985，107，： | 1 |
| 5 | Motion-based compression of underwater video imagery for the operations of unmanned submersible vehicles显示文摘 | Negahdaripour S Khamene A | 2000 | Computer Vision and Image Understanding2000，79，1： | 1 |
| 6 | Nattokinase:production and application显示文摘 | DABBAGH F NEGAHDARIPOUR M BERENJIAN A | 2014 | Applied Microbiology and Biotechnology2014，98，22： | 1 |
| 7 | Fast image blending using watersheds and graph cuts显示文摘 | Gracias N Mahoor M Negahdaripour S | 2009 | Image and Vision Computing2009，27，5： | 1 |
| 8 | Closed-form solution of absolute orientation using orthonormal matrices显示文摘 | Horn B K P Hilden H M Negahdaripour S | 1988 | Journal of the Optical Society America1988，5，7： | 1 |
| 9 | Closed-form solution of absolute orientation using orthonormal matrices 显示文摘 | Horn B Hilden H M Negahdaripour S | 1988 | Journal of the Optical Society of America A : Optics Image Science and Vision1988，5，7： | 1 |
| 10 | Revised definition of optical flow: integration of radiometric and geometric cues for dynamic scene analysis显示文摘 | | 1998 | IEEE Transactions on Pattern Analysis and Machine Intelligence1998，20，9： | 1 |
| 11 | Direct estimation of motion from sea floor images for automatic station-keeping of submersible platform显示文摘 | Negahdaripour S Xu X Jin L | 1999 | IEEE Journal of Oceanic Engineering1999，24，3： | 1 |
| 12 | Motion-based compression of underwater video imagery for the operations of unmanned submersible vehicles显示文摘 | Negahdaripour S Khamene A | 2000 | Compnter Vision and Image Understanding2000，79，1： | 1 |
| 13 | Closed-form Solution of Absolute Orientation Using Orthonormal Matrices显示文摘 | HORN B K P HILDEN H M NEGAHDARIPOUR S | 1988 | Journal of the Optical Society of America A1988，5，7： | 1 |
| 14 | Stereovisionimagingonsubmersibleplatformsfor3-Dmappingofbenthichabitatsandsea-floorstructures显示文摘 | NEGAHDAripourS MADJIDIH | 2003 | IEEEJournalofOceanicEn-gineering2003，28，4： | 1 |
| 15 | Fastimage blending using watersheds and graph cuts 显示文摘 | Gracias N Mahoor M Negahdaripour S | 2009 | Image and Vision Computing (S0262-8856)2009，27，5： | 1 |
| 16 | Epipolar geometry of opti- acoustic stereo imaging显示文摘 | NEGAHDARIPOUR S | 2007 | IEEE Trans on Pattern Analysis and Machine Intelligence2007，29，10： | 1 |
| 17 | Closed-form solution of absolute orientation using orthonormal matrices 显示文摘 | Horn BKP Hilden HM Negahdaripour S | 1988 | J Opt Soc Am A1988，5，7： | 1 |
| 18 | Revised definition of optical flow: Integration of radiometric and geometric cues for dynamic scene analysis 显示文摘 | Negahdaripour S | 1998 | IEEE Transactions on Pattern Analysis and Machine Intelligence1998，20，9： | 1 |
| 19 | Motion and structure from multiple cues:imagemotion,shading flow,and stereo disparity显示文摘 | Ali Khamene Shahriar Negahdaripour | | 0，，01： | 1 |
| 20 | A new method for the extraction of fetal ECG from the composite abdominal signal显示文摘 | Khamene A Negahdaripour S | 2000 | IEEE Transactions on Biomedical Engineering2000，47，4： | 1 |
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