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| 1 | Survival after inflammatory bowel disease-associated colorectal cancer in the Colon Cancer Family Registry显示文摘AIM: To investigate the survival of individuals with colorectal cancer (CRC) with inflammatory bowel disease (IBD-associated CRC) compared to that of individuals without IBD diagnosed with CRC. METHODS: Epidemiologic, clinical, and follow-up data were obtained from the Colon Cancer Family Registry (Colon CFR). IBD-associated cases were identified from self-report of physician diagnosis. For a subset of participants, medical records were examined to confirm self-report of IBD. Cox proportional hazards regression was applied to estimate adjusted hazard ratios (aHR) and 95%CI of mortality, comparing IBD-associated to non-IBD-associated CRC, adjusted for age at CRC diagnosis, sex, Colon CFR phase, and number of prior endoscopies. Following imputation to complete CRC stage information, adjustment for CRC stage was examined. RESULTS: A total of 7202 CRC cases, including 250 cases of IBD-associated CRC, were analyzed. Over a twelve year follow-up period following CRC diagnosis, 2013 and 74 deaths occurred among non-IBD associated CRC and IBD-associated CRC patients, respectively. The difference in survival between IBD-associated and non-IBD CRC cases was not statistically significant (aHR = 1.08; 95%CI: 0.85-1.36). However, the assumption of proportional hazards necessary for valid inference from Cox regression was not met over the entire follow-up period, and we therefore limited analyses to within five years after CRC diagnosis when the assumption of proportional hazards was met. Over this period, there was evidence of worse prognosis for IBD-associated CRC (aHR = 1.36; 95%CI: 1.05-1.76). Results were similar when adjusted for CRC stage, or restricted to IBD confirmed in medical records. CONCLUSION: These results support the hypothesis that IBD-associated CRC has a worse prognosis than non-IBD-associated CRC. | Scott V Adams Dennis J Ahnen John A Baron Peter T Campbell Steven Gallinger William M Grady Loic LeMarchand Noralane M Lindor John D Potter Polly A Newcomb | 2013 | World Journal of Gastroenterology2013，19，21： | 2 |
| 2 | The metabolism of a city:the case of Hong Kong显示文摘 | Newcombe K Kalina J D Aston A R | 1978 | AMBIO1978，，7： | 1 |
| 3 | Cellulase, clostfidia, and ethanol 显示文摘 | Demain A L Newcomb M Wu J H D | 2005 | Microbiol Mol Biol R2005，69，： | 1 |
| 4 | Adenylat e energycharge measurement in soils显示文摘 | Brookes P C Newcombe A D Jenkinson D S | 1987 | Soil Biol Biochem1987，19，2： | 1 |
| 5 | The metabolism of a city:the case of Hong Kong显示文摘 | Newcombe K Kalina J D Aston A R | 1978 | AMBIO1978，7，： | 1 |
| 6 | Cellulase, clostridia, and ethanol显示文摘 | Demain A L Newcomb M Wu J H D | 2005 | Microbiol Mol Biol R2005，，69： | 1 |
| 7 | Nuclear Fears and Concerns among College-students:A Cross-national-study of Attitudes显示文摘 | Rabow J Hernandez A Newcomb M D | 1990 | Political Psychology1990，11，4： | 1 |
| 8 | Analyses of expressed sequence tags from apple显示文摘 | Newcomb R D Crowhurst R N Gleave A P | 2006 | Plant Physiol2006，141，： | 1 |
| 9 | Permanent Deformation in Asphalt Concrete 显示文摘 | Drescher A K Newcomb D E | 1993 | Journal of Material in Civil Engineering ASCE1993，5，1： | 1 |
| 10 | Microspore development in Brassica napus and the effect of high temperature on division in vivo and in vitro 显示文摘 | Telmer C A Newcomb W Simmonds D H | 1993 | Protoplasma1993，，172： | 1 |
| 11 | Cellulase, clostridia, and ethanol 显示文摘 | Demain A L Newcomb M Wu J H D | 2005 | Microbiol Mol Biol Rev2005，69，： | 1 |
| 12 | Does preoperative atrial fibrillation portend a poorer prognosis in patients undergoing isolated aortic valve replacement- A multicentre Australian study显示文摘 | Saxena A Dinh D T Reid C M Smith J A Shardey G C Newcomb A E | 2013 | Can J Cardiol2013，29，： | 1 |
| 13 | Analysis of expressed sequence tags from apple显示文摘 | Newcomb R D Crowhurst R N Gleave A P | 2006 | Plant Physiol2006，141，： | 1 |
| 14 | Bioremediation of atrazine-contaiminated soil by repeated applications of atrazine-degrading bacteria显示文摘 | Newcombe D A Crowley D E | 1999 | Applied Microbiogy and Biotechnology1999，51，： | 1 |
| 15 | Analyses of expressed sequence tags from apple显示文摘 | NEWCOMB R D CROWHURST R N GLEAVE A P RIKKERINK E H A ALLAN A C BEUNING L L BOWEN J H GERA E JAMIESON K R JANSSEN B J LAING W A MCARTNEY S NAIN B ROSS G S SNOWDEN K C SOULEYRE E J F WALTON E F YAUK Y K | 2006 | Plant Physiology2006，141，： | 1 |
| 16 | The metabolism of a city: The case of Hong Kong显示文摘 | NEWCOMBE K KALINA J D ASTON A R | 1978 | AMBIO1978，7，： | 1 |
| 17 | Cellulase, Clostridia, and Ethanol显示文摘 | Demain A L Newcomb M Wu J H D | 2005 | Microbiology and Molecular Biology Reviews2005，，： | 1 |
| 18 | Bioremediation of soils contaminated with explosives 显示文摘 | LEWIS T A NEWCOMBE D A CRAWFORD R L | 2004 | Journal of Environmental Management2004，70，4： | 1 |
| 19 | The metabolism of a city: the case of Hong Kong显示文摘 | Newcombe K Kalina J D Aston A R | 1978 | Ambio1978，，7： | 1 |
| 20 | Cellulases,clostridia,and ethanol 显示文摘 | DEMAIN A L NEWCOMB M WU J H D | 2005 | Microbiol Mol Bio Rev2005，69，： | 1 |
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