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| 1 | Anti-cancer and anti-inflammatory activities of aronia (Aronia melanocarpa) leaves显示文摘Objective: To determine the anti-cancer effect of aronia leaf extract on SK-Hep1 cells using migration, metallo metrix proteinase-2/-9(MMP-2/-9) and MT-1 MMP expression and to evaluate the anti-inflammatory activities of the leaf extract. Methods: The effect of aronia leaf extract on cancer prevention was investigated. SK-Hep1 human liver cancer cell line was treated with aronia leaf extract at various concentractions. MTT assay was used to measure cancer cell growth inhibition, and wound migration assay was used for metastasis determination. The expression of MMP-2/-9 was measured at the protein level using zymography and the expression of MMP-2/-9 and MT-1 MMP was examined at the gene level by RT-PCR. Raw 264.7 macrophage cells were stimulated with lipopolysaccharides to induce inflammation, and then the inhibition of inflammation was evaluated by treatment of aronia leaf extract. Expressions of interleukin-6, tumor factor-d. Results: SK-Hep1 cell growth was inhibited毩, and nitric oxide(NO) were also determine in proportion to the concentration of aronia leaf extract. In migration assay, aronia leaf extract showed 61.3%-96.3% wound size inhibtion after treating 50-200 μg/mL of aronia leaf extract for 24 h. At the protein level, the expression of MMP-2 and MMP-9 decreased as the concentration of aronia leaf extract treated with SK-Hep1 cells increased. In addition, the same pattern as in the protein was also observed in the mRNA levels. The expressions of MMP-2 and MMP-9 protein were inhibited by 92.2% and 53.8%, respectively after treatment with 200 μg/mL aronia leaf extract. In addition, Raw 264.7 cells treated with aronia leaf extract did not affect cell survival. There was dose dependent inhibition of interleukine-6, tumor necrosis factor-a and nitric oxide after treating aronia leaf extract in lipopolysaccharides-treated Raw cell. Conclusions: The results show that aronia leaf has anticancer and and antimetastatic properties in SK-Hep1 and Raw 264.7 cells. | Nhuan Do Thi Eun-Sun Hwang | 2018 | Asian Pacific Journal of Tropical Biomedicine2018，8，12： | 3 |
| 2 | Assessment of Vietnam coastal wetland vulnerability for sustainable Use显示文摘 | Nhuan M T Ngoc N T M Huong N Q | 2009 | Journal of Wetlands Ecology2009，2，： | 1 |
| 3 | Carbon storage of a tropical mangrove forest in Mui Ca Mau National Park, Vietnam 显示文摘 | TUE NT DUNG LV NHUAN MT 2014 | 2014 | Catena2014，121，： | 1 |
| 4 | Impacts of Trade Liberalization on Employment in Vietnam: A System Generalized Method of Moments Estimation 显示文摘 | Kien Tran Nhuan and Yoon Heo | 2009 | The Developing Economies2009，47，1： | 1 |
| 5 | Assessment of vietnam coastal wetland vulnerability for sustainable use (case study in Xuanthuy Ramsar Site,Vietnam)显示文摘 | NHUAN M T NGOC N T M HUONG N Q | | 0，，1： | 1 |
| 6 | Sediment distribution and transport at the neat,shore zone of the Red River delta, Northern Vietnam显示文摘 | Duc D M Nhuan M T Ngoi C V | 2007 | Journal of Asian Earth Sciences2007，29，： | 1 |
| 7 | Production of succinic acid by anaerobiospirillum succiniciproducens显示文摘 | Nhuan P. Nghiem Brian H. Davison Bruce E. Suttle Gerald R. Richardson | 1997 | Applied Biochemistry and Biotechnology1997，，1： | 1 |
| 8 | Sediment distribution and transport at the nearshore zone of the Red River deha, Northern Vietnam 显示文摘 | Duc D M Nhuan M T Ngoi C V et nl | 2007 | Journal of Asian Earth Sciences2007，29，： | 1 |
| 9 | 白背飞虱可能与吡蚜酮抗性相关的蛋白质组学显示文摘运用双向电泳和质谱技术,分析了白背飞虱吡蚜酮抗性相关的蛋白质。在所有的蛋白点中,22个蛋白点被PMF成功识别。这些蛋白点展示了各种各样的细胞功能,主要包括:(1)碳水化合物转运和新陈代谢;(2)蛋白质新陈代谢和分子伴侣;(3)能量的产生和转化;(4)转录和翻译;(5)无机离子转运和新陈代谢;(6)氨基酸转运和新陈代谢;(7)脂质新陈代谢。绝大多数蛋白都没有报道与吡蚜酮抗性相关。 | 凌善锋 肖汉祥 简清梅 Nhuan P.Nghiem 张润杰 李燕芳 | 2017 | 中山大学学报(自然科学版)2017，56，2： | 0 |
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