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| 1 | Parameters of a severe disease course in ulcerative colitis显示文摘AIM:To detect high risk patients with a progressive disease course of ulcerative colitis(UC) requiring immunosuppressive therapy(IT).METHODS:A retrospective,multicenter analysis of 262 UC patients from eight German tertiary inflammatory bowel disease centres was performed.Patients were divided into two groups depending on the patients need to initiate immunosuppressive therapy in the disease course.A comparison between the two groups was made with regard to demographics,clinical and laboratory parameters obtained within three months after UC diagnosis and the response to first medical therapy.Using this data,a prognostic model was established to predict the individual patients probability of requiring an immunosuppressive therapy.RESULTS:In 104(39.7%) out of 262 patients,UC therapy required an immunosuppressive treatment.Patients in this group were significantly younger at time of diagnosis(HR = 0.981 ± 0.014 per year,P = 0.009),and required significantly more often a hospitalisation(HR = 2.5 ± 1.0,P < 0.001) and a systemic corticosteroid therapy at disease onset(HR = 2.4 ± 0.8,P < 0.001),respectively.Response to steroid treatment was significantly different between the two groups of patients(HR = 5.2 ± 3.9 to 50.8 ± 35.6 compared to no steroids,P = 0.016 to P < 0.001).Furthermore,in the IT group an extended disease(HR = 3.5 ± 2.4 to 6.1 ± 4.0 compared to proctitis,P = 0.007 to P = 0.001),anemia(HR = 2.2 ± 0.8,P < 0.001),thrombocytosis(HR = 1.9 ± 1.8,P = 0.009),elevated C-reactive protein(CRP)(HR = 2.1 ± 0.9,P < 0.001),and extraintestinal manifestations in the course of disease(HR = 2.6 ± 1.1,P = 0.004) were observed.Six simple clinical items were used to establish a prognostic model to predict the individual risk requiring an IT.This probability ranges from less than 2% up to 100% after 5 years.Using this,the necessity of an immunosuppressive therapy can be predicted in 60% of patients.Our model can determine the need for an immunosuppressive drug therapy or if a 'watch and wait' approach is reasonable already early in the treatment course of UC.CONCLUSION:Using six simple clinical parameters,we can estimate the patients individual risk of developing a progressive disease course. | Andreas Stallmach Luisa Nickel Thomas Lehmann Bernd Bokemeyer Martin Bürger Dietrich Hüppe Wolfgang Kruis Susanna Nikolaus Jan C Preiss Andreas Sturm Niels Teich Carsten Schmidt | 2014 | World Journal of Gastroenterology2014，20，35： | 2 |
| 2 | Identification of dialysis patients with panel-reactive memory T cells before kidney transplantation using an allogenie cell bank 显示文摘 | Andree H Nickel P Nasiadko C | 2006 | J Am Soc Nephrol2006，17，2： | 1 |
| 3 | NIH consensus definition and classification of prostatitis显示文摘 | KRIEGER J N NYBERG h JR NICKEL J C | 1999 | JAMA1999，282，3： | 1 |
| 4 | The role of copeptin as a diagnostic and prognostic biomarker for risk stratifi cation in the emergency department显示文摘 | Nickel C H Bingisser R Morgenthaler N G | 2012 | BMC Med2012，10，： | 1 |
| 5 | The role of copeptin as a diagnostic and prognostic biomarker for risk stratifi- cation in the emergency department显示文摘 | NICKEL C H BINGISSER R MORGENTHALER N G | 2012 | BMC Med2012，10，： | 1 |
| 6 | Addition of ytterium, cerium, and hafnium to combat the deleterious effect of sulfur impurity during oxidation of an Ni-Cr-A1 alloy显示文摘 | KHANNA A S WASSERFUHR C QUADAKKERS W J NICKEL H | 1989 | Mat Sci Eng1989，120，1： | 1 |
| 7 | Silodosin for men with chronic prostatitis/chronic pelvic pain syndrome:results of a phase II multicenter,double-blind,placebo controlled study显示文摘 | Nickel J C O'Leary M P Lepor H | 2011 | The Journal of urology2011，186，1： | 1 |
| 8 | Benign mixed epithelial stromal tumor of the kidney of possible mullerian origin显示文摘 | Beiko D T Nickel J C Boag A H | 2001 | J Urol2001，166，： | 1 |
| 9 | Time to initiation of pentosan polysulfate sodium treatment after interstitial cystitis diagnosis: effect on symptom improvement显示文摘 | NICKEL J C KAUFMAN D M ZHANG H F | 2008 | Urology2008，71，1： | 1 |
| 10 | Spin-Dependent Tunneling Junctions with A1N and AION Barri- ers显示文摘 | Manish Sharma Janice H Nickel Thomas C Anthony | 2000 | Appl Phys Lett2000，，77： | 1 |
| 11 | HGF promotes adhesion of ATP-depleted renal tubular epithelial cells in a MAPK-dependent manner 显示文摘 | Liu Z X Nickel C H Cantley L G | 2001 | Am J Physiol2001，281，： | 1 |
| 12 | The role of copeptin as a diagnostic and prog- nostic biomarker for risk strati? cation in the emer- gency department显示文摘 | NICKEL C H BINGISSER R MORGENTHALER N G | 2012 | BMC Med2012，10，： | 1 |
| 13 | Comparison of longterm effects of ovariectomy vs ovariohisterectomy in bitches 显示文摘 | Okkens A C Kooistra H S Nickel R F | 1997 | J Reprod Ferd Suppl1997，51，： | 1 |
| 14 | The role of copeptin as a diagnostic and prognostic biomarker for risk strati- fication in the emergency department显示文摘 | NICKEL C H BING|SSER R MORGENTHALER N G | 2012 | BMC Med2012，10，： | 1 |
| 15 | The role of copeptin as a diagnostic and prognostic biomarker for risk strati- fication in the emergency department显示文摘 | NICKEL C H BINGISSER R MORGENTHALER N G | 2012 | BMC Med2012，10，： | 1 |
| 16 | Interface structure and reaction kinetics between SiC and thick cobalt foils显示文摘 | LIM C S NICKEL H NAOUMIDS A | 1996 | J Mater Sci1996，31，： | 1 |
| 17 | Transporting clinical tools to new settings: cultural adaptation and validation of the emergency severity index in German 显示文摘 | Grossmann F F Nickel C H Christ M | 2011 | Ann Emerg Med2011，57，3： | 1 |
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