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| 1 | EXISTENCE OF THE MINIMAL POSITIVE SOLUTION OF SOME NONLINEAR ELLIPTIC SYSTEMS WHEN THE NONLINEARITY IS THE SUM OF A SUBLINEAR AND A SUPERLINEAR TERM显示文摘It is shown that there exists Λ>0 such that, for every λ∈(0,Λ), the semilinear elliptic system: - Δ u=λu|u| q-1 +u|u| p-1 -v inΩ, - Δ v=δu-γv in Ω, u=v=0 on Ω, where Ω∈R N(N≥2) is a bounded domain with smooth boundary and 0 | Nicolae Tarfulea (Department of Mathematics, the Pennsylvania State University, University Park, PA 16802, U S A) | 2000 | Applied Mathematics and Mechanics(English Edition)2000，21，3： | 2 |
| 2 | Bilobar atelectasis as clinical presentation of Mycoplasma pneumoniae infection 显示文摘 | SERENA P NICOLA U CHIARA G | 2011 | Pediatr Int2011，53，6： | 1 |
| 3 | Molecular weight abnormalities of the CTCF transcription factor: CTCF migrates aberrantly in SDS-PAGE and the size of the expressed protein is affected by the UTRs and sequences within the coding region of the CTCF gene 显示文摘 | Klenova E M Nicolas R H Sally U | 1997 | Nucleic Acids Research1997，25，3： | 1 |
| 4 | Immunogenicity and efficacy of codon optimized DNA vaccines encoding the F- protein of respiratory syncytial virus 显示文摘 | Nicola T Bettina T Klaus U | 2007 | Vaccine2007，25，41： | 1 |
| 5 | Bilobar atelectasis as clinical presentation of Mycoplasma pneumoniae infection显示文摘 | Serena P Nicola U Chiara G | 2011 | Pediatr Int2011，53，6： | 1 |
| 6 | Fetal cardiac evaluation at 11 -14 weeks by experienced obste- tricians in a low - risk population 显示文摘 | PAOLO V PASSAMONTI U NICOLA V | 2011 | Prenat Diagn2011，31，11： | 1 |
| 7 | How well does ASPECTS predict the outcome of acute stroke treated with IV tPA显示文摘 | Nicolas U Weir JH Pexman W | 2006 | Neurology2006，67，： | 1 |
| 8 | Annexin 2 Promotes the Formation of Lipid Microdomains Required for Calcium-regulated Exocytosis of Dense-CoreVesicles显示文摘 | Sylvette C G Nicolas V Emeline U J Derek K | 2005 | Molecular Biology of the Cell2005，16，33： | 1 |
| 9 | Procalcitonin as a diag- nostic test for sepsis in critically ill adults and a{ter sur- gery or trauma:a systematic review and meta-analysis显示文摘 | U span B Cohen R Nicolas | 2006 | Crib Caremed2006，34，： | 1 |
| 10 | Baseline neutrophil-lymphocyte ratio and platelet-lymphocyte ratio appear predictive of immune treatment related toxicity in hepatocellular carcinoma显示文摘BACKGROUND A well-recognized class effect of immune checkpoint inhibitors(ICI)is immune-related adverse events(IrAEs)ranging from low grade toxicities to life-threatening end organ damage requiring permanent discontinuation of ICI.Deaths are reported in<5%of patients treated with ICI.There are,however,no reliable markers to predict the onset and severity of IrAEs.We tested the association between neutrophil-lymphocyte ratio(NLR)and platelet-lymphocyte ratio(PLR)at baseline with development of clinically significant IrAEs(grade≥2)in hepatocellular carcinoma(HCC)patients treated with ICI.AIM To test the association between NLR and PLR at baseline with development of clinically significant IrAEs(grade≥2)in HCC patients treated with ICI.METHODS Data was extracted from an international database from a consortium of 11 tertiary-care referral centers.NLR=absolute neutrophil count/absolute lymphocyte count(ALC)and PLR=platelet count/ALC.Cutoff of 5 was used for NLR and 300 for PLR based on literature.We also tested the association between RESULTS Data was collected from 361 patients treated between 2016-2020 across the United States(67%),Asia(14%)and Europe(19%).Most patients received Nivolumab(n=255,71%).One hundred sixty-seven(46%)patients developed at least one IrAE,highest grade 1 in 80(48%),grade≥2 in 87(52%)patients.In a univariable regression model PLR>300 was significantly associated with a lower incidence of grade≥2 IrAEs(OR=0.40;P=0.044).Similarly,a trend was observed between NLR>5 and lower incidence of grade≥2 IrAEs(OR=0.58;P=0.097).Multivariate analyses confirmed PLR>300 as an independent predictive marker of grade≥2 IrAEs(OR=0.26;P=0.011),in addition to treatment with programmed cell death ligand 1(PD-1)/cytotoxic T lymphocyte-associated protein-4(OR=2.57;P=0.037)and PD-1/tyrosine kinase inhibitor(OR=3.39;P=0.01)combinations.Antibiotic use was not associated with IrAE incidence(OR=1.02;P=0.954).Patients treated with steroids had a>2-fold higher incidence of grade≥2 IrAEs(OR=2.74;P<0.001),although 74%were prescribed steroids for the treatment of IrAEs.CONCLUSION Given that high baseline NLR and PLR are associated with a decreased incidence of IrAEs,lower baseline NLR and PLR may be predictive biomarkers for the appearance of IrAEs in HCC treated with ICI.This finding is in keeping with several studies in solid tumors that have shown that baseline NLR and PLR appear predictive of IrAEs. | Sirish Dharmapuri UmutÖzbek Hiren Jethra Tomi Jun Thomas U Marron Anwaar Saeed Yi-Hsiang Huang Mahvish Muzaffar Matthias Pinter Lorenz Balcar Claudia Fulgenzi Suneetha Amara Arndt Weinmann Nicola Personeni Bernhard Scheiner Tiziana Pressiani Musharraf Navaid Bertram Bengsch Sonal Paul Uqba Khan Dominik Bettinger Naoshi Nishida Yehia Ibrahim Mohamed Arndt Vogel Anuhya Gampa James Korolewicz Antonella Cammarota Ahmed Kaseb Peter R Galle Anjana Pillai Ying-Hong Wan Alessio Cortellini Masatoshi Kudo Antonio D’Alessio Lorenza Rimassa David James Pinato Celina Ang | 2023 | World Journal of Gastrointestinal Oncology2023，15，11： | 0 |
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