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| 1 | Parameters of a severe disease course in ulcerative colitis显示文摘AIM:To detect high risk patients with a progressive disease course of ulcerative colitis(UC) requiring immunosuppressive therapy(IT).METHODS:A retrospective,multicenter analysis of 262 UC patients from eight German tertiary inflammatory bowel disease centres was performed.Patients were divided into two groups depending on the patients need to initiate immunosuppressive therapy in the disease course.A comparison between the two groups was made with regard to demographics,clinical and laboratory parameters obtained within three months after UC diagnosis and the response to first medical therapy.Using this data,a prognostic model was established to predict the individual patients probability of requiring an immunosuppressive therapy.RESULTS:In 104(39.7%) out of 262 patients,UC therapy required an immunosuppressive treatment.Patients in this group were significantly younger at time of diagnosis(HR = 0.981 ± 0.014 per year,P = 0.009),and required significantly more often a hospitalisation(HR = 2.5 ± 1.0,P < 0.001) and a systemic corticosteroid therapy at disease onset(HR = 2.4 ± 0.8,P < 0.001),respectively.Response to steroid treatment was significantly different between the two groups of patients(HR = 5.2 ± 3.9 to 50.8 ± 35.6 compared to no steroids,P = 0.016 to P < 0.001).Furthermore,in the IT group an extended disease(HR = 3.5 ± 2.4 to 6.1 ± 4.0 compared to proctitis,P = 0.007 to P = 0.001),anemia(HR = 2.2 ± 0.8,P < 0.001),thrombocytosis(HR = 1.9 ± 1.8,P = 0.009),elevated C-reactive protein(CRP)(HR = 2.1 ± 0.9,P < 0.001),and extraintestinal manifestations in the course of disease(HR = 2.6 ± 1.1,P = 0.004) were observed.Six simple clinical items were used to establish a prognostic model to predict the individual risk requiring an IT.This probability ranges from less than 2% up to 100% after 5 years.Using this,the necessity of an immunosuppressive therapy can be predicted in 60% of patients.Our model can determine the need for an immunosuppressive drug therapy or if a 'watch and wait' approach is reasonable already early in the treatment course of UC.CONCLUSION:Using six simple clinical parameters,we can estimate the patients individual risk of developing a progressive disease course. | Andreas Stallmach Luisa Nickel Thomas Lehmann Bernd Bokemeyer Martin Bürger Dietrich Hüppe Wolfgang Kruis Susanna Nikolaus Jan C Preiss Andreas Sturm Niels Teich Carsten Schmidt | 2014 | World Journal of Gastroenterology2014，20，35： | 2 |
| 2 | Fate and el-fect of ingested Bacillus cereus spores and vegetative cells in the intestinal tract of human-flora-associated rats 显示文摘 | ANDREA W BJARNE M H NIELS B H | 2006 | FEMS Immunology and Medical Microbiology2006，46，1： | 1 |
| 3 | Ecological footprint time series of Austria,the Philippines,and South Korea for 1961-1999:comparing the conventional approach to an 'actual land area' approach显示文摘 | Mathis W Chad M Karl H B Helmut H Niels N B Schulz B | 2004 | Land Use Policy2004，21，： | 1 |
| 4 | Land-use change and socio-economic metabolism in Austria--Pard : driving forces of land-use change :1950 - 1995显示文摘 | Fridolin K Helmut H Niels B | 2003 | Land Use Policy2003，20，1： | 1 |
| 5 | Prolonged hypobaric hypoxemia attenuates vasopressin secretion and renal response to osmostimu-lation in men显示文摘 | Morten H B Niels V O Troels D P | | 0，，： | 1 |
| 6 | Detection of Enterotoxic Bacillus cereus and Bacillus thuringiensis Strains by PCR Analysis显示文摘 | BJARNE M H NIELS B H | 2001 | Applied and Environmental Microbiology2001，67，1： | 1 |
| 7 | Green fluorescent protein-marked Pseudomonas fluorescens :localization, viability and activity in the natural barley rhizosphere 显示文摘 | NORMANDER B NIELS B H NYBROE O | 1999 | Applied and Environmental Microbiology1999，65，10： | 1 |
| 8 | Detection of enterotoxic Bacillus cereus and Bacillus thuringiensis strains by PCR analysis显示文摘 | Sjarne M H Niels B H | 2001 | Appliedand Environmental Microbiology2001，67，1： | 1 |
| 9 | Effect of nutritional support on clinical outcome in patients at nutritional risk显示文摘 | Niels Johansen Jens Kondrup Lise Munk Plum Line Bak Pernille N?rregaard Else Bunch Hanne B?rnthsen Jens Rikardt Andersen Irene H?jlund Larsen Anette Martinsen | 2003 | Clinical Nutrition2003，，4： | 1 |
| 10 | Analyzing lithium by weise ring oven,ion exchange separation and photoluminescence method by 8-hydroxyquinoline显示文摘 | NIELS H B | 1983 | Mikrochim Acta1983，2，34： | 1 |
| 11 | Effect of nutritional support on clinical outcome in patients at nutritional risk显示文摘 | Niels Johansen Jens Kondrup Lise Munk Plum Line Bak Pernille N?rregaard Else Bunch Hanne B?rnthsen Jens Rikardt Andersen Irene H?jlund Larsen Anette Martinsen | 2003 | Clinical Nutrition2003，，4： | 1 |
| 12 | Oxygen reduction on carbon supported platinum catalysts in high temperature polymer electrolytes 显示文摘 | Li Q F HANSA H NIELS J B | 2000 | Electrochimia Acta2000，45，： | 1 |
| 13 | Formation and Conversion of Oxygen Metabolites by Lactococcus lactis subsp, lactis ATCC 19435 under Different Growth Conditions 显示文摘 | NIEL W J HOFVENDAHL K HAGERDAL B H | 2002 | Appl Environ Microbiol2002，68，9： | 1 |
| 14 | Brain-computer interface technology: a review of the first international meeting显示文摘 | JONATHAN R W NIELS B WILLIAM J H | 2000 | IEEE Trans Rehabil Eng2000，8，2： | 1 |
| 15 | Linking pattern and process in cultural landscapes: An empirical study based on spatially explicit indicators 显示文摘 | WRBKAA T: ERBB K H NIELS B | 2004 | Land Use Policy2004，，21： | 1 |
| 16 | Fate and effect of ingested Bacillus cereus pores and vegetative cells in the intestinal tract of human-flora-associated rats显示文摘 | Andrea W Bjarne M H Niels B H | 2006 | FEMS lmmunology and Medical Microbiology2006，46，1： | 1 |
| 17 | Fate and effect of ingested Bacillus cereus spores and vegeta- tive cells in the intestinal tract of human-flora-associ- ated rats显示文摘 | Andrea W Bjarne M H Niels B H et a | 2006 | FEMS Immunology and Medical Micro- biology2006，46，1： | 1 |
| 18 | Exenatide reduces reperfusion injury in patients with ST-segment elevation myocardial infarction显示文摘 | Jacob L?nborg Niels Vejlstrup Henning Kelb?k Hans Erik B?tker Won Yong Kim Anders B. Mathiasen Erik J?rgensen Steffen Helqvist Kari Saunam?ki Peter Clemmensen Lene Holmvang Leif Thuesen Lars Romer Krusell Jan S. Jensen Lars K?ber Marek Treiman Jens Juul H | 2012 | European Heart Journal2012，，12： | 1 |
| 19 | Formation and Conversion of Oxygen Met abolites by Lactococcus lactis subsp ATCC 19435 under Different Growth Conditions显示文摘 | NIEL W J HOFVENDAHL K HAGERDAL B H | | 0，，9： | 1 |
| 20 | 显示文摘 | Nicolai Stuhr-Hansen Jorn B C Niels H | 2003 | Jorg Chem2003，68，4： | 1 |
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