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| 1 | Twenty-nine years after carbon monoxide intoxication 显示文摘 | Fereydoon R Roger W K Nirav M | 2001 | Cinical Neurology and Neurosurgery2001，103，： | 1 |
| 2 | Clinical usefulness and prognostic value of cardiac troponin I levels in acute pulmonary embolism显示文摘 | NIRAV J MEHTA K J LJAZ A K | 2003 | American Heart Journal2003，145，5： | 1 |
| 3 | Optimization models forassessing the peak capacity utilization of intelligent transportation sys-tems显示文摘 | NIRAV S SUBODHA K FAROKH B | 2012 | European Journal of Operational Research2012，216，1： | 1 |
| 4 | Development and characterization of siRNA lipoplexes: effect of dif- ferent lipids,in vitro evaluation in cancerous cell lines and in vivo toxicity study 显示文摘 | NIRAV K DIPESH B IMRAN V | 2014 | AAPS PharmSciTech2014，15，： | 1 |
| 5 | Fragility of statistically significant findings from randomized clinical trials of surgical treatment of humeral shaft fractures:A systematic review显示文摘BACKGROUND Despite recent meta-analyses of randomized controlled trials(RCTs),there remains no consensus regarding the preferred surgical treatment for humeral shaft fractures.The fragility index(FI)is an emerging tool used to evaluate the robustness of RCTs by quantifying the number of participants in a study group that would need to switch outcomes in order to reverse the study conclusions.AIM To investigate the fragility index of randomized control trials assessing outcomes of operative fixation in proximal humerus fractures.METHODS We completed a systematic review of RCTs evaluating the surgical treatment of humeral shaft fractures.Inclusion criteria included:articles published in English;patients randomized and allotted in 1:1 ratio to 2 parallel arms;and dichotomous outcome variables.The FI was calculated for total complications,each complication individually,and secondary surgeries using the Fisher exact test,as previously published.RESULTS Fifteen RCTs were included in the analysis comparing open reduction plate osteosynthesis with dynamic compression plate or locking compression plate,intramedullary nail,and minimally invasive plate osteosynthesis.The median FI was 0 for all parameters analyzed.Regarding individual outcomes,the FI was 0 for 81/91(89%)of outcomes.The FI exceeded the number lost to follow up in only 2/91(2%)outcomes.CONCLUSION The FI shows that data from RCTs regarding operative treatment of humeral shaft fractures are fragile and does not demonstrate superiority of any particular surgical technique. | Stephen Craig Morris Anirudh K Gowd Avinesh Agarwalla Wesley P Phipatanakul Nirav H Amin Joseph N Liu | 2022 | World Journal of Orthopedics2022，13，9： | 0 |
| 6 | Pediatric firearm-associated fractures:Analysis of management and outcomes显示文摘BACKGROUND Firearm-associated injuries(FAIs)are among the leading causes of morbidity and mortality in children living in the United States.Most victims of such injuries survive,but may experience compromised function related to musculoskeletal injuries.Although complex firearm-associated fractures(FAFs)often require specialized orthopaedic,vascular,and plastic surgical intervention,there is minimal research describing their management and outcomes.The purpose of this study is to describe the epidemiology and presentation of pediatric FAFs,as well as evaluate the management and outcomes of these injuries.AIM To describe the epidemiology and presentation of pediatric FAFs,as well as evaluate the management and outcomes of these injuries.METHODS A retrospective chart review was performed at a major,pediatric level 1 trauma center.The study included patients aged 18 or younger who presented with FAIs between 2008-2018.Additional data was collected on patients with FAFs including demographic and clinical data such as age,sex,race,payor type,fracture location,injury severity score(ISS),and radiographic and clinical outcomes.The management of FAFs was analyzed as well as need for readmission and reoperation.Descriptive statistics were used to summarize the results and univariate analyses were performed to assess differences between groups.RESULTS Between 2008 and 2018,there were a total of 61 patients who presented with FAIs.In this cohort,21 patients(34%)sustained FAFs(25 fractures)with a mean age of 11(Range:10 mo to 18 years old)at the time of presentation.Approximately 52%(n=11)of patients with FAFs were male,76%(n=8 and n=8,respectively)identified as black or other,and 71%(n=15)had government insurance.FAFs were most commonly noted in the upper extremity(n=7)and lower extremity(n=6).In patients with FAFs,the mean ISS at presentation was 11.38(Range:2-38),and 24%of patients(n=5)were classified as having a major trauma.There were no significant differences in age,sex,race,and payor type in FAF patients that presented with and without major trauma(P>0.05).When comparing FAF and non-FAF patients,there was a statistically significant difference in ISS(11.38 vs 14.45,P=0.02).In total,33%(n=7)of patients with FAFs required orthopaedic surgical management,which was most commonly comprised of debridement(n=6/7,86%),and 14%(n=1/7)of these patients required coordinated care with plastic and/or vascular surgery.There were no significant differences in age and payor type in patients with FAFs treated with and without orthopaedic surgery.Of the patients with FAFs,52%(n=11)had a minimum 90-d follow-up,and 48%(n=10)had a minimum 2-year follow-up.Two patients were readmitted within 90-d,while one patient required a reoperation within 2-years.CONCLUSION Over 25%of FAIs in pediatric patients result in FAFs.FAFs often present to pediatric trauma centers and the majority of these injuries occur in non-Caucasian males with government insurance.Most FAFs do not need orthopaedic surgical management;14%of these injuries require subspecialty care by orthopaedic surgery,vascular surgery,or plastic surgery.Patients with FAFs also have lower ISS compared to patients who sustained FAIs without fracture.Thus,these patients should be treated at pediatric trauma centers with specialty care and additional research is needed to focus prevention efforts,understand reasons for poor follow-up,and evaluate outcomes after injury. | Virginia Lieu Laura A Carrillo Nirav K Pandya Ishaan Swarup | 2021 | World Journal of Clinical Pediatrics2021，10，6： | 0 |
| 7 | Surgical interventions for anterior shoulder instability in rugby players: A systematic review显示文摘AIM: To systematically evaluate the evidence-based literature on surgical treatment interventions for elite rugby players with anterior shoulder instability. METHODS: We conducted a systematic review according to the PRISMA guidelines. A literature search was performed in PubM ed, EMBASE and Google Scholar using the following search terms: 'rugby' and 'shoulder' in combination with 'instability' or 'dislocation'. All articles published from inception of the included data sources to January 1st 2014 that evaluated surgical treatment of elite rugby players with anterior shoulder instability were examined. RESULTS: Only five studies were found that met the eligibility criteria. A total of 379 shoulders in 376 elite rugby union and league players were included. All the studies were retrospective cohort or case series studies. The mean Coleman Methodological Score for the 5 studies was 47.4(poor). Owing to heterogeneity amongst the studies, quantitative synthesis was not possible, however a detailed qualitative synthesis is reported. The overall recurrence rate of instability after surgery was 8.7%, and the mean return to competitive play, where reported, was 13 mo.CONCLUSION: Arthroscopic stabilization has been performed successfully in acute anterior instability and there is a preference for open Latarjet-type procedures when instability is associated with osseous defects. | Sanjeeve Sabharwal Nirav K Patel Anthony MJ Bull Peter Reilly | 2015 | World Journal of Orthopedics2015，6，4： | 0 |
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