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| 1 | 乳腺癌前哨淋巴结活检显示文摘目的 评价前哨淋巴结活检预测腋窝淋巴结有无肿瘤转移的准确性及其临床意义。方法 用99m锝 硫胶体作为示踪剂 ,用γ探测仪导向 ,对 70例临床分期为T1 2 N0 M0 的乳腺癌患者进行前哨淋巴结活检 ,所有的患者均同时行腋窝淋巴结清扫。HE染色阴性的前哨淋巴结再切片 ,用CK8、CK19、KP 1行免疫组织化学染色。 结果 70例患者中成功发现前哨淋巴结的有 6 7例 ,发现率为95 7% (6 7/ 70 )。前哨淋巴结的数量为 1~ 5枚 ,平均每例 1 6枚。非前哨淋巴结 5~ 2 0枚 ,平均每例12 3枚。 6 7例前哨淋巴结活检成功的患者中 ,2 9例患者 (43 3% )有腋窝淋巴结转移 ,其中前哨淋巴结有转移者 2 4例 (35 8% ) ,前哨淋巴结未发现转移而非前哨淋巴结有转移者 5例 (7 5 % )。 7例患者(10 4 % )只有前哨淋巴结为阳性淋巴结。前哨淋巴结活检的准确性为 92 5 % (6 2 / 6 7) ,假阴性率为7 5 % (5 / 6 7)。原发灶≤ 2cm的患者 ,前哨淋巴结活检的准确性为 10 0 %。 4 3例患者的 6 5枚HE染色阴性的前哨淋巴结 ,CK8及CK19免疫组织化学染色均为阴性。 结论 前哨淋巴结活检能较准确地预测腋窝淋巴结转移情况 ,对原发灶为T1的乳腺癌 ,前哨淋巴结活检的准确性为 10 0 %。同一层面切片行免疫组织化学染色并不能提高淋巴结微转移? | 沈坤炜 Nirmal Lamichhane 韩企夏 吴炅 陆劲松 张家新 柳光宇 邵志敏 沈镇宙 | 2002 | 中华外科杂志2002，40，5： | 31 |
| 2 | Brazilin from Caesalpinia sappan heartwood and its pharmacological activities:A review显示文摘Caesalpinia sappan L.(CS) is a plant of Leguminosae family,commonly known as Brazil or Sappan wood.CS is distributed in Southeast Asia and its dried heartwood has been used as traditional ingredient of food or beverages and has a wide variety of medicinal properties.Higher extraction yield of CS wood was achieved with 95% ethanol for 2 h.Chemical constituent's investigation of sappan wood resulled in the isolation of various structural types of phenolic components including one xanihone,one coumarin,three chalcones,two flavones three homoisoflavonoids and brazilin.Brazilin[(6a S-cis)-7,11b-dihydrobcnz[b]indeno[1.2-d]pyran-3.6a.9.10(6H)- tetroll.a major and active compound found in CS heartwood.Most of the folkloric uses of brazilin were validated by the scientific studies such as antioxidant,antibacterial,anti-inflammatory,anti-photoaging.hypoglycemic,vasorelaxant,hepatoproteetive and anti-acne activity.CS heartwood extract is safe and did not produce any acute or subacute toxicity in both male and female rats.Brazilin is the safe natural compound having potential to develop as a medicinal compound with application in food,beverage,cosmetics and pharmaceutical industries to screen its clinical use in modern medicine.The information gained could provide the important and potential approach for pharmaceutical researcher to implicate the knowledge of brazilin in the formulation of new drug and to reveal therapeutic and gaps requiring future research opportunities.More studies are needed to evaluate the potential application of brazilin as preservative and coloring agent in food processing industries. | Nilesh P Nirmal Mithun S Rajput Rangabhatla G.S.V.Prasad Mehraj Ahmad | 2015 | Asian Pacific Journal of Tropical Medicine2015，8，6： | 14 |
| 3 | 基于同步量测全尺度能量的配电网高阻故障动态检测方法显示文摘高阻故障(high impedance fault,HIF)可能造成重大经济损失、对人身安全构成威胁,因此HIF检测对配电网来说比较重要,而微型相量测量单元在配电网中的使用为配电网HIF动态检测提供有利条件。文章针对配电网HIF检测问题,提出一种基于同步全尺度能量的配电网高阻故障动态检测方法。检测包括2个阶段:第一阶段使用克尔内克积和变分模态分解将工频电流信号分解为多个固有模态,然后采用Teager-Kaiser能量算子计算所有尺度能量;第二阶段使用具有复合指标的改进主元分析方法对第一阶段获得的尺度能量矩阵进行检测,最后通过判别标准实现对HIF的识别。仿真和实例试验表明,该算法能够准确检测出HIF,对过渡阻抗、噪声均具有鲁棒性。 | 刘洋 赵艳雷 Nirmal Nair 姚维强 | 2020 | 电网技术2020，44，8： | 11 |
| 4 | Phylogenetic relationships of Cyrtandromoea and Wightia revisited: A new tribe in Phrymaceae and a new family in Lamiales显示文摘The familial placements of Cyrtandromoea Zoll. and Wightia Wall., two small and enigmatic South‐East Asian genera, have long been controversial in Lamiales. Here we adopt a two‐step approach to resolve their phylogenetic relationships. We initially reconstructed a large‐scale phylogeny of Lamiales using six chloroplast markers (atpB, matK, ndhF, psbBTNH, rbcL, and rps4). The results showed that both Cyrtandromoea and Wightia emerged in the LMPO clade, including Lamiaceae, Mazaceae, Phrymaceae, Paulowniaceae, and Orobanchaceae. Based on the second set of six chloroplast markers (atpB, matK, ndhF, rbcL, rps16, and trnL‐F) and two nuclear ribosomal regions (external transcribed spacer and internal transcribed spacer) for the analyses focusing on the LMPO clade, our results revealed that Cyrtandromoea was consistently nested within Phrymaceae, whereas Wightia was supported as sister to Phrymaceae by the chloroplast DNA dataset or sister to Paulowniaceae by the nuclear ribosomal DNA dataset. Morphological and anatomical evidence fully supports the inclusion of Cyrtandromoea in Phrymaceae, and an updated tribal classification is done for Phrymaceae with five tribes, that is, Cyrtandromoeeae Bo Li, Bing Liu, Su Liu & Y. H. Tan, trib. nov., Diplaceae Bo Li, Bing Liu, Su Liu & Y. H. Tan, trib. nov., Leucocarpeae, Mimuleae, and Phrymeae. The conflicting phylogenetic position of Wightia indicated by different genome markers results in difficulty placing the genus in either Phrymaceae or Paulowniaceae. Considering the distinct morphological differences between Wightia and other families in the LMPO clade, we here propose a new family, Wightiaceae Bo Li, Bing Liu, Su Liu & Y. H. Tan, fam. nov., to accommodate it, which is the 26th family recognized in Lamiales. | Bing Liu Yun-Hong Tan Su Liu Richard GOlmstead Dao-Zhang Min Zhi-Duan Chen Nirmal Joshee Brajesh NVaidya Richard CKChung Bo Li | 2020 | Journal of Systematics and Evolution2020，58，1： | 8 |
| 5 | TiO2 coated urchin-like SnO2 microspheres for efficient dye-sensitized solar cells显示文摘 | Amit Thapa Jiantao Zai Hytham Elbohy Prashant Poudel Nirmal Adhikari Xuefeng Qian Qiquan Qiao | 2014 | Nano Research2014，7，8： | 7 |
| 6 | Human sperm immobilization effect of Carica papaya seed extracts: an in vitro study显示文摘Aim: To examine if the seed extracts of Carica papaya, which showed antispermatogenic/sperm immobilization properties in animal models, could cause human sperm immobilization in vitro. Methods: Chloroform extract, benzene chromatographic fraction of the chloroform extract, its methanol and ethyl acetate sub-fractions and the isolated compounds from the sub-fractions i.e., ECP 1 & 2 and MCP 1 & 2, of the seeds of Cadca papaya were used at concentrations of 0.1%, 0.5%, 1% and 2%. Sperm motility was assessed immediately after addition of extracts and every 5 minutes thereafter for 30 minutes. Results: There were dose-dependent spermicidal effects showing an instant fall in the sperm motility to less than 20 % at 2 % concentration. Isolated compounds ECP 1 & 2 were more effective inducing a motility of less than 10%. Many of the spermatozoa became vibratory on the spot. Total inhibition of motility was observed within 20 - 25 min at all concentrations of all products. Scanning and transmission electron microscopy revealed deleterious changes in the plasma membrane of the head and mid-piece of spermatozoa. Sperm viability test and the number of abnormal spermatozoa after completion of incubation suggested that the spermatozoa were infertile. The effects were spermicidal but not spermiostatic as revealed by the sperm revival test. Conclusion: The results reveal spermicidal activity in vitro of the seed extracts of Carica papaya. | Nirmal K Lohiya Lalit K Kothari B Manivannan Pradyumna K Mishra Neelam Pathak | 2000 | Asian Journal of Andrology2000，2，2： | 6 |
| 7 | Management of neglected cervical spine dislocation: a study of six cases显示文摘没有神经病学的赤字的六忽视的颈的脊骨脱臼的一个案例系列,它是管理了 operatively.MethodsThe 学习的 ObjectiveTo 报告从 2010 年 8 月被进行到 2011 年 12 月,案例从医药教育和研究的研究生研究所的门诊部被选择,印度。病人在 30 ~ 50 年的年龄组。所有病人经由前面、以后的 approaches.ResultsDuring 被操作立即的手术后的时期,五(83.33%) 病人们有正常神经病学的地位。有 C 5-C6 subluxation 的(16.67%)病人在在更低的手足的 2/5 和在在 C 6 level.ConclusionThere 下面的上面的手足的 3/5 的水平和马达功率是的 C 6下面与感觉损失开发了神经病学的赤字在对颈的脊骨的忽视的分散注意力的屈曲损害的颅骨拖拉的角色都没为更多推迟比 3 个星期。以后由前面的途径列在后面节省许多时间。如果两条途径将在一样的坐被做,其次地对乐器学没有需要。但是如果上演过程是 planed,以后的稳定被推荐,,有在神经病学的地位的恶化的风险。 | Vijay Goni Nirmal Raj Gopinathan Vibhu Krishnan Rajesh Kumar Avinash Kumar | 2013 | Chinese Journal of Traumatology2013，16，4： | 6 |
| 8 | Low-cost high entropy alloy(HEA)for high-efficiency oxygen evolution reaction(OER)显示文摘Oxygen evolution reaction(OER)is the key step involved both in water splitting devices and rechargeable metal-air batteries,and hence,there is an urgent need for a stable and low-cost material for efficient OER.In the present investigation,Co-Fe-Ga-NiZn(CFGNZ)high entropy alloy(HEA)has been utilized as a low-cost electrocatalyst for OER.Herein,after cyclic voltammetry activation,CFGNZ-nanoparticles(NPs)are covered with oxidized surface and form high entropy(oxy)hydroxides(HEOs),exhibiting a low overpotential of 370 mV to achieve a current density of 10 mA/cm^(2)with a small Tafel slope of 71 mV/dec.CFGNZ alloy has higher electrochemical stability in comparison to state-of-the art RuO2 electrocatalyst as no degradation has been observed up to 10 h of chronoamperometry.Transmission electron microscopy(TEM)studies after 10 h of long-term chronoamperometry test showed no change in the crystal structure,which confirmed the high stability of CFGNZ.The density functional theory(DFT)based calculations show that the closeness of d(p)-band centers to the Fermi level(EF)plays a major role in determining active sites.This work highlights the tremendous potential of CFGNZ HEA for OER,which is the primary reaction involved in water splitting. | Lalita Sharma Nirmal Kumar Katiyar Arko Parui Rakesh Das Ritesh Kumar Chandra Sekhar Tiwary Abhisek K.Singh Aditi Halder Krishanu Biswas | 2022 | Nano Research2022，15，6： | 5 |
| 9 | 胸壁肿瘤切除后的一期修复重建显示文摘目的 观察胸壁肿瘤切除术后胸壁缺损一期修复重建的临床效果。 方法 1998年1月~2 0 0 3年3月外科治疗胸壁肿瘤31例。男2 0例,女11例。年龄8~72岁。原发性胸壁肿瘤2 1例,肺癌侵犯胸壁6例,乳腺癌术后复发2例,放射性坏死和皮肤癌各1例。切除肋骨2~7根,平均3.6根。缺损面积2 0~2 2 0 cm2 ,平均97.1cm2 。合并肺切除10例,部分膈肌切除2例,胸骨下段切除1例。单纯软组织修复7例(背阔肌+大网膜,背阔肌肌皮瓣,背阔肌肌瓣) ,单纯骨性重建5例(涤纶布或Prolene网) ,骨性合并软组织修复19例(背阔肌、胸大肌、背阔肌+阔筋膜或大网膜,与涤纶布或Prolene网修复)。 结果 术后发生并发症3例( 9.7% ) ,其中切口感染1例,软组织与修复物之间积液2例。无手术死亡。2 6例获5~5 7个月随访,术后生存时间6~5 7个月,中位生存时间2 2个月。 结论 胸壁肿瘤切除术后造成的巨大缺损。 | 檀振波 Nirmal Lamichhane 刘登湘 肖奇海 Binay Kumar Thakur | 2005 | 中国修复重建外科杂志2005，19，5： | 4 |
| 10 | 经番木瓜种子甲醇分馏物长期治疗后大鼠的精子特点和睾丸超微结构显示文摘番木瓜种子的短期避孕效果已经确认,本文旨在研究大鼠长期服用番木瓜种子甲醇分馏物避孕的安全性和避孕机制。连续360天每天给雄性大鼠(n=40)口服番木瓜种子甲醇分馏物50mg kg^-1;对照组大鼠(n=40)给予橄榄油作为赋形剂。停止给药后120天对大鼠恢复情况进行测定。测量精子参数、血清睾酮水平、生育率、睾丸组织学及超微结构、血液学及血清临床化学,以评价番木瓜种子甲醇分馏物的安全性和有效性。大鼠健康状况、器官重量、血液学和临床化学均未改变,体重增加,证明了该长期治疗的安全性。Sertoli细胞中细胞核和细胞质体积减小、细胞核特征正常、胞质器中空泡形成,精母细胞和精子细胞核变性显示出生精受到干扰,这些均说明其避孕机制。Leydig细胞正常。治疗第60天在Sertoli细胞中观察到初始效果,治疗120—240天后精母细胞和精子细胞开始受影响。治疗60天后精子总数和精子存活率显著降低,精子活力完全抑制,精子异常增加,血清睾酮水平正常,不育率达到100%。停止治疗120天后,包括生育率在内的所有发生改变的参数都恢复到对照水平。本研究表明用番木瓜种子甲醇分馏物长期治疗是安全的,其避孕机制是通过对睾丸中精子细胞分化产生影响,可能由Sertoli细胞因素调节。 | Boomi Manivannan Ruchi Mittal Shipra Goyal Abdul S. Ansari Nirmal K. Lohiya | 2009 | Asian Journal of Andrology2009，11，5： | 4 |
| 11 | Vibrational Spectroscopy of Stretching and Bending Modes of Nickel Tetraphenyl Porphyrin: an Algebraic Approach显示文摘我们由使用 U (2 ) 为 36 个震动的乐队计算镍 tetraphenyl 卟啉的震动的频率代数学的途径。在计算的代数学的参数与试验性的数据是精确的。 | Srinivasa Rao KARUMURI Joydeep CHOUDHURY Nirmal Kumar SARKAR Ramendu BHATTACHARJEE | 2009 | Chinese Physics Letters2009，26，9： | 3 |
| 12 | Enhancing stability through ligand-shell engineering: A case study with Au25(SR)18 nanoclusters显示文摘当保护 thiolate 的 Au nanoclusters (NC ) 在各种各样的领域里拉了可观的兴趣时,他们在水的答案的差的稳定性为实际应用仍然是一个主要障碍。这里,我们基于设计在答案改进 thiolated Au NC 的稳定性的 ligand 壳报导唯一的策略。由采用二 终止thiol 的 ligands 相对地在 NC 的表面上为功能的组充电了,我们证明在附近的 ligands 的相对地为充电的功能的组之间的静电的吸引力能在表面 ligands 之中放大协作,在能在水的答案把更高的保护提供给 Au 核心的 NC 表面上导致 pseudo-cage-like 结构的形成。在这研究开发的策略能被扩大到另外的金属 NC,进一步向实际应用程序铺平道路。 | Xun Yuan Nirmal Goswami Ivan Mathews Yong Yu Jianping Xie | 2015 | Nano Research2015，8，11： | 3 |
| 13 | Helical blade versus sliding hip screw for treatment of unstable intertrochanteric hip fractures: A biomechanical evaluation显示文摘 | Eric Strauss Joshua Frank Jason Lee Frederick J. Kummer Nirmal Tejwani | 2006 | Injury2006，，10： | 3 |
| 14 | Sperm motility inhibitory effect of the benzene chromatographic fraction of the chloroform extract of the seeds of Carica papaya in langur monkey, Presbytis entellus entellus显示文摘瞄准:为了估计苯的避孕功效,在一种长尾猴的 Carica 番大瓜树的种子的氯仿摘录的色析法的部分胡闹。方法:测试物质在 50 mg/kg 身体重量 / 天被给 p.o 到五只猴子 360 天。控制动物(n= 3 ) 是收到了橄榄油车辆。精子参数作为每世界健康组织标准,精子功能的测试,睾丸和 epididymis 的形态学, haematology,临床的生物化学,浆液睾丸激素和性欲被评估。360 天处理的后面的结束动物从处理被撤退,恢复模式被精液分析和精子估计功能的测试。结果:精子活动性的全部的抑制被观察跟随 60 天继续直到 360 天学习时期的处理。精子计数,百分比生存能力和百分比正常精子给一个激烈的衰落追随者看了 30 天处理。精子形态学显示出占优势的中间的片畸形。精子功能的测试在无菌的范围得分了。睾丸的组织学和超微结构在 Sertoli 房间和细菌房间揭示了 vacuolization。细胞质的细胞器的损失在 spermatocytes 和圆 spermatids 是明显的。对待的动物的 epididymis 的组织学和超微结构比得上控制动物的那些。Hematological 和浆液临床的参数和睾丸激素层次在整个学习时期在控制范围以内波动。恢复是明显的跟随处理退却的 60-120 天。结论:结果建议 Carica 番大瓜树的种子的氯仿摘录的色析法的部分显示出的苯没有不利毒性的避孕功效,通过精子活动性的抑制调停了。 | Nirmal K. Lohiya Boomi Manivannan Shipra Goyal Abdul S. Ansari | 2008 | Asian Journal of Andrology2008，10，2： | 3 |
| 15 | An Investigation of Landslide Susceptibility Using Logistic Regression and Statistical Index Methods in Dailekh District, Nepal显示文摘Landslide distribution and susceptibility mapping are the fundamental steps for landslide-related hazard and disaster risk management activities, especially in the Himalaya region which has resulted in a great deal of death and damage to property. To better understand the landslide condition in the Nepal Himalaya, we carried out an investigation on the landslide distribution and susceptibility using the landslide inventory data and 12 different contributing factors in the Dailekh district, Western Nepal. Based on the evaluation of the frequency distribution of the landslide, the relationship between the landslide and the various contributing factors was determined.Then, the landslide susceptibility was calculated using logistic regression and statistical index methods along with different topographic(slope, aspect, relative relief, plan curvature, altitude, topographic wetness index) and non-topographic factors(distance from river, normalized difference vegetation index(NDVI), distance from road, precipitation, land use and land cover, and geology), and 470(70%) of total 658 landslides. The receiver operating characteristic(ROC) curve analysis using 198(30%) of total landslides showed that the prediction curve rates(area under the curve, AUC) values for two methods(logistic regression and statistical index) were 0.826, and 0.823with success rates of 0.793, and 0.811, respectively. The values of R-Index for the logistic regression and statistical index methods were83.66 and 88.54, respectively, consisting of high susceptible hazard classes. In general, this research concluded that the cohesive and coherent natural interplay of topographic and non-topographic factors strongly affects landslide occurrence, distribution, and susceptibility condition in the Nepal Himalaya region. Furthermore, the reliability of these two methods is verified for landslide susceptibility mapping in Nepal’s central mountain region. | DIL Kumar RAI XIONG Donghong ZHAO Wei ZHAO Dongmei ZHANG Baojun NIRMAL Mani DAHAL WU Yanhong MUHAMMAD Aslam BAIG | 2022 | Chinese Geographical Science2022，32，5： | 2 |
| 16 | Getting started in endoscopic ear surgery显示文摘Endoscopic ear surgery(EES) is an exciting, rapidly developing and innovative field of otologic surgery.Technically and conceptually, EES is a significant departure from traditional microscopic transcanal approaches to the middle ear and canal that has shown very positive results with respect to patient outcomes. This review serves as a primer for the otologist and otology resident embarking on EES and discusses the theory surrounding the learning process, the optical chain for endoscopic surgery as well as other important underlying principles. | Peter Ryan Carolina Wuesthoff Nirmal Patel | 2020 | Journal of Otology2020，15，1： | 2 |
| 17 | Hybrid Machine Learning Model for Face Recognition Using SVM显示文摘Face recognition systems have enhanced human-computer interactions in the last ten years.However,the literature reveals that current techniques used for identifying or verifying faces are not immune to limitations.Principal Component Analysis-Support Vector Machine(PCA-SVM)and Principal Component Analysis-Artificial Neural Network(PCA-ANN)are among the relatively recent and powerful face analysis techniques.Compared to PCA-ANN,PCA-SVM has demonstrated generalization capabilities in many tasks,including the ability to recognize objects with small or large data samples.Apart from requiring a minimal number of parameters in face detection,PCA-SVM minimizes generalization errors and avoids overfitting problems better than PCA-ANN.PCA-SVM,however,is ineffective and inefficient in detecting human faces in cases in which there is poor lighting,long hair,or items covering the subject’s face.This study proposes a novel PCASVM-based model to overcome the recognition problem of PCA-ANN and enhance face detection.The experimental results indicate that the proposed model provides a better face recognition outcome than PCA-SVM. | Anil Kumar Yadav R.K.Pateriya Nirmal Kumar Gupta Punit Gupta Dinesh Kumar Saini Mohammad Alahmadi | 2022 | Computers, Materials & Continua2022，，8： | 2 |
| 18 | The Trends in Maternal Mortality between 1996 and 2009 in Guizhou, China: Ethnic Differences and Associated Factors显示文摘China bears a large burden of global maternal mortality, and the largest burden of maternal deaths in China is in poor western provinces. This study aimed to investigate the trends in maternal mortality and its associated factors in Guizhou province of western China between 1996 and 2009, and examine differences between minority and non-minority counties. A population-based, longitudinal, retrospective study was performed in a poor western province of China with a considerably large ethnic minority population. All 86 counties/districts of Guizhou were included with population at county, township and village level. Maternal mortality data were collected from routine reporting database of Guizhou Provincial Health Bureau. Trend and comparative analyses and multivariate linear regression analyses were performed using SPSS 17.0. Maternal mortality ratio(MMR) and its change over time, differences between ethnic groups were analyzed. A declining trend in maternal mortality and rising trend in hospital delivery in Guizhou was observed; ethnic differences between two ethnic groups persisted. The reduction in maternal mortality between 1996 and 2009 was related with increased gross domestic product, decreased male illiteracy rate, and increased hospital delivery rate. We found the declining trends in maternal mortality in Guizhou with persisting ethnic differences. The declining trends are related with economic development, hospital delivery and male illiteracy. Effective health education on maternal health is urgently needed for the minority groups, and basic education for the new generation should be enhanced to eradicate the illiteracy. | 杜清 练武 ?yvind Nss Espen Bjertness Bernadette Nirmal Kumar 石淑华 | 2015 | Journal of Huazhong University of Science and Technology(Medical Sciences)2015，35，1： | 2 |
| 19 | [9] TM4 Microarray Software Suite显示文摘 | Alexander I. Saeed Nirmal K. Bhagabati John C. Braisted Wei Liang Vasily Sharov Eleanor A. Howe Jianwei Li Mathangi Thiagarajan Joseph A. White John Quackenbush | 2006 | Methods in Enzymology2006，，： | 2 |
| 20 | Elbow dislocation with ipsilateral diaphyseal forearm bone fracture: A rare injury report with literature review显示文摘 | Vijay Goni Prateek Behera Umesh Kumar Meena Nirmal raj Gopinathan Narendranadh Akkina R.H.H. Arjun | 2015 | Chinese Journal of Traumatology2015，18，2： | 2 |
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