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| 1 | Comparative clinical trial of S-pantoprazole versus racemic pantoprazole in the treatment of gastro-esophageal reflux disease显示文摘AIM: To compare the effi cacy and tolerability of S-pan- toprazole (20 mg once a day) versus racemic Panto- prazole (40 mg once a day) in the treatment of gastro- esophageal reflux disease (GERD). METHODS: This multi-centre, randomized, double-blind clinical trial consisted of 369 patients of either sex suf- fering from GERD. Patients were randomly assigned to receive either one tablet (20 mg) of S-pantoprazole once a day (test group) or 40 mg racemic pantoprazole once a day (reference group) for 28 d. Patients were evaluated for reduction in baseline on d 0, GERD symptom score on d 14 and 28, occurrence of any adverse effect during the course of therapy. Gastrointestinal (GI) endoscopy was performed in 54 patients enrolled at one of the study centers at baseline and on d 28. RESULTS: Signifi cant reduction in the scores (mean and median) for heart burn (P < 0.0001), acid regurgitation (P < 0.0001), bloating (P < 0.0001), nausea (P < 0.0001) and dysphagia (P < 0.001) was achieved in both groups on d 14 with further reduction on continuing the therapy till 28 d. There was a statistically signifi cant difference in the proportion of patients showing improvement in acid regurgitation and bloating on d 14 and 28 (P = 0.004 for acid regurgitation; P = 0.03 for bloating) and heart burn on d 28 (P = 0.01) between the two groups, with a higher proportion in the test group than in the refer- ence group. Absolute risk reductions for heartburn/acid regurgitation/bloating were approximately 15% on d 14 and 10% on d 28. The relative risk reductions were 26%-33% on d 14 and 15% on d 28. GI endoscopy showed no signifi cant difference in healing of esophagitis (P = 1) and gastric erosions (P = 0.27) between the two groups. None of the patients in either group reported any adverse effect during the course of therapy.CONCLUSION: In GERD, S-pantoprazole (20 mg) is more effective than racemic pantoprazole (40 mg) in improving symptoms of heartburn, acid regurgitation, bloating and equally effective in healing esophagitis and gastric erosions. The relative risk reduction is 15%-33%. Both drugs are safe and well tolerated. | Vikas G Pai Nitin V Pai Hemant P Thacker Jaisingh K Shinde Vijay P Mandora Subhash S Erram | 2006 | World Journal of Gastroenterology2006，12，37： | 19 |
| 2 | Efficient immobilization of lecitaso in gelatin hydrogel and degumming of rice bran oil using a spinning basket reactor显示文摘 | GURRALA S KAVITHA G NITIN W F | 2008 | Journal of the American Oil Chemists'' Society2008，85，8： | 1 |
| 3 | Influence of prior corrosion on the high cycle fatigue behavior of microarc oxidation coated 6061-T6 Aluminum alloy显示文摘 | Nitin P W Jyothirmayi A Sundararajan G | 2011 | International Journal of Fatigue2011，33，： | 1 |
| 4 | Direct conversion of aldehydes to acyl azides using tert-butyl hypochlorite显示文摘 | Nitin D Arote Krishnacharya G Akarnanchi | 2007 | Tetrahedron Letters2007，48，32： | 1 |
| 5 | A compact failing film absorber显示文摘 | NITIN G GOSWAMI Y D | 2005 | J of Heat Transfer2005，127，： | 1 |
| 6 | Kinetics of microwave-assisted polymerization of ε-caprolactone显示文摘 | Sivalingam G Agarwal Nitin Madras Giridhar | 2004 | Journal of Applied Polymer Science2004，91，3： | 1 |
| 7 | Kinetic of microwave-assisted polymerization of ε-caprolactone显示文摘 | Sivalingam G Agarwal Nitin Masras Giridhat | 2004 | Journal of Applied Polymer Science2004，91，3： | 1 |
| 8 | Wireless sensor network : a review on data aggregation显示文摘 | Kiran M Kamal K Nitin G | | International Journal of Scientific & EngineeringResearch0，2，4： | 1 |
| 9 | Direct visualization of mRNA colocalization with mitochondria in living cells using molecular beacons 显示文摘 | Santangelo PJ Nitin N Bao G | 2005 | Journal of Biomedical Optics2005，10，： | 1 |
| 10 | A Conceptual Model forQuality of Service in the Supply Chain显示文摘 | Nitin seth S G Deshmukh Prem Vrat | 2006 | Interational Journal ofPhysical Distribution&Logistics Management2006，36，7： | 1 |
| 11 | Kinetics of electrooxidation of landfill leachate in a three-dimensional carbon bed electrochemical reactor 显示文摘 | RAO N N ROHIT M NITIN G | 2009 | Chemosphere2009，76，： | 1 |
| 12 | Nonlinear inferential multi-rate control of Kappa number at multiple locations in a continuous pulp digester显示文摘 | NITIN E AKHILL G | 2006 | Journal of Process Control2006，16，10： | 1 |
| 13 | Magnetic nanoparticle probes显示文摘 | LaConte L Nitin N Bao G | 2005 | Nanotoday2005，，5： | 1 |
| 14 | The 2012 Chitranjan Ranawat A- ward : Intraarticular Analgesia After TKA Reduces Pain : A Randomized, Double-blinded, Placebo-controlled, Prospective Study 显示文摘 | Nitin G James MK Peter FS | 2013 | Clin Orthop Relat Res2013，471，1： | 1 |
| 15 | Efficient immobilization of lecitase in gelatin hydrogel and degumming of rice bran oil using a spinning basket reactor显示文摘 | Gurrala S Kavitha G Nitin W F | 2008 | Journal of the American Oil Chemists Society2008，85，8： | 1 |
| 16 | Strategic Network 显示文摘 | RAN JAY G NITIN N | 2000 | Strategic Management Journal2000，21，3： | 1 |
| 17 | Effect of micro arc oxidation coatings on corrosion resistance of 6061-AI Alloy 显示文摘 | NITIN P W JYOTHIRMAYI A KRISHNA L R SUNDARARAJAN G | 2008 | Journal of Materials Engineering and Performance2008，17，5： | 1 |
| 18 | Estimation of bulk density of waterlogged soils from basic properties显示文摘 | Nitin G Patil Arun Chaturvedi | 2012 | Archives of Agronomy and Soil Science2012，58，5： | 1 |
| 19 | Thermal barrier coatings for gas-turbine engine applications显示文摘 | Nitin P P Maufice G Eric H J | 2002 | Science2002，296，5566： | 1 |
| 20 | Phenazepam: the drug that came in from the cold显示文摘 | Maskell PD De Paoli G Nitin Seetohul L | 2012 | J Forensic Leg Med2012，19，3： | 1 |
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