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| 1 | Transdermal delivery of 4-aminopyridine accelerates motor functional recovery and improves nerve morphology following sciatic nerve crush injury in mice显示文摘Oral 4-aminopyridine(4-AP)is clinically used for symptomatic relief in multiple sclerosis and we recently demonstrated that systemic 4-AP had previously unknown clinically-relevant effects after traumatic peripheral nerve injury including the promotion of re-myelination,improvement of nerve conductivity,and acceleration of functional recovery.We hypothesized that,instead of oral or injection administration,transdermal 4-AP(TD-4-AP)could also improve functional recovery after traumatic peripheral nerve injury.Mice with surgical traumatic peripheral nerve injury received TD-4AP or vehicle alone and were examined for skin permeability,pharmacokinetics,functional,electrophysiological,and nerve morphological properties.4-AP showed linear pharmacokinetics and the maximum plasma 4-AP concentrations were proportional to TD-4-AP dose.While a single dose of TD-4-AP administration demonstrated rapid transient improvement in motor function,chronic TD-4-AP treatment significantly improved motor function and nerve conduction and these effects were associated with fewer degenerating axons and thicker myelin sheaths than those from vehicle controls.These findings provide direct evidence for the potential transdermal applicability of 4-AP and demonstrate that 4-AP delivered through the skin can enhance in-vivo functional recovery and nerve conduction while decreasing axonal degeneration.The animal experiments were approved by the University Committee on Animal Research(UCAR)at the University of Rochester(UCAR-2009-019)on March 31,2017. | Andrew RClark Chia George Hsu M A Hassan Talukder Mark Noble John CElfar | 2020 | Neural Regeneration Research2020，15，1： | 3 |
| 2 | Protein kinase inhibitors:insights into drug design from structure 显示文摘 | Noble M E Endicott J A Johnson L N | 2004 | Science2004，303，5665： | 1 |
| 3 | Liver homeostasis with high-intensity ultrasound: repair and healing显示文摘 | Vaezy S Noble M L Keshavarzi A | 2004 | J Ultrasound Med2004，23，2： | 1 |
| 4 | Use of viral pathogens and indicators to differentiate between human and non-human fecal contamination in a microbial source tracking comparison study显示文摘 | Noble R T Alien S M Blackwood A D | 2003 | J Water Health2003，1，： | 1 |
| 5 | TGF-β1 a cytokine mediator of glomerulo- sclerosis and a target for therapeutic intervention显示文摘 | LonderW A Noble N A Ketteler M | 1995 | Kidney Int1995，47，49： | 1 |
| 6 | Enantiospecific synthesis of 3'-hetero-dideoxynu- cleoside analogues as potential anti-HIV agents显示文摘 | JONES M F NOBLE S A ROBERTSON C A | 1992 | J Chem Soc Perkin Trans 11992，11，： | 1 |
| 7 | The changing basis of performance measurement显示文摘 | Ghalayini A M Noble J S | 1996 | International Journal of Operations & Production Management1996，16，： | 1 |
| 8 | A forest simulation model for predicting eucalypt dynamics and habitat quality for arboreal marsupials 显示文摘 | Pausas J G Austin M P Noble A R | 1997 | Ecological Applications1997，7，5： | 1 |
| 9 | Second-line or subsequent systemic therapy for recurrent or progressive non-small cell lung cancer:a systematic review and practice guideline显示文摘 | Noble J Ellis P M Mackay J A Evans W K | 2006 | J Thorac Oncol2006，1，： | 1 |
| 10 | Recent patterns and mechanisms of carbon exchange by terrestrial ecosystems显示文摘 | Schimel D S House J I Hibbard K A Bousquet P Ciais P Peylin P Braswell B H Apps M J Baker D Bondeau A Canadell J Churkina C: Cramer W Denning A S Field CB Friedlingstein P Goodale C Heimann M Houghton RA Melillo J M Moore B 3rd Murdiyarso D Noble L Pacala S W Prentice I C Raupach M R Rayner P J Scholes R J Steffen W L Wirth C | 2001 | Nature2001，414，： | 1 |
| 11 | lne opucal properties of the finest fraction of lunar soil: Implications for space weathering 显示文摘 | Noble S K Pieters C M Taylor L A el al | 2001 | Meteoritics & Planetary Science2001，36，： | 1 |
| 12 | The changing basis of performance measurement显示文摘 | Ghalayini A M Noble J S | 1996 | International Journal of Operations & Production Management1996，16，： | 1 |
| 13 | Limitation of infarct size by trimetazidine in the rabbit 显示文摘 | Noble M I Belcher P R Drake-Holland A J | 1995 | Am J Cardiol1995，76，6： | 1 |
| 14 | The crystal structure of triacylglycerol lipase from Pseudomonas glumae reveals a partially redundant catalytic aspartate 显示文摘 | Cleasby A Johnson L N | 1993 | FEBS Lett1993，331，： | 1 |
| 15 | Human ClC-3 is not the swelling-activated chloride channel involved in cell volume regulation显示文摘 | Weylandt K H Valverde M A Nobles M | 2001 | J Biol Chem2001，276，17： | 1 |
| 16 | Structures of the CD44-hyaluronan complex provide insight into a fundamental carbohydrate-protein interaction显示文摘 | BANERJI S WRIGHT A J NOBLE M | 2007 | Nat Struct Mol Biol2007，14，3： | 1 |
| 17 | Effect of interferon gamma-1b on survival in patients with idiopathic pulmonary fibrosis (INSPIRE): a multicentre, randomised, placebo-controlled trial显示文摘 | Talmadge E King Carlo Albera Williamson Z Bradford Ulrich Costabel Phil Hormel Lisa Lancaster Paul W Noble Steven A Sahn Javier Szwarcberg Michiel Thomeer Dominique Valeyre Roland M du Bois | 2009 | The Lancet . 2009 (9685)2009，，： | 1 |
| 18 | The crystal structure of triacylglycerol lipase from Pseudomonas glumae reveals a partially redundant catalytic aspartate显示文摘 | Noble M E M Cleasby A Johnson L N | 1993 | FEBS Lett1993，331，12： | 1 |
| 19 | Observations of large-amplitude crossshore internal bores near the shelf break 显示文摘 | NOBLE M A XU J P | 2003 | Marine Envirenmental Research2003，56，： | 1 |
| 20 | The performance implica tions of entrepreneurial proclivity: a dynamic capabilities approach显示文摘 | Griffith D A Noble S M Chen Q | 2006 | Journal of Retailing2006，82，1： | 1 |
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