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| 1 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 2 | Liver homeostasis with high-intensity ultrasound: repair and healing显示文摘 | Vaezy S Noble M L Keshavarzi A | 2004 | J Ultrasound Med2004，23，2： | 1 |
| 3 | Relationship hindrance: Why would consumers not want a relationship with a retailer?显示文摘 | Noble S M and Phillips J | 2004 | Journal of Retailing2004，80，： | 1 |
| 4 | The Influence of C2C Communications in Online Brand Communities on Customer Purchase Behavior显示文摘 | Adjei M Noble S Noble C | | 0，，05： | 1 |
| 5 | Use of viral pathogens and indicators to differentiate between human and non-human fecal contamination in a microbial source tracking comparison study显示文摘 | Noble R T Alien S M Blackwood A D | 2003 | J Water Health2003，1，： | 1 |
| 6 | Transplantation of specific human astrocytes promotes functional recovery after spinal cord injury显示文摘 | Davies S J Shih C H Noble M | 2011 | PLoS One2011，6，17： | 1 |
| 7 | Industrial pricing, theory and managerial practice 显示文摘 | Noble P M Grucca T S | 1999 | Marketing Science1999，18，3： | 1 |
| 8 | Use of an explanted pacemaker connected to a regular screw_in lead for temporary pacing显示文摘 | Noble S Roffi M Burri H | 2011 | Rev Esp Cardiol2011，64，： | 1 |
| 9 | Enantiospecific synthesis of 3'-hetero-dideoxynu- cleoside analogues as potential anti-HIV agents显示文摘 | JONES M F NOBLE S A ROBERTSON C A | 1992 | J Chem Soc Perkin Trans 11992，11，： | 1 |
| 10 | Assessing the US Urban Forest Resource显示文摘 | Nowak D J Noble M H Sistnni S M | 2001 | Journal of Forestry2001，99，3： | 1 |
| 11 | Dietary energy intake at the age of 4 months predicts postnatal weight gain and childhood body mass index显示文摘 | Ong K K Emmett P M Noble S | 2006 | Pe- diatrics2006，117，3： | 1 |
| 12 | Single-machine scheduling with sequence dependent setup to minimize total weighted squared tardiness显示文摘 | SUN X Q NOBLE J S KLEIN C M | 1999 | IIE Transactions1999，31，2： | 1 |
| 13 | The changing basis of performance measurement显示文摘 | Ghalayini A M Noble J S | 1996 | International Journal of Operations & Production Management1996，16，： | 1 |
| 14 | An efficient process for production of N-acetylneuraminic acid using N-acetyl- neuraminic acid aldolase 显示文摘 | Mahmoudian M Noble D Drake C S | 1997 | Enzyme Microb Technol1997，20，5： | 1 |
| 15 | Recent patterns and mechanisms of carbon exchange by terrestrial ecosystems显示文摘 | Schimel D S House J I Hibbard K A Bousquet P Ciais P Peylin P Braswell B H Apps M J Baker D Bondeau A Canadell J Churkina C: Cramer W Denning A S Field CB Friedlingstein P Goodale C Heimann M Houghton RA Melillo J M Moore B 3rd Murdiyarso D Noble L Pacala S W Prentice I C Raupach M R Rayner P J Scholes R J Steffen W L Wirth C | 2001 | Nature2001，414，： | 1 |
| 16 | lne opucal properties of the finest fraction of lunar soil: Implications for space weathering 显示文摘 | Noble S K Pieters C M Taylor L A el al | 2001 | Meteoritics & Planetary Science2001，36，： | 1 |
| 17 | The changing basis of performance measurement显示文摘 | Ghalayini A M Noble J S | 1996 | International Journal of Operations & Production Management1996，16，： | 1 |
| 18 | The Influ ence of C2C Communications in Online Brand Com- munities on Customer Purchase Behavior显示文摘 | ADJEI M T NOBLE S M NOBLE C H | 2010 | Acade- my of Marketing Science2010，38，5： | 1 |
| 19 | Amoxieillin/Clavulanie acid: A review of its use in the management of pediatric pa- tients with acute otitis media 显示文摘 | Easton J Noble S and Perry C M | 2003 | Drugs2003，63，： | 1 |
| 20 | High precision Hf isotope measurements of MORB and OIB by thermal ionisation mass spectrometry: Insights into the depleted mantle 显示文摘 | Nowell G M Kempton P D Noble S R | 1998 | Chem Geol1998，149，： | 1 |
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