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| 1 | Catheter tract implantation metastases associated with percutaneous biliary drainage for extrahepatic cholangiocarcinoma显示文摘AIM: To estimate the incidence of catheter tract implantation metastasis among patients undergoing percutaneous transhepatic biliary drainage (PTBD) for extrahepatic cholangiocarcinoma, and to provide data regarding the management of this unusual complication of PTBD by reviewing cases reported in the literature.METHODS: A retrospective analysis of 67 consecutive patients who underwent PTBD before the resection of extrahepatic cholangiocarcinoma was conducted. The median follow-up period after PTBD was 106 mo. The English language literature (PubMed, National Library of Medicine, Bethesda, MD, USA), from January 1966through December 2004, was reviewed.RESULTS: Catheter tract implantation metastasis developed in three patients. The cumulative incidence of implantation metastasis reached a plateau (6%)at 20 mo after PTBD. All of the three patients with implantation metastasis died of tumor progression at 3, 9, and 20 mo after the detection of this complication. Among the 10 reported patients with catheter tract implantation metastasis from extrahepatic cholangiocarcinoma (including our three patients), two survived for more than 5 years after the excision of isolated catheter tract metastases.CONCLUSION: Catheter tract implantation metastasis is not a rare complication following PTBD for extrahepatic cholangiocarcinoma. Although the prognosis for patients with this complication is generally poor, the excision of the catheter tract may enable survival in selected patients with isolated metastases along the catheter tract. | Jun Sakata Yoshio Shirai Toshifumi Wakai Tatsuya Nomura Eiko Sakata Katsuyoshi Hatakeyama | 2005 | World Journal of Gastroenterology2005，11，44： | 31 |
| 2 | Function-preserving gastrectomy for gastric cancer in Japan显示文摘Surgery used to be the only therapy for gastric cancer, and since its ability to cure gastric cancer was the focus of attention, less attention was paid to functionpreserving surgery in gastric cancer, though it was studied for gastroduodenal ulcer. Maki et al developed pylorus-preserving gastrectomy for gastric ulcer in 1967. At the same time, the definition of early gastric cancer(EGC) was being considered, histopathological investigations of EGC were carried out, and the validity of modified surgery was sustained. After the development of H2-blockers, the number of operations for gastroduodenal ulcers decreased, and the number of EGC patients increased simultaneously. As a result, the indications for pylorus-preserving gastrectomy for EGC in the middle third of the stomach extended, and various alterations were added. Since then, many kinds of function-preserving gastrectomies have been performed and studied in other fields of gastric cancer, and proximal gastrectomy, jejunal pouch interposition, segmental gastrectomy, and local resection have been performed. On the other hand, from the overall perspective, it can be said that endoscopic resection, which was launched at almost the same time, is the ultimate function-preserving surgery under the current circumstances. The current function-preserving gastrectomies that are often performed and studied are pylorus-preserving gastrectomy and proximal gastrectomy. The reasons for this are that these procedures that can be performed with systemic lymph node dissection, and they include three important elements:(1) reduction of the extent of gastrectomy;(2) preservation of the pylorus; and(3) preservation of the vagal nerve. In addition, these operations are more likely to be performed with a laparoscopic approach as minimally invasive surgery. Of the above-mentioned three elements, reduction of the extent of gastrectomy is the most important in our view. Therefore, we should try to reduce the extent of gastrectomy if curability of the gastric cancer can still be achieved. However, if we preserve a wider residual stomach in functionpreserving gastrectomy, we should pay attention to the development of metachronous gastric cancer. | Eiji Nomura Kunio Okajima | 2016 | World Journal of Gastroenterology2016，22，26： | 23 |
| 3 | A rare case of hyaline-type Castleman disease in the liver显示文摘Castleman disease often develops in the neck, mediastinum and pulmonary hilum. Its onset in the peritoneal cavity is very rare. The patient, a woman in her 70s, was referred to our department for a detailed examination of an abdominal mass. On abdominal ultrasonography, computed tomography scan, magnetic resonance imaging and positron emission tomography, a mass approximately 15 mm in diameter was noted in the hepatic S6. We attempted radical treatment and conducted a laparoscope-assisted right lobectomy. On the basis of histopathological findings, the patient was diagnosed as having hyaline type Castleman disease in the liver, a very rare condition. | Hisaaki Miyoshi Shima Mimura Takako Nomura Joji Tani Asahiro Morishita Hideki Kobara Hirohito Mori Hirohito Yoneyama Akihiro Deguchi Takashi Himoto Naoki Yamamoto Keiichi Okano Yasuyuki Suzuki Tsutomu Masaki | 2013 | World Journal of Hepatology2013，5，7： | 14 |
| 4 | 应用64层CT对心肌灌注缺损、局部室壁运动及左室功能的综合评估显示文摘目的评估64层CT评价心肌灌注缺损(PD),局部室壁运动(RWM)和左室(Lv)功能的准确性。方法所有心肌梗死(MI)病人签署知情同意书。本研究经机构审查委员会批准并依从HIPAA法案。102例病人(34例近期患急性MI,68例未患MI)接受了心脏多层CT检查。分析心脏多层CT影像以评估心肌PD、RWM异常和LV功能。多层CT获得的LV总体功能及RWM与经胸超声心动图(TTE)对照。PD由多层CT检出,并评价其与心脏生化指标及SPECT心肌灌注成像的相关性。多层CT诊断急性MI的根据,是有与RWM异常相匹配的PD并与临床评估对照。结果多层CT获得的总体心功能(r=0.68)和RWM(K=0,79)与TIE相关性良好。 | R.C. Cury K. Nieman M.D. Shapiro J.Butler C.H. Nomura M. Ferencik 邱建星(译) 唐光健(校) | 2008 | 国际医学放射学杂志2008，31，5： | 10 |
| 5 | Calcium Signaling in Plant Endosymbiotic Organelles: Mechanism and Role in Physiology显示文摘最近的研究证明了叶绿体和线粒体以一种压力依赖者方式响应关於生命、不能生活的压力唤起特定的 Ca 2+ 信号。在叶绿体和线粒体表明分子的 Ca 2+ transporters 和 Ca 2+ 的鉴定暗示他们在控制象植物免疫和压力回答那样的不仅 intra-organellarfunctions,而且 extra-organellar 过程起作用。看来 organellar Ca 2+ 发信号可能比以前想是更重要的种房间功能。这评论简短总结什么 isknown 在植物线粒体和 chloroplasts.Key 词关于 Ca 2+ 的分子的基础发信号: | Hironari Nomura Takashi Shiinab | 2014 | Molecular Plant2014，7，7： | 10 |
| 6 | Endovascular technique using a snare and suture for retrieving a migrated peripherally inserted central catheter in the left pulmonary artery显示文摘We report a successful endovascular technique using a snare with a suture for retrieving a migrated broken peripherally inserted central catheter(PICC)in a chemotherapy patient.A 62-year-old male received monthly chemotherapy through a central venous port implanted into his right subclavian area.The patient completed chemotherapy without complications 1 mo ago;however,he experienced pain in the right subclavian area during his last chemotherapy session.Computed tomography on that day showed migration of a broken PICC in his left pulmonary artery,for which the patient was admitted to our hospital.We attempted to retrieve the ectopic PICC through the right jugular vein using a gooseneck snare,but were unsuccessful because the catheter was lodged in the pulmonary artery wall.Therefore,a second attempt was made through the right femoral vein using a snare with triple loops,but we could not grasp the migrated PICC.Finally,a string was tied to thetop of the snare,allowing us to curve the snare toward the pulmonary artery by pulling the string.Finally,the catheter body was grasped and retrieved.The endovascular suture technique is occasionally extremely useful and should be considered by interventional cardiologists for retrieving migrated catheters. | Hiroki Teragawa Takashi Sueda Yuichi Fujii Hiroaki Takemoto Yasushi Toyota Shuichi Nomura Keigo Nakagawa | 2013 | World Journal of Cardiology2013，5，9： | 9 |
| 7 | Confirming Stereochemical Structures of Strigolactones Produced by Rice and Tobacco显示文摘主要 strigolactones (SL ) 由米饭生产了(Oryza sativa L。cv。Nipponbare ) 并且烟草(Nicotiana tabacum L。cv。Michinoku 号码 1 ) 被净化,他们的 stereochemical 结构被在 ESILC/MS 和 GCMS 为他们的 NMR 和 CD 数据和保留时间和集体破碎与光学地纯的合成标准作比较决定。从米饭植物的根流出物净化的 SL 是 orobanchol, orobanchyl 醋酸盐,和 ent-2-epi-5-deoxystrigol。除了这些 SL, 7-oxoorobanchyl 醋酸盐并且通常认为三 methoxy-5-deoxystrigol 异构体被最小公倍数 /MS 检测。7-oxoorobanchyl 醋酸盐的生产似乎发生在早生长阶段,当它仅仅在在孵化的第一个星期期间收集的根流出物被检测。烟草的根流出物包含了至少 11 SL,包括其结构尚待被澄清的通常认为的 didehydro-orobanchol 的 solanacol, solanacyl 醋酸盐, orobanchol, ent-2-epi-orobanchol, orobanchyl 醋酸盐, ent-2-epi-orobanchyl 醋酸盐, 5-deoxystrigol, ent-2-epi-5-deoxystrigol,和三异构体。而且,二 sorgolactone 异构体然而并非 sorgolactone 被最小公倍数 /MS 分析作为次要的 SL 检测。注意米饭植物生产了仅仅 orobanchol 类型 SL 是吸引人的,源于 ent-2-epi-5-deoxystrigol,而是 orobanchol 类型和 strigol 类型 SL,源于 5-deoxystrigol 在烟草植物被检测。 | Xiaonan Xie Kaori Yoneyama Takaya Kisugi Kenichi Uchida Seisuke Ito Kohki Akiyama Hideo Hayashi Takao Yokota Takahito Nomura Koichi Yoneyama | 2013 | Molecular Plant2013，6，1： | 9 |
| 8 | Interferon alpha plus ribavirin combination treatment of Japanese chronic hepatitis C patients with HCV genotype 2:A project of the Kyushu University Liver Disease Study Group显示文摘瞄准:决定一座干扰素高山的功效哈并且为感染遗传型 2 的丙肝病毒(HCV ) 的日本病人的 ribavirin 联合治疗,多中心研究回顾地被分析。方法:总共,有 HCV 遗传型 2 的 173 个病人每天一个星期和 ribavirin 的 600-800 mg 为 24 wk 三次皮下地收到 interferon-alpha。结果:总的来说持续的 virological 反应(SVR ) ,在浆液的定义同样无法发现的 HCV RNA,在治疗的结束以后的 24 wk,在 84.4% 显著地高,(146/173 ) 由 intention-to-treat 分析。在 SVR 的有效差量有或没有 ribavirin (46.9% 对 92.9%) 的中止在病人之间被发现,但是没有差别有或没有 ribavirin 的剂量减小在那些之间被发现。在 SVR 的有效差量也与 16 或更与不到 16 wk 和病人在病人之间被发现 ribavirin 治疗(34.8% 对 92.0%) 的星期。结论:24-wk 干扰素和 ribavirin 治疗为有 HCV 遗传型 2 的日本病人是高度有效的。SVR 的重要预言者是 ribavirin 治疗的继续多达 16 个星期。 | Norihiro Furusyo Masaki Katoh Yuichi Tanabe Eiji Kajiwara Toshihiro Maruyama Junya Shimono Hironori Sakai Makoto Nakamuta Hideyuki Nomura Akihide Masumoto Shinji Shimoda Kazuhiro Takahashi Koichi Azuma Jun Hayashi Kyushu University Liver Disease Study Group | 2006 | World Journal of Gastroenterology2006，12，5： | 8 |
| 9 | 上海地区复合式太阳能-地源热泵季节性蓄热供热系统的模拟研究显示文摘本文以上海地区复合式太阳能-地源热泵季节性蓄热供热系统为研究对象,在蓄热模式和供热模式这两种运行模式下,利用TRNSYS软件建立系统模型,研究该系统在一个完整的蓄热季和供热季下,土壤温变特性、系统能量损失和系统热效率随时间的变化规律。结果表明:上海地区复合式太阳能-地源热泵季节性蓄热供热系统在蓄热季可实现土壤蓄热温度45.7℃,蓄热季土壤蓄热率为42.70%,蓄热效果良好。同时在供热季实现高效的热量供给,供热季太阳能保证率为0.3。系统全年性能系数(Coefficient of Performance,COP)为3.76,具有良好的节能效果。 | 李好 李勇 Shunkei SUZUKI Yasumitsu NOMURA 王如竹 | 2020 | 制冷技术2020，40，1： | 7 |
| 10 | Diabetes mellitus and metformin in hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC) is the leading cause of cancer-related death worldwide. Diabetes mellitus, a risk factor for cancer, is also globally endemic. The clinical link between these two diseases has been the subject of investigation for a century, and diabetes mellitus has been established as a risk factor for HCC. Accordingly, metformin, a first-line oral anti-diabetic, was first proposed as a candidate anti-cancer agent in 2005 in a cohort study in Scotland. Several subsequent large cohort studies and randomized controlled trials have not demonstrated significant efficacy for metformin in suppressing HCC incidence and mortality in diabetic patients; however, two recent randomized controlled trials have reported positive data for the tumor-preventive potential of metformin in non-diabetic subjects. The search for biological links between cancer and diabetes has revealed intracellular pathways that are shared by cancer and diabetes. The signal transduction mechanisms by which metformin suppresses carcinogenesis in cell lines or xenograft tissues and improves chemoresistance in cancer stem cells have also been elucidated. This review addresses the clinical and biological links between HCC and diabetes mellitus and the anti-cancer activity of metformin in clinical studies and basic experiments. | Koji Fujita Hisakazu Iwama Hisaaki Miyoshi Joji Tani Kyoko Oura Tomoko Tadokoro Teppei Sakamoto Takako Nomura Asahiro Morishita Hirohito Yoneyama Tsutomu Masaki | 2016 | World Journal of Gastroenterology2016，22，27： | 7 |
| 11 | Use of electron microscopy on microstructure characterization of high chromium cast irons显示文摘The physical metallurgy underlying the development of cast microstructures in abrasion resistant high chromium cast irons, and their structural modification by thermal treatments is relatively complex. Structural characterisation via electron microscopy therefore has a key role to play in furthering our understanding of the phase transformations that control the microstructures and hence the service performances of these irons as wear parts. This paper shows how both scanning and especially transmission electron microscopy can provide valuable information on the nature of eutectic and secondary carbides and on the matrix structures in these irons. Particular attention is given to current characterisation research on conventionally cast 30%Cr irons that are used for applications involving corrosive wear e.g. slurry pumps and on a semi-solid cast 27%Cr iron that has a potential for applications in industry. | J.T.H. Pearce T. Chairuangsri A. Wiengmoon N. Poolthong H. Nomura | 2007 | China Foundry2007，4，1： | 7 |
| 12 | Bleeding duodenal hemangioma: Morphological changes and endoscopic mucosal resection显示文摘Recently, the development of endoscopic procedures has increased the availability of minimally invasive treatments; however, there have been few case reports of duodenal hemangioma treated by endoscopic mucosal resection. The present report describes a case of duodenal hemangioma that showed various endoscopic changes over time and was treated by endoscopic mucosal resection. An 80-year-old woman presented with tarry stools and a loss of appetite. An examination of her blood revealed severe anemia, and her hemoglobin level was 4.2 g/dL. An emergency upper gastrointestinal endoscopy was performed. A red, protrusive, semipedunculated tumor (approximately 20 mm in diameter) with spontaneous bleeding on its surface was found in the superior duodenal angle. Given the semipedunculated appearance of the tumor, it was suspected to be an epithelial tumor with a differential diagnosis of hyperplastic polyp. The biopsy results suggested a telangiectatic hemangioma. Because this lesion was considered to be responsible for her anemia, endoscopic mucosal resection was performed for diagnostic and treatment purposes after informed consent was obtained. A histopathological examination of the resected specimen revealed dilated and proliferated capillary lumens of various sizes, which confirmed the final diagnosis of duodenal hemangioma. Neither anemia nor tumor recurrence has been observed since the endoscopic mucosal resection (approximately 1 year). Duodenal hemangiomas can be treated endoscopically provided that sufficient consideration is given to all of the possible treatment strategies. Interestingly, duodenal hemangiomas show morphological changes that are influenced by various factors, such as mechanical stimuli. | Noriko Nishiyama Hirohito Mori Hideki Kobara Shintarou Fujihara Takako Nomura Mitsuyoshi Kobayashi Tsutomu Masaki | 2012 | World Journal of Gastroenterology2012，18，22： | 7 |
| 13 | Exenatide improves hepatic steatosis by enhancing lipid use in adipose tissue in nondiabetic rats显示文摘AIM:To investigate the metabolic changes in skeletal muscle and/or adipose tissue in glucagon-like peptide-1-induced improvement of nonalcoholic fatty liver disease(NAFLD).METHODS:Male Wistar rats were fed either a control diet(control group)or a high-fat diet(HFD).After 4wk,the HFD-fed rats were subdivided into two groups;one group was injected with exenatide[HFD-Ex(+)group]and the other with saline[HFD-Ex(-)group]every day for 12 wk.The control group received saline and were fed a control diet.Changes in weight gain,energy intake,and oxygen consumption were analyzed.Glucose tolerance tests were performed after 8 wk of treatment.Histological assessments were performed in liver and adipose tissue.RNA expression levels of lipid metabolism related genes were evaluated in liver,skeletal muscle,and adipose tissue.RESULTS:Exenatide attenuated weight gain[HFDEx(-)vs HFD-Ex(+)]and reduced energy intake,which was accompanied by an increase in oxygen consumption and a decrease in the respiratory exchange ratio[HFD-Ex(-)vs HFD-Ex(+)].However,exenatide did not affect glucose tolerance.Exenatide reduced lipid content in the liver and adipose tissue.Exenatide did not affect the expression of lipid metabolism-related genes in the liver or skeletal muscle.In adipose tissue,exenatide significantly upregulated lipolytic genes,including hormone-sensitive lipase,carnitine palmitoyltransferase-1,long-chain acyl-CoA dehydrogenase,and acyl-CoA oxidase 1[HFD-Ex(-)vs HFD-Ex(+)].Exenatide also upregulated catalase and superoxide dismutase 2[HFD-Ex(-)vs HFD-Ex(+)].CONCLUSION:In addition to reducing appetite,enhanced lipid use by exenatide in adipose tissue may reduce hepatic lipid content in NAFLD,most likely by decreasing lipid influx into the liver. | Kosuke Tanaka Yuko Masaki Masatake Tanaka Masayuki Miyazaki Munechika Enjoji Makoto Nakamuta Masaki Kato Masatoshi Nomura Toyoshi Inoguchi Kazuhiro Kotoh Ryoichi Takayanagi | 2014 | World Journal of Gastroenterology2014，20，10： | 6 |
| 14 | Trisomy 3 may predict a poor response of gastric MALT lymphoma to Helicobacter pylori eradication therapy显示文摘AIM: To investigate the relation of the response to Helicobacter pylori eradication therapy to the depth of tumor invasion and chromosome abnormalities in patients with mucosaassociated lymphoid tissue (MALT) lymphoma and to determine the clinical value of aneuploidy.METHODS: We studied 13 patients with localized gastric MALT lymphoma of stage E1. Before eradication therapy,the depth of tumor invasion was assessed by endoscopic ultrasonography in 8 patients and by endoscopic examination and gastrointestinal series in the remaining patients. To detect chromosomal abnormalities, paraffin-embedded tissue sections of diagnostic biopsy specimens underwent tissuefluorescence in situ hybridization (FISH), using chromosomespecific α-satellite DNA probes for chromosomes 3,7,12,and 18 and YAC clones for t(11;18)(q21;q21).RESULTS: Seven of the 13 patients had complete regression(CR) in response to H pylori eradication therapy. No patient with CR had submucosal tumor invasion. Trisomy 18 was seen in 1 patient with CR, and both trisomies 12 and 18 were present in another patient with CR. All patients with no response or progressive disease had deep submucosal tumor invasion and showed t(11;18)(q21;q21) or trisomy 3. Trisomy 7 was not detected in this series of patients.CONCLUSION: The depth of tumor invasion is an accurate predictor of the response of stage E1 MALT lymphoma to H pylori eradication therapy and is closely associated with the presence of chromosomal abnormalities. Trisomy 3 may predict the aggressive development of MALT lymphoma. | Sawako Taji Kenichi Nomura Yosuke Matsumoto Hideaki Sakabe Naohisa Yoshida Shoji Mitsufuji Kazuhiro Nishida Shigeo Horiike Shigeo Nakamura Masuji Morita Masafumi Taniwaki | 2005 | World Journal of Gastroenterology2005，11，1： | 6 |
| 15 | Semaphorin 3A controls allergic and inflammatory responses in experimental allergic conjunctivitis显示文摘AIM: To assess the efficacy of topical Semaphorin 3A(SEMA3A) in the treatment of allergic conjunctivitis.METHODS: Experimental allergic conjunctivitis(EAC)mice model induced by short ragweed pollen(SRW) in 4-week-old of BALB/c mice, mice were evaluated using haematoxylin and eosin(H&E) staining, immunofluor-escence and light microscope photographs. Early phase took the samples in 24 h after instillation and late phase took the samples between 4 to 14 d after the start of treatment. The study use of topical SEMA3A(10 U, 100 U,1000 U) eye drops and subconjunctival injection of SEMA3 A with same concentration. For comparison, five types of allergy eyedrops were quantified using clinical characteristics.· RESULTS: Clinical score of composite ocular symptoms of the mice treated with SEMA3 A were significantly decreased both in the immediate phase and the late phase compared to those treated with commercial ophthalmic formulations and non-treatment mice. SEMA3 A treatment attenuates infiltration of eosinophils entering into conjunctiva in EAC mice. The score of eosinophil infiltration in the conjunctiva of SEMA3 A 1000 U-treated group were significantly lower than low-concentration of SEMA3 A treated groups and non-treated group. SEMA3 A treatment also suppressed T-cell proliferation in vitro and decreased serum total Ig E levels in EAC mice. Moreover, treatment of SEMA3 A suppressed Th2-related cytokines(IL-5, IL-13 and IL-4)and pro-inflammatory cytokines(IFN-γ, IL-17 and TNF-α)release, but increased regulatory cytokine IL-10 concentration in the conjunctiva of EAC mice.CONCLUSION: SEMA3 A as a biological agent, showed the beneficial activity in ocular allergic processes with the less damage to the intraocular tissue. It is expected that SEMA3 A may be contributed in patients with a more severe spectrum of refractory ocular allergic diseases including allergic conjunctivitis in the near future. | Junmi Tanaka Hideo Tanaka Nobuhisa Mizuki Eiichi Nomura Norihiko Ito Naoko Nomura Masayuki Yamane Tomonobu Hida Yoshio Goshima Hiroshi Hatano Hisashi Nakagawa | 2015 | International Journal of Ophthalmology(English edition)2015，8，1： | 5 |
| 16 | MicroRNA-31 expression in colorectal serrated pathway progression显示文摘MicroRNAs have been increasingly recognized as useful biomarkers for colorectal cancers(CRC).We have recently observed that microRNA-31(miR-31)expression is associated with BRAF mutation and prognosis in CRC.Moreover,high miR-31 expression is frequently detected in sessile serrated adenomas compared with hyperplastic polyps(HPs).These results suggest that miR-31 may contribute to the progression of serrated lesions.At a follow-up colonoscopy,we observed the case of a 75-year-old man with a 7-mm flat-elevated lesion in the cecum and diagnosed the lesion as an early invasive carcinoma with serrated features.Tissue specimens were obtained from the representative areas to compare the molecular alterations in the carcinoma component with those in the HP component.Higher miR-31 expression was observed in the carcinoma component(57-fold increase)and the HP component(8-fold increase)compared with the paired normal mucosa,suggesting that miR-31 may be one of the key molecules in serrated pathway progression. | Hironori Aoki Katsuhiko Nosho Hisayoshi Igarashi Miki Ito Kei Mitsuhashi Takafumi Naito Eiichiro Yamamoto Tokuma Tanuma Masafumi Nomura Hiroyuki Maguchi Toshiya Shinohara Hiromu Suzuki Hiroyuki Yamamoto Yasuhisa Shinomura | 2014 | World Journal of Gastroenterology2014，20，34： | 5 |
| 17 | Significance of a novel sucrose permeability test using serum in the diagnosis of early gastric cancer显示文摘AIM: To investigate the usefulness of sucrose permeability test using serum in the diagnosis of gastric diseases, with special reference to early gastric cancer (EGC).METHODS: A total of 63 subjects, including 11patients with gastric ulcer, 20 patients with gastric cancer (13, early; 7, advanced) and 32 healthy controls,were studied. Blood and urine samples were collected repeatedly for 5 h before and after the sucrose loading.Sucrose levels were measured by a newly developed enzymatic method.RESULTS: Serum sucrose levels started to increase15 min after loading, and peaked at 60 min in the gastric disease groups. The levels for gastric ulcer, EGC and advanced gastric cancer (AGC) at 60 min were significantly higher than that in the healthy controls(26.9±2.4, 34.4±5.0, and 71.8±15.6 vs 7.9±0.7 mol/L,respectively, P<0.01). The cut-off level set at 15.4 mol/L(60 min) offered the best distinction between EGC patients and healthy controls; and the sensitivity and specificity were 92.3% and 93.8%, respectively, while those of the urine method were 76.9% and 93.8%,respectively.CONCLUSIONS: The gastric permeability test using serum is reliable for the detection of EGC, and this test can provide results much earlier than the conventional urine method. This test may offer a useful alternative to more invasive tests for EGC. | Tadayuki Shishido Taketo Yamaguchi Takeo Odaka Masanori Seimiya Hiromitsu Saisho Fumio Nomura | 2005 | World Journal of Gastroenterology2005，11，44： | 5 |
| 18 | Lactogenic hormones alter cellular and extracellular microRNA expression in bovine mammary epithelial cell culture显示文摘Background: Bovine milk contains not only a variety of nutritional ingredients but also micro RNAs(mi RNAs) that are thought to be secreted by the bovine mammary epithelial cells(BMECs). The objective of this study was to elucidate the production of milk-related mi RNAs in BMECs under the influence of lactogenic hormones.Results: According to a microarray result of milk exosomal mi RNAs prior to cellular analyses, a total of 257 mi RNAs were detected in a Holstein cow milk. Of these, 18 major mi RNAs of interest in the milk were selected for an expression analysis in BMEC culture that was treated with or without dexamethasone, insulin, and prolactin(DIP) to induce a lactogenic differentiation. Quantitative polymerase chain reaction(q PCR) results showed that the expressions of mi R-21–5p(P = 0.005), mi R-26a(P = 0.016), and mi R-320a(P = 0.011) were lower in the DIP-treated cells than in the untreated cells. In contrast, the expression of mi R-339a(P = 0.017) in the cell culture medium were lower in the DIP-treated culture than in the untreated culture. Intriguingly, the mi R-148 a expression in cell culture medium was elevated by DIP treatment of BMEC culture(P = 0.018). The medium-to-cell expression ratios of mi R-103(P = 0.025), mi R-148a(P < 0.001), and mi R-223(P = 0.013) were elevated in the DIP-treated BMECs, suggesting that the lactogenic differentiation-induced secretion of these three mi RNAs in BMECs. A bioinformatic analysis showed that the mi RNAs down-regulated in the BMECs were associated with the suppression of genes related to transcriptional regulation, protein phosphorylation, and tube development.Conclusion: The results suggest that the mi RNAs changed by lactogenic hormones are associated with milk protein synthesis, and mammary gland development and maturation. The elevated mi R-148 a level in DIP-treated BMECs may be associated with its increase in milk during the lactation period of cows. | Susumu Muroya Tatsuro Hagi Ataru Kimura Hisashi Aso Masatoshi Matsuzaki Masaru Nomura | 2016 | Journal of Animal Science and Biotechnology2016，7，4： | 5 |
| 19 | Searching for a treatment for Alport syndrome using mouse models显示文摘Alport syndrome(AS) is a hereditary nephritis caused by mutations in COL4A3,COL4A4 or COL4A5 encoding the type IV collagen α3,α4,and α5 chains,which are major components of the glomerular basement membrane.About 20 years have passed since COL4A3,COL4A4,and COL4A5 were identified and the first Alport mouse model was developed using a knockout approach.The phenotype of Alport mice is similar to that of Alport patients,including characteristic thickening and splitting of the glomerular basement membrane.Alport mice have been widely used to study the pathogenesis of AS and to develop effective therapies.In this review,the newer therapies for AS,such as pharmacological interventions,genetic approaches and stem cell therapies,are discussed.Although some stem cel therapies have been demonstrated to slow the rena disease progression in Alport mice,these therapies demand continual refinement as research advances.In terms of the pharmacological drugs,angiotensin-converting enzyme inhibitors have been shown to be effective in Alport mice.Novel therapies that can provide a better outcome or lead to a cure are still awaited. | Kan Katayama Shinsuke Nomura Karl Tryggvason Masaaki Ito | 2014 | World Journal of Nephrology2014，3，4： | 5 |
| 20 | Narrow portion of the terminal choledochus is a cause of upstream biliary dilatation in patients with anomalous union of the pancreatic and biliary ducts显示文摘AIM: To clarify the pathogenesis of biliary dilatation associated with anomalous union of the pancreatic and biliary ducts (AUPBD).METHODS: Direct cholangiopancreatograms of 350 adult patients with or with suspicion of hepatobiliary or pancreatic disorders were reviewed. AUPBD was diagnosed cholangiopancreatographically, when the pancreaticobiliary ductal union was located above the narrow distal segment of the bile duct, which represents the action of the sphincter of Oddi. The narrow portion of the terminal choledochus was defined as symmetrical stricture of the common bile duct just above the pancreaticobiliary ductal union.RESULTS: AUPBD was found in 36 patients. Among cholangiopancreatographic features, the narrow portion of the terminal choledochus was the most pathognomonic for AUPBD (accuracy, 98%); it was present in 29 (81%)patients with AUPBD, but was not found in any patients without AUPBD. Among patients with AUPBD, biliary dilatation (>10 mm) was more frequent in those with the narrow portion of the terminal choledochus (23/29)than in those without (2/7; P = 0.018) AUPBD. Among the patients with both AUPBD and the narrow portion of the terminal choledochus, there was a strong negative correlation between the minimum diameter of the narrow portion and the maximum diameter of the choledochus (r = -0.78, P<0.001), suggesting that the degree of biliary narrowing at the narrow portion correlates with that of upstream biliary dilatation.CONCLUSION: The narrow portion of the terminal choledochus, a pathognomonic radiologic feature of AUPBD, may be a cause of biliary dilatation in patients with AUPBD. | Tatsuya Nomura Yoshio Shirai Toshifumi Wakai Naoyuki Yokoyama Jun Sakata Katsuyoshi Hatakeyama | 2005 | World Journal of Gastroenterology2005，11，41： | 5 |
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