|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Effectiveness of hepatitis B virus vaccination program in Egypt:Multicenter national project显示文摘AIM:To assess the effectiveness of hepatitis B virus(HBV) vaccination program among fully vaccinated children.METHODS:A national community based crosssectional study was carried out in 6 governorates representing Egypt. A total of 3600 children aged from 9 mo to 16 years who were fully vaccinated with HBV vaccine during infancy were recruited. Face to face interviews were carried out and sera were evaluated for hepatitis B surface antigen(HBsA g),anti-HBV core antibodies(total) and quantitative detection of hepatitis B surface antibody using enzyme linked immunoassays techniques. Samples positive to HBs Ag/anti-HBV core antibodies were subjected to quantitative HBV-DNA detection by real time polymerase chain reaction with 3.8 IU/L detection limit. RESULTS:Sero-protection was detected among 2059 children(57.2%) with geometric mean titers 75.4 ± 3.6 IU/L compared to 3.1 ± 2.1 IU/L among nonseroprotected children. Multivariate logistic analysis revealed that older age and female gender were the significant predicting variables for having non seroprotective level,with adjusted odds ratio 3.3,9.1and 14.2 among children aged 5 to < 10,10 to < 15 and ≥ 15 years respectively compared to those < 5 years and 1.1 among girls compared to boys with P < 0.01. HBs Ag was positive in 0.11% and breakthrough infection was 0.36% and 0.39% depending on positivity of anti-HBc and DNA detection respectively. The prevalence of HBV infection was significantly higher among children aged ≥ 7 years(0.59%) compared to 0.07% among younger children with odds ratio equal to 8.4(95%CI:1.1-64.2) and P < 0.01.The prevalence was higher among girls(0.48%) than boys(0.29%) with P > 0.05. C ON C LU S I ON :T he E gy pt ian c ompuls or y H B V vaccination program provides adequate protection. Occult HBV infection exists among apparently healthy vaccinated children. Adherence to infection control measures is mandatory. | Iman I Salama Samia M Sami Zeinab Nabil Ahmed Said Manal H El-Sayed Lobna A El Etreby Thanaa M Rabah Dalia M Elmosalami Amany T Abdel Hamid Somaia I Salama Aida M Abdel Mohsen Hanaa M Emam Safaa M Elserougy Amal I Hassanain Naglaa F Abd Alhalim Fatma A Shaaban Samia A Hemeda Nihad A Ibrahim Ammal M Metwally | 2015 | World Journal of Hepatology2015，7，22： | 2 |
| 2 | Carbon dioxide capture and re- covery by means of TSA and/or VSA显示文摘 | Nabil T Georges G C6cile V | 2009 | Greenhouse Gas Con- trol2009，，3： | 1 |
| 3 | Genotyping of Streptococcus agalactiae (group B streptococci ) isolated from vaginal and rectal swabs of women at 35 - 37 weeks of pregnancy显示文摘 | Nabil A E A Inge T Greert C | 2009 | BMC Infectious Diseases2009，9，： | 1 |
| 4 | Theobroma cacao improves bone growth by modulating defective ciliogenesis in a mouse model of achondroplasia显示文摘A gain-of-function mutation in the fibroblast growth factor receptor 3 gene(FGFR3)results in achondroplasia(ACH),the most frequent form of dwarfism.Constitutive activation of FGFR3 impairs bone formation and elongation and many signal transduction pathways.Identification of new and relevant compounds targeting the FGFR3 signaling pathway is of broad importance for the treatment of ACH,and natural plant compounds are prime drug candidate sources.Here,we found that the phenolic compound(-)-epicatechin,isolated from Theobroma cacao,effectively inhibited FGFR3’s downstream signaling pathways.Transcriptomic analysis in an Fgfr3 mouse model showed that ciliary mRNA expression was modified and influenced significantly by the Indian hedgehog and PKA pathways.(-)-Epicatechin is able to rescue mRNA expression impairments that control both the structural organization of the primary cilium and ciliogenesis-related genes.In femurs isolated from a mouse model(Fgfr3^(Y367C/+))of ACH,we showed that(-)-epicatechin eliminated bone growth impairment during 6 days of ex vivo culture.In vivo,we confirmed that daily subcutaneous injections of(-)-epicatechin to Fgfr3^(Y367C/+) mice increased bone elongation and rescued the primary cilium defects observed in chondrocytes.This modification to the primary cilia promoted the typical columnar arrangement of flat proliferative chondrocytes and thus enhanced bone elongation.The results of the present proof-of-principle study support(-)-epicatechin as a potential drug for the treatment of ACH. | Ludovic Martin Nabil Kaci Catherine Benoist-Lasselin Marine Mondoloni Suzanne Decaudaveine Valentin Estibals Maxence Cornille Léa Loisay Justine Flipo Benoît Demuynck Maria de la Luz Cádiz-Gurrea Florent Barbault Salvador Fernández-Arroyo Laurent Schibler Antonio Segura-Carretero Emilie Dambroise Laurence Legeai-Mallet | 2022 | Bone Research2022，10，1： | 1 |
| 5 | Reducing blood loss at abdominal myomectomy with preoperative use of dinopros- tone intravaginal suppository: a randomized placebo - con- trolled pilot study 显示文摘 | Shokeir T Shalaby H Nabil H | 2013 | Eur J Obstet Gynecol Reprod Biol2013，166，1： | 1 |
| 6 | Improvement of Bacillus thuringiensis delta-endotoxin production by overcome of carbon catabolite repression through adequate control of aeration显示文摘 | DHOUHA G NABIL Z HASSEN T | 2007 | Enzyme and Microbial Technology2007，40，4： | 1 |
| 7 | Seminal BAX and BCL2 gene and protein expressions in infertile men with varicocele显示文摘 | Mostafa T Rashed L Nabil N | 2014 | Urolo- gy2014，84，3： | 1 |
| 8 | In vivo functional discrimination between plant thioredoxins by heterologous expression in the yeast Saccharomyces cerevisiae 显示文摘 | Nabil M Dominique T Lionel V | 1989 | Plant Biology1989，，95： | 1 |
| 9 | Heavy crude oil viscosity reduction and rheology for pipeline transportation 显示文摘 | SHADI W HASAN MAMDOUH T GHANNAM NABIL ESMAIL | 2010 | Fuel2010，89，： | 1 |
| 10 | Radiographic evaluation of transverse sacral fracture 显示文摘 | Nabil AE Fady FS Aleksander T | 2001 | Proquest Health and Medical Complete2001，24，： | 1 |
| 11 | Heavy crude oil vicosity reduction and rheology for pipeline transportation显示文摘 | SHADI W H MAMDOUH T G NABIL E | 2010 | Fuel2010，89，： | 1 |
| 12 | Multiple myeloma pre- senting as bilateral breast lumps in pregnant woman显示文摘 | Racem B Afef K Nabil T | 2013 | Inter J Hematol2013，98，4： | 1 |
| 13 | 2-Deoxy-D- glucose attenuates harmaline induced tremors in rats显示文摘 | Mohammad T Mohammed A Nabil B | 2002 | Brain Research2002，945，2： | 1 |
| 14 | Rheological properties of carboxymethyl cellulose显示文摘 | Mamdouh T Ghannam M Nabil Esmail | 1997 | Journal of Applied Polymer Science1997，64，2： | 1 |
| 15 | Cost-effective heuristics for planning GMPLS-based transport networks 显示文摘 | Nabil Naas Mouftah H T | | Optical Switching and Networking0，7，1： | 1 |
| 16 | Muhiple myeloma presenting as bilateral breast lumps in pregnant woman 显示文摘 | Racem B Mef K Nabil T | 2013 | Inter J Hematol2013，98，4： | 1 |
| 17 | Heavy crude oil viscosity reduction and rheology for pipeline transportation显示文摘 | Shadi W H Mamdouh T G Nabil E | 2010 | Fuel2010，89，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员