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| 1 | Galectin-3 and IL-33/ST2 axis roles and interplay in dietinduced steatohepatitis显示文摘Immune reactivity and chronic low-grade inflammation(metaflammation) play an important role in the pathogenesis of obesity-associated metabolic disorders, including type 2 diabetes and nonalcoholic fatty liver disease(NAFLD), a spectrum of diseases that include liver steatosis, nonalcoholic steatohepatitis(NASH), fibrosis, and cirrhosis. Increased adiposity and insulin resistance contribute to the progression from hepatic steatosis to NASH and fibrosis through the development of proinflammatory and profibrotic processes in the liver, including increased hepatic infiltration of innate and adaptive immune cells, altered balance of cytokines and chemokines, increased reactive oxygen species generation and hepatocellular death. Experimental models of dietary-induced NAFLD/NASH in mice on different genetic backgrounds or knockout mice with different immune reactivity are used for elucidating the pathogenesis of NASH and liver fibrosis. Galectin-3(Gal-3), a unique chimera-type β-galactoside-binding protein of the galectin family has a regulatory role in immunometabolism and fibrogenesis. Mice deficient in Gal-3 develop pronounced adiposity, hyperglycemia and hepatic steatosis, as well as attenuated liver inflammation and fibrosis when fed an obesogenic high-fat diet. Interleukin(IL)-33, a member of the IL-1 cytokine family, mediates its effects through the ST receptor, which is present on immune and nonimmune cells and participates in immunometabolic and fibrotic disorders. Recent evidence, including our own data, suggests a protective role for the IL-33/IL-33R(ST2) signaling pathway in obesity, adipose tissue inflammation and atherosclerosis, but a profibrotic role in NASH development. The link between Gal-3 and soluble ST2 in myocardial fibrosis and heart failure progression has been demonstrated and we have recently shown that Gal-3 and the IL-33/ST2 pathway interact and both have a profibrotic role in diet-induced NASH. This review discusses the current evidence on the roles of Gal-3 and the IL-33/ST2 pathway and their interplay in obesity-associated hepatic inflammation and fibrogenesis that may be of interest in the development of therapeutic interventions to prevent and/or reverse obesity-associated hepatic inflammation and fibrosis. | Nada Pejnovic Ilija Jeftic Nemanja Jovicic Nebojsa Arsenijevic Miodrag L Lukic | 2016 | World Journal of Gastroenterology2016，22，44： | 9 |
| 2 | Evolution of the Social Network of Scientific Collaboration 显示文摘 | Barabasi A L Jeong H Nada Z | 2002 | Physica A-Statistical Me- chanics and Its Applications2002，311，34： | 1 |
| 3 | Ion exchange properties of car- boxylated bagasse显示文摘 | Nada A A Hassan M L | 2006 | Journal of Applied Polymer Sci- ence2006，102，2： | 1 |
| 4 | Over expression of spermidine synthase enhances tolerance to multiple environmental stresses and up-regulates the expression of various stress-regulated genes in transgenic Arabidopsis thaliana显示文摘 | Kasukabe Y He L Nada K | 2004 | Plant Cell Physiol2004，45，6： | 1 |
| 5 | Overexpression of spermidine synthase enhances tolerance to multiple environmental stresses and up-regulates the expression of various stressregulated genes in transgenic Arabidopsis thaliana显示文摘 | KASUKABE Y HE L NADA K | 2004 | Plant Cell Physiol2004，45，6： | 1 |
| 6 | Psychosocial aspects of induced abortion 显示文摘 | Nada L | 1997 | Clinical Obstetrics and Gynecology1997，40，： | 1 |
| 7 | Psychiatric aspects of induced abortion 显示文摘 | Nada L | 2011 | The Journal of Nervous and Mental Disease2011，199，： | 1 |
| 8 | Chemlnform Abstract: High-Yielding Two-Step Synthesis of 6,8-Disubstituted N-9-Unprotected Purines 显示文摘 | Nada I Michel L | 2009 | J Comb Chem2009，11，： | 1 |
| 9 | Themal behavior of cellulose and some cellulose derivatives显示文摘 | Nada A M A Hassan M L | 2000 | Polymer Degradation and Stability2000，67，1： | 1 |
| 10 | Differential adsorption of heavy metal ions by cotton stalk cation exehang-ers containing multiple functional group显示文摘 | Nada A A El-Wakil N A Hassan M L | 2006 | Journal of Applied Polymer Science2006，101，6： | 1 |
| 11 | Overexpression of spermidine synthase enhances tolerance to multiple environmental stresses and up-regulates the expression of various stress-regulated genes in transgenic Arabidopsisthaliana 显示文摘 | Kasukabe Y He L Nada K | 2004 | Plant Cell Physiol2004，45，6： | 1 |
| 12 | Noise detection and elimination in data preprocessing experiments in medical domains显示文摘 | G Dragan L Nada D Saso | 2000 | Applied Artificial Intelligence2000，，14： | 1 |
| 13 | Overexpression of spermidine synthase enhances tolerance to multiple environmental stresses and upregulates the expression of various stress-regulated genes in transgenic Arabidopsis thaliana 显示文摘 | Kasukabe Y He L X Nada K | 2004 | Plant Cell Phys2004，45，6： | 1 |
| 14 | Nasr Customer Lifetime Value:Marketing Models And Appliesliom显示文摘 | i Paul D Berger Nada L | | 0，，01： | 1 |
| 15 | Utilization of lignocellulosic fibers in molded polyester composites 显示文摘 | Hassan M L Nada A M A | 2003 | J Appl Polym Sci2003，87，4： | 1 |
| 16 | The Drosophila pepti- doglycan-recognition protein LF interacts with peptidoglycan recognition protein LC to downregulate the Imd pathway显示文摘 | Nada B Franck C Philippe L | 2011 | EMBO Rep2011，12，4： | 1 |
| 17 | Combined use of serum and urinary antibody for diagnosis of tuberculosis显示文摘 | Singh KK Dong Y Hinds L Keen MA Belisle JT ZollaPazner S Achkar JM Nadas AJ Arora VK Laal S | 2003 | Jinfect Dis2003，188，3： | 1 |
| 18 | Forecasting international quarterly tourist flows using error-correction and time-series models 显示文摘 | Kulendran Nada King Maxwell L | 1997 | International Journal of Forecasting1997，13，： | 1 |
| 19 | Relevant factors in scorch gengeration in fire retarded flexible polyurethane foams 显示文摘 | Luda M P Nada P Costa L | 2004 | Polym Degrad Stab2004，86，1： | 1 |
| 20 | Phosphorylated cationexchangers from cotton stalks and their constituents显示文摘 | NADA A M A HASSAN M L | 2006 | Apply Polym Sci2006，89，： | 1 |
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