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| 1 | Endoscopic naso-pancreatic drainage for the treatment of pancreatic fistula occurring after LDLT显示文摘Pancreatic fistula is a quite rare complication in patients who undergo living donor liver transplantation(LDLT).However,in the cases that show pancreatic fistula,the limited volume of the graft and the resultant inadequate liver function may complicate the management of the fistula.As a result,the pancreatic fistula may result in the death of the patient.We present 2 cases in whichendoscopic treatment was effective against pancreatic fistulas that developed after LDLT.In case 1,a 61-yearold woman underwent LDLT for primary biliary cirrhosis.Because of a portal venous thrombus caused by a splenorenal shunt,the patient underwent portal vein reconstruction,and a splenorenal shunt was ligated on postoperative day(POD)7.The main pancreatic duct was injured during the manipulation to achieve hemostasis,thereby necessitating open drainage.However,discharge of pancreatic fluid continued even after POD 300.Endoscopic naso-pancreatic drainage(ENPD)was performed,and this procedure resulted in a remarkable decrease in drain output.The refractory pancreatic fistula healed on day 40 after ENPD.In case 2,a 58-year-old man underwent LDLT for cirrhosis caused by the hepatitis C virus.When the portal vein was exposed during thrombectomy,the pancreatic head was injured,which led to the formation of a pancreatic fistula.Conservative therapy was ineffective;therefore,ENPD was performed.The pancreatic fistula healed on day 38 after ENPD.The findings in these 2 cases show that endoscopic drainage of the main pancreatic duct is a less invasive and effective treatment for pancreatic fistulas that develop after LDLT. | Akihisa Nagatsu Toshiya Kamiyama Satoru Todo Masahiko Taniguchi Tomomi Suzuki Hiroyuki Furukawa Tsuyoshi Shimamura Kenichiro Yamashita Hiroshi Kawakami Daisuke Abo | 2011 | World Journal of Gastroenterology2011，17，30： | 5 |
| 2 | High HbA1c is a risk factor for complications after hepatectomy and influences for hepatocellular carcinoma without HBV and HCV infection显示文摘Background:Currently,the population with type 2 diabetes mellitus(DM)is increasing worldwide.However,the influence of DM or hyperglycemia on the outcome of resected hepatocellular carcinoma(HCC)is unclear.Methods:We analyzed 756 patients with HCC who underwent hepatectomy.These patients were assigned to an HbA1c≥7.0%(H-A1c;n=100)or HbA1c<7.0%(L-A1c;n=656)group depending on their HbA1c level at admission.We investigated prognoses,clinicopathological characteristics and surgical outcomes including morbidities of HCC patients with high HbA1c,prognoses according to the treatment for DM were also investigated.Results:Among all patients and those with hepatitis B virus(HBV)and hepatitis C virus(HCV)infection,overall survival(OS)and relapse-free survival(RFS)did not differ significantly between the H-A1c and L-A1c groups.In contrast,the 5-year OS rate of the H-A1c group was 55%and that of the L-A1c group 71%among patients without HBV and HCV(NBNC patients)(P=0.03).Among NBNC patients,the median RFS of the H-A1c group was 13 months,and that of the L-A1c group was 26 months(P=0.02).In addition,metformin use was an independent favorable factor for both OS and RFS.The H-A1c group had significantly higher rates of hyperbilirubinemia,wound infection,and pneumonia.Conclusions:HCC patients with high HbA1c might have poor prognoses for both survival and recurrence in NBNC-HCC.High HbA1c may also be a risk factor for morbidities after hepatectomy.Metformin use may constitute a good option for NBNC patients with HCC. | Shingo Shimada Toshiya Kamiyama Tatsuya Orimo Akihisa Nagatsu Hirofumi Kamachi Akinobu Taketomi | 2021 | Hepatobiliary Surgery and Nutrition2021，10，4： | 2 |
| 3 | Biochemistry of postmortem brains in Parkinson's disease: historical overview and future prospects 显示文摘 | Nagatsu T Sawada M | 2007 | J Neural Transm Supp2007，72，： | 1 |
| 4 | Isoquinoline neurotoxins in the brain and Parkinson's disease 显示文摘 | Nagatsu T | 1997 | Neurosci Res1997，29，2： | 1 |
| 5 | Changes in cytokines and neurotrophins in Parkinson' s disease显示文摘 | Nagatsu T Mogi M Ichinose H | 2000 | Neural Transm Suppl2000，60，： | 1 |
| 6 | A new antibiotic, polyoxin A显示文摘 | Suzuki S Isono K Nagatsu J | 1965 | The Journal of Antibiotics1965，18，： | 1 |
| 7 | Progress in monoamine oxidase(MAO) research in relation to genetic engineering显示文摘 | Nagatsu T | 2004 | Neurotoxicology2004，25，12： | 1 |
| 8 | Sesquiterpene glycosides from cotton oil cake 显示文摘 | Zhang H L Nagatsu A Okuyama H | 1998 | Phytochemistry1998，48，4： | 1 |
| 9 | Seeds of a possible natural hybrid between herbicide-resistant Brassica napus and Brassica rapa detected on a riverbank in Japan 显示文摘 | Aono M Wakiyama S Nagatsu M Kaneko Y Nishizawa T Nakajima N Tamaoki M Kubo A Saji H | 2011 | Genet Mod Crops2011，2，3： | 1 |
| 10 | Cytokines in Parkinson * s dis-ease 显示文摘 | Nagatsu T Mogi M Ichinose H | 2000 | J Neural Transm Suppl2000，58，： | 1 |
| 11 | Peroxisome proliferator-activated receptor γligands isolated from adlay seed显示文摘 | Yokoi H Mizukami H Nagatsu A | | 0，，04： | 1 |
| 12 | Cytokine production of activated microglia and decrease in neurotrophic factors of neurons in the hippocampus of Lewy body disease brains显示文摘 | Kazuhiro Imamura Nozomi Hishikawa Kenji Ono Hiromi Suzuki Makoto Sawada Toshiharu Nagatsu Mari Yoshida Yoshio Hashizume | 2005 | Acta Neuropathologica2005，，2： | 1 |
| 13 | New lignan glycosides from Chinese medicinal plant, Sinopodophyllurn emodi显示文摘 | Zhao C Q Nagatsu A Hatano K etal | 2003 | Chem Pharm Bull2003，51，3： | 1 |
| 14 | J Phys Chem B显示文摘 | Hu J Shao D D Chen C L Sheng G D Li J X Wang X K Nagatsu M | 2010 | 114:67792010，114，： | 1 |
| 15 | Tyrosine hydroxylase: human isoforms, structure and regulation in physiology and pathology显示文摘 | Nagatsu T | 1995 | Essays Biochem1995，30，： | 1 |
| 16 | Hydroxy monounsaturated fatty acids as agonists for peroxi- some proliferator-acti vated receptors 显示文摘 | Yokoi H Mizukami H Nagatsu A | 2010 | Biol Pharm Bull2010，33，5： | 1 |
| 17 | Molecular mechanism of the relation of monoamine oxidase B and its inhibitors to Parkinson's disease: possible implications of glial cells 显示文摘 | Nagatsu T Sawada M | 2006 | J Neural Transm Suppl2006，，71： | 1 |
| 18 | Carbon nanotubes as adsorbents in environmental pollution management: a review显示文摘 | Ren X Chen C Nagatsu M | 2011 | Chemical Engineering Journal2011，170，2： | 1 |
| 19 | Eu- ropium adsorption on multiwall carbon nanotube/ iron oxide magnetic composite in the presence of polyacrylic acid 显示文摘 | CHEN C L WANG X K NAGATSU M | 2009 | Environmental Science Technology2009，43，7： | 1 |
| 20 | New flavonoids from seed skin of Xantho- ceras sorbifolia显示文摘 | Rashmi Nagatsu Akito | 2011 | Journal of Medicinal Plants Research2011，5，6： | 1 |
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