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| 1 | Assessment of neovascularization within carotid plaques in patients with ischemic stroke显示文摘AIM:To assess neovascularization within human ca-rotid atherosclerotic soft plaques in patients with isch-emic stroke.METHODS:Eighty-one patients with ischemic stroke and 95 patients without stroke who had soft athero-sclerotic plaques in the internal carotid artery were studied.The thickest soft plaque in each patient was examined using contrast-enhanced ultrasound.Time-intensity curves were collected from 5 s to 3 min after contrast injection.The neovascularization within the plaques in the internal carotid artery was evaluated using the ACQ software built into the scanner by 2 of the experienced investigators who were blinded to the clinical history of the patients.RESULTS:Ischemic stroke was present in 7 of 33 patients(21%) with grade Ⅰ plaque,in 14 of 51 pa-tients(28%) with grade Ⅱ plaque,in 26 of 43 patients(61%) with grade Ⅲ plaque,and in 34 of 49 patients(69%) with grade Ⅳ plaque(P < 0.001 comparing grade Ⅳ plaque with grade I plaque and with grade Ⅱ plaque and P = 0.001 comparing grade Ⅲ plaque with grade Ⅰ plaque and with grade Ⅱ plaque).Analysis of the time intensity curves revealed that patients with ischemic stroke had a significantly higher intensity of enhancement(IE) than those without ischemic stroke(P < 0.01).The wash-in time(WT) of plaque was signifi-cantly shorter in stroke patients(P < 0.05).The sensi-tivity and specificity for IE in the plaque were 82% and 80%,respectively,and for WT were 68% and 74%,respectively.There was no significant difference in the peak intensity or time to peak between the 2 groups.CONCLUSION:This study shows that the higher the grade of plaque enhancement,the higher the risk of ischemic stroke.The data suggest that the presence of neovascularization is a marker for unstable plaque. | Wilbert S Aronow Chandra K Nair David Cosgrove | 2010 | World Journal of Cardiology2010，2，4： | 29 |
| 2 | 肿瘤体积、厚度和T分类作为手术治疗舌鳞状细胞癌效果的预测因子显示文摘背景:根据TNM分类,在同一分类中具有良好预后的浅表肿瘤与深度浸润、预后不好的肿瘤常被混淆。方法:对588例未接受过治疗的舌癌患者进行回顾研究。使用肿瘤体积和厚度作为单独的模型,二元逻辑回归用于确定淋巴结转移和包膜外扩散(ECS)的预测价值。生成C指数以量化T分类、厚度和存活的肿瘤体积的预测准确性。 | Mair M Nair D Nair S 赵泽亮 | 2018 | 中国口腔颌面外科杂志2018，16，5： | 7 |
| 3 | Role of AXL in invasion and drug resistance of colon and breast cancer cells and its association with p53 alterations显示文摘AIM To characterize AXL receptor tyrosine kinase(AXL)expression in relationship to tumor protein P53(TP53gene,p53 protein)and its role in tumor invasion and response to therapy.METHODS We used 14 cell lines,including 3 isogenic pairs carrying mutant/knockout p53,to gain insight into the relationship between AXL and TP53.These included HCT116,HCT116.p53 mutant,RKO,and RKO.p53-/-lines(all from colon cancers)as well as breast cancer cell lines MCF7 and 1001(MCF7-p53 mutant clone).He La cell line was used as a positive control for epithelial to mesenchymal transition(EMT).AXL expression was determined by Western blotting using rabbit monoclonal antibody clone C89E7.AXL si RNA silencing was performed and followed by collagen invasion assay.Cell viability analysis using the sulforhodamine B assay and the invasion assay were performed after exposure to chemotherapeutic agents(doxorubicin for breast cancer cells;5FU or irinotecan for colon cancer cells).RESULTS We showed that the introduction of p53 mutations or knockout increased expression levels of AXL in isogenic cells compared to the matching p53 wild-type parental cells.Overall,we found a trend for correlation between the potential EMT candidate AXL,p53 alterations,and EMT markers in colorectal and breast cancers.The expression of AXL in RKO cells,a rare colon cancer cell line with inactive Wnt signaling,suggests that the AXL oncogene might provide an alternative genetic pathway for colorectal carcinogenesis in the absence of Wnt signaling activation and TP53 mutation.AXL silencing in the TP53 mutant isogenic cell lines 1001,HCT116.p53 mutant and RKO.P53-/-was>95%efficient and the silenced cells were less invasive compared to the parental TP53 wild-type cells.AXL silencing showed a subtle trend to restore colon cancer cell sensitivity to5FU or irinotecan.Importantly,AXL expressing cells developed more invasive potential after exposure to chemotherapy compared to the AXL-silenced cells.CONCLUSION AXL is influenced by p53 status and could cause the emergence of aggressive clones after exposure to chemotherapy.These findings could have applications in cancer management. | Wael M Abdel-Rahman Noura A Al-khayyal Vidhya A Nair S R Aravind Maha Saber-Ayad | 2017 | World Journal of Gastroenterology2017，23，19： | 7 |
| 4 | Atrial tachyarrhythmia in adult congenital heart disease显示文摘The adult congenital heart disease(ACHD) population continues to grow and most cardiologists, emergency room physicians and family doctors will intermittently come into contact with these patients. Oftentimes this may be in the setting of a presentation with atrial tachyarrhythmia; one of the commonest late complications of ACHD and problem with potentially serious implications. Providing appropriate initial care and ongoing management of atrial tachyarrhythmia in ACHD patients requires a degree of specialist knowledge and an awareness of certain key issues. In ACHD, atrial tachyarrhythmia is usual y related to the abnormal anatomy of the underlying heart defect and often occurs as a result of surgical scar or a consequence of residual hemodynamic or electrical disturbances. Arrhythmias significantly increase mortality and morbidity in ACHD and are the most frequent reason for ACHD hospitalization. Intra-atrial reentrant tachycardia and atrial fibrillation are the most prevalent type of arrhythmia in this patient group. In hemodynamically unstable patients, urgent cardioversion is required. Acute management of the stable patient includes anticoagulation, rate control, and electrical or pharmacological cardioversion. In ACHD, rhythm control is the preferred management strategy and can often be achieved. However, in the long-term, medication side-effects can prove problematic. Electrophysiology studies and catheter ablation are important treatments modalities and in certain cases, surgical or percutaneous treatment of the underlying cardiac defect has a role. ACHD patients, especially those with complex CHD, are at increased risk of thromboembolic events and anticoagulation is usually required. Female ACHD patients of child bearing age may wish to pursue pregnancies. The risk of atrial arrhythmias is increased during pregnancy and management of atrial tachyarrhythmia during pregnancy needs specific consideration. | Arsha Karbassi Krishnakumar Nair Louise Harris Rachel M Wald S Lucy Roche | 2017 | World Journal of Cardiology2017，9，6： | 3 |
| 5 | Simplified chemical deposition technique for good quality SnS thin films显示文摘 | Nair M T S Nair P K | 1991 | Semicon Sci Technol1991，6，： | 2 |
| 6 | Bone marrow- generated dendritic cells pulsed with tumor extracts or tumor RNA induc ed antitumor immunity against central nervous system tumors显示文摘 | Ashley DM Faiola B Nair S | 1997 | J Exp Med1997，186，7： | 2 |
| 7 | 重组脊髓灰质炎病毒用于治疗复发胶质母细胞瘤(英文)显示文摘Background The prognosis of patients with recurrent World Health Organization(WHO)grade IV malignant glioma is dismal,and there is currently no effective therapy.We conducted a dose-finding and toxicity study in this population of patients,evaluating convection-enhanced,intratumoral delivery of the recombinant nonpathogenic polio-rhinovirus chimera(PVSRIPO).PVSRIPO recognizes the poliovirus receptor CD155,which is widely expressed in neoplastic cells of solid tumors and in major components of the tumor microenvironment.Methods We enrolled consecutive adult patients who had recurrent supratentorial WHO grade IV malignant glioma,confirmed on histopathological testing,with measurable disease(contrast-enhancing tumor of≥1 cm and≤5.5 cm in the greatest dimension).The study evaluated seven doses,ranging between 107 and 1010 50%tissue-culture infectious doses(TCID50),first in a dose-escalation phase and then in a dose-expansion phase.Results From May 2012 through May 2017,a total of 61 patients were enrolled and received a dose of PVSRIPO.Dose level-1(5.0×107TCID50)was identified as the phase 2 dose.One dose-limiting toxic effect was observed;a patient in whom dose level 5(1010TCID50)was administered had a grade 4 intracranial hemorrhage immediately after the catheter was removed.To mitigate locoregional inflammation of the infused tumor with prolonged glucocorticoid use,dose level 5 was deescalated to reach the phase 2 dose.In the dose-expansion phase,19%of the patients had a PVSRIPO-related adverse event of grade 3 or higher.Overall survival among the patients who received PVSRIPO reached a plateau of 21%(95%confidence interval,11 to 33)at 24 months that was sustained at 36 months.Conclusions Intratumoral infusion of PVSRIPO in patients with recurrent WHO grade IV malignant glioma confirmed the absence of neurovirulent potential.The survival rate among patients who receivedPVSRIPO immunotherapy was higher at 24 and 36 months than the rate among historical controls. | Desjardins A Gromeier M Herndon JE 2nd Beaubier N Bolognesi DP Friedman AH Friedman HS McSherry F Muscat AM Nair S Peters KB Randazzo D Sampson JH Vlahovic G Harrison WT McLendon RE Ashley D Bigner DD | 2018 | 中华神经外科疾病研究杂志2018，17，4： | 2 |
| 8 | 多壁碳纳米管制备有机光伏电池(英文)显示文摘以芝麻油为原料,采用化学气相沉积法合成出多壁碳纳米管(MWCNTs),经功能化改性、切短后用作有机光伏太阳能电池的添加剂。该有机光伏电池以聚3-辛基噻吩为光敏分子,PCBM为激子离化剂。结果表明,添加MWCNTs与功能化且切短的fc-MWCNTs,有机光伏电池的功率转换效率能分别提高22%和40%。由于较高的空穴迁移率,激子离化后,P3OT产生空穴的收集和运输得到提高。功能化和切短的fc-MWCNTs增加了其在P3OT,PCBM中的分散性,进而提高功率转换效率。 | Samrat Paul Bijumani Rajbongshi Birinchi Bora Ranjith G Nair S K Samdarshi | 2017 | 新型炭材料2017，32，1： | 2 |
| 9 | Induetian of pullulanase production in Bacillus cereus FDTA - 13 显示文摘 | NAIR S U SINGHAL R S KAMAT MY | 1998 | Bioresource Technology1998，4，： | 1 |
| 10 | Expression of a truncated Pasteurella multocida toxin antigen in Bordetella bronchiseptica显示文摘 | Rajeev S Nair R V Kania SA Bemis D A | 2003 | Vet Microbiol2003，94，4： | 1 |
| 11 | Gelation of proteins from washed muscle of threadfin bream ( Nemipterus japonicus ) under mild acidic conditions 显示文摘 | Chawla S P Venugopal V Nair P M | 1996 | J Food Sci1996，61，2： | 1 |
| 12 | Human tumor cell growth inhibition by nontoxic anthocyanidins, the pigments in fruits and vegetables 显示文摘 | Zhang Y Vareed S K Nair M G | 2005 | Life Sci2005，76，： | 1 |
| 13 | Benzoxazine-bismaleimide blends; Curing and thermal properties显示文摘 | Santhosh Kumar K S Reghunadhan Nair C P Sadhana R | 2007 | European Polymer Journal2007，43，12： | 1 |
| 14 | One-pot synthesis of 2,4-benzodiazepin-l-ones using benzotriazole methodology显示文摘 | Katrizky A R Nair S K | 2002 | J Org Chem2002，67，23： | 1 |
| 15 | Genetic characterization of 2006 - 2008 isolates of chikungunya virus from Kerala, South Indi- a,by whole genome sequence analysis显示文摘 | Sreekumar E Issac A Nair S | 2010 | Virus Genes2010，40，1： | 1 |
| 16 | Selective removal of impulse noise based on homogeneity level information显示文摘 | Pok G Liu J C Nair A S | 2003 | IEEE Trans on Image Processing2003，12，1： | 1 |
| 17 | Obesity and its effect on survival in patients undergoing orthotopic liver transplantation in the United States 显示文摘 | Nair S Verma S Thuluvath PJ | 2002 | Hepatology2002，35，1： | 1 |
| 18 | Microbial status of apical root ca- nal system of human mandibular first molar with primary apical pe- riodontitis after' one- visit' endodontic treatment显示文摘 | Nair PNR Henry S Cano V | 2005 | Oral Surg O- ral Med Oral Pathol Oral Radiol Endod2005，99，2： | 1 |
| 19 | Multivalent RNA aptamers that inhibit CTLA-4 and enhance tumor immunity 显示文摘 | Santulli-Marotto S Nair S K Rusconi C | 2003 | Cancer Res2003，63，： | 1 |
| 20 | A one-step conversion of benzene to phenol with a palladium membrane显示文摘 | Niwa S I Eswaramoorthy M Nair J | 2002 | Science2002，295，： | 1 |
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