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| 1 | Effect of Tongxieyaofang decoction on colonic mucosal protein expression profiles in rats with visceral hypersensitivity显示文摘OBJECTIVE: To explore the underlying mechanism of action of Tongxieyaofang decoction in rats with visceral hypersensitivity using proteomics technology.METHODS: Twenty-four female Sprague-Dawley rats were randomly divided into three groups: control group, irritable bowel syndrome(IBS) group and Tongxieyaofang treatment group. An IBS model, characterized as visceral hypersensitivity, was established using the odour of mothballs as conditional stimulation and colorectal distension combined with classic physical restraint as non-conditional stimulation. Rats were intragastrically treated with Tongxieyaofang(2 or 4 m L · kg^(-1)· d^(-1))for 4 weeks. On the 45 th day, the rats were dissected and the colonic mucosal proteins were extracted. Differential protein spots were screened by fluorescent two-dimensional differential gel electrophoresis(2 D-DIGE), and identified by matrix-assisted laser desorption/ionisation time of flight mass spectrometry(MALDI-TOF-MS). Western blotting experiments were performed to verify the changes observed in 2 D-DIGE and MALDI-TOF-MS.RESULTS: It was found that the visceral sensitivity of rats in the Tongxieyaofang treatment group(4 m L/kg) was lower than that in the IBS group(P <0.01). Sixty-one protein spots were differentially expressed between the IBS group and the Tongxieyaofang treatment group. Of these, 23 spots were upregulated in the Tongxieyaofang treatment group, while 38 spots were downregulated. Three specific proteins were successfully identified from the five protein spots with the most obvious changes. The two upregulated proteins were transgelin(TAGLN) and acetaldehyde dehydrogenase 2(Aldh2) and the downregulated protein was cytokeratin 8(CK8).CONCLUSION: Tongxieyaofang can dose-dependently ameliorate visceral hypersensitivity in rats and the mechanism of action may involve the upregulation of TAGLN and Aldh2 and the downregulation of CK8. | Lin Yongjun Ding Ying Lü Bin Liu Nan | 2020 | Journal of Traditional Chinese Medicine2020，40，2： | 4 |
| 2 | EUS-assisted band ligation of small duodenal stromal tumors and follow-up by EUS显示文摘 | Siyu Sun Nan Ge Sheng Wang Xiang Liu Qingjie Lü | 2009 | Gastrointestinal Endoscopy2009，，3： | 1 |
| 3 | Alternatives to albumin administration in hepatocellular carcinoma patients undergoing hepatectomy: an open, randomized clinical trial of efficacy and safety显示文摘背景在与肝疾病对待病人的人工的胶体的价值是争论的。对手术后的煽动性的反应的改变第二等的肝功能上的 intravascular 卷代替政体的效果不被知道。在这研究,我们在经历 hepatectomy 澄清白朊管理是否能被 90 个连续 hepatocellular 癌病人安排了的另外的体积代替 products.Methods 代替的 hepatocellular 癌病人评估了不同体积代替政体的效果因为 hepatectomy 有希望地被使随机化收到20%人的白朊(哈),6% hydroxyethyl 淀粉( HES )或喂奶的 Ringer 为手术后的体积代替是答案( LR )。血液动力学,肝功能和煽动性的反应参数在手术后的天被记录一,三,和五在整个调查 period.Results,显著地,更少的体积在 HA 和 HES 组被要求。尽管在所有组的病人有类似的基线价值,血浆 osmolality 在 HA 和 HES 组是显著地更高的。全部的 bilirubin (TB ) ,丙氨酸 aminotransferase (中高音) ,和 aspartate aminotransferase (著名计算机生产厂商) 在所有组从基线增加了,并且没在组之间显著地不同。C 反应的蛋白质(CRP ) 与在经历 hepatectomy 的 hepatocellular 癌病人的另外的 groups.Conclusions 相比在 HES 组是显著地更低的,哈能被 HES 或 LR 在很好选择的病人代替。血液动力学的稳定性,肝功能,和手术后的临床的结果能相等地在 HES 组被完成;另外, HES 们可以在尖锐阶段反应上施加更有利的效果。(登记在中国临床的试用登记, ChiCTR-TRC-10000790 ) | YANG Jian WANG Wen-tao YAN Lü-nan XU Ming-qing YANG Jia-yin | 2011 | Chinese Medical Journal2011，，10： | 1 |
| 4 | Recruitment of older adults into randomized controlled trials:Issues and lessons learned from two community-based exercise interventions in Shanghai显示文摘Background: With the increasing need for high-quality exercise interventions in China, relatively little is known about issues and challenges related to recruitment of older Chinese adults into exercise-based disease prevention interventions. This study aims to describe the recruitment process and outcomes of 2 exercise interventions conducted in Shanghai, China.Methods: Recruitment information was ascertained from 2 community-based randomized controlled trials for 2 exercise interventions, the first designed to improve health outcomes for older women with knee osteoarthritis and the second to study changes in cognitive function in adults with mild cognitive impairment. Results were summarized in terms of recruitment sources, number screened, screening-to-enrollment ratios, and costs.Results: Recruitment was primarily achieved through working with local residential divisions(i.e., neighborhood associations and residential committees). Both studies achieved their planned target number of older adults(45 and 46, respectively) within a 1-year time frame, with a screening-to-randomized ratio of 5:1 and demonstrated excellent retention rates(range 87%–93%) at 6 months. The recruitment cost for the 2studies averaged RMB 189(about USD 30) per initial recruit and RMB 738(about USD 119) per participant randomized. Some major issues encountered during the recruitment process included(1) the use of community neighborhoods to support the conduct of the projects,(2) access to participants, and(3) feasibility.Conclusion: Analysis of the 2 randomized controlled trials has provided valuable insights into the recruitment process and identified resources that can help better planning and recruitment for future interventions. Recommendations aimed at increasing the success of future recruitment efforts are provided. | Lingyan Huang Jiaojiao Lü Nan Chen Yu Liu | 2016 | Journal of Sport and Health Science2016，5，3： | 1 |
| 5 | Endoscopic band ligation of small gastric stromal tumors and follow-up by endoscopic ultrasonography显示文摘 | Siyu Sun Nan Ge Caixia Wang Mengchun Wang Qingjie Lü | 2007 | Surgical Endoscopy2007，，4： | 1 |
| 6 | Numerical simulation on gradient cooling behavior of jumbo slab ingot显示文摘Shrinkage porosity defect is often found in an air cooled jumbo steel ingot, which will influence the quality of the final rolled plates. In practical production, some rolled plates are frequently rejected due to the serious shrinkage porosity of the ingot. To improve the quality of the ingot, a new cooling method, gradient cooling process (in which the upper part of the ingot is air cooled and the lower part is spray cooled) was put forward in this study. The solidification behaviors for a 60 t jumbo slab ingot under gradient cooling condition were simulated using the ProCast software, and the results were compared with those of an ingot by air cooling condition. The solidifying tendency, temperature field and distribution of shrinkage porosities in the ingot under different cooling conditions were analyzed. Simulation results show that under gradient cooling condition the solidification of the slab ingot progresses in an upward manner along the vertical z axis and in a centripetal manner along the horizontal x and y axes. Gradient cooling can efficiently reduce shrinkage porosity of the jumbo slab ingot by optimizing the solidification sequence, and making the position of shrinkage porosity move from near the middle height of the ingot (under air cooling condition) towards the head of the ingot; and the secondary shrinkage is eliminated. In addition, the solidification time of the ingot under gradient cooling is 7.3 h in this simulation, which is 2.7 h faster than that under air cooling. A 60 t jumbo slab ingot was successfully produced under gradient cooling condition. The ingot was rolled to a plate with a thickness of 100 mm and length of 18,000 mm, and ultrasonic flaw detection was performed. Some porosity was found along the axis of the plate at 4,900 - 6,000 mm from the head of the plate, indicating that the position of the defect is moved towards the head of the ingot. This distribution trend of the defect is consistent with the simulated result. | Lü Nan Jin Yonglong Li Shengli Ai Xingang Yuan Xiaoguang | 2013 | China Foundry2013，10，2： | 1 |
| 7 | EUS-assisted band ligation of small duodenal stromal tumors and follow-up by EUS显示文摘 | Siyu Sun Nan Ge Sheng Wang Xiang Liu Qingjie Lü | 2009 | Gastrointestinal Endoscopy2009，，3： | 1 |
| 8 | Endoscopic band ligation of small gastric stromal tumors and follow-up by endoscopic ultrasonography显示文摘 | Siyu Sun Nan Ge Caixia Wang Mengchun Wang Qingjie Lü | 2007 | Surgical Endoscopy2007，，4： | 1 |
| 9 | Endoscopic band ligation of small gastric stromal tumors and follow-up by endoscopic ultrasonography显示文摘 | Siyu Sun Nan Ge Caixia Wang Mengchun Wang Qingjie Lü | 2007 | Surgical Endoscopy2007，，4： | 1 |
| 10 | T-614 alters the production of matrix metalloproteinases (MMP-1 andMMP-3) and inhibits the migratory expansion of rheumatoid synovial fibroblasts, in vitro显示文摘 | Fang Du Liang-jing Lü Jia-lin Teng Nan Shen Ping Ye Chun-de Bao | 2012 | International Immunopharmacology2012，，1： | 1 |
| 11 | Enhanced Degradation of Methyl Parathion in the Ligand Stabilized Soluble Mn(Ⅲ)-Sulfite System显示文摘The ligand-stabilized soluble Mn(Ⅲ) recognized as active intermediate can potentially mediate the attenuation of contaminants. In this study,the abiotic degradation behaviors of methyl parathion in the ligand stabilized Mn(Ⅲ)-sulfite system were investigated. The results showed that the yield of soluble Mn(Ⅲ) produced from the redox reaction of MnO2 and oxalic acid was dependent linearly on the dosage of Mn O2 and caused the decomposition of methyl parathion up to 50.1% in Mn(Ⅲ)-sulfite system after 30 minutes. The fitted pseudo-first-order reaction constants of methyl parathion degradation increased with the increasing of the amount of produced Mn(Ⅲ) but was not effected linearly by the addition of sulfite. Other ligands,including pyrophosphate and oxalic acid,acted as effective complexing agents to stabilize soluble Mn(Ⅲ),and exhibited competitive effect on methyl parathion degradation with sulfite. The formation of Mn(Ⅲ)-sulfite complexes is the critical step in the system to produce abundant reactive oxygen species identified as SO3·-to facilitate methyl parathion degradation. The hydrolysis and oxidation of methyl parathion were acknowledged as two primary transformation mechanisms in Mn(Ⅲ)-sulfite system. These findings indicate that naturally ligands-stabilized soluble Mn(Ⅲ) can be generated and could oxidatively decompose organophosphate pesticides such as methyl parathion. | Caixiang Zhang Xiaoping Liao You Lü Chao Nan | 2019 | Journal of Earth Science2019，30，4： | 1 |
| 12 | Method for determining the best frequency band for eavesdropping the display image of a PC显示文摘The display image of the video display unit (VDU) can be reconstructed by receiving and analyzing the unexpected electromagnetic noise emanated from a personal computer system.This fact is one of the information leakage threats in information security.Therefore, in order to choose the best frequency range for receiving the electromagnetic compromising emanations form a PC display effectively and quickly, a method based on the correlation power analysis (CPA) and the common equipments is proposed.Firstly, the frequency spectrum of 10 MHz to 1 GHz is measured about 10 times respectively when the PC is displaying the white-black vertical strips image and black image.The frequency range which contains the display information can be obtained through the CPA.And then, the special image signal is searched around the dot frequency and harmonics.If the special signal disappears when displaying the total black image, it can be judged to be the real special signal.Finally, the best receiving frequency range can be chosen by comprehensive considering the results of CPA and the signal to noise ratio (SNR) of the special image signal.In order to check the validity of the chosen frequency range, eavesdropping experiments are carried out.The results demonstrate that the selected frequency range can retrieve the higher quality image than other frequency bands. | DU Yu-lei Lü Ying-hua ZHANG Jin-ling ZHANG Nan | 2013 | The Journal of China Universities of Posts and Telecommunications2013，20，4： | 0 |
| 13 | Community Dynamics of Seed Rain in Mixed Evergreen Broad-leaved and Deciduous Forests in a Subtropical Mountain of Central China显示文摘Seed dispersal is a key process within community dynamics.The spatial and temporal variations of seed dispersal andthe interspecific differences are crucial for understanding species coexistence and community dynamics.This might alsohold for the mixed evergreen broadleaved and deciduous forests in the mountains of subtropical China,but until now littleexisting knowledge is available for this question.In 2001,we chose to monitor the seed rain process of our mixed evergreenbroad-leaved and deciduous forest communities in Mount Dalaoling National Forest Park,Yichang,Hubei Province,China.The preliminary analyses show obvious variations in seed rain density,species compositions and timing of seed rain amongfour communities.The average seed rain densities of the four communities are 2.43±5.15,54.13±182.75,10.05±19.30and 24.91±58.86 inds./m^2,respectively;about one tenth the values in other studies in subtropical forests of China.In eachcommunity,the seed production is dominated by a limited number of species,and the contributions from the others aregenerally minor.Fecundity of evergreen broadleaved tree species is weaker than deciduous species.The seed rain of fourcommunities begins earlier than September,and stops before December,peaking from early September to late October.The beginning date,ending date and peak times of seed rain are extensively varied among the species,indicating differenttypes of dispersal strategies.According to the existing data,the timing of seed rain is not determined by the climateconditions in the same period,while the density of seed rain may be affected by the disturbances of weather variations ata finer temporal resolution. | Ze-Hao Shen Yuan-Yuan Tang Nan Lü Jun Zhao Dao-Xing Li Gong-Fang Wang | 2007 | Journal of Integrative Plant Biology2007，49，9： | 9 |
| 14 | Shenfuqiangxin Capsule inhibits apoptosis through mitogen-activated protein kinase signal pathway in rats with cardio-renal syndrome induced by infrarenal aortic-clamping显示文摘OBJECTIVE: To investigate the effect of Shenfuqiangxin capsule and the underlying mechanism on cardio-renal syndrome(CRS) in rats induced by infrarenal aortic-clamping after renal ischaemia.METHODS: Male Wistar rats underwent infrarenal aortic-clamping after renal ischaemia or sham operation. The surviving CRS rats were divided randomly into three groups: CRS group(CRS + 10 m L·kg-1·d-1pure water by gavage), SFQX group(CRS + 13.2 g crude drug·kg- 1·d- 1Shenfuqiangxin by gavage),and handleregionpeptide(HRP)group(CRS+10mg/kg HRP by vein). Sham operation rats were given10 m L·kg-1·d-1pure water. Treatments were given8 weeks after surgery, which lasted for 4 weeks. Therats were detected for heart structure and function by transthoracic echocardiography. PPR m RNA was detected by Reverse Transcription Polymerase Chain Reaction(RT-PCR). To determine whether the mitogen-activated protein kinase(MAPK) signal pathway is included in the heart and kidney protective function of Shenfuqiangxin capsule, MAPK related proteins such as posophorylated C-Jun amino terminal kinase(p-JNK), posophorylated extracellular signal-regulated kinase ?(p-ERK1/2), posophorylated p38(p-p38) were examined by Western Blot.Apoptosis in heart and kidney tissues were detected by d UTP Nick End Labeling staining.RESULTS: Shenfuqiangxin capsule alleviated myocardial apoptosis and inhibited PRR m RNA expression and p-JNK, p-ERK1/2, p-p38 proteins expression in CRS rats.CONCLUSION: All the results suggest that Shenfuqiangxin capsule improves the injured heart and kidney function maybe through inhibition of MAPK response pathway. | Wang Lei Wang Zi Yuan Ling Hao Di LüNan Li Xu | 2017 | Journal of Traditional Chinese Medicine2017，37，1： | 3 |
| 15 | Adapting ecosystem restoration for sustainable development in a changing world显示文摘The world population exceeded eight billion in 2022 and will continue to grow rapidly in the coming decades.To support the survival andwell-being of this large and growing population,numerous natural resources have been overexploited,and a large amount of waste has been generated,inducing forms of ecosystem degradation,such as biodiversity loss,productivity decline,and environmental pollution,which undermine the capacity of sustainable development for socioecological systems at multiple scales.As a countermeasure for this problem,a land-degradation-neutral world by 2030 has been established as a critical component of the Sustainable Development Goals. | Xing Wu Yihe Lü Junze Zhang Nan Lu Wei Jiang Bojie Fu | 2023 | The Innovation2023，4，1： | 1 |
| 16 | Kinetic study on co-combustion of pulverized anthracite and bituminite for blast furnace injection显示文摘Combustion behavior of single pulverized coals(PCs)and co-combustion characteristics of anthracite(AT)and bituminite(BT)blends with 20 wt.%volatile were studied by thermogravimetric experiments.The results indicated that reaction characteristics of PCs were closely related to their functional group structure and consequently,the pyrolysis of PCs with highly active functional groups initiated at lower temperatures.It was also noticed that the discrepancy of functional group structures between AT and BT might impair their interaction during combustion.The early exhaust of BT at low temperatures would possibly lead to an independent combustion of volatile and residual carbon and eventually the inefficient combustion of their blend.However,the mixing of AT and BT with similar functional group structures was more likely to achieve blends with superior combustion property.Simultaneously,non-isothermal kinetic analysis mani-fested that the combustion of blends followed random pore model(RPM),and therefore,the parameters calculated by RPM were more accurate to describe their combustion behavior.The kinetic calculation results showed that the activation energy required for decomposition of blends in early combustion stage was much lower owing to the excellent activity of volatile,while residual carbon with stable aromatic hydrocarbon demanded more energy to initiate its combustion. | Li-chun Yang Qing-hai Pang Zhi-jun He Jun-hong Zhang Wen-long Zhan Nan Lü | 2021 | Journal of Iron and Steel Research(International)2021，28，8： | 0 |
| 17 | Fabrication of Large-scale Nanostructure by Langmuir-Blodgett Technique显示文摘Monolayer of polymer latex spheres was prepared at the air/water interface and deposited onto glass slides through Langmuir?Blodgett (LB) technique. Large-scale, high quality hexagonally close-packed domains were found in scanning elec- tron microscopic pictures. Details of the monolayer-forming ability were discussed. Suitable surface characteristics of the col- loidal particles, especially the hydrophilic and hydrophobic properties, are the keys for the formation of ordered monolayer films. The film can be transferred onto various kinds of substrates, even high curvature surface articles, such as fibers, decorations etc, can also be used as substrates. The advantages of this fabrication method of polymer latex spheres monolayer are fast, flexible, simple and very neat. | Lü Zhi-cheng Ruan Wei-dong Ji Nan Ren Lu-quan Cong Qian Zhao Bing | 2006 | Journal of Bionic Engineering2006，3，2： | 0 |
| 18 | Detection of captopril based on its enhanced resonance light scattering signals of fluorosurfactant-capped gold nanoparticles显示文摘In this study,based on its enhancement effect on resonance light scattering (RLS) of fluorosurfactant (FSN)-capped gold nanoparticles (GNPs),we reported a simple approach for the rapid sensing of captopril. Under optimum conditions,the lowest detectable concentration of captopril through this approach (S/N=3) was 0.01μg/mL. The calibration curve was linear over the range of 0.08-4.0μg/mL for the detection of captopril. The recoveries of captopril were found to fall in the range between 99% and 100%. We have validated the applicability of our method through the analyses of captopril in pharmaceutical formulations. Good agreements were obtained for the determination of captopril between the present approach and official method. | Nan Zhang,Chao Lü State Key Laboratory of Chemical Resource Engineering,Beijing University of Chemical Technology,Beijing 100029,China. | 2010 | Journal of Pharmaceutical Analysis2010，22，2： | 0 |
| 19 | Hepatic venous outflow reconstruction in adult right lobe living donor liver transplantation without middle hepatic vein显示文摘背景重建困难、挑战性在没有中间的肝的静脉(MHV ) 的成年正确脑叶生活施主肝移植(LDLT ) 的肝的静脉的流出。门静脉和静脉的流出阻塞的过多的灌注将导致接枝的尖锐拥挤,最终导致主要 nonfunction。尽管各种各样的重建模式在许多国家被探索了,当前没有清楚的一致。在这研究,我们描述一种技术没有 MHV.Methods A ,用正确脑叶接枝在 LDLT 与劣等的静脉 cava ( IVC )在流出吻合阻止接枝的“ chocking ”回顾的分析从没有 MHV ,用正确脑叶接枝经历 LDLT 的 55 个接受者在临床的数据上被进行或肝的静脉的流出的重建。施主的恰好肝的静脉(RHV ) 与接受者 IVC 的三角形的开始被吻合;劣等的恰好肝的静脉(IRHV ) 足够大,直接被吻合到 IVC。大 saphenous 静脉(GSV ) 被用于重要 MHV tributaries.Results 的重建没有死亡发生在任何施主。55 个接受者,复杂并发症发生在 6,包括 hepaticvein 苛评(1 个盒子) , small-for-size 症候群(1 ) ,肝的动脉血栓(1 ) ,肠的流血(1 ) ,胆汁漏(1 )(1 ) ,左 subphrenic 脓肿和肺的感染。三个病人的一个总数死了,从 small-for-size 症候群的并且二从多重系统机关 failure.Conclusions,多重洞的垂直吻合与肝的静脉流出被重建。这种技术减轻生活施主的外科的风险,保证优秀静脉的排水,并且阻止脉管的 thromboses 和主要 nonfunction。 | WU Hong YANG Jia-yin YAN Lü-nan LI Bo ZENG Yong WEN Tian-fu ZHAO Ji-chun WANG Wen-tao XU Ming-qing LU Qiang CHEN Zhe-yu MA Yu-kui LI Jin | 2007 | Chinese Medical Journal2007，，11： | 27 |
| 20 | Transdiaphragnatic exposure for direct atrioatrial anastomosis in liver transplantation显示文摘在 Budd-Chiari 症候群的背景肝移植仍然保持争论;然而,一些改进技术导致更好的结果。我们为 Budd-Chiari 症候群与 atrioatrial 吻合报导肝移植的中期的后续结果并且与结束阶段肝 disease.Methods 为病人与 atrioatrial 吻合探索肝移植的指示九个病人(六 Budd-Chiari 症候群,一结束阶段 hepatolithiasis ,一 hepatocellular 癌和一医不好的牙槽的包虫病)从 199 在四川大学的韦斯特中国医院里与 atrioatrial 吻合经历了肝移植八个肝移植使用的 cadaveric orthotopic 肝和一个一生活施主肝。起作用的技术都是为直接 atrioatrial 吻合和由在 venovenous bypass.Results 的帮助下的 cryopreserved 静脉 cava 接枝的劣等的静脉 cava 的代替的 transdiaphragmatic 暴露肝移植是成功的。二个病人收缩了肺的感染和尖锐拒绝发生在另一种情况中。与合适的治疗,所有病人恢复了很好并且有生活的好质量。迄今为止,他们被跟随了在上面为超过 24 个月。唯一的死亡跟随了在为直接 atrioatrial 吻合和劣等的静脉 cava 的 cryopreserved 静脉 cava graftreplacement 的肝 transplantation.Conclusions Transdiaphragmatic 暴露以后的三年是的肝的癌的复发为有因此扩大肝移植的指示的结束阶段肝疾病的病人可能。 | XU Ming-qing CHEN Zhe-yu YAN Lü-nan ZENG Yong WEN Tian-fu LI Bo ZHAO Ji-chun WANG Wen-tao YANG Jia-yin | 2010 | Chinese Medical Journal2010，，24： | 5 |
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