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	题名	作者	年代	出处	被引量
1	On tolerability and safety of a maintenance treatment with 6-thioguanine in azathioprineor 6-mercaptopurine intolerant IBD patients显示文摘AIM: To determine the tolerability and safety profile of a low-dose maintenance therapy with 6-TG in azathioprine (AZA) or 6-mercaptopurine (6-MP) intolerant inflammatory bowel disease (IBD) patients over a treatment period of at least 1 year.METHODS: Database analysis.RESULTS: Twenty out of ninety-five (21%) patients discontinued 6-TG (mean dose 24.6 mg; mean 6-TGN level 540 pmol/8×108 RBC) within 1 year. Reasons for discontinuation were GI complaints (31%), malaise (15%)and hepatotoxicity (15%). Hematological events occurred in three patients, one discontinued treatment. In the 6-TG-tolerant group, 9% (7/75) could be classified as hepatotoxicity. An abdominal ultrasound was performed in 54% of patients, one patient had splenomegaly.CONCLUSION: The majority of AZA or 6-MP-intolerant IBD patients (79%) is able to tolerate maintenance treatment with 6-TG (dosages between 0.3 and 0.4 mg/kg per d). 6-TG may still be considered as an escape maintenance immunosuppressant in this difficult to treat group of patients, taking into account potential toxicity and efficacy of other alternatives. The recently reported hepatotoxicity is worrisome and 6-TG should therefore be administered only in prospective trials.	Nanne KH de Boer Luc JJ Derijks Lennard PL Gilissen Daniel W Hommes Leopold GJB Engels Sybrand Y de Boer Gijsbertus den Hartog Piet M Hooymans Anja BU M(?)kelburg Barend D Westerveld Anton HJ Naber Chris JJ Mulder Dirk J de Jong	2005	World Journal of Gastroenterology2005，11，35：	4
2	Ploidy of broccoli regenerated from microspore culture versus anther culture显示文摘	Wang M Farnham M W Nannes J S P	1999	Plant Breeding1999，118，3：	1
3	Ploidy of broccoli regenerated from microspore culture versus anther culture 显示文摘	WANG M FARNHAM M W NANNES J S P	1999	Plant Breeding1999，118，：	1
4	Single quantum dots in silica spheres by microemulsion synthesis 显示文摘	DARBANDI M THOMANN R NANN T	2005	Chemistry of Materials2005，17，23：	1
5	Single quantum dots in silica spheres by microemulsion synthesis 显示文摘	DARBANDI M THOMANN R NANN T	2005	Chem Mater2005，17，23：	1
6	Kinet-ics of ilmenite dissolution in hydrochloric acid 显示文摘	Jacobus P van Dyk Nanne M Vegter PC Pistorius	2002	Hydro-metallurgy2002，65，：	1
7	Heat shock proteins, molecular chaperones, and the stress response: Evolutionary and ecological physiology显示文摘	Feder M E Hofi'nann G E	1999	Annu Rev Physiol1999，61，：	1
8	Single Quantum Dots in Silica Spheres by Mieroemulsion Synthesis 显示文摘	Darbandi M Thomann R Nann T	2005	Chem Mater2005，17，23：	1
9	Synthesis and structural Metalastability of CdTe Nanowires显示文摘	Kumar S Ade M Nann T	2005	Chem Eur J2005，11，：	1
10	Ploidy of broccoli regenerated from microspore culture versus anther culture显示文摘	WANG M FARNHAM M W NANNES J S P	1999	Plant Breeding1999，118，：	1
11	Kinetics of ilmenite dissolution in hydrochloric acid 显示文摘	Jacobus P van Dyk Nanne M Vegter P Chris Pistorius	2002	Hydrometallurgy2002，65，：	1
12	Single Quantum Dots in Silica Spheres by Microemulsion Synthesis显示文摘	Darbandi M Thomarm R Nann T	2005	Chem Mater2005，17，23：	1
13	Consequences of Regret Aversion:Effects of Expected Feedback on Risky Decision Making显示文摘	Zeelenberg M Jane B Joop V D P Nanne K De Vries	1996	Organizational Behavior and Human Decision Processes1996，65，2：	1
14	Single quantum dots in silica spheres by micreemulsion synthesis 显示文摘	DARBANDI M THOMANN R NANN T	2005	Chem Mater2005，17，23：	1
15	Zinc and sa- linity effects on membrane transport in Chara conniv- ens 显示文摘	Rygol J Arnold W M Zimmen'nann U	1992	Plant Cell and Environment1992，015，1：	1
16	查看详情显示文摘	Resch-Genger U Grabolle M Cavaliere-Jaricot S Nitschke R Nann T		0，，：	1
17	Expression of the proto oncogene c-myc in human stenotic aortocoronary by passgrafts显示文摘	Hilker M Tell nann G Buerke M	2001	Patho Res Pract2001，197，12：	1
18	Read-out concepts for multiplexed bead-based fluorescence immunoassays on centrifugal microfluidic platforms显示文摘	Riegger L Grumanna M Nann T		0，，：	1
19	Conse- quences of Regret Aversion:Effects of Expected Feedback on Risky Decision Making显示文摘	Zeelenberg M Jane B Joop V D P Nanne K de Vries	1996	Organizational Behavior and Human Decision Processes1996，65，2：	1
20	Intradialytic renal hemodynamics potential consequences for the management of the acute renal failure显示文摘	Nanns M Sigler MH Teehan BP	1997	Nephrol Dial Transplant1997，12，：	1

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