|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Octreotide ameliorates gastric lesions in chronically mild stressed rats显示文摘AIM:To evaluate the effect of chronic mild stress(CMS) on the emergence of gastric ulcers and possible modulation by octreotide,a synthetic somatostatin analogue. METHODS:Adult male Wistar rats were subjected to nine different unpredictable random stress procedures for 21 d,a multifactorial interactional animal model for CMS.Octreotide was administered daily for 21 d at two dose levels(50 and 90μg/kg)before exposure to stress procedure.Macro-and microscopical assessments were made,in addition to quantification of plasma corticosterone and gastric mucosal inflammatory,oxidative stress, and apoptotic biomarkers. RESULTS:Exposure to CMS elevated plasma corticosterone(28.3±0.6μg/dL,P=0.002),an event that was accompanied by gastric lesions(6.4±0.16 mm,P=0.01) and confirmed histopathologically.Moreover,the insult elevated gastric mucosal lipid peroxides(13±0.5 nmol/g tissue,P=0.001),tumor necrosis factor-α(3008.6±78.18 pg/g tissue,P<0.001),prostaglandin E2(117.1 ±4.31 pg/g tissue,P=0.002),and caspase-3 activity (2.4±0.14 OD/mg protein,P=0.002).Conversely,CMS mitigated interleukin-10(627.9±12.82 pg/g tissue,P= 0.001).Furthermore,in animals exposed to CMS,octreotide restored plasma corticosterone(61%and 71%from CMS,P=0.002)at both dose levels.These beneficial effects were associated with a remarkable suppression of gastric lesions(38%and 9%from CMS,P=0.01)and reversal of derangements in gastric mucosa. CONCLUSION:The current investigation provides evidence that exposure to CMS induces gastric ulceration, which was alleviated by administration of octreotide possibly possessing antioxidant,anti-inflammatory,and anti-apoptotic actions. | Noha N Nassar Mona F Schaalan Hala F Zaki Dalaal M Abdallah | 2011 | World Journal of Gastroenterology2011，17，9： | 6 |
| 2 | Unsaturated polyester resins based on rosin maleic anhydride adduct as corrosion protections of steel 显示文摘 | ATI'A A M NASSAR I F BEDAWY H M | 2007 | Reactive & Functional Polymers2007，67，7： | 1 |
| 3 | Real-time PCR hTERT mRNA pattern in tumor core,edge, resection margin, and lymph nodes in laryngeal tumors: relation to proliferative index and impact on prognosis 显示文摘 | Eissa S Kenawy G Moteleb F A El-Magkhzangy A N Nassar M | 2005 | Clin Bioehem2005，38，： | 1 |
| 4 | Adsorption equilibria of basic dyestuff onto palm-fruit bunch particles 显示文摘 | Nassar M M Hamoda M F Radwan G H | 1995 | Water Science and Technology1995，32，11： | 1 |
| 5 | An Efficient Technique for Incremental Updating of Association Rules 显示文摘 | Gharib T F Taha M Nassar H | 2008 | Journal of Hybrid Intelligent Systems2008，5，1： | 1 |
| 6 | Bayesian estimation for the exponentiated Weibull model显示文摘 | Nassar M M Eissa F H | 2004 | Communica- tions in Statistics Theory and Methods2004，33，10： | 1 |
| 7 | An Efficient Algorithm for Incremental Mining of Temporal Association Rules显示文摘 | Gharib T F Nassar H Taha M | 2010 | Data & Knowledge Engineering2010，69，4： | 1 |
| 8 | Corrosion inhibition of tubing steel during acidization of oil and gas wells显示文摘 | MIGAHED M A NASSAR I F | | 0，，6： | 1 |
| 9 | Isolation of rabies vires in Artibeus fimbriatus bat in the State of Sao Paulo, Brazil显示文摘 | Cunha E M Lara Mdo C Nassar A F | 2005 | Rev Saude Publica2005，39，4： | 1 |
| 10 | Biological control of Sclerotinia minor using a chitinolytic bacterium and actinomycetes 显示文摘 | Tarabily E I Soliman K A Nassar M H Sivasithamparam K McKenna F Hardy G E ST J | 2000 | Plant Pathol2000，49，： | 1 |
| 11 | Drought tolerant stem anatomy characteristics in Manihot esculenta(Euphorbiaceae)and a wild relative显示文摘 | Nassar N M Abreu L F Teodoro D A | 2010 | Genet Mol Res2010，9，2： | 1 |
| 12 | Photo-synthetic properties of three Brazilian seaweeds显示文摘 | Chaloub R M Reinert F Nassar C A G | | Revista Brasileira De B0，，： | 1 |
| 13 | Bayesian Estimation for the Expo- nentiated Weibull Model, Commun Star Theory Methods 显示文摘 | Nassar M M Eissa F H | 2004 | 33 (10)2004，，： | 1 |
| 14 | Adsorption equilibri of basic dye stuff onto palm fruit bunch particles显示文摘 | NASSAR M M HAMODA M F RADWAN G H | 1995 | Water Sci Technol1995，32，： | 1 |
| 15 | Neurokinin A level in hypoxic-ischemic encephalopathy 显示文摘 | Nassar M F E1-Sayed H L Fouad N T | 2008 | Pediatrics International2008，，50： | 1 |
| 16 | Drought toler- ant stem anatomy characteristics in Manihot esculenta (Euphorbiace- ae) and a wild relative 显示文摘 | Nassar N M A Abreu L F A Teodoro D A P | 2010 | Genetics and Molecular Research2010，9，2： | 1 |
| 17 | Intravenous immunoglobulin for treatment of toxic epidermal necrolysis显示文摘 | NASSER M BITTERMAN-DEUTSCH O NASSAR F | 2005 | Am J Med Sci2005，329，2： | 1 |
| 18 | Bayesian estimation for the exponentiated-weibull model显示文摘 | Nassar M M Eissa F H | 2004 | Commun Statist Theory Meth2004，33，10： | 1 |
| 19 | Carcinoma of pancreas presenting as a decrease in visual acuity 显示文摘 | Haj M Nassar F | 2002 | Hepatogastroenterology2002，49，44： | 1 |
| 20 | Adsorption equilibrium of basic dye stuff onto palm fruit bunch particles显示文摘 | Nassar M M Hamoda M F Radwan G H | 1995 | Water Sci Technol1995，32，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员