|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 帕博利珠单抗单用或与放疗联用治疗转移性非小细胞肺癌:两个随机试验的汇总分析显示文摘背景放疗可以提高整个机体对免疫治疗的应答。在Ⅱ期PEMBRO-RT研究和Ⅰ/Ⅱ期MDACC研究中,患有转移性非小细胞肺癌(NSCLC)的患者被随机分配入组,接受免疫治疗(帕博利珠单抗)+放疗联合疗法,或免疫治疗单一疗法。当上述2个研究单独分析时,联合疗法组显示出潜在获益。由于每个研究的样本量较小,缓解率和结局并未显示出统计学意义,然而却有显著的临床获益。因此,本研究进行汇总分析,来判断放疗是否会改善转移性NSCLC患者的免疫治疗应答。方法PEMBRO-RT和MDACC研究纳入标准:患者年龄≥18岁,患有转移性NSCLC,且有≥1处未经放疗照射的病灶,以便进行射野外应答监测。PEMBRO-RT研究纳入曾接受过化疗患者,MDACC研究纳入曾接受过治疗或新诊断患者。2个研究中的患者均未接受过免疫治疗。在PEMBRO-RT研究中患者被等比例随机分配入组,并根据吸烟状态进行分层(分为<10年组和≥10年组)。MDACC研究的患者根据放疗计划可行性被等比例随机分配入2个受试组。由于联合治疗组的干预本质,每个研究中的放疗均不适用盲法。在2个研究中,不论是否进行放疗,均静脉滴入帕博利珠单抗(每3周200 mg)。在PEMBRO-RT研究中,在放疗(24 Gy 3次分割照射)结束后1周给予第1剂帕博利珠单抗。在MDACC研究中,在第1次放疗(50 Gy 4次分割照射或45 Gy 15次分割照射)同时给予帕博利珠单抗。仅检测未经照射病灶的应答。本研究的终点为最佳射野外(远隔)应答率(ARR)、最佳射野外疾病控制率(ACR)、12周时ARR、12周时ACR、无进展生存期(PFS)和总生存期(OS)。2个研究的意向治疗(ITT)人群均纳入分析。PEMBRO-RT研究(NCT02492568)和MDACC研究(NCT02444741)均在ClinicalTrials.gov上注册。发现纳入148例患者,76例接受帕博利珠单抗治疗,72例接受帕博利珠单抗+放疗治疗。所有患者随访时间中位数为33个月[四分位距(IQR):32.4~33.6]。148例患者中124例(84%)组织学特征为非鳞癌,111例(75%)患者曾经接受过化疗。组间没有基线特征差异,包括PD-L1表达状态和转移灶体积。最常见的照射部位为肺转移灶(39%,28/72)、胸腔内淋巴结(21%,15/72)和非原发灶(17%,12/72)。帕博利珠单抗组和联合治疗组的最佳ARR分别为19.7%(15/76)和41.7%(30/72),OR=2.96,95%CI:1.42~6.20,P=0.0039;最佳ACR分别为43.4%(33/76)和65.3%(47/72),OR=2.51,95%CI:1.28~4.91,P=0.0071;PFS中位数分别为4.4(IQR:2.9~5.9)和9.0个月(IQR:6.8~11.2),HR=0.67,95%CI:0.45~0.99,P=0.045;OS中位数分别为8.7(IQR:6.4~11.0)和19.2个月(IQR:14.6~23.8),OR=0.67,95%CI:0.54~0.84,P=0.0004。在汇总分析中没有发现新的安全问题。解读帕博利珠单抗免疫疗法+放疗显著提高转移性NSCLC患者的应答和改善治疗结局。这些结果需要在三期临床试验中进行验证。 | 陈大卫(翻译) 于金明(校对) Willemijn S M E Theelen Vivek Verma Brian P Hobbs Heike M U Peulen Joachim G J V Aerts Idris Bahce Anna Larissa N Niemeijer Joe Y Chang Patricia M de Groot Quynh-Nhu Nguyen Nathan I Comeaux George R Simon Ferdinandos Skoulidis Steven H Lin Kewen He Roshal Patel John Heymach Paul Baas James W Welsh | 2021 | 中华肿瘤防治杂志2021，28，24： | 49 |
| 2 | Phylogenetic alpha and beta diversity in tropical tree assemblages along regionalscale environmental gradients in northwest South America显示文摘Aims Environmental gradients are drivers of species diversity;however,we know relatively little about the evolutionary processes underlying these relationships.A potentially powerful approach to studying diversity gradients is to quantify the phylogenetic structure within and between assemblages arrayed along broad spatial and environmental gradients.Here,we evaluate the phylogenetic structure of plant assemblages along an environmental gradient with the expectation that the habitat specialization of entire lineages is an important evolutionary pattern influencing the structure of tree communities along environmental gradients.Methods We evaluated the effect of several environmental variables on the phylogenetic structure of plant assemblages in 145 plots distributed in northwestern South America that cover a broad environmental gradient.The phylogenetic alpha diversity was quantified for each plot and the phylogenetic beta diversity between each pair of plots was also quantified.Both the alpha and beta diversity measures were then related to spatial and environmental gradients in the study system.Important Findings We found that gradients in temperature and potential evapotranspiration have a strong relationship with the phylogenetic alpha diversity in our study system,with phylogenetic overdispersion in low temperatures and phylogenetic clustering at higher temperatures.Further,the phylogenetic beta diversity between two plots increases with an increasing difference in temperature,whereas annual precipitation was not a significant predictor of community phylogenetic turnover.We also found that the phylogenetic structure of the plots in our study system was related to the degree of seasonal flooding and seasonality in precipitation.In particular,more stressful environments such as dry forests and flooded forests showed phylogenetic clustering.Finally,in contrast with previous studies,we find that phylogenetic beta diversity was not strongly related to the spatial distance separating two forest plots,which may be the result of the importance of the three independent mountain ranges in our study system,which generate a high degree of environmental variation over very short distances.In conclusion,we found that environmental gradients are important drivers of both phylogenetic alpha and phylogenetic beta diversities in these forests over spatial distance. | Sebastián González-Caro María Natalia Umaña Esteban Álvarez Pablo R.Stevenson Nathan G.Swenson | 2014 | Journal of Plant Ecology2014，7，2： | 17 |
| 3 | Management of water resources for quality and quantity 显示文摘 | Vijayan G Nathan N S Subramanian R S | 1999 | Journal of Indian Water Works Association1999，，： | 2 |
| 4 | A randomised comparison of parecoxib versus placebo for pain management following minor day stay gynaecological surgery显示文摘 | Luscombe K S McDonnell N J Muchatuta N A Paech M J Nathan E A | 2010 | Anaesthesia and Intensive Care2010，，1： | 2 |
| 5 | Evidence of neutrophil functional defect despite inflammation in stable cirrhosis显示文摘 | Giovanni Tritto Zois Bechlis Vanessa Stadlbauer Nathan Davies Rubén Francés Naina Shah Rajeshwar P. Mookerjee Jose Such Rajiv Jalan | 2011 | Journal of Hepatology2011，，3： | 2 |
| 6 | Comparison of one -dimensional and two- dimensional models for wet surface fin efficiency of a plate - fin - tube heat exchanger 显示文摘 | Liang S Y Wong T N Nathan G K | 2000 | Applied Thermal Engineering2000，20，10： | 1 |
| 7 | Plasma interleukin-4,interleukin-10,and interleukin-13 concentrations and complications after coronary artery bypass graft surgery显示文摘 | Nathan N Preux PM Feiss P | | 0，，： | 1 |
| 8 | Molecular analysis of surgical margins in head and neck squamous cell carcinoma patients显示文摘 | Nathan CA Amirghahri N Rice C | 2002 | Laryngoscope2002，112，12： | 1 |
| 9 | Interstitial lung diseases in children显示文摘 | Clement A Nathan N Epaud R | | 0，，05： | 1 |
| 10 | Membranes for hydrogen separation显示文摘 | Nathan W O Tina M N | 2007 | Chemical Reviews2007，107，10： | 1 |
| 11 | Influence of propofol concentrations on multipulse transcranial motor evoked potentials显示文摘 | Nathan N Tabaraud F Lacroix F | 2003 | Br J Anaesth2003，91，4： | 1 |
| 12 | A randomized controlled pilot study of adherence to transfusion strategies in cardiac surgery显示文摘 | Shehata N Burns LA Nathan H | 2012 | Transfusion2012，52，1： | 1 |
| 13 | Glucocorticoid receptor gene polymorphisms associated with progression of lung disease in young patients with cystic fibrosis显示文摘 | Corvol H Nathan N Charlier C | 2007 | Respir Res2007，8，： | 1 |
| 14 | Induction with propofol targetconcentration infusion vs 8% sevoflurane inhalation and alfentanil in hypertensive patients显示文摘 | Nathan N Vial G Benrhaiem M | 2001 | Anaesthesia2001，56，3： | 1 |
| 15 | Molecular analysis of surgical margins in head and neck squamous cell carcinoma patients 显示文摘 | Nathan C A Amirghahri N Rice C Abreo F W Shi R Stucker F J | 2002 | Laryngoscope2002，112，： | 1 |
| 16 | Classification of Underwater Mammals Using Feature Extraction Based on Time-Frequency Analysis and BCM Theory 显示文摘 | QUYEN Q H LEON N C NATHAN I | 1998 | IEEE Transactions on Signal Processing1998，46，5： | 1 |
| 17 | Induction with propofol target - concentration infusion vs 8% sevoflurane in- halation and alfentanil in hypertensive pations显示文摘 | Nathan N Vial G Benrhaiem M | 2001 | Anaesthesi- a2001，81，： | 1 |
| 18 | Dynamics of Bose-Einstein Condensates Under the Influence of Periodic and Harmonic Potentials显示文摘 | N HAWK BERRY J NATHAN KUTZ | 2007 | Phys Rev E2007，75，03： | 1 |
| 19 | Relationship-specificity, incomplete contracts and the pattern of trade显示文摘 | Nathan N | 2007 | Quarterly Journal of Economics2007，5，： | 1 |
| 20 | Dispositional Approach to Customer Satisfaction and Behavior显示文摘 | BURNS Gary N BOWLING Nathan A | 2010 | Journal of Business and Psychology2010，25，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员