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| 1 | 潜隐性疾病风险与生命早期砷暴露的关联机制:当前的研究趋势与科学缺口显示文摘[背景]全球约有数百万人的饮用水中无机砷水平对人体有害,尤其是农村地区和发展中国家。重要生长发育时期的无机砷暴露与多种不良健康效应相关,包括成年时期出现的不良健康效应。探索生命早期的无机砷暴露与后期潜隐性疾病(尤其是癌症)之间的分子作用机制得到研究者的广泛关注。[目标]本研究汇总了现有研究发现的生命早期无机砷暴露与成年期癌症风险增加背后的分子机制。[讨论]表观遗传重编码影响了基因表达功能改变、肿瘤干细胞形成和免疫调控是生命早期无机砷暴露引起潜在致癌效应的可能机制。[结论]越来越多的证据揭示了生命早期的无机砷暴露与之后癌症的形成有关。未来的研究应通过动物实验验证致病机制的假说,同时进行人群研究将生命早期的无机砷暴露、分子改变和潜在的疾病结局整合起来。 | Kathryn A.Bailey Allan H.Smith Erik J.Tokar Joseph H.Graziano Kyoung-Woong Kim Panida Navasumrit Mathuros Ruchirawat Apinya Thiantanawat William A.Suk Rebecca C.Fry 黄馨缘(译) | 2016 | 环境与职业医学2016，33，4： | 3 |
| 2 | Exposure assessment of benzene in Thai workers, DNA-repair capacity and influence of genetic polymorphisms 显示文摘 | Sifirat Chanvaivit Panida Navasumrit Potchanee Hunsonti | 2007 | Mutation Research2007，626，： | 1 |
| 3 | Ethanol-induced free radicals and hepatic DNA strand breaks are prevented in vivo by antioxidants:Effects of acute and chronic ethanolexposure显示文摘 | Ward TH Dodd NJ | 2000 | Carcinogenesis2000，21，1： | 1 |
| 4 | Ethanol-induced free radicals and hepatic DNA strand breaks are prevented in vivo by antioxidants:effects of acute and chronic ethanol exposure显示文摘 | Navasumrit P Ward TH Dodd NJ | 2000 | Carcinogenesis2000，21，1： | 1 |
| 5 | Environmental and occupational exposure to benzene in Thailand 显示文摘 | Navasumrit P Chanvalvit S Intarasunanont P | 2005 | Chem Biol Interact2005，7583，： | 1 |
| 6 | Assessment of potential cancer risk in children exposed to urban air pollution in Bangkok, Thailand 显示文摘 | Ruchirawat M Settachan D Navasumrit P | 2007 | Toxicology Letters2007，168，3： | 1 |
| 7 | Oxidative DNA damage and repair in children exposed to low levels of arsenic in utero and during early childhood:application of salivary and urina- ry biomarkers 显示文摘 | Hinhumpatch P Navasumrit P Chaisatra K | 2013 | Toxicol Appl Pharmacol2013，273，3： | 1 |
| 8 | Biomonitoring of ben- zene and 1,3-butadiene exposure and early biological effects in traf- fic policemen 显示文摘 | Arayasiri M Mahidol Ch Navasumrit P | 2010 | Sci Total Environ2010，408，20： | 1 |
| 9 | Measurement of genotoxic air pollutant exposures in street vendors and school children in and near Bangkok显示文摘 | RUCHIRAWAT M NAVASUMRIT P SETTACHAN D | 2005 | Toxicology and Applied Pharmacolog2005，206，2： | 1 |
| 10 | Oxidative DNA damage and influence of genetic polymorphisms among urban and rural schoolchildren exposed to benzene 显示文摘 | BUTHBUMRUNG N MAHIDOL C NAVASUMRIT P | 2008 | Chem Biol Interact2008，172，： | 1 |
| 11 | Polybrominated diphenyl ethers(PBDEs)in ambient air samples at the electronic waste(e-waste)reclamation site显示文摘Polybrominated diphenyl ethers(PBDEs)have been used as flame retardants in various building materials,plastic and other polymers,airplanes,electronics,etc.All or some of their congeners have been already banned in many countries,due to their persistency and adverse health effects.In this study,we are focusing on e-wastes as a source of emission of PBDEs in ambient air during reclamation processes.The ambient air particulate matter(PM)samples were collected at and near an e-waste reclamation site in Bangkok,Thailand.Results showed the presence of various homologues,viz:tri-,tetra-,penta-,hexa-,and hepta-PBDEs in both PM2.5 and total suspended particle(TSP)samples.The comparison of samples as a function of distance from the reclamation site indicated elevated levels of PBDEs in close proximity to the e-waste site.Interestingly,a shift in the congener pattern was observed with lower brominated PBDEs being more prevalent in nearby off-site samples as compared to the PM collected at the e-waste site.The total penta-PBDEs concentration is almost double in the e-waste site PM2.5 compared to the control site samples.For TSP,tetra,penta,and hepta-PBDEs congeners are at higher concentrations at the e-waste sites and its vicinity compared to reference sites.Overall,a clear trend can be observed indicating a debromination of PBDEs to more toxic tri and tetra congeners during the reclamation process and PBDEs are being translocated from treated materials to ambient air PM.BDE 30 is uniquely detected in our studies as a dominant final debromination product,that can be used as a marker of thermal e-waste activity.This work indicates potential hazards related to the reclamation of e-wastes and remediation of sites containing PBDEs.In particular,thermal treatment methods can lead to congener transformation and increased emissions of more toxic lower brominated congeners. | Ajit Ghimire Albert Leo N.dela Cruz Roberto Wong Panida Navasumrit Stephania Cormier Slawomir M.Lomnicki | 2019 | Waste Disposal and Sustainable Energy2019，1，1： | 1 |
| 12 | Oxidative DNA damage and inflammatory responses in cultured human cells and in humans exposed to traffic-related particles 显示文摘 | Vattanasit U Navasumrit P Khadka MB | 2014 | Int J Hyg Environ Health2014，217，1： | 1 |
| 13 | Oxidative DNA damage and inflammatory responses in cullured human ceils and in humans exposed to traffic-related particles显示文摘 | Vattanasit U Navasumrit P Khadka MB | 2014 | Int J Hyg Environ Heahh2014，217，： | 1 |
| 14 | Measurement of genotoxic air pollutant exposures in street vendors and school children in and near Bangkok显示文摘 | Ruchirawat M Navasumrit P Settachan D | 2005 | Toxicology and Applied Pharmacology2005，206，： | 1 |
| 15 | Effects of low-dose gamma radiation on DNA damage,chromosomal aberration and expression of repair genes in human blood cells显示文摘 | Sudprasert W Navasumrit P Ruchirawat M | | 0，，06： | 1 |
| 16 | Effects of low - dose gamma radiation on DNA damage, chromosom alaberration and expression of repair genes in human blood cells 显示文摘 | Wanwisa Sudprasert Panida Navasumrit Mathuros Ruchirawar | 2006 | international journal of hygiene and environmental health2006，，： | 1 |
| 17 | Effects of low- dose gamma radiation on DNA damage,chromosomal aberration and ex- pression of repair genes in human blood cells显示文摘 | SUDPRASERT W NAVASUMRIT P RUCHIRAWAT M | 2006 | Environ Health2006，209，6： | 1 |
| 18 | Ethanol-induced free radicals and hepatic DNA strand breaks are prevented in vivo by antioxidants: effects of acute and chronic ethanol exposure显示文摘 | Ward TH Dodd NJ | 2000 | Carcinogenesis2000，21，1： | 1 |
| 19 | Activation of inflammation NF-KB signaling in infants born to arsenic exposed mothers 显示文摘 | Fry RC Navasumrit P Valiathan C | 2007 | PLoS Genet2007，3，： | 1 |
| 20 | Exposure assessment of benzene in Thai workers, DNA-repair capacity and influence of genetic polymorphisms 显示文摘 | Chanvaivit S Navasumrit P | 2007 | Mutat Res2007，626，12： | 1 |
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