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| 1 | Endocrine disrupting chemicals in mixture and obesity,diabetes and related metabolic disorders显示文摘Obesity and associated metabolic disorders represent a major societal challenge in health and quality of life with large psychological consequences in addition to physical disabilities. They are also one of the leading causes of morbidity and mortality. Although, different etiologic factors including excessive food intake and reduced physical activity have been well identified, they cannot explain the kinetics of epidemic evolution of obesity and diabetes with prevalence rates reaching pandemic proportions. Interestingly, convincing data have shown that environmental pollutants, specifically those endowed with endocrine disrupting activities, could contribute to the etiology of these multifactorial metabolic disorders. Within this review, we will recapitulate characteristics of endocrine disruption. We will demonstrate that metabolic disorders could originate from endocrine disruption with a particular focus on convincing data from the literature. Eventually, we will present how handling an original mouse model of chronic exposition to a mixture of pollutants allowed demonstrating that a mixture of pollutants each at doses beyond their active dose could induce substantial deleterious effects on several metabolic end-points. This proof-of-concept study, as well as other studies on mixtures of pollutants, stresses the needs for revisiting the current threshold model used in risk assessment which does not take into account potential effects of mixtures containing pollutants at environmental doses, e.g., the real life exposure. Certainly, more studies are necessary to better determine the nature of the chemicals to which humans are exposed and at which level, and their health impact. As well, research studies on substitute products are essential to identify harmless molecules. | Brigitte Le Magueresse-Battistoni Emmanuel Labaronne Hubert Vidal Danielle Naville | 2017 | World Journal of Biological Chemistry2017，8，2： | 4 |
| 2 | Effects of transforming growth factor-beta 1 on human adrenocoritical fasciculata-reticularis cell differentiated functions显示文摘 | Lebrethon MC Jaillard C Naville D | 1994 | J Clin Endocrinol Metab1994，79，4： | 1 |
| 3 | Analgesics for the treatment of pain in children 显示文摘 | CHARLS B NAVIL F SETHNA M B | 2002 | N Engl J Med2002，347，14： | 1 |
| 4 | Premature terminator analysis sheds light on a hidden world of bacterial transcriptional attenuation显示文摘 | Naville M Gautheret D | 2010 | Genome Biol2010，11，9： | 1 |
| 5 | Functional relationships between three novel homozygous mutations in the ACTH receptor gene and familial glucocorticoid deficiency显示文摘 | Penhoat A Naville D E1 Mourabit H | 2002 | J Sol Med2002，80，7： | 1 |
| 6 | Activator protein-1 is necessary for angiotensln- Ⅱ stimulation of human adrenocorticotropin receptor gene transcription 显示文摘 | Naville D Bordet E Berthelon M C | 2001 | Eur J Biochem2001，268，6： | 1 |
| 7 | Pain Prevalence and Trajectories Following Pediatric Spinal Fusion Surgery显示文摘 | Christine B. Sieberg Laura E. Simons Mark R. Edelstein Maria R. DeAngelis Melissa Pielech Navil Sethna M. Timothy Hresko | 2013 | Journal of Pain2013，，12： | 1 |
| 8 | An assessment of the potential impact of climate change on flood risk in Mmnbai显示文摘 | RANGER N HALLEGATFE S BHA33'ACHARYA S BACHU M PRIYA S DHORE K RAFIQUE F MATHUR P NAVILLE N HENRIET F HERWEIjER C POHIT S COFEE Morlot J | 2011 | Climatic Change2011，104，1： | 1 |
| 9 | Exclusion of the adrenocorticotropin (ACTH) roceptor(MC2R) locus in some families with ACTH resistance but no mutations of the MC2R coding sequence (familial glucocorticoid deficiency type 2) 显示文摘 | Naville D Weber A Genin E | 1998 | J Clin Endocrinol Metab1998，83，10： | 1 |
| 10 | Analgesics for the treatment of pain in children显示文摘 | Charls B Navil F Sethna MB | 2002 | N Engl J Med2002，347，14： | 1 |
| 11 | Two-phase flow of volatile hydrocarbons显示文摘 | Kniazeff V J Naville S A | 1965 | SPEJ1965，3744，： | 1 |
| 12 | Genomic structure andpromoter characterization of human ACTH receptor gene显示文摘 | Naville D Jaillard C Barjhoux L | 1997 | Bio-chem Biophys Res Commun1997，230，1： | 1 |
| 13 | Control of production of insulin-like growth factor I by pig Leydig and Sertoli cells cultured alone or together显示文摘 | NAVILLE D CHATELAIN P G AVALLET O | 1990 | Mol Cell Endocrinol1990，70，3： | 1 |
| 14 | There Steroidogemic Factor-1 Binding Elements Are Required for nstitutive and cAMP-Regulated Expression of the Human Adrenocorticotropin Receptor Gene显示文摘 | Naville D Penhoat A Darand P | 1999 | Biochem Biophys Res Commun1999，255，1： | 1 |
| 15 | Activator protein-1 is necessary for angiotensin-Ⅱ stimulation of human adrenocorticotropin receptor gene transcription显示文摘 | Naville D Border E Berthelon MC | 2001 | Eur J Biochem2001，68，6： | 1 |
| 16 | Single-pass classification of all noncoding sequences in a bacterial genome using phylogenetic profiles 显示文摘 | MARCHAIS A NAVILLE M BOHN C | 2009 | Genome Res2009，19，： | 1 |
| 17 | AR- Nold : a web tool for the prediction of Rho-independent transcrip- tion terminators 显示文摘 | Naville M Ghuillot-Gaudeffroy A Marchais A Gautheret D | 2011 | RNA Biol2011，8，1： | 1 |
| 18 | Nonclassic lipoid congenital adrenal hyperplasia masquerading as familial glucocorticoid deficiency 显示文摘 | Metherell LA Naville D Halaby G | 2009 | J Clin Endocrinol Metab2009，94，10： | 1 |
| 19 | 完美风暴——欧洲电信市场大淘汰显示文摘在经历了几年的迅猛增长和有关第三代(3G)无线通讯服务的盲目乐观之后。 | Jean Baron-Mazloumian Martin Naville | 2001 | 中国企业家2001，，11： | 0 |
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