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| 1 | Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome显示文摘 | Giulio Marchesini Elisabetta Bugianesi Gabriele Forlani Fernanda Cerrelli Marco Lenzi Rita Manini Stefania Natale Ester Vanni Nicola Villanova Nazario Melchionda Mario Rizzetto | 2003 | Hepatology2003，，4： | 5 |
| 2 | Incidence and treatment of mediastinal leakage after esophagectomy:Insights from the multicenter study on mediastinal leaks显示文摘BACKGROUND Mediastinal leakage(ML) is one of the most feared complications of esophagectomy. A standard strategy for its diagnosis and treatment has beendifficult to establish because of the great variability in their incidence and mortality rates reported in the existing series.AIM To assess the incidence, predictive factors, treatment, and associated mortality rate of mediastinal leakage using the standardized definition of mediastinal leaks recently proposed by the Esophagectomy Complications Consensus Group(ECCG).METHODS Seven Italian surgical centers(five high-volume, two low-volume) affiliated with the Italian Society for the Study of Esophageal Diseases designed and implemented a retrospective study including all esophagectomies(n = 501) with intrathoracic esophagogastric anastomosis performed from 2014 to 2017.Anastomotic MLs were defined according to the classification recently proposed by the ECCG.RESULTS Fifty-nine cases of ML were recorded, yielding an overall incidence of 11.8%(95%CI: 9.1%-14.9%). The surgical approach significantly influenced the occurrence of ML: the proportion of leakage was 10.5% and 9% after open and hybrid esophagectomy(HE), respectively, and doubled(20%) after totally minimally invasive esophagectomy(TMIE)(P = 0.016). No other predictive factors were found. The 30-and 90-d overall mortality rates were 1.4% and 3.2%,respectively; the 30-and 90-d leak-related mortality rates were 5.1% and 10.2%,respectively; the 90-d mortality rates for TMIE and HE were 5.9% and 1.8%,respectively. Endoscopy was the first-line treatment in 49% of ML cases, with the need for retreatment in 17.2% of cases. Surgery was needed in 44.1% of ML cases.Endoscopic treatment had the lowest mortality rate(6.9%). Removal of the gastric tube with stoma formation was necessary in 8(13.6%) cases.CONCLUSION The incidence of ML after esophagectomy was high mainly in the TMIE group.However, the general and specific(leak-related) mortality rates were low. Early treatment(surgical or endoscopic) of severe leaks is mandatory to limit related mortality. | Uberto Fumagalli Gian Luca Baiocchi ANDrea Celotti Paolo Parise ANDrea Cossu Luigi Bonavina Daniele Bernardi Giovanni de Manzoni Jacopo Weindelmayer Giuseppe Verlato Stefano Santi Giovanni Pallabazzer Nazario Portolani Maurizio Degiuli Rossella Reddavid Stefano de Pascale | 2019 | World Journal of Gastroenterology2019，25，3： | 3 |
| 3 | Recurrence in node-negative advanced gastric cancer:Novel findings from an in-depth pathological analysis of prognostic factors from a multicentric series显示文摘AIM To analyze the clinicopathological characteristics of patients with both node-negative gastric carcinoma and diagnosis of recurrence during follow-up. METHODS We enrolled 41 patients treated with curative gastrectomy for p T2-4 a N0 gastric carcinoma between 1992 and 2010,who developed recurrence(Group 1). We retrospectively selected this group from the prospectively collected database of 4 centers belonging to the Italian Research Group for Gastric Cancer,and compared them with 437 p T2-4 a N0 patients without recurrence(Group 2). We analyzed lymphatic embolization,microvascular infiltration,perineural infiltration,and immunohistochemical determination of p53,Ki67,and HER2 in Group 1 and in a subgroup of Group 2(Group 2 bis) of 41 cases matched with Group 1 according to demographic and pathological characteristics. RESULTS T4 a stage and diffuse histotype were associated with recurrence in the group of p N0 patients. In-depth pathological analysis of two homogenous groups of p N0 patients,with and without recurrence during longterm follow-up(groups 1 and 2 bis),revealed two striking patterns: lymphatic embolization and perineural infiltration(two parameters that pathologists can easily report),and p53 and Ki67,represent significant factors for recurrence.CONCLUSION The reported pathological features should be considered predictive factors for recurrence and could be useful to stratify node-negative gastric cancer patients for adjuvant treatment and tailored follow-up. | Gian Luca Baiocchi Sarah Molfino Carla Baronchelli Simone Giacopuzzi Daniele Marrelli Paolo Morgagni Maria Bencivenga Luca Saragoni Carla Vindigni Nazario Portolani Maristella Botticini Giovanni De Manzoni | 2017 | World Journal of Gastroenterology2017，23，45： | 3 |
| 4 | Association of nonalcoholic fatty liver disease with insulin resistance显示文摘 | Giulio Marchesini Mara Brizi Antonio M Morselli-Labate Giampaolo Bianchi Elisabetta Bugianesi Arthur J McCullough Gabriele Forlani Nazario Melchionda | 1999 | The American Journal of Medicine1999，，5： | 2 |
| 5 | Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome显示文摘 | Giulio Marchesini Elisabetta Bugianesi Gabriele Forlani Fernanda Cerrelli Marco Lenzi Rita Manini Stefania Natale Ester Vanni Nicola Villanova Nazario Melchionda Mario Rizzetto | 2003 | Hepatology2003，，4： | 2 |
| 6 | Metformin in non-alcoholic steatohepatitis显示文摘 | Giulio Marchesini Giampaolo Bianchi Sara Tomassetti Marco Zoli Nazario Melchionda | 2001 | The Lancet2001，，9285： | 2 |
| 7 | Early exposure to caffeine affects gene expression of adenosine receptors,DARPP-32 and BDNF without affecting sensibility and morphology of developing zebrafish(Danio rerio)显示文摘 | Capiotti K M Menezes F P Nazario L R | 2011 | Neurotoxicology and Teratology2011，33，6： | 1 |
| 8 | Major histocompatibility complex class Ⅱ polymorphisms and risk of cervical cancer in Puerto Rican women显示文摘 | Climent C Nazario CM Umpierre S | 2007 | P R Health Sci J2007，26，2： | 1 |
| 9 | 诸葛家族到底布了多大一个局?显示文摘“卧龙”诸葛亮、“冢虎”司马懿终生为敌,谁也没有料到,他们的子孙会结为姻亲,主宰华夏百年命运。 | 陆弃 Nazario罗尼 | 2018 | 环球人文地理2018，0，1： | 1 |
| 10 | C60-Based Electroactive Organofullerenes显示文摘 | Nazario Martin | 1998 | Chem Rev1998，98，7： | 1 |
| 11 | Safety and efficacy of metallic stents in the management of colorectal obstruction 显示文摘 | Stefanidis D Brown K Nazario H | 2005 | JSLS2005，9，4： | 1 |
| 12 | Synthesis of photo- andelectroactive stilbenoid dendrimers carrying dibutylamino peripheral groups显示文摘 | Jose L S Rafael G Nazario M | 2001 | Organic Letters2001，3，17： | 1 |
| 13 | Lactobacillus plantarum reduces Streptococcus pyogenes virulence by modulating the IL-17, IL-23 and Toll-like receptor 2/4 expressions in human epithelial cells显示文摘 | Antonietta Rizzo Antonio Losacco Caterina Romano Carratelli Nazario Bevilacqua | 2013 | International Immunopharmacology2013，，： | 1 |
| 14 | Maiorhisto?compatibility complex class II polymorphisrns and risk of cervical cancer in Puerto Rican women显示文摘 | Climent C Nazario CM Umpierre S et a1 | 2007 | P R Health Sci J2007，26，2： | 1 |
| 15 | Treatment of venous thromboembolism显示文摘 | Nazario R Delorenzo LJ Maguire AG | 2002 | Cardiol Rev2002，10，4： | 1 |
| 16 | Peginterferon alfa-2b and ribavirin in patients with hepatitis C virus and decompensated cirrhosis: A controlled study显示文摘 | Angelo Iacobellis Massimo Siciliano Francesco Perri Brigida E. Annicchiarico Gioacchino Leandro Nazario Caruso Laura Accadia Giuseppe Bombardieri Angelo Andriulli | 2006 | Journal of Hepatology2006，，2： | 1 |
| 17 | Impact of Microvascular Dysfunction on Left Ventricular Remodeling and Long-Term Clinical Outcome After Primary Coronary Angioplasty for Acute Myocardial Infarction显示文摘 | Leonardo Bolognese Nazario Carrabba Guido Parodi Giovanni M. Santoro Piergiovanni Buonamici Giampaolo Cerisano David Antoniucci | 2004 | Circulation: Journal of the American Heart Association2004，，9： | 1 |
| 18 | Effects of experimental hy-pothyroidism on myelin sheath structural organization显示文摘 | Ferreira AA Nazario JC Pereira MJ | 2004 | J Neurocytol2004，33，2： | 1 |
| 19 | Self-l:porled physical activity in Hispanic adults living with HIV: comparison with accelerometer and pedometer显示文摘 | Ramlrez-Marrero FA Rivera-Bmwn AM Nazario CM | 2008 | J As- soc Nurses AIDS Care2008，19，4： | 1 |
| 20 | DDoS Attack Evolution显示文摘 | Jose Nazario | 2008 | Network Security2008，，7： | 1 |
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