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| 1 | Recent advances in gastric cancer early diagnosis显示文摘Gastric cancer(GC) remains an important cause of cancer death worldwide with a high mortality rate due to the fact that the majority of GC cases are diagnosed at an advanced stage when the prognosis is poor and the treatment options are limited. Unfortunately, the existing circulating biomarkers for GC diagnosis and prognosis display low sensitivity and specificity and the GC diagnosis is based only on the invasive procedures such as upper digestive endoscopy. There is a huge need for less invasive or non-invasive tests but also highly specific biomarkers in case of GC. Body fluids such as peripheral blood, urine or saliva,stomach wash/gastric juice could be a source of specific biomarkers, providing important data for screening and diagnosis in GC. This review summarized the recently discovered circulating molecules such as microRNAs, long non-coding RNAs, circular RNAs, which hold the promise to develop new strategies for early diagnosis of GC. | Laura Necula Lilia Matei Denisa Dragu Ana I Neagu Cristina Mambet Saviana Nedeianu Coralia Bleotu Carmen C Diaconu Mihaela Chivu-Economescu | 2019 | World Journal of Gastroenterology2019，25，17： | 70 |
| 2 | Stability of nano-/microsized particles in deionized water and electroless nickel solutions显示文摘 | NECULA B S APACHITEI I FRATILA-APACHITEI L E TEODOSIU C DUSZCZYK J | | 0，，： | 1 |
| 3 | Modified De Martonne aridity index:application to the Napa basin,California显示文摘 | Botzan T M Marino M A Necula A I | 1998 | Physical Geography1998，19，： | 1 |
| 4 | Modified De Martonnearidity index:application to t he Napa basin,California显示文摘 | Botzan T M Marino M A Necula A I | 1998 | Physical Geography1998，19，： | 1 |
| 5 | Stability of nano-/microsized particles in deionized water and electroless nickle solutionsp显示文摘 | Necula B S Apachitei I Fratila-Apachitei L E | 2007 | Colloid and Interface Science2007，314，： | 1 |
| 6 | An electron microscopical study on the growth of TiO2-Ag antibacterial coatings on Ti6Al7Nb biomedical al oy显示文摘 | Necula BS Apachitei I Tichelaar FD | | 0，，： | 1 |
| 7 | Sta- bility of nano/micro - sized particles in demonized water and electroless nickel solutions 显示文摘 | Necula B S Apachitei I ratila - Apachitei E | 2007 | Journal of Colloid and Interface Science2007，314，2： | 1 |
| 8 | Modified De Martonne aridity index:application to the Napa basin,California显示文摘 | Botzan T M Mari?o M A Necula A I | 1998 | Physical Geography1998，19，1： | 1 |
| 9 | An electron microscop-ical study on the growth of Ti02 - Ag antibacterial coatings onTi6A17Nb biomedical alloy显示文摘 | Necula BS Apachitei I Tichelaar FD | 2011 | Acta Biomater2011，7，6： | 1 |
| 10 | Efficient topology determination of implicitly defined algebraic plane curves显示文摘 | Gonzalez-Vega L Necula I | 2002 | Comput Aided Geom Design2002，19，9： | 1 |
| 11 | Gastrointestinal cancer stem cells as targets for innovative immunotherapy显示文摘The role of cancer stem cells in gastrointestinal cancer-associated death has been widely recognized.Gastrointestinal cancer stem cells(GCSCs)are considered to be responsible for tumor initiation,growth,resistance to cytotoxic therapies,recurrence and metastasis due to their unique properties.These properties make the current therapeutic trials against GCSCs ineffective.Moreover,recent studies have shown that targeting stem cell surface markers or stemness associated pathways might have an additional off-target effect on the immune system.Recent advances in oncology and precision medicine have opened alternative therapeutic strategies in the form of cancer immunotherapy.This approach differs from classical anti-cancer therapy through its mechanism of action involving the activation and use of a functional immune system against tumor cells,instead of aiming physically destruction of cancer cells through radio-or chemotherapy.New immunological approaches for GCSCs targeting involve the use of different immune cells and various immune mechanisms like targeting specific surface antigens,using innate immune cells like the natural killer and T cells,T-cell chimeric antigen receptor technology,dendritic cell vaccine,or immune checkpoint inhibitors.In this respect,better understandings of immune regulatory mechanisms that govern anti-tumor response bring new hope in obtaining long-term remission for cancer therapy. | Mihaela Chivu-Economescu Laura G Necula Lilia Matei Denisa Laura Dragu Ana I Neagu Irina Alexiu Coralia Bleotu Carmen Cristina Diaconu | 2020 | World Journal of Gastroenterology2020，26，14： | 1 |
| 12 | Efficient topology determination of implicitly defined algebraic plane curves显示文摘 | GONZALEZ-VEGA L I NECULA | 2002 | Computer Aided Geomet- ric Design2002，19，9： | 1 |
| 13 | Enrichment of anodic MgO layers with Ag nanoparticles for bi- omedical applications显示文摘 | Necula BS Fratila - Apachitei LE Berkani A Apachitei I Duszc- syk J | 2009 | J Mater Sci Mater Med2009，20，： | 1 |
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