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| 1 | Outcomes of submucosal(T1b) esophageal adenocarcinomas removed by endoscopic mucosal resection显示文摘AIM To investigate the outcomes and recurrences of p T1 b esophageal adenocarcinoma(EAC) following endoscopic mucosal resection(EMR) and associated treatments.METHODS Patients undergoing EMR with pathologically confirmed T1 b EAC at two academic referral centers were retrospectively identified.Patients were divided into 4 groups based on treatment following EMR:Endoscopic therapy alone(group A),endoscopic therapy with either chemotherapy,radiation or both(group B),surgicalresection(group C) or no further treatment/lost to follow-up(<12 mo)(group D).Pathology specimens were reviewed by a central pathologist.Follow-up data was obtained from the academic centers,primary care physicians and/or referring physicians.Univariate analysis was performed to identify factors predicting recurrence of EAC.RESULTS Fifty-three patients with T1 b EAC underwent EMR,of which 32(60%) had adequate follow-up ≥ 12 mo(median 34 mo,range 12-103).There were 16 patients in group A,9 in group B,7 in group C and 21 in group D.Median follow-up in groups A to C was 34 mo(range 12-103).Recurrent EAC developed overall in 9 patients(28%) including 6(38%) in group A(median:21 mo,range:6-73),1(11%) in group B(median:30 mo,range:30-30) and 2(29%) in group C(median 21 mo,range:7-35.Six of 9 recurrences were local;of the 6 recurrences,5 were treated with endoscopy alone.No predictors of recurrence of EAC were identified.CONCLUSION Endoscopic therapy of T1 b EAC may be a reasonable strategy for a subset of patients including those either refusing or medically unfit for esophagectomy. | Darren D Ballard Neel Choksi Jingmei Lin Eun-Young Choi B Joseph Elmunzer Henry Appelman Douglas K Rex Hala Fatima William Kessler John M DeWitt | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，20： | 2 |
| 2 | Solubilization and purification of enzymatically active glutathione S - transferase ( pGEX ) fusion protein显示文摘 | FRANGIONI J V NEEL B G | 1993 | Anal Biochem1993，210，1： | 1 |
| 3 | Cytology of bone marrow显示文摘 | Grindem C B Neel J A Juopperi T A | | 0，，： | 1 |
| 4 | Role of the tyrosine phosphatase SHP-1 in K562 cell differentiation 显示文摘 | Bruecher-Encke B Griffin J Neel B | 2001 | Leukemia2001，15，9： | 1 |
| 5 | Growth factor-inducible alternative splicing of nontransmembrane phosphotyrosine phosphatase PTP-1B pre-mRNA显示文摘 | SHIFRIN V I NEEL B G | 1993 | J Biol Chem1993，268，25： | 1 |
| 6 | Two human c-onc genes are located on the long arm of chromosome 8 显示文摘 | Neel B G Jhanwar S C Chaganti R S Hayward W S | 1982 | Proc Natl Acad Scl USA1982，79，24： | 1 |
| 7 | The 'Shp' ing news: SH2 domaincontaining tyrosine phosphatases in cell signaling 显示文摘 | Neel B G Gu H Pao L | 2003 | Trends Biochem Sci2003，28，6： | 1 |
| 8 | The shpingnews SH2 domain-containing tyrosine phosphatases in cell signaling显示文摘 | GU H PAO L | 2003 | Thends Biochem Sci2003，28，： | 1 |
| 9 | New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3 - kinase/AKT pathway 显示文摘 | CANTLEY L C NEEL B G | 1999 | Proc Natl Acad Sci USA1999，96，8： | 1 |
| 10 | Electric fieldsuppression of epileptiform activity in hippocampal slices显示文摘 | Gluckman B J Neel E J Netoff T I | 1996 | Journal of Neurophysiology1996，76，6： | 1 |
| 11 | Using game theory to analyze wireless ad hoc networks显示文摘 | Srivastava V Neel J O MacKenzie A B | 2015 | IEEE Communications Surveys and Tutorials2015，7，14： | 1 |
| 12 | Avian leukosis virus-induced tumors have common proviral integration sites and synthesize discrete new RNAs:oncogenesis by promoter insertion显示文摘 | NEEL B G HAYWARD W S ROBINSON H L | 1981 | Cell1981，23，2： | 1 |
| 13 | The'Shp' ing news: SH2 domain2eontaining tyrosine phosphatases in cell signaling 显示文摘 | Neel B G Gu H Pao L | 2003 | Trends Bioehem Sci2003，28，6： | 1 |
| 14 | The 'Gab' in signal transduction显示文摘 | Gu H Neel B G | 2003 | Trends Cell Biol2003，13，3： | 1 |
| 15 | New insights into tumor suppression:PTEN suppression tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway显示文摘 | CANTLEY L C NEEL B G | 1999 | Proc Natl Acad Sci USA1999，96，8： | 1 |
| 16 | The 'Shp' ing news:SH2 domain-containing tyrosine phosphatases in cell signaling显示文摘 | Neel B G Gu H H Pao L L | 2003 | Trends Biochem Sci2003，28，6： | 1 |
| 17 | Chloroplast DNA diversity in populations of wild and cultivated barley显示文摘 | Neele D B Saghai M A Allard R W | 1988 | Genetics1988，120，： | 1 |
| 18 | Early glottic carcinoma treated with open laryngeal procedures 显示文摘 | Thomas J V Olsen K D Neel H B | 1994 | Arch Otolaryngol Head Neck Surg1994，120，： | 1 |
| 19 | The tyrosine phosphatase Shp2 (PTPN 11) in eancer显示文摘 | Chan G Kalaitzidis D Neel B G | 2008 | Cancer Metaslasis Rev2008，27，2： | 1 |
| 20 | Using game theory to analyze wireless ad hoc networks 显示文摘 | Srivastava V Neel J O MacKenzie A B | 2005 | IEEE Communications Surveys and Tutorials2005，7，14： | 1 |
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