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| 1 | Targeting inflammation in diabetes: Newer therapeutic options显示文摘Inflammation has been recognised to both decrease beta cell insulin secretion and increase insulin resis-tance. Circulating cytokines can affect beta cell function directly leading to secretory dysfunction and increased apoptosis. These cytokines can also indirectly affect beta cell function by increasing adipocyte inflamma-tion.The resulting glucotoxicity and lipotoxicity further enhance the inflammatory process resulting in a vicious cycle. Weight reduction and drugs such as metformin have been shown to decrease the levels of C-Reactive Protein by 31% and 13%, respectively. Pioglitazone, insulin and statins have anti-inflammatory effects. In-terleukin 1 and tumor necrosis factor-α antagonists are in trials and NSAIDs such as salsalate have shown an improvement in insulin sensitivity. Inhibition of 12-lipo-oxygenase, histone de-acetylases, and activation of sirtuin-1 are upcoming molecular targets to reduce in-flammation. These therapies have also been shown to decrease the conversion of pre-diabetes state to diabe-tes. Drugs like glicazide, troglitazone, N-acetylcysteine and selective COX-2 inhibitors have shown benefit in diabetic neuropathy by decreasing inflammatory mark-ers. Retinopathy drugs are used to target vascular en-dothelial growth factor, angiopoietin-2, various protein-ases and chemokines. Drugs targeting the proteinases and various chemokines are pentoxifylline, inhibitors of nuclear factor-kappa B and mammalian target of rapa-mycin and are in clinical trials for diabetic nephropathy. Commonly used drugs such as insulin, metformin, per-oxisome proliferator-activated receptors, glucagon like peptide-1 agonists and dipeptidyl peptidase-4 inhibitors also decrease inflammation. Anti-inflammatory thera-pies represent a potential approach for the therapy of diabetes and its complications. | Neeraj Kumar Agrawal Saket Kant | 2014 | World Journal of Diabetes2014，5，5： | 41 |
| 2 | PCSK9 inhibitors: A new era of lipid lowering therapy显示文摘Hyperlipidemia is a well-established risk factor for developing cardiovascular disease(CVD). The recent American College of Cardiology and American Heart Association guidelines on lipid management emphasize treatment of individuals at increased risk for developing CVD events with 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors(statins) at doses proven to reduce CVD events. However, there are limited options for patients who are either intolerant to statin therapy, develop CVD despite being on maximally tolerated statin therapy, or have severe hypercholesterolemia. Recently the Food and Drug Administration approved two novel medications for low-density lipoprotein(LDL)-cholesterol reduction: Evolocumab and Alirocumab. These agents target and inactivate proprotein convertase subtilsinkexin type 9(PCSK9), a hepatic protease that attaches and internalizes LDL receptors into lysosomes hence promoting their destruction. By preventing LDL receptor destruction, LDL-C levels can be lowered 50%-60% above that achieved by statin therapy alone. This review explores PCSK-9 biology and the mechanisms available to alter it; clinical trials targeting PCSK9 activity, and the current state of clinically available inhibitors of PCSK9. | Rahul Chaudhary Jalaj Garg Neeraj Shah Andrew Sumner | 2017 | World Journal of Cardiology2017，9，2： | 23 |
| 3 | Optimal distributed generation allocation in radial distribution systems considering customer-wise dedicated feeders and load patterns显示文摘Distribution system planners usually provide dedicated feeders to its different class of customers,each of whom has its own characteristic load pattern which varies hourly and seasonally.A more realistic modeling should be devised by considering the daily and seasonal variations in the aggregate load patterns of different class of customers.This paper addresses a new methodology to provide integrated solution for the optimal allocation of distributed generations and network reconfiguration considering load patterns of customers.The objectives considered are to maximize annual energy loss reduction and to maintain a better node voltage profile.Bat algorithm(BA)is a new bio-inspired search algorithm which has shown an advance capability to reach into the promising region,but its exploration is inadequate.The problem is solved by proposing the improved BA(IBA).The proposed method is investigated on the benchmark IEEE 33-bus test distribution system and the results are very promising. | Neeraj KANWAR Nikhil GUPTA K.R.NIAZI Anil SWARNKAR | 2015 | Journal of Modern Power Systems and Clean Energy2015，3，4： | 16 |
| 4 | Antihyperglycemic activity,antihyperlipedemic activity,haematological effects and histopathological analysis of Sapindus mukorossi Gaerten fruits in streptozotocin induced diabetic rats显示文摘Objective:To investigate the antihyperglycemic and antihyperlipidemie properties of hydroalcoholic extract of fruits of Sapindus mukorossi Caerlen and its beneficial effect on haeniatological parameters with histopathological analysis in streptpzotocin induced diabetic rats.Methods:Sapindus mukorossi fruits extract(250 and 500 mg/kg body weight) and standard drug glybenclamide(0.5 mg/kg body weight) were administered to diabetic rats.Effect of extract on hyperglycemia,hyperlipidemia and hematological parameters was studied in diabetic rats.Histopathological changes in diabetic rat pancreas were also observed after extract and glybenclamide treatment.Results:Daily oral administration of Sapindus mukorossi fruits extract(250 and 500 mg/kg body weight) and glybenclamide for 20 days showed beneficial effects on blood glucose level(P<0.01) and lipid level.The extract has a favorable effect on the histopathological changes of the pancreas in streptozotocin induced diabetes.Conclusions: These findings reveal that the hydroalcoholic extract of Sapindus mukorossi fruits extract possesses antihyperglycemic and antihyperlipidemie properties.In addition.the extract can prevent various complications of diabetes and improve some haeniatological parameters. | Neeraj Verma G Amresh P K Sahu Neelam Mishra Anil P Singh Ch V Rao | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，7： | 14 |
| 5 | Cryptanalysis and improvement of a certificateless signcryption scheme without bilinear pairing显示文摘 | Wenbo SHI Neeraj KUMAR Peng GONG Zezhong ZHANG | 2014 | Frontiers of Computer Science2014，8，4： | 11 |
| 6 | Hepatoprotective potential of ethanolic extract of Ziziphus oenoplia(L.)Mill roots against antitubercular drugs induced hepatotoxicity in experimental models显示文摘Objective:To evaluate the hepatoprotective potential of ethanolic(50%) extract of Ziziphus oenoplia(L.) Mill(Z.oenoplia) root against isoniazid(INH) and rifampicin(RIF) induced liver damage in animal models.Methods:Five groups of six rats each were selected for the study.Ethanolic extract at a dose of 150 and 300 mg/kg as well as silymarin(100 mg/kg) were administered orally once daily for 21 d in INH + RIF treated groups.The serum levels of glutamic oxaloacetic transaminase(SGOT),glutamate pyruvate transaminase(SGPT),alkaline phosphatase (SALP),and bilirubin were estimated along with activities of superoxide dismutase,catalase, glutathione S-transferase,glutathione peroxidase,and hepatic melondialdehyde formation. Histopathological analysis was carried out to assess injury to the liver.Result:The considerably elevated serum enzymatic activities of glutamic oxaloacetic transaminase,glutamate pyruvate transaminase,alkaline phosphatase and bilirubin due to INH + RIF treatment were restored towards norma) in a dose dependent manner after the treatment with ethanolic extract of Z.oenoplia roots.Meanwhile,the decreased activities of superoxide dismutase,catalase, glutathione S-transferase and glutathione peroxidase were also restored towards normal dose dependency.In addition,ethanolic extract also significantly prevented the elevation of hepatic melondialdehyde formation in the liver of INH + RIF intoxicated rats in a dose dependent manner. The biochemical observations were supplemented with histopathological examination of rat liver sections.Conclusions:The results of this study slrongly indicate that ethanolic extract of Z.oenoplia has a potent hepatoprotective action against INH + RIF induced hepatic damage in rats. | Ch V Rao AKS Rawat Anil P Singh Arpita Singh Neeraj Verma | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，4： | 6 |
| 7 | Antioxidant activity and identification of bioactive compounds from leaves of Anthocephalus cadamba by ultra-performance liquid chromatography/electrospray ionization quadrupole time of flight mass spectrometry显示文摘Objective:To evaluate the antioxidant potential of different extract/fractions of Anthocephalus cadamba(A.cadamba)(Roxb.) Miq.(Rubiaceae) and study the tentative identification of their active constituents.Methods:The extract/fractions were screened for antioxidant activity using various in vitro assays viz.DPPH assay,ABTS assay,superoxide anion radical scavenging assay, reducing power assay and plasmid DNA nicking assay.Total phenolic content of extract/fractions was determined by colorimetric method.An ultra-performance LC-electrospray-quadrupoletime of flight mass spectrometry method was used to analyse the active constituents of extract/ fractions of A.cadamba.Results:The ethyl acetate fraction was found to be most active fraction in all the assays as compared to other extract/fractions.The IC50 value of ethyl acetate fraction (ETAC fraction) was 21.24μg/mL,1.12μg/mL,9.68μg/mL and S7.81μg/mL in DPPH assay, ABTS assay,reducing power assay and superoxide scavenging assay respectively.All the extract/ fractions also showed the potential to protect the plasmid DNA(pBR322) against the attack of hydroxyl radicals generated by Fenton’s reagent.The bioactive compounds were identified by UPLC-ESI-QTOF-MS,by comparing the mass andλmax with literature values.Conclusions:The potential of the extract/fractions to scavenge different free radicals in different systems indicated that they may be useful therapeutic agents for treating radical-related pathologic damage. | Madhu Chandel Upendra Sharma Neeraj Kumar Bikram Singh Satwinderjeet Kaur | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，12： | 6 |
| 8 | Intramedullary devices in the management of Judet III and IV paediatric radial neck fractures显示文摘这研究的 PurposeThe 目的是讨论在儿科学的光线的颈破裂的管理使用的不同 intramedullary 设备的结果并且建议方法与孤立的 Judet III 避免 technique.MethodsThirty 病人的陷井, IV 破裂在这未来的研究被包括。我和 II 破裂和光线的颈破裂与另外的损害联系了的 Judet 被排除。最后的结果用 Metaizeau 功能的得分系统被分级,牛津肘 Score.ResultsThe 功能的结果对好在 30 个盒子(80%) 中的 24 个中优秀。吝啬的牛津肘分数是 44.32。吝啬的后续是 40.11 个月。看见的复杂并发症是 radiocapitellar 关节穿入 - 在平均数 4.87 星期的 6 个盒子,排水量 - 6,光线的 epiphyseal 硬化 - 5,并且 heterotopic 骨化 - 1 根 case.ConclusionIntramedullary K 电线可以导致 radiocapitellar 关节穿入。钛有弹性的钉子系统不应该是被使用完全他们不能阻止排水量的固定设备。常规后续是直到至少 6 个星期必要的。有 Judet IV 破裂并且需要打开减小的病人应该被给看守预后。纸加亮这种技术的陷井并且关于类型做建议植入,在 Judet IV 的后续和耐心的 counselling 断裂。 | Manish Kiran Colin Bruce Harvey George Neeraj Garg Roger Walton | 2018 | Chinese Journal of Traumatology2018，21，1： | 5 |
| 9 | Life style modification improves insulin resistance and liver histology in patients with non-alcoholic fatty liver disease显示文摘AIM: To study the effect of regular aerobic exercise on insulin resistance, serum aminotransferase and liver histology in nonalcoholic fatty liver disease (NAFLD) patients. METHODS: Sixty (mean age 40.0 ± 8.5 years, 75% male) NAFLD patients were included in the study. After baseline anthropometric measurement i.e., body mass index (BMI), waist circumference (WC); all patients were advised regular aerobic exercise for 30 min/d, for at least 5 d/wk and trained to achieve around 70% of his maximal heart rate. In addition, moderately energy restricted diet was advised to patients with high BMI (> 25 kg/m 2 ). Monthly follow up was done by measuring BMI, WC, aspartate aminotransferase, and alanine aminotransferase (ALT). Insulin resistance was calculated using homeostasis model assessment (HOMA) of insulin resistance (HOMA-IR) model, at baseline and after 6mo. Insulin resistance was arbitrarily considered altered when it was ≥ 2. Liver biopsy was done in a section of patients at baseline and after 6 mo. RESULTS: Seventy percent (42/60) patients were overweight or obese; 95% (57/60) had central obesity (WC > 90 cm in men, > 80 cm in women). In the 45 exercise compliant patients insulin resistance decreased from 6.4 ± 6.1 to 1.3 ± 1.0, BMI from 26.7 ± 3.3 kg/m 2 to 25.0 ± 3.3 kg/m 2 , WC from 95.7 ± 8.9 cm to 90.8 ± 7.3 cm and ALT from 84.8 ± 43.5 U/L to 41.3 ± 18.2 U/L (P < 0.01). In 15 exercise noncompliant patient's insulin resistance, BMI, WC and ALT did not show significant change at 6 mo follow up. Six of 8 patients in compliant group on repeat liver biopsy showed significant change in steatosis and necroinflammation. Nonalcoholic steatohepatitis scores improved form 5.3 ± 1.5 to 3.35 ± 1.5. The decline in insulin resistance correlated with decline in ALT (P = 0.01, r s = 0.90) and liver histology (P = 0.03, r s = 0.73). CONCLUSION: Life style modification improves insulin resistance resulting in improvement in ALT and liver histology in NAFLD patients. | Ganesh Bhat Chalamalasetty Sreenivasa Baba Amaresh Pandey Neeraj Kumari Gourdas Choudhuri | 2012 | World Journal of Hepatology2012，4，7： | 5 |
| 10 | 硼酸铝晶须增强铝基复合材料的显微组织、力学性能和磨损性能显示文摘通过传统的粉末冶金技术制备不同含量硼酸铝晶须(ABOw)(5%, 10%, 15%,质量分数)增强的商业纯铝基复合材料,并对其显微组织特征和力学性能进行研究。采用粉末冶金方法有效混合铝粉和ABOw,将混合粉冷压后在600℃下烧结。通过光学显微镜(OM)、扫描电子显微镜(SEM)、能谱分析(EDS)、透射电子显微镜(TEM)和X射线衍射(XRD)对烧结后的复合材料进行显微组织表征,测定复合材料的孔隙率随ABOw含量的变化,研究ABOw含量变化对复合材料的力学性能,包括硬度、抗弯强度和抗压强度的影响,及复合材料在恒定载荷下、不同滑动距离下的干滑动磨损行为。结果表明,当ABOw含量为10%(质量分数)时,复合材料具有最大的抗弯强度和抗压强度,分别为172 MPa和324 MPa,并且硬度得到改善,约为HV 40.2。但是,随着ABOw含量的进一步增加,性能降低。含10%ABOw复合材料的耐磨性能也得到显著提高。Al-10%ABOw复合材料优异的综合性能归因于其具有良好的界面结合性能、低的孔隙率和好的组织均匀性。 | Neeraj PANDEY ICHAKRABARTY Kalpana BARKANE NSMEHTA MRMAJHI | 2020 | Transactions of Nonferrous Metals Society of China2020，30，7： | 5 |
| 11 | Outcome predictors for severely brain-injured patients directly admitted or transferred from emergency departments to a trauma center显示文摘Dear editor,After sustaining severe traumatic brain injury(TBI),patients frequently require invasive mechanical ventilation(MV).However,up to 26%of patients require tracheostomy due to failure to wean from the ventilator.[1]The decision of when to perform tracheostomy is important as it balances the risk between avoiding prolonged MV and avoiding risk of tracheostomy.Early predictors for tracheostomy,i.e.,clinical factors when patients first present to an Emergency Department after trauma or when patient fi rst arrive at a regional trauma center,can help clinicians’medical decision-making process. | Ryne Jenkins Nicholas A.Morris Bryce Haac Richard Van Besien Deborah MStein Neeraj Badjatia Amir Medic Gaurika Mester Quincy K.Tran | 2020 | World Journal of Emergency Medicine2020，11，2： | 4 |
| 12 | Evaluation of anti-apoptotic activity of different dietary antioxidants in renal cell carcinoma against hydrogen peroxide显示文摘Objective:To evaluate the anti-apoptotic and radical scavenging activities of dietary phenolics, namely ascorbic acid,a-tocopherol acetate,citric acid,salicylic acid,and estimate H_2O_2induced apoptosis in renal cell carcinoma cells.Methods:The intracellular antioxidant potency of antioxidants was investigated.H_2O-2-induced apoptosis in RCC-26 was assayed with the following parameters:cell viability(%apoptosis),nucleosomal damage and DNA fragmentation, bcl-2 levels and flow cytometery analysis(ROS production evaluation).Results:Ine anticancer properties of antioxidants such as ascorbic acid,a- tocopherol acetate,citric acid,salicylic acid with perdurable responses were investigated.It was observed that these antioxidants had protective effect(anti-apoptotic activity) against hydrogen peroxide(H_2O_2) in renal cell carcinoma(RCC-26) cell line.Conclusions:This study reveals and proves the anticancer properties.However,in cancer cell lines anti-apoptotic activity can indirectly reflect the cancer promoter activity through radicals scavenging,and significantly protect nucleus and bcl-2. | Garg Neeraj K Mangal Sharad Sahu Tejram Mehta Abhinav Vyas Suresh P Tyagi Rajeev K | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，1： | 4 |
| 13 | SecBCS: a secure and privacy-preserving blockchain-based crowdsourcing system显示文摘A robust and scalable crowd management infrastructure is crucial in addressing operational challenges when deploying high-density sensors and actuators in a smart city. While crowdsourcing is widely used in crowd management, conventional solutions, such as Upwork and Amazon Mechanical Turk, generally depend on a trusted third-party platform. There exist several potential security concerns(e.g., sensitive leakage, single point of failure and unfair judgment) in such a centralized paradigm. Hence, a recent trend in crowdsourcing is to leverage blockchain(a decentralized ledger technology) to address some of the existing limitations. A small number of blockchain-based crowdsourcing systems(BCSs) with incentive mechanisms have been proposed in the literature, but they are generally not designed with security in mind. Thus, we study the security and privacy requirements of a secure BCS and propose a concrete solution(i.e., SecBCS)with a prototype implementation based on JUICE. | Chao LIN Debiao HE Sherali ZEADALLY Neeraj KUMAR Kim-Kwang Raymond CHOO | 2020 | Science China(Information Sciences)2020，63，3： | 4 |
| 14 | Anti-arthritis activity of roots of Hemidesmus indicus R.Br.(Anantmul)in rats显示文摘Objective:To investigate the protective effects of hydroalcoholic and its fractions from roots of Hemidesmus indicus on arthritis in in vitro models of rodents.Methods:Preliminary phytochemical analysis and thin-layer chromoatography were performed to analyze constituents of hydroalcoholic extract and its three fraction namely ethyl acetate fraction,chloroform fraction and residual fraction of mot of Hemidesmus indicus.Arthritis rats models were established by Complete Freund’s Adjuvant.The parameters including paw edema,body weight,arthritic index,erythrocyte sedimentation rate,serum rheumatoid factor,serum C-reactive protein,serum nitrite level,and histopathology of synovial joints were observed.Methotrexate was taken as positive control.Results:Rats treated with hydroalcoholic extract(450 mg/kg,p.o.),ethyl acetate (75 mg/kg,p.o.),chloroform(60 mg/kg,p.o) and residual fractions(270 mg/kg,p.o.),showed significant decrease in physical and biochemical parameters compared with arthritic model rats. Hydroalcoholic extract and its ethyl acetate fraction of Hemidesmus indicus showed significantly higher anti-arthritic activity than chloroform and residual fraction.Histopathological analysis demonstrated that both of hydroalcoholic extract and its ethyl acetate fraction had comparable anti-arthritic activity with methotrexates.Conclusions:The present study suggests that Hemidesmus indicus has protective activity against arthritis and the activity might be attributed to presence of terpenoid in hydroalcoholic extract,as well as in ethyl acetate fraction. | Alka Mehta Neeraj K Sethiya Chetan Mehta GB Shah | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，2： | 4 |
| 15 | Who benefits from percutaneous closure of patent foramen ovale vs medical therapy for stroke prevention? In-depth and updated metaanalysis of randomized trials显示文摘BACKGROUND A few randomized clinical trials(RCT) and their meta-analyses have found patent foramen ovale closure(PFOC) to be beneficial in prevention of stroke compared to medical therapy. Whether the benefit is extended across all groups of patients remains unclear.AIM To evaluate the efficacy and safety of PFOC vs medical therapy in different groups of patients presenting with stroke, we performed this meta-analysis of RCTs.METHODS Electronic search of PubMed, EMBASE, Cochrane Central, CINAHL and ProQuest Central and manual search were performed from inception through September 2018 for RCTs. Ischemic stroke(IS), transient ischemic attack(TIA), a composite of IS, TIA and systemic embolism(SE), mortality, major bleeding,atrial fibrillation(AF) and procedural complications were the major outcomes.Random-effects model was used to perform analyses.RESULTS Meta-analysis of 6 RCTs including 3560 patients showed that the PFOC,compared to medical therapy reduced the risk of IS [odds ratio: 0.34; 95%confidence interval: 0.15-0.78; P = 0.01] and the composite of IS, TIA and SE [0.55(0.32-0.93); P = 0.02] and increased the AF risk [4.79(2.35-9.77); P < 0.0001]. No statistical difference was observed in the risk of TIA [0.86(0.54-1.38); P = 0.54],mortality [0.74(0.28-1.93); P = 0.53] and major bleeding [0.81(0.42-1.56); P = 0.53]between two strategies. Subgroup analyses showed that compared to medical therapy, PFOC reduced the risk of stroke in persons who were males, ≤ 45 years of age and had large shunt or atrial septal aneurysm.CONCLUSION In certain groups of patients presenting with stroke, PFOC is beneficial in preventing future stroke compared to medical therapy. | Khagendra Dahal Adil Yousuf Hussam Watti Brannen Liang Sharan Sharma Jharendra Rijal Pavan Katikaneni Kalgi Modi Neeraj TANDon Michael Azrin Juyong Lee | 2019 | World Journal of Cardiology2019，11，4： | 4 |
| 16 | 利用卫星遥感和GIS技术测定印度切蒂斯格尔地区干旱热带森林的土地利用、生物量和碳贮量(英文)显示文摘2001-2002年间,利用卫星遥感和GIS技术研究印度切蒂斯格尔邦的赖布尔地区干旱热带森林的土地利用、生物量和碳贮量情况。主要森林类型为:柚木森林、混合林、衰退森林和婆罗双树混交林。在这些不同森林类型中,立地的坡度和坡面影响森林植被类型、生物量和碳贮量。不同森林类型中,木材积蓄积量、生物量和碳贮量的变化范围分别为:35.59~64.31 m3·hm-2、45.94~78.31Mg·hm-2和22.97~33.27Mg·hm-2。混合林中每公顷的木材蓄积量、生物量和碳贮量最大,衰退森林中的最低。混合林、柚木森林、衰退森林和婆罗双树混交林的总碳量分别为8170.72 Mg、81656.91 Mg、7833.23 Mg和7470.45 Mg。蒂斯格尔邦地区干旱热带森林处于不成熟的生长阶段,且具有很强的碳回收潜力。图6表7参49。 | Arvind Bijalwan S.L.Swamy Chandra Mohan Sharma Neeraj Kumar Sharma A.K.Tiwari | 2010 | Journal of Forestry Research2010，21，2： | 3 |
| 17 | Investigation of tuberculosis clusters in Dehradun city of India显示文摘Objective:To investigate the presence of statistically significant geographical clusters of tuberculosis(TB) using Geographical Information System and spatial scan statistics in Dehradun, India.Methods:The spatial scan statistic implemented with a software program,SaTScan v6.1, was used to test the presence of statistically significant spatial clusters of TB and to identify their approximate locations(P<0.05 for primary clusters and P<0.1 for secondary clusters). Geographical Information System was used for geographical analysis.Results:Significant high rate spatial clusters were identified in seven wards of the Dehradun Municipal area. Conclusions:There is sufficient evidence about the existence of statistically significant TB clusters in seven wards of Dehradun,India.The purely spatial scan statistics methodology used in this study has a potential use in surveillance of TB for detecting the true clusters of the disease. | Neeraj Tiwari Vineeta Kandpal Ajoy Tewari K.Ram Mohan Rao Tolia VS | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，6： | 3 |
| 18 | Milk exosomes:Nature’s abundant nanoplatform for theranostic applications显示文摘Exosomes are a unique subpopulation of naturally occurring extracellular vesicles which are smaller intracellular membrane nanoparticle vesicles.Exosomes have proven to be excellent nanocarriers for carrying lipids,proteins,mRNAs,non-coding RNAs,and DNAs,and disseminating long-distance intercellular communications in various biological processes.Among various cell-line or biological fluid derived exosomes,milk exosomes are abundant in nature and exhibit many nanocarrier characteristics favorable for theranostic applications.To be an effective delivery carrier for their clinical translation,exosomes must inbuilt loading,release,targeting,and imaging/tracking characteristics.Considering the unmet gaps of milk exosomes in theranostic technology it is essential to focus the current review on drug delivery and imaging applications.This review delineates the efficiency of exosomes to load therapeutic or imaging agents and their successful delivery approaches.It is emphasized on possible modifications of exosomes towards increasing the stability and delivery of agents.This article also summarizes the specific applications and the process of developing milk exosomes as a future pharmaceutical drug delivery vehicle. | Benilde Adriano Nycol M.Cotto Neeraj Chauhan Meena Jaggi Subhash C.Chauhan Murali M.Yallapu | 2021 | Bioactive Materials2021，6，8： | 2 |
| 19 | 白念珠菌SSK1突变株对氟康唑敏感性的初步研究显示文摘目的探讨氟康唑作用于白念珠菌双组分信号传导途径SSK1突变株SSK21后药物敏感性的变化。方法采用微量液体稀释法和固醇测定法测定野生株(CAF2-1)和突变株(SSK21)的最小抑菌浓度(MIC);并应用RT-PCR观察氟康唑作用前后,SSK1的表达变化。结果氟康唑对CAF2-1的MIC为16μg/mL,对SSK21为0.032μg/mL。加入氟康唑后,CAF2-1的SSK1表达明显增加,60min时达到最多。结论 SSK21对氟康唑高度敏感,SSK1基因及其相关的重要基因与药物敏感性的关系值得进一步研究,从而为新的抗真菌药物和治疗途径的研发提供参考。 | 李筱芳 Neeraj Chauhan Richard Calderone 刘维达 | 2010 | 中国真菌学杂志2010，5，5： | 2 |
| 20 | 建立林业部和非政府组织间的信任——印度参与式森林经营的政策和实践 | Neeraj Kumar Negi 李文英 | 2000 | 林业与社会2000，，5： | 2 |
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