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| 1 | Over expression of resistin in adipose tissue of the obese induces insulin resistance显示文摘AIM: To compare resistin mRNA expression in subcutaneous adipose tissue (SAT) and its correlation with insulin resistance (IR) in postmenopausal obese women. METHODS: A total of 68 postmenopausal women (non obese = 34 and obese = 34) were enrolled for the study. The women of the two groups were age matched (49-70 years). Fasting blood samples were collected at admission and abdominal SAT was obtained during surgery for gall bladder stones or hysterectomy. Physical parameters [age, height, weight, body mass index (BMI)] were measured. Biochemical (plasma insulin and plasma glucose) parameters were estimated by enzymatic methods. RNA was isolated by the Trizol method.SAT resistin mRNA expression was done by real time- reverse transcription polymerase chain reaction (RT-PCR) by using Quanti Tect SYBR Green RT-PCR master mix. Data was analyzed using independent Student's t test, correlation and simple linear regression analysis. RESULTS: The mean weight (52.81 ± 8.04 kg vs 79.56 ± 9.91 kg; P < 0.001), BMI (20.23 ± 3.05 kg/m 2 vs 32.19 ± 4.86 kg/m 2 ; P < 0.001), insulin (8.47 ± 3.24 U/mL vs 14.67 ± 2.18 U/mL; P < 0.001), glucose (97.44 ± 11.31 mg/dL vs 109.67 ± 8.02 mg/dL; P < 0.001) and homeostasis model assessment index (2.01 ± 0.73 vs 3.96 ± 0.61; P < 0.001) were significantly higher in postmenopausal obese women compared to postmenopausal non obese women. The mean serum resistin level was also significantly higher in postmeno-pausal obese women compared to postmenopausal non obese women (9.05 ± 5.15 vs 13.92 ± 6.32, P < 0.001). Furthermore, the mean SAT resistin mRNA expression was also significantly (0.023 ± 0.008 vs 0.036 ± 0.009; P < 0.001) higher and over expressed 1.62 fold (upregulated) in postmenopausal obese women compared to postmenopausal non obese women. In postmeno-pausal obese women, the relative SAT resistin mRNA expression showed positive (direct) and significant correlation with BMI (r = 0.78, P < 0.001) and serum resistin (r = 0.76, P < 0.001). Furthermore, the SAT resistin mRNA expression in postmenopausal obese women also showed significant and direct association (r = 0.45, P < 0.01) with IR, while in postmenopausal non obese women it did not show any association (r = -0.04, P > 0.05). CONCLUSION: Increased SAT resistin mRNA expres-sion probably leads to inducing insulin resistance and thus may be associated with obesity-related disorders in postmenopausal obese women. | Sadashiv Sunita Tiwari S Dhananjai Bhola N Paul Sandeep Kumar Abhijit Chandra Mahendra PS Negi | 2012 | World Journal of Diabetes2012，3，7： | 10 |
| 2 | A comparative study of optical designs and solar flux concentrating characteristics of a linear Fresnel reflector solar concentrator with tubular absorber显示文摘 | Sootha G D Negi B S | 1994 | Solar Energy Materials and Solar Cells1994，32，2： | 1 |
| 3 | Establishment and growth of Quercus flvribunda seedhngs after a mast year显示文摘 | Negi A G Singh S P | 1998 | Journal of Vegetation Science1998，7，： | 1 |
| 4 | Cytomorphologic study of Hashimoto/s thyroiditis and its serologic correlation: a study of 150 cases显示文摘 | Singh N Kumar S Negi VS | 2009 | Aeta2009，53，5： | 1 |
| 5 | Comparison of the conventional diagnostic modalities, bactec culture and polymerase chain reaction test for diagnosis of tuberculosis 显示文摘 | Negi SS Khan SF Gupta S | 2005 | Indian J Med Microbial2005，23，1： | 1 |
| 6 | An overview of the eye in diabetes显示文摘 | Negi A Vernon S A | 2003 | J R Soc Med2003，96，： | 1 |
| 7 | Ethylene regulates lateral root formation and auxin transport in Arabidopsis thaliana显示文摘 | Negi S Ivanchenko M G Muday G K | 2008 | The Plant Journal2008，55，2： | 1 |
| 8 | Use of purified soluble antigens of sheep poxvirus in serodiagnoss显示文摘 | RAO T V S NEGI B S BANSAL M P | 1997 | Indian Journal of Animal Sciences1997，67，： | 1 |
| 9 | Curcuminamino acid conjugates: Synthesis, antioxidant and antimutagenic attributes 显示文摘 | PARVATHY K S NEGI P S SRINIVAS P | 2010 | Food Chem2010，120，2： | 1 |
| 10 | Antioxidant and an- timutagenic activities of pomegranate peel extracts 显示文摘 | NEGI P S JAYAPRAKASHA G K IENA B S | 2003 | Food Chem- istry2003，80，3： | 1 |
| 11 | The study of renal osteodystrophy in adenine-induced chronic renal failure of rats 显示文摘 | Negi S | 1998 | J Wakayama Med Soc1998，49，： | 1 |
| 12 | Antioxidant and antimutagenic activities of pomegranate peel extracts显示文摘 | Negi P S Jayaprakasha G K Jena B S | 2003 | Food Chemistry2003，80，： | 1 |
| 13 | Guaranteeing secrecy using artificial noise 显示文摘 | Goel S Negi R | 2008 | IEEE Transactions on Wireless Communications2008，7，6： | 1 |
| 14 | Guaranteeing secrecy using artificial noise显示文摘 | Goel S Negi R | 2008 | IEEE Trans WC2008，7，6： | 1 |
| 15 | Development and standardization of a rapid diagnosis test for sheep pox显示文摘 | RAO T V S NEGI B S BANSAL M P | 1997 | Indian J Coup Microbiol Immunol Infect Dis1997，18，1： | 1 |
| 16 | Antioxidant and antimutagenic activities of pomegranate peel extracts 显示文摘 | Negi P S Jayaprakasha G K Jena B S | 2003 | Food Chemistry2003，80，3： | 1 |
| 17 | RP - HPLC method for the quan- titation of glabridin inYashti - madhu ( Glycyrrhiza glabra) 显示文摘 | Shanker K Fatima A Negi A S | 2007 | Chro- matographia2007，65，1112： | 1 |
| 18 | Guaranteeing secrecy using artificial noise 显示文摘 | Goel S Negi R | 2008 | IEEE Transactions on Wireless Communication2008，7，6： | 1 |
| 19 | Genetic dissection of the role of ethylene in regulating auxin-dependent lateral and adventitious root formation in tomato显示文摘 | Negi S Sukumar P Liu X | 2010 | The Plant Journal2010，61，1： | 1 |
| 20 | Guaranteeing secrecy using artificial noise显示文摘 | Goel S Negi R | 2008 | IEEE Trans Wireless Commun2008，7，6： | 1 |
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