| 3 | 打破物理隔离,建立高效安全云上新型管理体系显示文摘安全与连接是一对相生相克的孪生兄弟,企业在数字化转型过程中需要掌握两者之间的平衡点。只有实现了安全和联结的平衡,才能在新的管理体系中做到高效安全兼顾。互联网的发展打破了事物之间的物理间隔,把空间上不相关联的事物通过信息传递的方式连接起来,加速了世界的交流互动,并带来生产、生活方式的巨大转变。但事物之间的联系从来不是绝对的,安全是打破互联网无限连接的另一个力量。为了保证一定程度上业务、系统的安全,物理间隔和万物互联便相生相对。 | Alex Nehmy | 2023 | 数字经济2023，，3： | 0 |
| 4 | A novel supplement with yeast b-glucan, prebiotic, minerals and Silybum marianum synergistically modulates metabolic and inflammatory pathways and improves steatosis in obese mice显示文摘Objective: To evaluate the synergic effects of a novel oral supplement formulation, containing prebiotics,yeast b-glucans, minerals and silymarin(Silybum marianum), on lipid and glycidic metabolism, inflammatory and mitochondrial proteins of the liver, in control and high-fat diet-induced obese mice.Methods: After an acclimation period, 32 male C57 BL/6 mice were divided into the following groups:nonfat diet(NFD) vehicle, NFD supplemented, high-fat diet(HFD) vehicle and HFD supplemented. The vehicle and experimental formulation were administered orally by gavage once a day during the last four weeks of the diet(28 consecutive days). We then evaluated energy homeostasis, inflammation, and mitochondrial protein expression in these groups of mice.Results: After four weeks of supplementation, study groups experienced reduced glycemia, dyslipidemia,fat, and hepatic fibrosis levels. Additionally, proliferator-activated receptor-α, AMP-activated protein kinase-1α, peroxisome proliferator-activated receptor γ co-activator-1α, and mitochondrial transcription factor A expression levels were augmented;however, levels of inhibitor of nuclear factor-κB kinase subunit a and p65 nuclear factor-κB expression, and oxidative markers were reduced. Notably, the cortisol/C-reactive protein ratio, a well-characterized marker of the hypothalamic–pituitary–adrenal axis immune interface status, was found to be modulated by the supplement.Conclusion: We discovered that the novel supplement was able to modify different antioxidant, metabolic and inflammatory pathways, improving the energy homeostasis and inflammatory status, and consequently alleviated hepatic steatosis. | Victor Abou Nehmi Gilson Masahiro Murata Ruan Carlos Macêdo de Moraes Gabriely Cristina AlvesLima Danielle Araujo De Miranda Katrin Radloff Raquel Galvao Figuerêdo Costa Joyce de Cassia Rosade Jesus Jéssica Alves De Freitas Nayara Izabel Viana Ruan Pimenta Katia Ramos Moreira Leite JoséPinhata Otoch Ana Flávia Marcal Pessoa | 2021 | Journal of Integrative Medicine2021，19，5： | 0 |
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