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| 1 | Augmenting peripheral nerve regeneration using stem cells: A review of current opinion显示文摘Outcomes following peripheral nerve injury remain frustratingly poor. The reasons for this are multifactorial, although maintaining a growth permissive environment in the distal nerve stump following repair is arguably the most important. The optimal environment for axonal regeneration relies on the synthesis and release of many biochemical mediators that are temporally and spatially regulated with a high level of incompletely understood complexity. The Schwann cell(SC) has emerged as a key player in this process. Prolonged periods of distal nerve stump denervation, characteristic of large gaps and proximal injuries, have been associated with a reduction in SC number and ability to support regenerating axons. Cell based therapy offers a potential therapy for the improvement of outcomes following peripheral nerve reconstruction. Stem cells have the potential to increase the number of SCs and prolong their ability to support regeneration. They may also have the ability to rescue and replenish populations of chromatolytic and apoptotic neurons following axotomy. Finally, they can be used in non-physiologic ways to preserve injured tissues such as denervated muscle while neuronal ingrowth has not yet occurred. Aside from stem cell type, careful consideration must be given to differentiation status, how stem cells are supported following transplantation and how they will be delivered to the site of injury. It is the aim of this article to review current opinions on the strategies of stem cell based therapy for the augmentation of peripheral nerve regeneration. | Neil G Fairbairn Amanda M Meppelink Joanna Ng-Glazier Mark A Randolph Jonathan M Winograd | 2015 | World Journal of Stem Cells2015，7，1： | 12 |
| 2 | Efficacy of pancreatoscopy for pancreatic duct stones:A systematic review and meta-analysis显示文摘BACKGROUND Pancreatic duct stones can lead to significant abdominal pain for patients.Per oral pancreatoscopy(POP)-guided intracorporal lithotripsy is being increasingly used for the management of main pancreatic duct calculi(PDC)in chronic pancreatitis.POP uses two techniques:Electrohydraulic lithotripsy(EHL)and laser lithotripsy(LL).Data on the safety and efficacy are limited for this procedure.We performed a systematic review and meta-analysis with a primary aim to calculate the pooled technical and clinical success rates of POP.The secondary aim was to assess pooled rates of technical success,clinical success for the two individual techniques,and adverse event rates.AIM To perform a systematic review and meta-analysis of POP,EHL and LL for management of PDC in chronic pancreatitis.METHODS We conducted a comprehensive search of multiple electronic databases and conference proceedings including PubMed,EMBASE,Cochrane,Google Scholar and Web of Science databases(from 1999 to October 2019)to identify studies with patient age greater than 17 and any gender that reported on outcomes of POP,EHL and LL.The primary outcome assessed involved the pooled technical success and clinical success rate of POP.The secondary outcome included the pooled technical success and clinical success rate for EHL and LL.We also assessed the pooled rate of adverse events for POP,EHL and LL including a subgroup analysis for the rate of adverse event subtypes for POP:Hemorrhage,post-endoscopic retrograde cholangiopancreatography pancreatitis(PEP),perforation,abdominal pain,fever and infections.Technical success was defined as the rate of clearing pancreatic duct stones and clinical success as the improvement in pain.Randomeffects model was used for analysis.Heterogeneity between study-specific estimates was calculated using the Cochran Q statistical test and I2 statistics.Publication bias was ascertained,qualitatively by visual inspection of funnel plot and quantitatively by the Egger test.RESULTS A total of 16 studies including 383 patients met the inclusion criteria.The technical success rate of POP was 76.4%(95%CI:65.9-84.5;I2=64%)and clinical success rate was 76.8%(95%CI:65.2-85.4;I2=66%).The technical success rate of EHL was 70.3%(95%CI:57.8-80.3;I2=36%)and clinical success rate of EHL was 66.5%(95%CI:55.2-76.2;I2=19%).The technical success rate of LL was 89.3%(95%CI:70.5-96.7;I2=70%)and clinical success rate of LL was 88.2%(95%CI:66.4-96.6;I2=77%).The incidence of pooled adverse events for POP was 14.9%(95%CI:9.2-23.2;I2=49%),for EHL was 11.2%(95%CI:5.9-20.3;I2=15%)and for LL was 13.1%(95%CI:6.3-25.4;I2=31%).Subgroup analysis of adverse events showed rates of PEP at 7%(95%CI:3.5-13.6;I2=38%),fever at 3.7%(95%CI:2-6.9;I2=0),abdominal pain at 4.7%(95%CI:2.7-7.8;I2=0),perforation at 4.3%(95%CI:2.1-8.4;I2=0),hemorrhage at 3.4%(95%CI:1.7-6.6;I2=0)and no mortality.There was evidence of publication bias based on funnel plot analysis and Egger’s test.CONCLUSION Our study highlights the high technical and clinical success rates for POP,EHL and LL.POP-guided lithotripsy could be a viable option for management of chronic pancreatitis with PDC. | Syed M Saghir Harmeet S Mashiana Babu P Mohan Banreet S Dhindsa Amaninder Dhaliwal Saurabh Chandan Neil Bhogal Ishfaq Bhat Shailender Singh Douglas G Adler | 2020 | World Journal of Gastroenterology2020，26，34： | 5 |
| 3 | The protein kinase B/Akt signalling pathway in human malignancy显示文摘 | Karleen M Nicholson Neil G Anderson | 2002 | Cellular Signalling2002，，5： | 2 |
| 4 | 显示文摘 | O'Neil M Marohn J Mclendon G | 1990 | J Phys Chem1990，94，： | 1 |
| 5 | Male gender role con-flict :Psychometric issues and relations to psychological distress 显示文摘 | Good G E Robertson J M O'Neil J M | 1995 | Journal of Counseling Psychology1995，42，1： | 1 |
| 6 | A Tutorial on Particle Filters for Online Nonlinear/Non-Gaussian Bayesian Tracking显示文摘 | Sanjeev A M Simon M Neil G | 2002 | IEEE Trans on Signal Processing2002，50，2： | 1 |
| 7 | A tutorial on particle filters for on-line non-linear/non-Gaussian Bayesian traeking 显示文摘 | Sanjeev A Simon M Neil G | 2002 | IEEE Transactions on Signal Processing2002，50，2： | 1 |
| 8 | Fatty acid synthase effect on bovine adipose fat and milk fat 显示文摘 | Chris A M Neil G C Belinda C G | 2007 | Mammalian Ge- nome2007，18，1： | 1 |
| 9 | Harrisl,earning def- icits in congenitally hydrocephalic rats and prevention by early shunt treatment 显示文摘 | Hazel C Jones Katia M Rivera Neil G | 1995 | Child 's Nerv Syst1995，11，： | 1 |
| 10 | Tracing the density impulse in rural settlement systems: A quantitative analysis of the factors underlying rural population density across south-eastem Australia, 1981 - 2001 显示文摘 | Neil M A Peter J S Trevor G | 2005 | Population and Environment2005，27，2： | 1 |
| 11 | The relationship between the quantum yield of photosynthesis electron transport and quenching of chlorophyll fluorescence 显示文摘 | Bernard G Jean M B Neil R B | 1989 | Biochem biophys acta1989，990，1： | 1 |
| 12 | Resonance frequency analysis of implants subjected to immediate or early functional occlusal loading显示文摘 | Roland G Lars S Neil M | 2004 | Clin Oral Impl Res2004，15，4： | 1 |
| 13 | A Tutorial on particle filters for online nonlinear/non gaussian bayesian tracking显示文摘 | SANJEEV A M SIMON M NEIL G | 2002 | IEEE Transactions on Signal Processing2002，50，2： | 1 |
| 14 | Simultaneous quantitation of plasma doxorubicin and Prochlorperazine content by high performance liquid chromatography 显示文摘 | Caihong M Neil G Kasi SS | 1997 | J Chromatogr B1997，703，： | 1 |
| 15 | Incidence of Sal- monella contamination in broiler chickens in Saskatchewan 显示文摘 | Bhargava K K O'Neil J B Prior M G | 1983 | Can J Med1983，47，1： | 1 |
| 16 | Continuous infusion of lorazepam,midazolam,and propofol for sedsition of the ritically ill surgery trauma patient:a prospecttvc,randomized comparison显示文摘 | McCollam J S O′Neil M G Norcross E D | 1999 | Crit Care Med1999，27，11： | 1 |
| 17 | A tutorial on particle filters for on-line no-linear/non-Gaussian Bayesian tracking显示文摘 | Sanjeev A Simon M Neil G | 2002 | IEEE Trans on Signal Processing2002，50，2： | 1 |
| 18 | Effects of changing sparial scale on the analysis of landscape pattern显示文摘 | Turner M G O' Neil R V Gardner R H | 1989 | Landscape Ecology1989，3，： | 1 |
| 19 | The protein kinase B/Akt signalling pathway in human malignancy显示文摘 | Karleen M Nicholson Neil G Anderson | 2002 | Cellular Signalling2002，，5： | 1 |
| 20 | CD4^sup +^CD25^sup +^Foxp3^sup +^ Tregs resolve experimental lung injury in mice and are present in humans with acute lung injury显示文摘 | D’Alessio Franco R Tsushima Kenji Aggarwal Neil R West Erin E Willett Matthew H Britos Martin F Pipeling Matthew R Brower Roy G Tuder Rubin M McDyer John F King Landon S | 2009 | Journal of Clinical Investigation2009，，10： | 1 |
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