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| 1 | A 2D scintillator-based proton detector for high repetition rate experiments显示文摘We present a scintillator-based detector able to measure the proton energy and the spatial distribution with a relatively simple design.It has been designed and built at the Spanish Center for Pulsed Lasers(CLPU)in Salamanca and tested in the proton accelerator at the Centro de Micro-Análisis de Materiales(CMAM)in Madrid.The detector is capable of being set in the high repetition rate(HRR)mode and reproduces the performance of the radiochromic film detector.It represents a new class of online detectors for laser-plasma physics experiments in the newly emerging high power laser laboratories working at HRR. | M.Huault D.De Luis J.I.Apinaniz M.De Marco C.Salgado N.Gordillo C.Gutierrez Neira J.A.Perez-Hemandez R.Fedosejevs G.Gatti L.Roso L.Volpe | 2019 | High Power Laser Science and Engineering2019，7，4： | 2 |
| 2 | 术中应用荧光素钠有利于胶质母细胞瘤浸润边缘的手术切除(英文)显示文摘Objective Extent of resection is an important prognostic factor in patients undergoing surgery for glioblastoma( GBM).Recent evidence suggests that intravenously administered fluorescein sodium associates with tumor tissue,facilitating safe maximal resection of GBM. In this study,the authors evaluate the safety and utility of intraoperative fluorescein guidance for the prediction of histopathological alteration both in the contrast-enhancing( CE) regions,where this relationship has been established,and into the nonCE( NCE),diffusely infiltrated margins. Methods Thirty-two patients received fluorescein sodium( 3 mg/kg) intravenously prior to resection. Fluorescence was intraoperatively visualized using a Zeiss Pentero surgical microscope equipped with a YELLOW 560 filter.Stereotactically localized biopsy specimens were acquired from CE and NCE regions based on preoperative MRI in conjunction with neuronavigation. The fluorescence intensity of these specimens was subjectively classified in real time with subsequent quantitative image analysis,histopathological evaluation of localized biopsy specimens,and radiological volumetric assessment of the extent of resection.Results Bright fluorescence was observed in all GBMs and localized to the CE regions and portions of the NCE margins of the tumors,thus serving as a visual guide during resection. Gross-total resection( GTR) was achieved in 84% of the patients with an average resected volume of 95%,and this rate was higher among patients for whom GTR was the surgical goal( GTR achieved in 93. 1% of patients,average resected volume of 99. 7%). Intraoperative fluorescein staining correlated with histopathological alteration in both CE and NCE regions,with positive predictive values by subjective fluorescence evaluation greater than 96% in NCE regions. Conclusions Intraoperative administration of fluorescein provides an easily visualized marker for glioma pathology in both CE and NCE regions of GBM. These findingssupport the use of fluorescein as a microsurgical adjunct for guiding GBM resection to facilitate safe maximal removal. | Neira JA Ung TH Sims J Malone HR Chow DS Samanamud JL Zanazzi GJ Guo X Bowden SG Zhao B Sheth SA McKhann GM 2nd Sisti MB Canoll P D'Amico RS Bruce JN | 2016 | 中华神经外科疾病研究杂志2016，15，5： | 2 |
| 3 | Thetranscriptional repressor RYBP is a natively unfoldedprotein which folds upon binding to DNA显示文摘 | Neira JL Román-Trufero M Contreras LM | 2009 | Biochemis-try2009，48，6： | 1 |
| 4 | Fat liquefaction:effect of low-level laser energy on adipose tissue显示文摘 | Neira R Arroyave J Ramirez H | 2002 | Plast Reconstr Surg2002，110，3： | 1 |
| 5 | Hierarchical SLAM: Realtime accurate mapping of large environments 显示文摘 | C Estrada J Neira J D Tardos | 2005 | IEEE Transactions on Robotics (S1552-3098)2005，21，4： | 1 |
| 6 | Fat liquefaction: effect of low-level laser energy on adipose tissue显示文摘 | Neira R Arroyave J Ramirez H | 2002 | Plast Reconstr Surg2002，110，3： | 1 |
| 7 | Enteral nutrition through long-term jejunostomy显示文摘 | Femandez T Neira P Enrtquez C | 2008 | Nutr Hosp2008，23，1： | 1 |
| 8 | Data association in stochastic mapping using the joint compatibility test 显示文摘 | NEIRA J TARDOS J D | 2001 | IEEE Transactions on Robotics and Automation2001，17，6： | 1 |
| 9 | Phenolic character- ization of commercial enological tannins显示文摘 | Elias Obreque - Slier Alvaro Pe? a - Neira | 2009 | Eur Food Res Technol2009，229，： | 1 |
| 10 | Study of graft copolymerization on secondary cellulosic fiber with acrylonitrile 显示文摘 | Catalan R Neira A Rivas B | 2002 | J Appl Polym Sci2002，90，1： | 1 |
| 11 | Long-term ehanges in the mean trophie level of Central Chile fisherylandings显示文摘 | ARANCIBIA H NEIRA S | 2005 | Scientia Marina2005，69，2： | 1 |
| 12 | Fat liquefaction:effect of lowlevel laser energy on adipose tissue显示文摘 | Neira R Arroyave J Ramirez H | 2002 | Plast Reconstr Surg2002，110，3： | 1 |
| 13 | Data association in stochastic mapping using the joint compatibility test 显示文摘 | NEIRA J TARDOS J D | 2001 | IEEE Trans on Robotics and Automation2001，17，6： | 1 |
| 14 | Effects of high-dose of intravenous immunoglobulin and antibiotics on survival for severe sepsis underging surgery显示文摘 | RODRIGUEZ A RELLO J NEIRA J | 2005 | Shock2005，23，4： | 1 |
| 15 | Climatechange:a time of need and opportunity for the health sector显示文摘 | MCMICHAEL A J NEIRA M BERTOLLINI R | 2009 | Lancet2009，374，9707： | 1 |
| 16 | Low-level laser-assisted liposuction:the Neira 4 L technique显示文摘 | Neira R Toledo L Arroyave J | 2006 | Plast Surg2006，33，1： | 1 |
| 17 | Fat:Liquefaction:efect of low-level laser energy on adipose tissue显示文摘 | Neira R Arroyave J Ramirez H | 2002 | Plast Reconstr Surg2002，110，3： | 1 |
| 18 | The role of food in the epidemiology of cholera显示文摘 | Albert MJ Neira M Motarjemi Y | 1997 | World Health Stat Q1997，50，12： | 1 |
| 19 | oral sildenafil in infants with persistent pulmonary hypertension of the newborn: a pilot ran- domized blinded study 显示文摘 | Baquero H Soliz A Neira F | 2006 | Pediatrics2006，117，4： | 1 |
| 20 | The complex associations among sleep quality, anxiety-depression, and quality of life in patients with extreme obesity显示文摘 | Araghi MH1 Jagielski A Neira I | 2013 | Sleep2013，36，12： | 1 |
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