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| 1 | Device-associated infection rates, mortality, length of stay and bacterial resistance in intensive care units in Ecuador: International Nosocomial Infection Control Consortium's findings显示文摘AIM To report the results of the International Nosocomial Infection Control Consortium(INICC) study conducted in Quito, Ecuador.METHODS A device-associated healthcare-acquired infection(DAHAI) prospective surveillance study conducted from October 2013 to January 2015 in 2 adult intensive care units(ICUs) from 2 hospitals using the United States Centers for Disease Control/National Healthcare Safety Network(CDC/NHSN) definitions and INICC methods. RESULTS We followed 776 ICU patients for 4818 bed-days. The central line-associated bloodstream infection(CLABSI) rate was 6.5 per 1000 central line(CL)-days, the ventilator-associated pneumonia(VAP) rate was 44.3 per 1000 mechanical ventilator(MV)-days, and the catheterassociated urinary tract infection(CAUTI) rate was 5.7 per 1000 urinary catheter(UC)-days. CLABSI and CAUTI rates in our ICUs were similar to INICC rates [4.9(CLABSI) and 5.3(CAUTI)] and higher than NHSN rates [0.8(CLABSI) and 1.3(CAUTI)]- although device use ratios for CL and UC were higher than INICC and CDC/NSHN's ratios. By contrast, despite the VAP rate was higher than INICC(16.5) and NHSN's rates(1.1), MV DUR was lower in our ICUs. Resistance of A. baumannii to imipenem and meropenem was 75.0%, and of Pseudomonas aeruginosa to ciprofloxacin and piperacillin-tazobactam was higher than 72.7%, all them higher than CDC/NHSN rates. Excess length of stay was 7.4 d for patients with CLABSI, 4.8 for patients with VAP and 9.2 for patients CAUTI. Excess crude mortality in ICUs was 30.9% for CLABSI, 14.5% for VAP and 17.6% for CAUTI. CONCLUSION DA-HAI rates in our ICUs from Ecuador are higher than United States CDC/NSHN rates and similar to INICC international rates. | Estuardo Salgado Yepez Maria M Bovera Victor D Rosenthal Hugo A González Flores Leonardo Pazmino Francisco Valencia Nelly Alquinga Vanessa Ramirez Edgar Jara Miguel Lascano Veronica Delgado Cristian Cevallos Gasdali Santacruz Cristian Pelaéz Celso Zaruma Diego Barahona Pinto | 2017 | World Journal of Biological Chemistry2017，8，1： | 23 |
| 2 | Imaging plaque inflammation in asymptomatic cocaine addicted individuals with simultaneous positron emission tomography/magnetic resonance imaging显示文摘BACKGROUND Chronic cocaine use is associated with stroke, coronary artery disease and myocardial infarction, resulting in severe impairments or sudden mortality. In the absence of clear cardiovascular symptoms, individuals with cocaine use disorder (iCUD) seeking addiction treatment receive mostly psychotherapy and psychiatric pharmacotherapy, with no attention to vascular disease (i.e., atherosclerosis). Little is known about the pre-clinical signs of cardiovascular risk in iCUD and early signs of vascular disease are undetected in this underserved population. AIM To assess inflammation, plaque burden and plaque composition in iCUD aiming to detect markers of atherosclerosis and vascular disease. METHODS The bilateral carotid arteries were imaged with positron emission tomography/magnetic resonance imaging (PET/MRI) in iCUD asymptomatic for cardiovascular disease, healthy controls, and individuals with cardiovascular risk. PET with 18F-fluorodeoxyglucose (18F-FDG) evaluated vascular inflammation and 3-D dark-blood MRI assessed plaque burden including wall area and thickness. Drug use and severity of addiction were assessed with standardized instruments. RESULTS The majority of iCUD and controls had carotid FDG-PET signal greater than 1.6 but lower than 3, indicating the presence of mild to moderate inflammation. However, the MRI measure of wall structure was thicker in iCUD as compared to the controls and cardiovascular risk group, indicating greater carotid plaque burden. iCUD had larger wall area as compared to the healthy controls but not as compared to the cardiovascular risk group, indicating structural wall similarities between the non-control study groups. In iCUD, wall area correlated with greater cocaine withdrawal and craving. CONCLUSION These preliminary results show markers of carotid artery disease burden in cardiovascular disease-asymptomatic iCUD. Broader trials are warranted to develop protocols for early detection of cardiovascular risk and preventive intervention in iCUD. | Keren Bachi Venkatesh Mani Audrey E Kaufman Nadia Alie Rita Z Goldstein Zahi A Fayad Nelly Alia-Klein | 2019 | World Journal of Radiology2019，11，5： | 2 |
| 3 | Cluster model DFT study of the intermediates of benzene to phenol oxidation by N2O on FeZSM-5 zeolites显示文摘 | NELLY A K GEORGII M Z EMIEL J M | 2003 | Catalysis Letters2003，86，： | 1 |
| 4 | Activated carbon cloth as anode lbr sullhte removal in a microbial tirol cell显示文摘 | Feng Z Nelli R John R V | 2008 | Fnviron Sci Tecbnol2008，42，13： | 1 |
| 5 | Diagnosis and treatment of cervical tuberculous lymphadenitis 显示文摘 | Weiler Z Nelly P Baruchin A M | 2000 | J Oral Maxillofac Surg2000，58，5： | 1 |
| 6 | Diagnosis and treat- ment of cervical tuberculous lymphadenitis显示文摘 | Weiler Z Nelly P Baruchin AM | 2000 | J Oral Max- illofac Surg2000，58，5： | 1 |
| 7 | Diagnosis and treatment of cer-vical tuberculous lymphadenitis显示文摘 | Weiler Z Nelly P Baruchin AM | 2000 | J Oral Maxillofac Surg2000，58，5： | 1 |
| 8 | Activated carbon cloth as anode for sulfate removal in a microbial fuel cell 显示文摘 | FENG Z NELLI R JOHN R V | 2008 | Environmental Science and Technology2008，42，13： | 1 |
| 9 | Diagnosis and treatment of cervical tuberculous lymphadenitis显示文摘 | Weiler Z Nelly P Baruchin AM | 2000 | J Oral Maxillofac Surg2000，58，5： | 1 |
| 10 | Diagnosis and treatment of cervical tuberculous lymphadenitis 显示文摘 | Weiler Z Nelly P Baruchin AM | 2000 | J Oral Maxillofac Surg2000，58，5： | 1 |
| 11 | Randomized controlled trial of prenatal zinc supplementation and fetal bone growth显示文摘 | Mario M Laura E C Nelly Z | 2004 | Am J Clin Nutr2004，79，： | 1 |
| 12 | Elevated-pres- sure mixed-coolants Joule-Thomson cryocooling 显示文摘 | Maytal B Z Nellis G F Klein S A | 2006 | Cryo- genics2006，46，1： | 1 |
| 13 | Diagnosis and treatment of cervical tuberculous lymphadenitis 显示文摘 | Weiler Z Nelly P Baruchin AM | 2000 | J Oral MaxilIofac Surg2000，58，5： | 1 |
| 14 | Diagnosis and treatment of cer- vical tuberculous lymphadenitis显示文摘 | Weiler Z Nelly P Baruchin A M | 2000 | J Oral Maxillofac Surg2000，58，： | 1 |
| 15 | Randomized controlled trial of prenatal zinc supplementation and fetal bone growth显示文摘 | Mario M Laura E C Nelly Z | 2004 | Am J Clin Nutr2004，79，： | 1 |
| 16 | Effects of neoadjuvant chemotherapy vs chemoradiotherapy in the treatment of esophageal adenocarcinoma:A systematic review and meta-analysis显示文摘BACKGROUND Neoadjuvant therapy is an essential modality for reducing the clinical stage of esophageal cancer;however,the superiority of neoadjuvant chemotherapy(nCT)or neoadjuvant chemoradiotherapy(nCRT)is unclear.Therefore,a discussion of these two modalities is necessary.AIM To investigate the benefits and complications of neoadjuvant modalities.METHODS To address this concern,predefined criteria were established using the PICO protocol.Two independent authors performed comprehensive searches using predetermined keywords.Statistical analyses were performed to identify significant differences between groups.Potential publication bias was visualized using funnel plots.The quality of the data was evaluated using the Risk of Bias Tool 2(RoB2)and the GRADE approach.RESULTS Ten articles,including 1928 patients,were included for the analysis.Significant difference was detected in pathological complete response(pCR)[P<0.001;odds ratio(OR):0.27;95%CI:0.16-0.46],30-d mortality(P=0.015;OR:0.4;95%CI:0.22-0.71)favoring the nCRT,and renal failure(P=0.039;OR:1.04;95%CI:0.66-1.64)favoring the nCT.No significant differences were observed in terms of survival,local or distal recurrence,or other clinical or surgical complications.The result of RoB2 was moderate,and that of the GRADE approach was low or very low in almost all cases.CONCLUSION Although nCRT may have a higher pCR rate,it does not translate to greater long-term survival.Moreover,nCRT is associated with higher 30-d mortality,although the specific cause for postoperative complications could not be identified.In the case of nCT,toxic side effects are suspected,which can reduce the quality of life.Given the quality of available studies,further randomized trials are required. | Armand Csontos Alíz Fazekas Lajos Szakó Nelli Farkas Csenge Papp Szilárd Ferenczi Szabolcs Bellyei Péter Hegyi András Papp | 2024 | World Journal of Gastroenterology2024，30，11： | 0 |
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