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| 1 | Lipocalin 2 stimulates bone fibroblast growth factor 23 production in chronic kidney disease显示文摘Bone-produced fibroblast growth factor 23(FGF23)increases in response to inflammation and iron deficiency and contributes to cardiovascular mortality in chronic kidney disease(CKD).Neutrophil gelatinase-associated lipocalin(NGAL or lipocalin 2;LCN2 the murine homolog)is a pro-inflammatory and iron-shuttling molecule that is secreted in response to kidney injury and may promote CKD progression.We investigated bone FGF23 regulation by circulating LCN2.At 23 weeks,Col4a3KO mice showed impaired kidney function,increased levels of kidney and serum LCN2,increased bone and serum FGF23,anemia,and left ventricular hypertrophy(LVH).Deletion of Lcn2 in CKD mice did not improve kidney function or anemia but prevented the development of LVH and improved survival in association with marked reductions in serum FGF23.Lcn2 deletion specifically prevented FGF23 elevations in response to inflammation,but not iron deficiency or phosphate,and administration of LCN2 increased serum FGF23 in healthy and CKD mice by stimulating Fgf23 transcription via activation of cAMP-mediated signaling in bone cells.These results show that kidney-produced LCN2 is an important mediator of increased FGF23 production by bone in response to inflammation and in CKD.LCN2 inhibition might represent a potential therapeutic approach to lower FGF23 and improve outcomes in CKD. | Guillaume Courbon Connor Francis Claire Gerber Samantha Neuburg Xueyan Wang Emily Lynch Tamara Isakova Jodie LBabitt Myles Wolf Aline Martin Valentin David | 2021 | Bone Research2021，9，3： | 4 |
| 2 | Mode of Aaction of Fenamidone: Similarities and Differences with Known QoI显示文摘 | NEUBURGER M BEFFA R VILLIER A | 2003 | Pflanzenschutz-Nachrichten Bayer2003，56，3： | 1 |
| 3 | Structural investigation by extended X-ray absorption fine structure spectroscopy of the iron center of mitochondrial aconitase in higher plant cells显示文摘 | Jordanov J Courtois-Verniquet F Neuburger M | 1992 | J Biol Chem1992，267，16： | 1 |
| 4 | Planar chiral asymmetric naphthalenediimide cyclophanes:synthesis,characterization and tunable FRET properties显示文摘 | GABUTTI S SCHAFFNER S NEUBURGER M | | 0，，07： | 1 |
| 5 | Pilar leiomyoma:a case report and review of the literature显示文摘 | Latoni JD Neuburg M Matloub HS | 2000 | Ann Plast Surg2000，45，6： | 1 |
| 6 | Body mass index as an influencing factor for outcome of trabectome surgery 显示文摘 | Anton A Neuburger M Jordan JF | 2014 | Klin Monbl Augenhei- lkd2014，231，11： | 1 |
| 7 | Update on management of infections in cancer and stem cell transplant patients显示文摘 | Neuburger S Maschmeyer G | 2006 | Ann Hematol2006，85，6： | 1 |
| 8 | A model for the bacterial leaching of copper sulphide ores in pilot-scale columns显示文摘 | Neuburg H J Castillo J A Herrera M N Wiertz J V Vargas T Badilla-Ohlbaum R | 1991 | Int J Min Proc1991，31，2： | 1 |
| 9 | Unstrained InA1N/GaN HEMT structure 显示文摘 | NEUBURGER M ZIMMERMANN T KOHN E | 2004 | Int J High Speed Electron Syst2004，14，3： | 1 |
| 10 | Reduction of pulmonary edema by short-acting local anesthetics 显示文摘 | Konrad C J Schuepfer GK Neuburger M | 2006 | Reg Anesth Pain Med2006，31，3： | 1 |
| 11 | Inflam- mation and infection complications of 2285 perineural catheters: a prospective study 显示文摘 | Neuburger M Buttner J Blumenthal S | 2007 | Acta Anaesthesiol Scand2007，51，1： | 1 |
| 12 | Vertical infraclavicular block of brachial plexus:a clinical study of the reliability of a new method for plexusanaesthesia of the upper extremity显示文摘 | Neuburger M Kaiser H Rembold-Schuster I | | 0，，7： | 1 |
| 13 | Vertical infraclavicular block of brachial plexus: a clinical study of the reliability of a new method for plexus anaesthesia of the upper extremity显示文摘 | Neuburger M Kaiser H Rembold-Schuster I | 1998 | Anaesthesist1998，47，7： | 1 |
| 14 | Global gene expression profiling in whole-blood samples from individuals exposed to metal fumes显示文摘 | WANG Z NEUBURG D LI C | 2005 | Environ Health Perspect2005，113，： | 1 |
| 15 | Clinical results of the clarion magnetless cochlear implant显示文摘 | Weber BP Neuburger J Goldring JE | 1999 | Ann Otol Rhinol Laryngol1999，108，1： | 1 |
| 16 | 1 - Lithio- 2, 2 - diphenyl - 1 - (phenylsulfonyl)ethen: Synthese und Kristallstruktur显示文摘 | Müller V J Neuburger M Zehnder M | 1995 | Helve Chim Acta1995，78，： | 1 |
| 17 | Total Synthesis of Cyrneine A显示文摘 | Elamparuthi E Fellay C Neuburger M | 2012 | Angewandte Chemic International Edition2012，51，17： | 1 |
| 18 | 1 - Lithio - 2,2 - diphenyl- 1 - (phenylsul{onyl) ethen: Synthese and Kristallstruktur显示文摘 | Mller V J Neuburger M Zehnder M | 1995 | Helve Chim Acta1995，78，： | 1 |
| 19 | Development of language and speech perception in congenitally,profoundly deaf children as a function of age at cochlear implantation显示文摘 | SVIRSKY M A TEOH S W NEUBURGER H | 2004 | Audiol Neurootol2004，9，： | 1 |
| 20 | Intraorganelle localization and substrate specificities of the mitochondrial acyl - CoA : sn - glycerol - 3 - phosphate O - acyl - transferase and acyl - CoA : 1 - acyl - sn - glycerol - 3 - phosphate O - acyltransferase from potato tubers and pea leaves 显示文摘 | Frentzen M Neuburger M Joyard J | 1990 | Eur J Biochem1990，69，1： | 1 |
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