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| 1 | Epigenetic profiles of pre-diabetes transitioning to type 2 diabetes and nephropathy显示文摘AIM: To examine DNA methylation profiles in a longitudinal comparison of pre-diabetes mellitus(Pre-DM) subjects who transitioned to type 2 diabetes mellitus(T2DM).METHODS: We performed DNA methylation study in bisulphite converted DNA from Pre-DM(n = 11) at baseline and at their transition to T2 DM using Illumina Infinium Human Methylation27 Bead Chip, that enables the query of 27578 individual cytosines at Cp G loci throughout the genome, which are focused on the promoter regions of 14495 genes.RESULTS: There were 694 Cp G sites hypomethylated and 174 Cp G sites hypermethylated in progression from Pre-DM to T2 DM, representing putative genes involved in glucose and fructose metabolism, inflammation, oxidative and mitochondrial stress, and fatty acid metabolism. These results suggest that this high throughput platform is able to identify hundreds of prospective Cp G sites associated with diverse genes that may reflect differences in Pre-DM compared with T2 DM. In addition, there were Cp G hypomethylation changes associated with a number of genes that may be associated with development of complications of diabetes, such as nephropathy. These hypomethylation changes were observed in all of the subjects.CONCLUSION: These data suggest that some epigenomic changes that may be involved in the progression of diabetes and/or the development of complications may be apparent at the Pre-DM state or during the transition to diabetes. Hypomethylation of a number of genes related to kidney function may be an early marker for developing diabetic nephropathy. | Thomas A Vander Jagt Monica H Neugebauer Marilee Morgan Donald W Bowden Vallabh O Shah | 2015 | World Journal of Diabetes2015，6，9： | 5 |
| 2 | Relationship Between High Aortic Pulse Pressure and Extension of Coronary Atherosclerosis in Males显示文摘 | Parenica J Kala P Jarkovsky J Poloczek M Bocek O Jerábek P Neugebauer P Vytiska M Parenicová I Tomcíková D Goldbergová M Pávková Spinar J | 2011 | Physiological Research2011，，1： | 1 |
| 3 | The Early History of the Astrolabe显示文摘 | Neugebauer O | 1949 | Isis1949，，40： | 1 |
| 4 | Determinants of depressive symptoms in the early weeks after miscarriage显示文摘 | Neugebauer R Kline J O'Connor P | | 0，，： | 1 |
| 5 | TheFLOWLENS: A Focus-and-context VisualizationApproach for Exploration of Blood Flow in CerebralAneurysms 显示文摘 | Gasteiger R Neugebauer M Beuing O | 2011 | IEEE Transactions on Visualization andComputer Graphics (SI 077-2626)2011，17，12： | 1 |
| 6 | In situ spectro-electrochemical character-rization of poly (3,4-ethy-lenedioxythiophene)显示文摘 | Kvarnstr(o)m C Neugebauer H Blomquist S | 1999 | Electrochim Acta1999，44，： | 1 |
| 7 | Thgbit ben Qurra' On the Solar Year' and 'On the Motion of the Eighth Sphere' 显示文摘 | Neugebauer O | 1962 | Proceedings of the American Philosophical Society1962，106，26： | 1 |
| 8 | On the Planetary Theory of Copernicus显示文摘 | Neugebauer O | 1968 | Vistas in Astronomy1968，10，1： | 1 |
| 9 | The Early History of the Astrolabe显示文摘 | Neugebauer O | 1949 | Isis1949，40，： | 1 |
| 10 | A novel piezo vibration platform for probe dynamic performance calibration 显示文摘 | Liang R Jusko O Ludicke F Neugebauer M | 2001 | Measurement Science and Technology2001，12，9： | 1 |
| 11 | Distinguishing be- tween pain intensity and pain resolution: using acute post-surgical pain trajectories to predict chronic post-surgical pain 显示文摘 | Ahhaus A Arr6nz Becker O Neugebauer E | 2014 | Eur J Pain2014，18，4： | 1 |
| 12 | Norm inequalities for the minimal operator and maximal operator, and differentiation of the integral显示文摘 | Cruz-Uribe D S F O Neugebauer C J | 1997 | Publ Mat1997，41，： | 1 |
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